JP2007529204A5 - - Google Patents
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- Publication number
- JP2007529204A5 JP2007529204A5 JP2007503106A JP2007503106A JP2007529204A5 JP 2007529204 A5 JP2007529204 A5 JP 2007529204A5 JP 2007503106 A JP2007503106 A JP 2007503106A JP 2007503106 A JP2007503106 A JP 2007503106A JP 2007529204 A5 JP2007529204 A5 JP 2007529204A5
- Authority
- JP
- Japan
- Prior art keywords
- tim
- seq
- polypeptide
- amino acid
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 150000001413 amino acids Chemical class 0.000 claims 16
- 101100369802 Caenorhabditis elegans tim-1 gene Proteins 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 230000000069 prophylactic effect Effects 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 230000029662 T-helper 1 type immune response Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55252304P | 2004-03-12 | 2004-03-12 | |
| US60/552,523 | 2004-03-12 | ||
| US62255904P | 2004-10-27 | 2004-10-27 | |
| US60/622,559 | 2004-10-27 | ||
| PCT/US2005/008423 WO2005090573A2 (en) | 2004-03-12 | 2005-03-14 | Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255899A Division JP2012070749A (ja) | 2004-03-12 | 2011-11-24 | Ｔｉｍ−１、ｔｉｍ−２、およびｔｉｍ−４の機能を調節することによって免疫応答を調節する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007529204A JP2007529204A (ja) | 2007-10-25 |
| JP2007529204A5 true JP2007529204A5 (https=) | 2008-05-01 |
| JP4903128B2 JP4903128B2 (ja) | 2012-03-28 |
Family
ID=34994427
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503106A Expired - Fee Related JP4903128B2 (ja) | 2004-03-12 | 2005-03-14 | Ｔｉｍ−１、ｔｉｍ−２、およびｔｉｍ−４の機能を調節することによって免疫応答を調節する方法 |
| JP2011255899A Pending JP2012070749A (ja) | 2004-03-12 | 2011-11-24 | Ｔｉｍ−１、ｔｉｍ−２、およびｔｉｍ−４の機能を調節することによって免疫応答を調節する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011255899A Pending JP2012070749A (ja) | 2004-03-12 | 2011-11-24 | Ｔｉｍ−１、ｔｉｍ−２、およびｔｉｍ−４の機能を調節することによって免疫応答を調節する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7741271B2 (https=) |
| EP (1) | EP1735445B1 (https=) |
| JP (2) | JP4903128B2 (https=) |
| KR (1) | KR20060130731A (https=) |
| CN (1) | CN102861319A (https=) |
| AU (1) | AU2005224634A1 (https=) |
| BR (1) | BRPI0508553A (https=) |
| CA (1) | CA2558371C (https=) |
| IL (1) | IL178002A (https=) |
| MX (1) | MXPA06010419A (https=) |
| RU (1) | RU2006136011A (https=) |
| TW (1) | TW200539890A (https=) |
| WO (1) | WO2005090573A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2258793T5 (es) * | 1996-05-24 | 2010-01-25 | Biogen Idec Ma Inc. | Moduladores de la regeneracion tisular. |
| EP2025345A1 (en) * | 2002-12-30 | 2009-02-18 | Biogen Idec MA Inc. | KIM-1 antagonists and use to modulate immune system |
| KR20070037570A (ko) * | 2004-03-24 | 2007-04-05 | 텔로스 파마슈티칼스 인코포레이티드 | 백신에 대한 면역반응을 향상시키는 보강제로서의 조성물및 이의 사용 방법 |
| KR101213894B1 (ko) * | 2005-03-02 | 2012-12-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Ｔｈ2 매개성 병태를 치료하기 위한 ｋｉｍ-1 항체 |
| WO2007101254A2 (en) * | 2006-02-28 | 2007-09-07 | Telos Pharmaceuticals Llc | Compositions and methods for the treatment of immune system disorders |
| WO2009064290A1 (en) * | 2007-11-13 | 2009-05-22 | Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Structure of tim family members |
