JP4903128B2 - Tim−1、tim−2、およびtim−4の機能を調節することによって免疫応答を調節する方法 - Google Patents

Tim−1、tim−2、およびtim−4の機能を調節することによって免疫応答を調節する方法 Download PDF

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JP4903128B2
JP4903128B2 JP2007503106A JP2007503106A JP4903128B2 JP 4903128 B2 JP4903128 B2 JP 4903128B2 JP 2007503106 A JP2007503106 A JP 2007503106A JP 2007503106 A JP2007503106 A JP 2007503106A JP 4903128 B2 JP4903128 B2 JP 4903128B2
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tim
polypeptide
cells
seq
binding
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JP2007529204A (ja
JP2007529204A5 (https=
Inventor
ビジャイ ケー. クチュルー,
スモーン チャクラバルティ,
テリー ストロム,
シン シャオ チェン,
ジェニファー メイヤーズ,
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Beth lsrael Deaconess Medical Center
Brigham and Womens Hospital Inc
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Beth lsrael Deaconess Medical Center
Brigham and Womens Hospital Inc
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JP2007503106A 2004-03-12 2005-03-14 Tim−1、tim−2、およびtim−4の機能を調節することによって免疫応答を調節する方法 Expired - Fee Related JP4903128B2 (ja)

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Application Number Priority Date Filing Date Title
US55252304P 2004-03-12 2004-03-12
US60/552,523 2004-03-12
US62255904P 2004-10-27 2004-10-27
US60/622,559 2004-10-27
PCT/US2005/008423 WO2005090573A2 (en) 2004-03-12 2005-03-14 Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function

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JP2011255899A Division JP2012070749A (ja) 2004-03-12 2011-11-24 Tim−1、tim−2、およびtim−4の機能を調節することによって免疫応答を調節する方法

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JP2007529204A JP2007529204A (ja) 2007-10-25
JP2007529204A5 JP2007529204A5 (https=) 2008-05-01
JP4903128B2 true JP4903128B2 (ja) 2012-03-28

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JP2011255899A Pending JP2012070749A (ja) 2004-03-12 2011-11-24 Tim−1、tim−2、およびtim−4の機能を調節することによって免疫応答を調節する方法

