JP2007525501A5 - - Google Patents

Download PDF

Info

Publication number
JP2007525501A5
JP2007525501A5 JP2007500725A JP2007500725A JP2007525501A5 JP 2007525501 A5 JP2007525501 A5 JP 2007525501A5 JP 2007500725 A JP2007500725 A JP 2007500725A JP 2007500725 A JP2007500725 A JP 2007500725A JP 2007525501 A5 JP2007525501 A5 JP 2007525501A5
Authority
JP
Japan
Prior art keywords
chromatography
antibody
resin
multimodal
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007500725A
Other languages
English (en)
Japanese (ja)
Other versions
JP4848356B2 (ja
JP2007525501A (ja
Filing date
Publication date
Priority claimed from SE0400501A external-priority patent/SE0400501D0/xx
Priority claimed from SE0402558A external-priority patent/SE0402558D0/xx
Application filed filed Critical
Priority claimed from PCT/SE2005/000293 external-priority patent/WO2005082483A1/en
Publication of JP2007525501A publication Critical patent/JP2007525501A/ja
Publication of JP2007525501A5 publication Critical patent/JP2007525501A5/ja
Application granted granted Critical
Publication of JP4848356B2 publication Critical patent/JP4848356B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007500725A 2004-02-27 2005-02-25 抗体精製法 Expired - Lifetime JP4848356B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0400501A SE0400501D0 (sv) 2004-02-27 2004-02-27 Antibody purification
SE0400501-3 2004-02-27
SE0402558A SE0402558D0 (sv) 2004-10-21 2004-10-21 A process for the purification of antibodies
SE0402558-1 2004-10-21
PCT/SE2005/000293 WO2005082483A1 (en) 2004-02-27 2005-02-25 A process for the purification of antibodies

Publications (3)

Publication Number Publication Date
JP2007525501A JP2007525501A (ja) 2007-09-06
JP2007525501A5 true JP2007525501A5 (https=) 2008-04-10
JP4848356B2 JP4848356B2 (ja) 2011-12-28

Family

ID=34914633

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007500725A Expired - Lifetime JP4848356B2 (ja) 2004-02-27 2005-02-25 抗体精製法

Country Status (9)

Country Link
US (1) US7750129B2 (https=)
EP (1) EP1718386A1 (https=)
JP (1) JP4848356B2 (https=)
KR (1) KR101150050B1 (https=)
AU (1) AU2005216847B2 (https=)
CA (1) CA2552639C (https=)
IL (1) IL176745A (https=)
NZ (1) NZ548126A (https=)
WO (1) WO2005082483A1 (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2583578C (en) 2004-10-21 2014-04-01 Ge Healthcare Bio-Sciences Ab Chromatography ligand
CN100395001C (zh) * 2006-01-26 2008-06-18 合肥工业大学 一种半固定配位色谱分离方法
CA2645739A1 (en) * 2006-03-20 2007-09-27 Medarex, Inc. Protein purification
CN102887955A (zh) 2006-04-05 2013-01-23 艾博特生物技术有限公司 抗体纯化
WO2008008872A2 (en) * 2006-07-14 2008-01-17 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
WO2008085116A1 (en) * 2007-01-10 2008-07-17 Ge Healthcare Bio-Sciences Ab Mult i -modal ion exchange chromotography resins
EP2139573B1 (en) 2007-03-28 2016-11-09 DPx Holdings B.V. Expanded bed column and disposable chromatography
EP2027875A1 (en) * 2007-08-23 2009-02-25 Octapharma AG A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC)
WO2009054226A1 (ja) * 2007-10-26 2009-04-30 Asahi Kasei Chemicals Corporation たんぱく質の精製方法
BRPI0821467B8 (pt) * 2007-12-31 2021-05-25 Baxalta GmbH composição de furina recombinante, método para produzir a composição de furina recombinante, e, método para produzir uma proteína madura utilizando a composição de furina recombinante
WO2009126603A1 (en) * 2008-04-08 2009-10-15 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
EP2300497B1 (en) * 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii
US20110166332A1 (en) * 2008-09-12 2011-07-07 Ge Healthcare Bio-Sciences Ab Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions
KR20100070994A (ko) 2008-12-18 2010-06-28 토소가부시키가이샤 액체 크로마토그래피용 충전 재료 및 해당 충전 재료에 의한 생체고분자의 분리·정제 방법
JPWO2010071208A1 (ja) 2008-12-19 2012-05-31 武田薬品工業株式会社 抗体の精製方法
JPWO2011001963A1 (ja) 2009-07-03 2012-12-13 旭化成ケミカルズ株式会社 多孔質基材に固定されたグラフト鎖に結合しているアミノ基及びアルキル基を有する多孔膜を用いた抗体の精製方法
WO2011012302A1 (en) 2009-07-28 2011-02-03 Instraction Gmbh Specific sorbent for binding proteins and peptides, and separation method using the same
EP2490780A4 (en) * 2009-10-20 2014-04-09 Merck Sharp & Dohme USE OF A MIXED MODE CHROMATOGRAPHY FOR THE DETECTION AND PURIFICATION OF BASIC ANTIBODY PRODUCTS
KR101951446B1 (ko) 2010-03-30 2019-02-22 옥타파마 아게 성장 인자 단백질을 정제하는 방법
WO2011121020A1 (en) 2010-03-30 2011-10-06 Octapharma Ag A process for purifying vitamin k dependent proteins such as coagulation factor ix
JP6014588B2 (ja) * 2010-06-23 2016-10-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 液体混合物の製造方法
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US20140187749A1 (en) * 2011-06-16 2014-07-03 Dsm Ip Assets B.V. Single unit chromatography antibody purification
SG10201605397PA (en) 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
US8802448B2 (en) 2011-07-27 2014-08-12 Pall Corporation Mixed mode ligands
JP6092892B2 (ja) 2011-12-15 2017-03-08 プレステージ バイオファーマ プライベート リミテッド 抗体の精製方法
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9890191B2 (en) 2012-09-03 2018-02-13 Kaneka Corporation Mixed-mode antibody affinity separation matrix and purification method using the same, and the target molecules
SI2895188T1 (en) 2012-09-11 2018-05-31 Coherus Biosciences, Inc. CORRECTED QUALITY ETHANERCEPT WITH HIGH QUALITY AND EXCELLENT EXPERIENCE
EP2919902B1 (en) 2012-11-13 2020-01-01 GE Healthcare BioProcess R&D AB Multimodal anion exchange matrices
CN103217489B (zh) * 2013-01-15 2016-03-09 珠海市丽珠单抗生物技术有限公司 一种测定蛋白纯化工艺过程中样品的糖基化和末端修饰情况的方法
KR20150112978A (ko) * 2013-02-06 2015-10-07 에이전시 포 사이언스, 테크놀로지 앤드 리서치 단백질 제제 내의 응집체 함량을 감소시키기 위한 혼합 다관능 금속 친화성 표면들
WO2014134147A1 (en) 2013-02-26 2014-09-04 Natrix Separations Inc. Mixed-mode chromatography membranes
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
JPWO2015041218A1 (ja) 2013-09-17 2017-03-02 株式会社カネカ 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20160251441A1 (en) * 2013-10-25 2016-09-01 Medimmune, Llc Antibody purification
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
PL3116891T3 (pl) * 2014-03-10 2020-07-27 Richter Gedeon Nyrt. Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania
JP6702587B2 (ja) 2014-03-14 2020-06-03 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 生物粒子の精製用分離マトリックス
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
DE102016004432A1 (de) 2016-04-12 2017-10-12 Sartorius Stedim Biotech Gmbh Multimodales Adsorptionsmedium mit multimodalen Liganden, Verfahren zu dessen Herstellung und dessen Verwendung
EP4549463A3 (en) * 2016-06-17 2025-07-30 F. Hoffmann-La Roche AG Purification of multispecific antibodies
US11020686B2 (en) 2016-08-16 2021-06-01 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
JP7102401B2 (ja) 2016-10-25 2022-07-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド クロマトグラフィーデータ解析のための方法およびシステム
CA3073935A1 (en) 2017-09-19 2019-03-28 Regeneron Pharmaceuticals, Inc. Methods of reducing particle formation and compositions formed thereby
MX2020008000A (es) * 2018-01-30 2021-01-08 Exothera Sa Procedimiento para la purificacion de proteinas.
TWI853823B (zh) 2018-07-02 2024-09-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
AU2019332764B2 (en) * 2018-08-31 2025-05-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
EA202192422A1 (ru) 2019-03-05 2021-12-09 Ридженерон Фармасьютикалз, Инк. Человеческий сывороточный альбумин в составах
CN114213525B (zh) * 2021-12-30 2024-05-28 科兴生物制药股份有限公司 一种生长激素的纯化方法
CN119034260B (zh) * 2024-09-10 2025-09-05 中国地质大学（武汉） 一种利用强阳离子树脂分离三价锑和五价锑的系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU581927A1 (ru) * 1975-12-31 1977-11-30 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Устройство дл получени стерильных растворов дочерних радиоактивных изотопов медицинского назначени
SE462046C (sv) 1982-08-23 1998-04-27 Pharmacia Biotech Ab Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
AU5957794A (en) * 1992-12-21 1994-07-19 Uab Research Foundation, The Compositions and method for the inhibition of phagocytes
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
GB9519197D0 (en) 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
US6498236B1 (en) 1996-08-30 2002-12-24 Upfront Chromatography A/S Isolation of immunoglobulins
WO1999012572A1 (en) * 1997-09-10 1999-03-18 University Of Florida Compounds and method for the prevention and treatment of diabetic retinopathy
SE9904197D0 (sv) 1999-11-22 1999-11-22 Amersham Pharm Biotech Ab A method for anion exchange adsorption on matrices carrying mixed mode ligands
SE0002688D0 (sv) * 2000-07-17 2000-07-17 Amersham Pharm Biotech Ab Adsorption method and ligands
WO2002053288A2 (en) * 2000-12-31 2002-07-11 Amersham Biosciences Ab A method for the manufacture of compositions containing low concentrations of salts
JP2004517310A (ja) * 2001-01-05 2004-06-10 プロ・ケム インク 精製器具及び方法
WO2002057498A1 (en) * 2001-01-22 2002-07-25 Emergen, Inc. Isotopically enriched nucleic acids and associated methods for the production and purification thereof
US6652853B2 (en) * 2001-03-08 2003-11-25 Ludwig Institute For Cancer Research Method for treating cancer using A33 specific antibodies and chemotherapeutic agents
SE0103084D0 (sv) * 2001-09-14 2001-09-14 Amersham Pharm Biotech Ab Generation of ion exchange media

