JP2008538923A5 - - Google Patents

Info

Publication number

JP2008538923A5

JP2008538923A5 JP2008509012A JP2008509012A JP2008538923A5 JP 2008538923 A5 JP2008538923 A5 JP 2008538923A5 JP 2008509012 A JP2008509012 A JP 2008509012A JP 2008509012 A JP2008509012 A JP 2008509012A JP 2008538923 A5 JP2008538923 A5 JP 2008538923A5

Authority

JP

Japan

Prior art keywords

nicotinamide riboside

seq

nucleotide sequence

cell

nicotinamide

Prior art date

2006-04-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 16
• 235000020956 nicotinamide riboside Nutrition 0.000 claims 16
• 239000011618 nicotinamide riboside Substances 0.000 claims 16
• 108010021066 nicotinamide riboside kinase Proteins 0.000 claims 16
• 229920001184 polypeptide Polymers 0.000 claims 13
• 102000004196 processed proteins & peptides Human genes 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 210000004027 cell Anatomy 0.000 claims 11
• 239000002773 nucleotide Substances 0.000 claims 11
• 125000003729 nucleotide group Chemical group 0.000 claims 11
• 238000000034 method Methods 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 9
• 239000000651 prodrug Substances 0.000 claims 9
• 229940002612 prodrug Drugs 0.000 claims 9
• 150000001413 amino acids Chemical group 0.000 claims 8
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 4
• DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108030003379 NAD(+) synthases Proteins 0.000 claims 2
• -1 Nicotine riboside Chemical class 0.000 claims 2
• 230000030833 cell death Effects 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 235000005152 nicotinamide Nutrition 0.000 claims 2
• 239000011570 nicotinamide Substances 0.000 claims 2
• 230000035755 proliferation Effects 0.000 claims 2
• 108020004635 Complementary DNA Proteins 0.000 claims 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
• 108091000080 Phosphotransferase Proteins 0.000 claims 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 210000004748 cultured cell Anatomy 0.000 claims 1
• 238000001212 derivatisation Methods 0.000 claims 1
• 235000015872 dietary supplement Nutrition 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 239000008267 milk Substances 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 229960003966 nicotinamide Drugs 0.000 claims 1
• 229960002715 nicotine Drugs 0.000 claims 1
• SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
• 229960003512 nicotinic acid Drugs 0.000 claims 1
• 230000037361 pathway Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
• 102000020233 phosphotransferase Human genes 0.000 claims 1
• 230000035945 sensitivity Effects 0.000 claims 1
• 229960004799 tryptophan Drugs 0.000 claims 1
• 230000035899 viability Effects 0.000 claims 1