JP2007521253A5 - - Google Patents
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- Publication number
- JP2007521253A5 JP2007521253A5 JP2006516595A JP2006516595A JP2007521253A5 JP 2007521253 A5 JP2007521253 A5 JP 2007521253A5 JP 2006516595 A JP2006516595 A JP 2006516595A JP 2006516595 A JP2006516595 A JP 2006516595A JP 2007521253 A5 JP2007521253 A5 JP 2007521253A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline
- less
- dexoxyglumide
- value
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims 11
- 239000012043 crude product Substances 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000000691 measurement method Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000008025 crystallization Effects 0.000 claims 3
- 239000010419 fine particle Substances 0.000 claims 3
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- -1 disaggregants Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- QNQZBKQEIFTHFZ-GOSISDBHSA-N dexloxiglumide Chemical compound CCCCCN(CCCOC)C(=O)[C@@H](CCC(O)=O)NC(=O)C1=CC=C(Cl)C(Cl)=C1 QNQZBKQEIFTHFZ-GOSISDBHSA-N 0.000 claims 1
- 229950010525 dexloxiglumide Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229940023144 sodium glycolate Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000474A ITTO20030474A1 (it) | 2003-06-23 | 2003-06-23 | Procedimento per la preparazione di dexloxiglumide |
| ITTO2003A000474 | 2003-06-23 | ||
| PCT/IB2004/002208 WO2004113271A2 (en) | 2003-06-23 | 2004-06-21 | A method for the preparation of crystalline dexloxiglumide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007521253A JP2007521253A (ja) | 2007-08-02 |
| JP2007521253A5 true JP2007521253A5 (https=) | 2012-10-11 |
| JP5197955B2 JP5197955B2 (ja) | 2013-05-15 |
Family
ID=33524063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006516595A Expired - Fee Related JP5197955B2 (ja) | 2003-06-23 | 2004-06-21 | 結晶性デキスロキシグルミドの製造法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7662994B2 (https=) |
| EP (1) | EP1646607B1 (https=) |
| JP (1) | JP5197955B2 (https=) |
| AT (1) | ATE478839T1 (https=) |
| AU (1) | AU2004249526B2 (https=) |
| CA (1) | CA2529018C (https=) |
| DE (1) | DE602004028830D1 (https=) |
| DK (1) | DK1646607T3 (https=) |
| ES (1) | ES2351662T3 (https=) |
| IT (1) | ITTO20030474A1 (https=) |
| PT (1) | PT1646607E (https=) |
| WO (1) | WO2004113271A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863330B2 (en) * | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1217123B (it) | 1987-02-05 | 1990-03-14 | Rotta Research Lab | Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
| DE69112917T2 (de) * | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
| US7122083B2 (en) * | 2002-04-02 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Apparatus and process used in growing crystals |
-
2003
- 2003-06-23 IT IT000474A patent/ITTO20030474A1/it unknown
-
2004
- 2004-06-21 CA CA2529018A patent/CA2529018C/en not_active Expired - Fee Related
- 2004-06-21 PT PT04743871T patent/PT1646607E/pt unknown
- 2004-06-21 AU AU2004249526A patent/AU2004249526B2/en not_active Ceased
- 2004-06-21 WO PCT/IB2004/002208 patent/WO2004113271A2/en not_active Ceased
- 2004-06-21 AT AT04743871T patent/ATE478839T1/de active
- 2004-06-21 EP EP04743871A patent/EP1646607B1/en not_active Expired - Lifetime
- 2004-06-21 ES ES04743871T patent/ES2351662T3/es not_active Expired - Lifetime
- 2004-06-21 DK DK04743871.8T patent/DK1646607T3/da active
- 2004-06-21 DE DE602004028830T patent/DE602004028830D1/de not_active Expired - Lifetime
- 2004-06-21 JP JP2006516595A patent/JP5197955B2/ja not_active Expired - Fee Related
- 2004-06-21 US US10/562,013 patent/US7662994B2/en not_active Expired - Fee Related
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