| WO2009131572A1 (en) * | 2008-04-22 | 2009-10-29 | Government Of The U.S. As Represented By The Secretary Of The Department Of Health And Human Service | Structure of tim family members |
| US9758794B2 (en) | 2008-04-22 | 2017-09-12 | Rutgers, The State University Of New Jersey | HCV E2 construct compositions and methods |
| CA2722423A1 (en) * | 2008-04-22 | 2009-10-29 | Rutgers, The State University | Hcv e2 construct compositions and methods |
| US10519233B2 (en) | 2011-11-21 | 2019-12-31 | University Of Tsukuba | Activity modulator, medicinal agent comprising same, use of CD300A gene-deficient mouse, and anti-CD300A antibody |
| US9850309B2 (en) | 2012-11-07 | 2017-12-26 | University Of Tsukuba | Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell |
| WO2014081598A1 (en) * | 2012-11-20 | 2014-05-30 | The Brigham And Women's Hospital, Inc. | Diagnosis and treatment of endometriosis and related conditions |
| KR101510742B1 (ko) | 2013-05-13 | 2015-04-10 | (주)케어젠 | 비만세포―특이적 아팝토시스-유도용 펩타이드 및 이의 용도 |
| EP3148564B1 (en) * | 2014-06-02 | 2020-01-08 | Children's Medical Center Corporation | Methods and compositions for immunomodulation |
| US10755078B2 (en) * | 2015-04-10 | 2020-08-25 | President And Fellows Of Harvard College | Methods and devices for live cell imaging analysis |
| US20180153986A1 (en) * | 2015-04-24 | 2018-06-07 | The Brigham And Women's Hospital, Inc. | Interactions between ceacam and tim family members |
| US20170328919A1 (en) * | 2016-05-11 | 2017-11-16 | Leuvas Therapeutics | BLOCKADE OF TIM-1 PATHWAYS and P-SELECTIN PATHWAYS IN TREATMENT OF NEUROINFLAMMATORY DEGENERATIVE DISEASE |
| KR102602137B1 (ko) * | 2016-07-06 | 2023-11-13 | 브리스톨-마이어스 스큅 컴퍼니 | Tim-4 길항제 및 pd-1 길항제의 조합물 및 사용 방법 |
| AU2017335634A1 (en) | 2016-09-27 | 2019-03-14 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| BR112019020959A2 (pt) * | 2017-04-10 | 2020-05-05 | Immatics Biotechnologies Gmbh | peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer |
| AU2018297285A1 (en) | 2017-07-06 | 2020-01-30 | Yale University | Compositions and methods for treating or preventing endocrine FGF-linked diseases |
| EP4714966A2 (en) | 2017-09-26 | 2026-03-25 | Cero Therapeutics Holdings, Inc. | Chimeric engulfment receptor molecules and methods of use |
| JP2021506792A (ja) * | 2017-12-13 | 2021-02-22 | イエール ユニバーシティ | 内分泌型ｆｇｆ２３関連疾患を処置または防止するための組成物および方法 |
| EP3774906A1 (en) | 2018-03-28 | 2021-02-17 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
| MX2020010241A (es) | 2018-03-28 | 2020-10-16 | Cero Therapeutics Inc | Composiciones de inmunoterapia celular y usos de las mismas. |
| US20240191192A1 (en) * | 2021-04-08 | 2024-06-13 | Takeda Pharmaceutical Company Limited | Method for activating t-cells |
| WO2025064933A1 (en) * | 2023-09-22 | 2025-03-27 | The Trustees Of Columbia University In The City Of New York | Restoring tim4 in liver macrophages to treat non-alcoholic steatohepatitis (nash) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069196A1 (en) | 1995-03-03 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| US6455685B1 (en) | 1995-03-03 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| JP2001501831A (ja) | 1996-10-09 | 2001-02-13 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | ガレクチン８、ガレクチン９、ガレクチン１０、およびガレクチン１０ｓｖ |
