ATE442774T1 - Myod-knockout maus als bakterienzellwandbestandteil-unansprechender tiermodell - Google Patents
Myod-knockout maus als bakterienzellwandbestandteil-unansprechender tiermodellInfo
- Publication number
- ATE442774T1 ATE442774T1 AT05077734T AT05077734T ATE442774T1 AT E442774 T1 ATE442774 T1 AT E442774T1 AT 05077734 T AT05077734 T AT 05077734T AT 05077734 T AT05077734 T AT 05077734T AT E442774 T1 ATE442774 T1 AT E442774T1
- Authority
- AT
- Austria
- Prior art keywords
- bacterial cell
- knockout mouse
- mouse
- tlr2
- gene
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 3
- 238000011813 knockout mouse model Methods 0.000 title abstract 3
- 238000010171 animal model Methods 0.000 title 1
- 210000002421 cell wall Anatomy 0.000 title 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 abstract 3
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 abstract 3
- 102100024333 Toll-like receptor 2 Human genes 0.000 abstract 3
- 230000008685 targeting Effects 0.000 abstract 3
- 210000002459 blastocyst Anatomy 0.000 abstract 2
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010028921 Lipopeptides Proteins 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003850 cellular structure Anatomy 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5055—Cells of the immune system involving macrophages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Environmental Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP736599 | 1999-01-14 | ||
| JP22828299 | 1999-08-12 | ||
| JP30923899 | 1999-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442774T1 true ATE442774T1 (de) | 2009-10-15 |
Family
ID=27277581
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00900372T ATE405155T1 (de) | 1999-01-14 | 2000-01-13 | Modellmaus, die nicht auf bakterielle zellkomponenten anspricht. |
| AT05077734T ATE442774T1 (de) | 1999-01-14 | 2000-01-13 | Myod-knockout maus als bakterienzellwandbestandteil-unansprechender tiermodell |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00900372T ATE405155T1 (de) | 1999-01-14 | 2000-01-13 | Modellmaus, die nicht auf bakterielle zellkomponenten anspricht. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7078585B1 (de) |
| EP (2) | EP1142472B1 (de) |
| JP (2) | JP4197580B2 (de) |
| AT (2) | ATE405155T1 (de) |
| AU (1) | AU777334B2 (de) |
| CA (2) | CA2368217C (de) |
| DE (2) | DE60042986D1 (de) |
| WO (1) | WO2000041561A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1366077B1 (de) | 2000-09-15 | 2011-05-25 | Coley Pharmaceutical GmbH | Verfahren zum hochdurchsatzscreening von auf cpg basierenden immunagonisten und -antagonisten |
| CA2446458A1 (en) * | 2001-05-09 | 2002-11-14 | Yale University | Toll/interleukin-1 receptor adaptor protein (tirap) |
| JP2005137333A (ja) * | 2003-11-10 | 2005-06-02 | Japan Science & Technology Agency | Ｔｂｋ１ノックアウトマウスを用いたスクリーニング方法 |
| AU2005274985A1 (en) * | 2004-07-19 | 2006-02-23 | Schering Corporation | MyD88 as a therapeutic target for cancer |
-
2000
- 2000-01-13 DE DE60042986T patent/DE60042986D1/de not_active Expired - Lifetime
- 2000-01-13 EP EP00900372A patent/EP1142472B1/de not_active Expired - Lifetime
- 2000-01-13 AT AT00900372T patent/ATE405155T1/de not_active IP Right Cessation
- 2000-01-13 JP JP2000593182A patent/JP4197580B2/ja not_active Expired - Lifetime
- 2000-01-13 EP EP05077734A patent/EP1716752B1/de not_active Expired - Lifetime
- 2000-01-13 US US09/889,324 patent/US7078585B1/en not_active Expired - Lifetime
- 2000-01-13 DE DE60039964T patent/DE60039964D1/de not_active Expired - Lifetime
- 2000-01-13 AU AU20037/00A patent/AU777334B2/en not_active Expired
- 2000-01-13 WO PCT/JP2000/000132 patent/WO2000041561A1/ja active IP Right Grant
- 2000-01-13 AT AT05077734T patent/ATE442774T1/de not_active IP Right Cessation
- 2000-01-13 CA CA002368217A patent/CA2368217C/en not_active Expired - Lifetime
- 2000-01-13 CA CA2509345A patent/CA2509345C/en not_active Expired - Lifetime
-
2005
- 2005-12-12 JP JP2005358329A patent/JP4070216B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2509345A1 (en) | 2000-07-20 |
| EP1142472A1 (de) | 2001-10-10 |
| EP1716752A1 (de) | 2006-11-02 |
| DE60039964D1 (de) | 2008-10-02 |
| US7078585B1 (en) | 2006-07-18 |
| JP4197580B2 (ja) | 2008-12-17 |
| EP1142472A4 (de) | 2004-03-24 |
| JP2006101884A (ja) | 2006-04-20 |
| CA2368217A1 (en) | 2000-07-20 |
| ATE405155T1 (de) | 2008-09-15 |
| CA2368217C (en) | 2009-08-25 |
| AU2003700A (en) | 2000-08-01 |
| AU777334B2 (en) | 2004-10-14 |
| CA2509345C (en) | 2013-03-12 |
| JP4070216B2 (ja) | 2008-04-02 |
| EP1716752B1 (de) | 2009-09-16 |
| EP1142472B1 (de) | 2008-08-20 |
| WO2000041561A1 (fr) | 2000-07-20 |
| DE60042986D1 (de) | 2009-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |