JP2007523771A - マイクロニードルアレイの成形方法 - Google Patents

マイクロニードルアレイの成形方法 Download PDF

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Publication number
JP2007523771A
JP2007523771A JP2006554275A JP2006554275A JP2007523771A JP 2007523771 A JP2007523771 A JP 2007523771A JP 2006554275 A JP2006554275 A JP 2006554275A JP 2006554275 A JP2006554275 A JP 2006554275A JP 2007523771 A JP2007523771 A JP 2007523771A
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JP
Japan
Prior art keywords
negative
microneedle
plastic material
insert
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006554275A
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English (en)
Japanese (ja)
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JP2007523771A5 (https=
Inventor
アール． ブーン，メアリー
ジェイ． カーター，チャド
エル． フレデリックソン，フランクリン
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3M Innovative Properties Co
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3M Innovative Properties Co
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Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of JP2007523771A publication Critical patent/JP2007523771A/ja
Publication of JP2007523771A5 publication Critical patent/JP2007523771A5/ja
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/37—Mould cavity walls, i.e. the inner surface forming the mould cavity, e.g. linings
    • B29C45/372—Mould cavity walls, i.e. the inner surface forming the mould cavity, e.g. linings provided with means for marking or patterning, e.g. numbering articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/37—Mould cavity walls, i.e. the inner surface forming the mould cavity, e.g. linings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/72—Heating or cooling
    • B29C45/73—Heating or cooling of the mould
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/0085—Manufacture of substrate-free structures using moulds and master templates, e.g. for hot-embossing
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D1/00—Electroforming
    • C25D1/10—Moulds; Masks; Masterforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties
    • A61B2017/00893—Material properties pharmaceutically effective
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/72—Heating or cooling
    • B29C45/73—Heating or cooling of the mould
    • B29C2045/7393—Heating or cooling of the mould alternately heating and cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
    • B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
    • B29C33/3857—Manufacturing moulds, e.g. shaping the mould surface by machining by making impressions of one or more parts of models, e.g. shaped articles and including possible subsequent assembly of the parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2669—Moulds with means for removing excess material, e.g. with overflow cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56—Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/561—Injection-compression moulding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Electrochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
JP2006554275A 2004-02-23 2005-02-22 マイクロニードルアレイの成形方法 Withdrawn JP2007523771A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54678004P 2004-02-23 2004-02-23
PCT/US2005/005466 WO2005082596A1 (en) 2004-02-23 2005-02-22 Method of molding for microneedle arrays

Publications (2)

Publication Number Publication Date
JP2007523771A true JP2007523771A (ja) 2007-08-23
JP2007523771A5 JP2007523771A5 (https=) 2008-03-21

Family

ID=34910812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006554275A Withdrawn JP2007523771A (ja) 2004-02-23 2005-02-22 マイクロニードルアレイの成形方法

Country Status (4)

Country Link
US (1) US20070191761A1 (https=)
EP (1) EP1718452A1 (https=)
JP (1) JP2007523771A (https=)
WO (1) WO2005082596A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009061197A (ja) * 2007-09-08 2009-03-26 Kagawa Univ Ｕｖ硬化樹脂製の微小針母型の製造方法
JP2010058384A (ja) * 2008-09-04 2010-03-18 Toppan Printing Co Ltd 針状体製造方法、針状体製造装置および針状体
JP2012524637A (ja) * 2009-04-24 2012-10-18 コリウム インターナショナル， インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
US8383027B2 (en) 2008-03-12 2013-02-26 Fujifilm Corporation Method of fabricating a template for a concave array mold, a concave array mold and a needle array sheet
JP2018524209A (ja) * 2015-06-30 2018-08-30 ザ ジレット カンパニー リミテッド ライアビリティ カンパニーＴｈｅ Ｇｉｌｌｅｔｔｅ Ｃｏｍｐａｎｙ Ｌｌｃ ポリマー刃先構造及びその製造方法
KR20190080548A (ko) * 2017-12-28 2019-07-08 주식회사 더마젝 마이크로 니들 패치의 제조 방법
JP2020508801A (ja) * 2017-09-08 2020-03-26 エス‐スキン．カンパニー リミテッド マイクロニードルテンプレート及びこれを用いて製造されるマイクロニードル