| US6027916A (en) | 1996-10-09 | 2000-02-22 | Human Genome Sciences, Inc. | Galectin 9 and 10SV Polynucleotides |
| US6190909B1 (en) | 1997-04-17 | 2001-02-20 | Millennium Pharmaceuticals, Inc. | TH2-specific gene |
| AU1824499A (en) * | 1997-12-30 | 1999-07-19 | Chiron Corporation | Human cxc chemokine ((tim-1)) |
| AU2451199A (en) * | 1998-01-07 | 1999-07-26 | Human Genome Sciences, Inc. | 36 human secreted proteins |
| WO2001055301A2 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| AU2001243142A1 (en) * | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2001240076A1 (en) * | 2000-03-08 | 2001-09-17 | National Jewish Medical And Research Center | Phosphatidyl serine receptors and uses thereof |
| WO2002081517A2 (en) | 2001-01-19 | 2002-10-17 | Curagen Corporation | Novel polypeptides and nucleic acids encoded thereby |
| US7553939B2 (en) | 2001-06-29 | 2009-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes and methods of use thereof |
| US7838220B2 (en) | 2001-06-29 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes associated with immune disease |
| US7470428B2 (en) | 2002-01-30 | 2008-12-30 | The Brigham And Women's Hospital, Inc. | Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
| DE10213762A1 (de) * | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Int | Neues costimulierendes Molekül und dessen Verwendung |
| EP2025345A1 (en) * | 2002-12-30 | 2009-02-18 | Biogen Idec MA Inc. | KIM-1 antagonists and use to modulate immune system |
| CA2541006C (en) * | 2003-10-03 | 2015-02-17 | Brigham And Women's Hospital | Tim-3 polypeptides |
| KR20070037570A (ko) * | 2004-03-24 | 2007-04-05 | 텔로스 파마슈티칼스 인코포레이티드 | 백신에 대한 면역반응을 향상시키는 보강제로서의 조성물및 이의 사용 방법 |
-
2005
- 2005-03-11 TW TW094107611A patent/TW200539890A/zh unknown
- 2005-03-14 US US11/080,091 patent/US7741271B2/en not_active Expired - Lifetime
- 2005-03-14 EP EP05732272.9A patent/EP1735445B1/en not_active Expired - Lifetime
- 2005-03-14 AU AU2005224634A patent/AU2005224634A1/en not_active Abandoned
- 2005-03-14 CN CN2012100590620A patent/CN102861319A/zh active Pending
- 2005-03-14 CA CA2558371A patent/CA2558371C/en not_active Expired - Fee Related
- 2005-03-14 KR KR1020067021139A patent/KR20060130731A/ko not_active Withdrawn
- 2005-03-14 WO PCT/US2005/008423 patent/WO2005090573A2/en not_active Ceased
- 2005-03-14 JP JP2007503106A patent/JP4903128B2/ja not_active Expired - Fee Related
- 2005-03-14 BR BRPI0508553-5A patent/BRPI0508553A/pt not_active IP Right Cessation
- 2005-03-14 RU RU2006136011/13A patent/RU2006136011A/ru not_active Application Discontinuation
- 2005-03-14 MX MXPA06010419A patent/MXPA06010419A/es not_active Application Discontinuation
-
2006
- 2006-09-11 IL IL178002A patent/IL178002A/en not_active IP Right Cessation
-
2010
- 2010-04-26 US US12/767,434 patent/US20110045002A1/en not_active Abandoned
-
2011
- 2011-11-24 JP JP2011255899A patent/JP2012070749A/ja active Pending
-
2013
- 2013-01-25 US US13/750,092 patent/US20130195895A1/en not_active Abandoned
-
2014
- 2014-10-01 US US14/503,768 patent/US20150079085A1/en not_active Abandoned
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