Similar Documents

Publication Publication Date Title
JP2007525501A5 (https=)
CA2552639A1 (en) A process for the purification of antibodies
Rusli et al. Recent developments of liquid chromatography stationary phases for compound separation: from proteins to small organic compounds
Salimi et al. Protein A and protein A/G coupled magnetic SiO2 microspheres for affinity purification of immunoglobulin G
Josić et al. Application of membranes and compact, porous units for the separation of biopolymers
Zachariou et al. Application of immobilized metal ion chelate complexes as pseudocation exchange adsorbents for protein separation
JP2008517906A5 (https=)
Lee et al. Negative chromatography: Progress, applications and future perspectives
SE0400501D0 (sv) Antibody purification
JP2010534336A5 (https=)
EP1918372A4 (en) FOR BINDING TO IMMOBILIZABLE LOBULIN G-NUCLEIC ACID AND USE THEREOF
JPS63249052A (ja) 親和クロマトグラフイ用吸着材
Tishchenko et al. Purification of the specific immunoglobulin G1 by immobilized metal ion affinity chromatography using nickel complexes of chelating porous and nonporous polymeric sorbents based on poly (methacrylic esters): effect of polymer structure
Bereli et al. Histidine containing macroporous affinity cryogels for immunoglobulin G purification
SE0400490D0 (sv) Plasmid purification
Gunasena et al. Organic monoliths for hydrophilic interaction electrochromatography/chromatography and immunoaffinity chromatography
JP2008503754A5 (https=)
Chiu et al. Isolation of lysozyme from hen egg albumen using glass fiber-based cation-exchange membranes
Dong et al. Functionalizing microporous membranes for protein purification and protein digestion
Zang et al. Direct site-specific immobilization of protein A via aldehyde-hydrazide conjugation
Rajak et al. Purification of monoclonal antibodies, IgG1, from cell culture supernatant by use of metal chelate convective interaction media monolithic columns
Champagne et al. Pseudoaffinity chromatography using a convective interaction Media®-disk monolithic column
Wongchuphan et al. Application of dye-ligands affinity adsorbent in capturing of rabbit immunoglobulin G
Tripathi et al. Integrated approach for β-glucosidase purification from non-clarified crude homogenate using macroporous cryogel matrix
Batista-Viera et al. Affinity chromatography