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US (4) US7741271B2 (https=)
EP (1) EP1735445B1 (https=)
JP (2) JP4903128B2 (https=)
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258793T5 (es) * 1996-05-24 2010-01-25 Biogen Idec Ma Inc. Moduladores de la regeneracion tisular.
EP2025345A1 (en) * 2002-12-30 2009-02-18 Biogen Idec MA Inc. KIM-1 antagonists and use to modulate immune system
KR20070037570A (ko) * 2004-03-24 2007-04-05 텔로스 파마슈티칼스 인코포레이티드 백신에 대한 면역반응을 향상시키는 보강제로서의 조성물및 이의 사용 방법
KR101213894B1 (ko) * 2005-03-02 2012-12-20 바이오겐 아이덱 엠에이 인코포레이티드 Th2 매개성 병태를 치료하기 위한 kim-1 항체
WO2007101254A2 (en) * 2006-02-28 2007-09-07 Telos Pharmaceuticals Llc Compositions and methods for the treatment of immune system disorders
WO2009064290A1 (en) * 2007-11-13 2009-05-22 Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Structure of tim family members
WO2009131572A1 (en) * 2008-04-22 2009-10-29 Government Of The U.S. As Represented By The Secretary Of The Department Of Health And Human Service Structure of tim family members
US9758794B2 (en) 2008-04-22 2017-09-12 Rutgers, The State University Of New Jersey HCV E2 construct compositions and methods
CA2722423A1 (en) * 2008-04-22 2009-10-29 Rutgers, The State University Hcv e2 construct compositions and methods
US10519233B2 (en) 2011-11-21 2019-12-31 University Of Tsukuba Activity modulator, medicinal agent comprising same, use of CD300A gene-deficient mouse, and anti-CD300A antibody
US9850309B2 (en) 2012-11-07 2017-12-26 University Of Tsukuba Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell
WO2014081598A1 (en) * 2012-11-20 2014-05-30 The Brigham And Women's Hospital, Inc. Diagnosis and treatment of endometriosis and related conditions
KR101510742B1 (ko) 2013-05-13 2015-04-10 (주)케어젠 비만세포―특이적 아팝토시스-유도용 펩타이드 및 이의 용도
EP3148564B1 (en) * 2014-06-02 2020-01-08 Children's Medical Center Corporation Methods and compositions for immunomodulation
US10755078B2 (en) * 2015-04-10 2020-08-25 President And Fellows Of Harvard College Methods and devices for live cell imaging analysis
US20180153986A1 (en) * 2015-04-24 2018-06-07 The Brigham And Women's Hospital, Inc. Interactions between ceacam and tim family members
US20170328919A1 (en) * 2016-05-11 2017-11-16 Leuvas Therapeutics BLOCKADE OF TIM-1 PATHWAYS and P-SELECTIN PATHWAYS IN TREATMENT OF NEUROINFLAMMATORY DEGENERATIVE DISEASE
KR102602137B1 (ko) * 2016-07-06 2023-11-13 브리스톨-마이어스 스큅 컴퍼니 Tim-4 길항제 및 pd-1 길항제의 조합물 및 사용 방법
AU2017335634A1 (en) 2016-09-27 2019-03-14 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
BR112019020959A2 (pt) * 2017-04-10 2020-05-05 Immatics Biotechnologies Gmbh peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer
AU2018297285A1 (en) 2017-07-06 2020-01-30 Yale University Compositions and methods for treating or preventing endocrine FGF-linked diseases
EP4714966A2 (en) 2017-09-26 2026-03-25 Cero Therapeutics Holdings, Inc. Chimeric engulfment receptor molecules and methods of use
JP2021506792A (ja) * 2017-12-13 2021-02-22 イエール ユニバーシティ 内分泌型fgf23関連疾患を処置または防止するための組成物および方法
EP3774906A1 (en) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
MX2020010241A (es) 2018-03-28 2020-10-16 Cero Therapeutics Inc Composiciones de inmunoterapia celular y usos de las mismas.
US20240191192A1 (en) * 2021-04-08 2024-06-13 Takeda Pharmaceutical Company Limited Method for activating t-cells
WO2025064933A1 (en) * 2023-09-22 2025-03-27 The Trustees Of Columbia University In The City Of New York Restoring tim4 in liver macrophages to treat non-alcoholic steatohepatitis (nash)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069196A1 (en) 1995-03-03 2003-04-10 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
US6455685B1 (en) 1995-03-03 2002-09-24 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of immune disorders
US6066322A (en) 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
JP2001501831A (ja) 1996-10-09 2001-02-13 ヒューマン ジノーム サイエンシーズ,インコーポレイテッド ガレクチン8、ガレクチン9、ガレクチン10、およびガレクチン10sv
US6027916A (en) 1996-10-09 2000-02-22 Human Genome Sciences, Inc. Galectin 9 and 10SV Polynucleotides
US6190909B1 (en) 1997-04-17 2001-02-20 Millennium Pharmaceuticals, Inc. TH2-specific gene
AU1824499A (en) * 1997-12-30 1999-07-19 Chiron Corporation Human cxc chemokine ((tim-1))
AU2451199A (en) * 1998-01-07 1999-07-26 Human Genome Sciences, Inc. 36 human secreted proteins
WO2001055301A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
AU2001243142A1 (en) * 2000-02-03 2001-08-14 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001240076A1 (en) * 2000-03-08 2001-09-17 National Jewish Medical And Research Center Phosphatidyl serine receptors and uses thereof
WO2002081517A2 (en) 2001-01-19 2002-10-17 Curagen Corporation Novel polypeptides and nucleic acids encoded thereby
US7553939B2 (en) 2001-06-29 2009-06-30 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US7838220B2 (en) 2001-06-29 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes associated with immune disease
US7470428B2 (en) 2002-01-30 2008-12-30 The Brigham And Women's Hospital, Inc. Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
DE10213762A1 (de) * 2002-03-26 2003-10-09 Boehringer Ingelheim Int Neues costimulierendes Molekül und dessen Verwendung
EP2025345A1 (en) * 2002-12-30 2009-02-18 Biogen Idec MA Inc. KIM-1 antagonists and use to modulate immune system
CA2541006C (en) * 2003-10-03 2015-02-17 Brigham And Women's Hospital Tim-3 polypeptides
KR20070037570A (ko) * 2004-03-24 2007-04-05 텔로스 파마슈티칼스 인코포레이티드 백신에 대한 면역반응을 향상시키는 보강제로서의 조성물및 이의 사용 방법

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US20050261224A1 (en) 2005-11-24
US20150079085A1 (en) 2015-03-19
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US20130195895A1 (en) 2013-08-01
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JP2007529204A (ja) 2007-10-25
AU2005224634A1 (en) 2005-09-29
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US20110045002A1 (en) 2011-02-24
CA2558371C (en) 2013-08-27
IL178002A (en) 2011-12-29
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