JP2007522131A5 - - Google Patents
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- JP2007522131A5 JP2007522131A5 JP2006551392A JP2006551392A JP2007522131A5 JP 2007522131 A5 JP2007522131 A5 JP 2007522131A5 JP 2006551392 A JP2006551392 A JP 2006551392A JP 2006551392 A JP2006551392 A JP 2006551392A JP 2007522131 A5 JP2007522131 A5 JP 2007522131A5
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- Prior art keywords
- rpe
- cells
- dogs
- pharmaceutical composition
- cell
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims 36
- 238000000034 method Methods 0.000 claims 16
- 241000282472 Canis lupus familiaris Species 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000010171 animal model Methods 0.000 claims 6
- 206010058314 Dysplasia Diseases 0.000 claims 4
- 201000007737 Retinal degeneration Diseases 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 108091008695 photoreceptors Proteins 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 230000004258 retinal degeneration Effects 0.000 claims 4
- 102100035846 Pigment epithelium-derived factor Human genes 0.000 claims 3
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 3
- 210000001082 somatic cell Anatomy 0.000 claims 3
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 2
- 102100032982 CCR4-NOT transcription complex subunit 9 Human genes 0.000 claims 2
- 101150032562 CNOT9 gene Proteins 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 102100040826 Photoreceptor disk component PRCD Human genes 0.000 claims 2
- 101710089989 Photoreceptor disk component PRCD Proteins 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 238000002583 angiography Methods 0.000 claims 2
- 238000009227 behaviour therapy Methods 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 238000001493 electron microscopy Methods 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000011990 functional testing Methods 0.000 claims 2
- 238000011813 knockout mouse model Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 108090000102 pigment epithelium-derived factor Proteins 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 235000019155 vitamin A Nutrition 0.000 claims 2
- 239000011719 vitamin A Substances 0.000 claims 2
- 229940045997 vitamin a Drugs 0.000 claims 2
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 101001073422 Homo sapiens Pigment epithelium-derived factor Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 230000032459 dedifferentiation Effects 0.000 claims 1
- 108010007093 dispase Proteins 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 238000012546 transfer Methods 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53896404P | 2004-01-23 | 2004-01-23 | |
| PCT/US2005/002273 WO2005070011A2 (en) | 2004-01-23 | 2005-01-24 | Improved modalities for the treatment of degenerative diseases of the retina |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012040491A Division JP2012148085A (ja) | 2004-01-23 | 2012-02-27 | 網膜変性疾患治療のための改良された様式 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007522131A JP2007522131A (ja) | 2007-08-09 |
| JP2007522131A5 true JP2007522131A5 (enExample) | 2008-03-21 |
Family
ID=34807248
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551392A Pending JP2007522131A (ja) | 2004-01-23 | 2005-01-24 | 網膜変性疾患治療のための改良された様式 |
| JP2012040491A Pending JP2012148085A (ja) | 2004-01-23 | 2012-02-27 | 網膜変性疾患治療のための改良された様式 |
| JP2014016135A Ceased JP2014079650A (ja) | 2004-01-23 | 2014-01-30 | 網膜変性疾患治療のための改良された様式 |
| JP2015025500A Ceased JP2015096556A (ja) | 2004-01-23 | 2015-02-12 | 網膜変性疾患治療のための改良された様式 |
| JP2016152133A Withdrawn JP2016195862A (ja) | 2004-01-23 | 2016-08-02 | 網膜変性疾患治療のための改良された様式 |
| JP2017254812A Ceased JP2018086274A (ja) | 2004-01-23 | 2017-12-28 | 網膜変性疾患治療のための改良された様式 |
| JP2019170249A Pending JP2019217356A (ja) | 2004-01-23 | 2019-09-19 | 網膜変性疾患治療のための改良された様式 |
| JP2020105536A Ceased JP2020146575A (ja) | 2004-01-23 | 2020-06-18 | 網膜変性疾患治療のための改良された様式 |
| JP2022124147A Pending JP2022153630A (ja) | 2004-01-23 | 2022-08-03 | 網膜変性疾患治療のための改良された様式 |
| JP2024007584A Pending JP2024038460A (ja) | 2004-01-23 | 2024-01-22 | 網膜変性疾患治療のための改良された様式 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012040491A Pending JP2012148085A (ja) | 2004-01-23 | 2012-02-27 | 網膜変性疾患治療のための改良された様式 |
| JP2014016135A Ceased JP2014079650A (ja) | 2004-01-23 | 2014-01-30 | 網膜変性疾患治療のための改良された様式 |
| JP2015025500A Ceased JP2015096556A (ja) | 2004-01-23 | 2015-02-12 | 網膜変性疾患治療のための改良された様式 |
| JP2016152133A Withdrawn JP2016195862A (ja) | 2004-01-23 | 2016-08-02 | 網膜変性疾患治療のための改良された様式 |
| JP2017254812A Ceased JP2018086274A (ja) | 2004-01-23 | 2017-12-28 | 網膜変性疾患治療のための改良された様式 |
| JP2019170249A Pending JP2019217356A (ja) | 2004-01-23 | 2019-09-19 | 網膜変性疾患治療のための改良された様式 |
| JP2020105536A Ceased JP2020146575A (ja) | 2004-01-23 | 2020-06-18 | 網膜変性疾患治療のための改良された様式 |
| JP2022124147A Pending JP2022153630A (ja) | 2004-01-23 | 2022-08-03 | 網膜変性疾患治療のための改良された様式 |
| JP2024007584A Pending JP2024038460A (ja) | 2004-01-23 | 2024-01-22 | 網膜変性疾患治療のための改良された様式 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US7736896B2 (enExample) |
| EP (8) | EP2438815A3 (enExample) |
| JP (10) | JP2007522131A (enExample) |
| KR (3) | KR101398356B1 (enExample) |
| CN (3) | CN104434979A (enExample) |
| AU (6) | AU2005207042B2 (enExample) |
| BR (1) | BRPI0507074A (enExample) |
| CA (2) | CA2555370C (enExample) |
| ES (1) | ES2721174T3 (enExample) |
| HK (2) | HK1216068A1 (enExample) |
| IL (3) | IL177015B (enExample) |
| MX (4) | MX375061B (enExample) |
| NZ (1) | NZ548929A (enExample) |
| SG (4) | SG188122A1 (enExample) |
| WO (1) | WO2005070011A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8043614B2 (en) | 2004-03-09 | 2011-10-25 | Ahlfors Jan-Eric W | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
| EP2438815A3 (en) | 2004-01-23 | 2012-10-03 | Advanced Cell Technology, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| AU2005304978A1 (en) | 2004-11-04 | 2006-05-18 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells |
| CN1966080B (zh) * | 2005-11-17 | 2011-06-08 | 李凌松 | 一种治疗老年痴呆症、帕金森病的神经干细胞注射液 |
| US7541186B2 (en) * | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| EP3133150A3 (en) | 2006-05-03 | 2017-04-19 | Astellas Institute for Regenerative Medicine | Derivation of embryonic stem cells and embryo-derived cells |
| US9133435B2 (en) * | 2007-01-18 | 2015-09-15 | Riken | Method for induction/differentiation into photoreceptor cell |
| EP2982744A1 (en) | 2007-02-23 | 2016-02-10 | Advanced Cell Technology, Inc. | Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells |
| EP3640326A1 (en) * | 2007-04-18 | 2020-04-22 | Hadasit Medical Research Services & Development Limited | Stem cell-derived retinal pigment epithelial cells |
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US20090028831A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Kentucky Research Foundation | Stem cell regulator, compositions and methods of use |
| KR101849336B1 (ko) * | 2007-10-12 | 2018-04-16 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | Ｒｐｅ 세포의 개선된 생산 방법 및 ｒｐｅ 세포의 조성물 |
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| CA2721952C (en) * | 2008-04-22 | 2019-11-12 | Regenerative Research Foundation | Retinal pigment epithelial stem cells |
| CA3066806C (en) | 2009-08-24 | 2023-03-07 | David M. Gamm | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| IL281453B (en) * | 2009-11-17 | 2022-07-01 | Astellas Inst For Regenerative Medicine | Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells |
| JP5876045B2 (ja) | 2010-07-12 | 2016-03-02 | ユニバーシティー オブ サザン カリフォルニア | 幹細胞と標的組織の相互接続を促進する生体適合性基材およびそれを埋め込む方法 |
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| EP2707479B1 (en) | 2011-05-13 | 2018-01-10 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
| CN111265551A (zh) | 2011-05-18 | 2020-06-12 | 加利福尼亚大学董事会 | 用于治疗视网膜疾病的组合物及方法 |
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| RU2730937C1 (ru) * | 2019-11-01 | 2020-08-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Миндрава России) | Способ трансплантации клеток ретинального пигментного эпителия (РПЭ), дифференцированных из индуцированных плюрипотентных стволовых клеток человека, при атрофии ретинального пигментного эпителия |
| JPWO2022191216A1 (enExample) | 2021-03-09 | 2022-09-15 | ||
| JPWO2023090427A1 (enExample) | 2021-11-19 | 2023-05-25 | ||
| JPWO2023176906A1 (enExample) | 2022-03-16 | 2023-09-21 | ||
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