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
AU2005306429B2 (en) 2004-11-18 2011-04-14 3M Innovative Properties Company Microneedle array applicator and retainer
EP2388078B1 (en) 2004-11-18 2013-03-20 3M Innovative Properties Co. Method of contact coating a microneedle array
KR101224257B1 (ko) 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
WO2006062974A2 (en) * 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
US20080108958A1 (en) * 2004-12-10 2008-05-08 3M Innovative Properties Company Medical Device
CA2629193C (en) 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007075806A2 (en) * 2005-12-23 2007-07-05 3M Innovative Properties Company Manufacturing microneedle arrays
WO2007112309A2 (en) 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20080063866A1 (en) * 2006-05-26 2008-03-13 Georgia Tech Research Corporation Method for Making Electrically Conductive Three-Dimensional Structures
WO2008004781A1 (en) * 2006-07-03 2008-01-10 Honam Petrochemical Corp. Micro neddle roller assembly
KR100792382B1 (ko) * 2006-07-03 2008-01-08 호남석유화학 주식회사 마이크로 니들 롤러와 그 성형 금형
JP4396776B2 (ja) * 2006-07-27 2010-01-13 凸版印刷株式会社 マイクロニードルの製造方法
US8529958B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
JPWO2008053720A1 (ja) * 2006-10-31 2010-02-25 コニカミノルタオプト株式会社 マスター及びマイクロ反応器
WO2008062832A1 (en) * 2006-11-22 2008-05-29 Toppan Printing Co., Ltd. Microneedle array and process for production thereof
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008157592A1 (en) 2007-06-20 2008-12-24 3M Innovative Properties Company Ultrasonic injection molding on a web
JP2009039171A (ja) * 2007-08-06 2009-02-26 Dai Ichi Kasei Kk 微細針形状突起物及びその成形金型及びその製造方法
US9007670B2 (en) 2007-08-28 2015-04-14 Lg Electronics Inc. Injection moldings, injection-molding apparatus and method thereof
US8012329B2 (en) * 2008-05-09 2011-09-06 3M Innovative Properties Company Dimensional control in electroforms
JP2012509106A (ja) * 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
WO2010078323A1 (en) * 2008-12-29 2010-07-08 Sung-Yun Kwon Method of manufacturing solid solution peforator patches and uses thereof
CN102458559B (zh) * 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
MX2012012317A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Arreglo de microagujas moldeado por inyeccion y metodo para formar el arreglo de microagujas.
JP5860033B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド ｓｉＲＮＡ送達用の医療デバイス
EP2563455A4 (en) 2010-04-28 2014-02-19 Kimberly Clark Co METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER
CA2797204C (en) 2010-04-28 2018-06-12 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
CA2800253C (en) 2010-05-28 2022-07-12 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
WO2012038244A1 (en) * 2010-09-23 2012-03-29 Paul Scherrer Institut Injection molded micro-cantilever and membrane sensor devices and process for their fabrication
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
WO2012103205A2 (en) * 2011-01-26 2012-08-02 Carmell Therapeutics Corporation Barbs for fixation of biologic plastics
CN103442876B (zh) 2011-03-15 2016-07-13 3M创新有限公司 精确成形的制品的超声辅助的模制以及方法
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
US20140296796A1 (en) * 2011-11-02 2014-10-02 Chee Yen Lim Plastic microneedle strip
JP6277953B2 (ja) * 2012-02-29 2018-02-14 凸版印刷株式会社 針状体の製造方法
EP2822745A1 (en) * 2012-03-08 2015-01-14 Danmarks Tekniske Universitet Silane based coating of aluminium mold
US8663537B2 (en) 2012-05-18 2014-03-04 3M Innovative Properties Company Injection molding apparatus and method
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
CA3130120A1 (en) 2013-03-12 2014-10-09 Corium, Inc. Microprojection applicators
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6689187B2 (ja) 2013-03-15 2020-04-28 コリウム， インコーポレイテッド 複数の衝突微小突起アプリケータおよび使用方法
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
RU2711567C2 (ru) 2013-03-15 2020-01-17 Кориум, ИНК. Микрочип для доставки лекарственного средства и способы его использования
KR101724655B1 (ko) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
KR20180054603A (ko) * 2015-09-17 2018-05-24 에이오에프 가부시키가이샤 마이크로 니들
JP6271614B2 (ja) * 2016-02-11 2018-01-31 Ｎｉｓｓｈａ株式会社 収納シート、マイクロニードルシートの梱包体
WO2017151806A1 (en) 2016-03-01 2017-09-08 Kitotech Medical, Inc. Microstructure-based systems, apparatus, and methods for wound closure
JP6732373B2 (ja) * 2016-03-31 2020-07-29 花王株式会社 微細中空突起具の製造方法、及び微細中空突起具
WO2017187410A1 (en) * 2016-04-28 2017-11-02 Sabic Global Technologies B.V. Microneedles made from polycarbonate-polycarbonate/polysiloxane copolymer compositions
JP6626403B2 (ja) * 2016-05-10 2019-12-25 富士フイルム株式会社 凹状パターンを有するモールドの作製方法、及びパターンシートの製造方法
US10562200B2 (en) 2016-06-28 2020-02-18 The Gillette Company Llc Polymeric cutting edge structures and method of manufacturing polymeric cutting edge structures
US20190388669A1 (en) * 2017-01-30 2019-12-26 Sabic Global Technologies B.V. Microneedles made from polycarbonate-polycarbonate/polysiloxane copolymer compositions
MX2020003424A (es) 2017-10-16 2020-12-07 Tufts College Sistema y metodo para hacer microagujas.
WO2019188796A1 (ja) * 2018-03-27 2019-10-03 富士フイルム株式会社 凹状台座パターンを有するモールドの作製方法及びパターンシートの製造方法
CN111300712B (zh) * 2018-12-11 2024-12-20 尹忠 一种给药微针的制备模具及制备方法
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
CN110625864A (zh) * 2019-10-24 2019-12-31 上海微创生命科技有限公司 微针制备装置及微针制备方法
WO2021168345A1 (en) 2020-02-19 2021-08-26 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
BR112022022039A2 (pt) 2020-04-28 2022-12-13 Ticona Llc Conjunto de microagulhas
CN113082500B (zh) * 2021-02-26 2024-08-13 北京大学 经皮输送装置及制备方法
US11957346B2 (en) 2022-02-18 2024-04-16 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
CN116238073B (zh) * 2023-01-10 2025-07-22 北京化工大学 一种拼装式中空微针阵列的制备方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) * 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
US4304241A (en) * 1978-09-05 1981-12-08 Aller-Screen, Inc. Skin testing device
US4237906A (en) * 1978-12-06 1980-12-09 Havstad Harold R Antigen injection assembly
JPS6058010B2 (ja) * 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4515543A (en) * 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5152917B1 (en) * 1991-02-06 1998-01-13 Minnesota Mining & Mfg Structured abrasive article
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
SG64333A1 (en) * 1993-09-13 1999-04-27 Minnesota Mining & Mfg Abrasive article method of manufacture of same method of using same for finishing and a production tool
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
JP2725637B2 (ja) * 1995-05-31 1998-03-11 日本電気株式会社 電子回路装置およびその製造方法
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
ATE231015T1 (de) * 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6021559A (en) * 1996-11-01 2000-02-08 3M Innovative Properties Company Methods of making a cube corner article master mold
US6248281B1 (en) * 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
FR2770125B1 (fr) * 1997-10-29 2005-02-25 Arthrex Inc Instrument de recuperation de suture
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
DE69839969D1 (de) * 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2573801A (en) * 1999-11-02 2001-05-14 University Of Hawaii Method for fabricating arrays of micro-needles
DE60022540T2 (de) * 1999-11-15 2006-06-14 Velcro Ind Befestigungselement für die haut
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
ES2717656T3 (es) * 2000-11-30 2019-06-24 Valeritas Inc Dispositivo con microsonda amovible sustancialmente libre sobre el alojamiento
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
WO2002100466A2 (en) * 2001-06-08 2002-12-19 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2500453A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
WO2003051284A2 (en) * 2001-10-29 2003-06-26 Becton, Dickinson And Company Method and device for the delivery of a substance
EP1451584B1 (en) * 2001-11-09 2011-05-11 3dbiosurfaces Technologies, LLC High surface area substrates for microarrays and methods to make same
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
AU2002357372B2 (en) * 2001-12-20 2008-11-20 Alza Corporation Skin-piercing microprojections having piercing depth control
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
KR20120087197A (ko) * 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
WO2004019777A2 (en) * 2002-08-29 2004-03-11 Becton Dickinson And Company Substance delivery via rotating mocroabrading surface
EP1590034B1 (en) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
US6841333B2 (en) * 2002-11-01 2005-01-11 3M Innovative Properties Company Ionic photoacid generators with segmented hydrocarbon-fluorocarbon sulfonate anions
WO2005000382A2 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
EP1643918A1 (en) * 2003-07-02 2006-04-12 Alza Corporation Microprojection array immunization patch and method
BRPI0413360A (pt) * 2003-08-04 2006-10-10 Alza Corp método e dispositivo para aumentar o fluxo de agentes transdérmicos
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
WO2005044364A1 (en) * 2003-11-10 2005-05-19 Agency For Science, Technology And Research Microneedles and microneedle fabrication
US20070083151A1 (en) * 2003-12-29 2007-04-12 Carter Chad J Medical devices and kits including same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009061197A (ja) * 2007-09-08 2009-03-26 Kagawa Univ Ｕｖ硬化樹脂製の微小針母型の製造方法
US8383027B2 (en) 2008-03-12 2013-02-26 Fujifilm Corporation Method of fabricating a template for a concave array mold, a concave array mold and a needle array sheet
JP2010058384A (ja) * 2008-09-04 2010-03-18 Toppan Printing Co Ltd 針状体製造方法、針状体製造装置および針状体
JP2012524637A (ja) * 2009-04-24 2012-10-18 コリウム インターナショナル， インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
JP2018524209A (ja) * 2015-06-30 2018-08-30 ザ ジレット カンパニー リミテッド ライアビリティ カンパニーＴｈｅ Ｇｉｌｌｅｔｔｅ Ｃｏｍｐａｎｙ Ｌｌｃ ポリマー刃先構造及びその製造方法
JP2020508801A (ja) * 2017-09-08 2020-03-26 エス‐スキン．カンパニー リミテッド マイクロニードルテンプレート及びこれを用いて製造されるマイクロニードル
KR20190080548A (ko) * 2017-12-28 2019-07-08 주식회사 더마젝 마이크로 니들 패치의 제조 방법
KR102249834B1 (ko) 2017-12-28 2021-05-10 주식회사 더마젝 마이크로 니들 패치의 제조 방법

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