JP2004536585A5 - - Google Patents
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- Publication number
- JP2004536585A5 JP2004536585A5 JP2002587582A JP2002587582A JP2004536585A5 JP 2004536585 A5 JP2004536585 A5 JP 2004536585A5 JP 2002587582 A JP2002587582 A JP 2002587582A JP 2002587582 A JP2002587582 A JP 2002587582A JP 2004536585 A5 JP2004536585 A5 JP 2004536585A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- tirap
- seq
- tlr4
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004196 processed proteins & peptides Human genes 0.000 claims 53
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 229920001184 polypeptide Polymers 0.000 claims 49
- 101000637726 Homo sapiens Toll/interleukin-1 receptor domain-containing adapter protein Proteins 0.000 claims 39
- 102100032120 Toll/interleukin-1 receptor domain-containing adapter protein Human genes 0.000 claims 38
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 24
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 24
- 108091033319 polynucleotide Proteins 0.000 claims 24
- 239000002157 polynucleotide Substances 0.000 claims 24
- 102000040430 polynucleotide Human genes 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 239000005557 antagonist Substances 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 238000012216 screening Methods 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 claims 5
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 230000035772 mutation Effects 0.000 claims 5
- 150000003384 small molecules Chemical class 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000007877 drug screening Methods 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 108700031308 Antennapedia Homeodomain Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 102000044006 human TIRAP Human genes 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28973801P | 2001-05-09 | 2001-05-09 | |
| US28981501P | 2001-05-09 | 2001-05-09 | |
| US28986601P | 2001-08-29 | 2001-08-29 | |
| US10139802A | 2002-03-19 | 2002-03-19 | |
| PCT/US2002/014915 WO2002090520A2 (en) | 2001-05-09 | 2002-05-09 | Toll/interleukin-1 receptor adaptor protein (tirap) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536585A JP2004536585A (ja) | 2004-12-09 |
| JP2004536585A5 true JP2004536585A5 (https=) | 2005-12-22 |
Family
ID=27493201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587582A Pending JP2004536585A (ja) | 2001-05-09 | 2002-05-09 | トル／インターロイキン−１受容体アダプタータンパク質（ｔｉｒａｐ） |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6960343B2 (https=) |
| EP (1) | EP1401281A4 (https=) |
| JP (1) | JP2004536585A (https=) |
| AU (1) | AU2002305539A1 (https=) |
| CA (1) | CA2446458A1 (https=) |
| WO (1) | WO2002090520A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| CA2432542A1 (en) * | 2000-12-22 | 2002-07-04 | Synovis Limited | Methods of modulating toll-related receptor (trr) signaling |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| JP2004073073A (ja) * | 2002-08-16 | 2004-03-11 | Japan Science & Technology Corp | エンドトキシン及びリポタンパク・リポペプチド不応答性モデル非ヒト動物 |
| US20040191833A1 (en) * | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Selective activation of cellular activities mediated through a common toll-like receptor |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
| CA2882022A1 (en) | 2003-09-11 | 2005-03-24 | Walter Newman | Monoclonal antibodies against hmgb1 |
| US20060002941A1 (en) * | 2004-01-23 | 2006-01-05 | Vievax Corp. | Compositions comprising immune response altering agents and methods of use |
| US20050244410A1 (en) * | 2004-04-29 | 2005-11-03 | Ashlyn Bassiri | Toll-like receptor 9 effector agents and uses thereof |
| KR20070094802A (ko) | 2004-12-20 | 2007-09-21 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | ＭｙＤ８８ 동종이량체화 억제제 |
| WO2006081576A2 (en) | 2005-01-28 | 2006-08-03 | Galenbio, Inc. | Immunologically active compositions |
| WO2006113530A2 (en) * | 2005-04-15 | 2006-10-26 | University Of Maryland, Baltimore | Selective inhibition of tlr4 signaling |
| CN101842107B (zh) * | 2007-07-26 | 2014-04-23 | 雷文斯治疗公司 | 抗微生物肽，组合物和使用方法 |
| WO2009111588A1 (en) | 2008-03-04 | 2009-09-11 | Liquidia Technologies, Inc. | Immunomodulator particles and methods of treating |
| EP2625196B1 (en) | 2010-10-05 | 2016-03-23 | Kemijski Institut | Fusion polypeptides comprising tir and dimerization domain for modulation of tlr/innate immunity signaling |
| KR101566107B1 (ko) | 2014-04-18 | 2015-11-05 | 영남대학교 산학협력단 | Tlr6 tir 도메인의 ３차 구조 및 이를 이용한 약물 스크리닝 방법 |
| EP3978929A1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
| US10227408B2 (en) | 2015-02-19 | 2019-03-12 | Compugen Ltd. | Anti-PVRIG antibodies and methods of use |
| EP3095444A1 (en) | 2015-05-20 | 2016-11-23 | Dublin City University | A method of treating peripheral inflammatory disease |
| CN110088132B (zh) | 2016-08-17 | 2020-10-27 | 康姆普根有限公司 | 抗tigit抗体，抗pvrig抗体及其组合 |
| CN110799213A (zh) | 2017-06-01 | 2020-02-14 | 康姆普根有限公司 | 三联组合抗体疗法 |
| KR20200084569A (ko) * | 2019-01-03 | 2020-07-13 | 주식회사 젠센 | Tlr4 신호전달 경로를 억제하는 펩타이드 및 그 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6271349B1 (en) * | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| US6399584B1 (en) * | 1998-03-18 | 2002-06-04 | Institute Curie | Pharmaceutical composition containing ezrin mutated on tyrosine 353 |
| US7029861B1 (en) * | 1998-09-15 | 2006-04-18 | Board Of Regents, The University Of Texas System | LPS-response gene compositions and methods |
| ATE405155T1 (de) * | 1999-01-14 | 2008-09-15 | Japan Science & Tech Agency | Modellmaus, die nicht auf bakterielle zellkomponenten anspricht. |
| EP1165788A2 (en) * | 1999-04-05 | 2002-01-02 | Incyte Pharmaceuticals, Inc. | Molecules of the immune system |
| US6506769B2 (en) * | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| AU2001263236A1 (en) | 2000-05-17 | 2001-11-26 | Immunex Corporation | Human myd88 adapter-like protein and functional fragments thereof |
-
2002
- 2002-05-09 CA CA002446458A patent/CA2446458A1/en not_active Abandoned
- 2002-05-09 EP EP02734367A patent/EP1401281A4/en not_active Withdrawn
- 2002-05-09 JP JP2002587582A patent/JP2004536585A/ja active Pending
- 2002-05-09 AU AU2002305539A patent/AU2002305539A1/en not_active Abandoned
- 2002-05-09 WO PCT/US2002/014915 patent/WO2002090520A2/en not_active Ceased
- 2002-07-03 US US10/188,947 patent/US6960343B2/en not_active Expired - Fee Related
-
2005
- 2005-09-16 US US11/229,066 patent/US7285535B2/en not_active Expired - Lifetime
-
2007
- 2007-10-15 US US11/974,728 patent/US20080096250A1/en not_active Abandoned
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