CA2529018C - A method for the preparation of crystalline dexloxiglumide and products obtained thereby - Google Patents

A method for the preparation of crystalline dexloxiglumide and products obtained thereby Download PDF

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Publication number
CA2529018C
CA2529018C CA2529018A CA2529018A CA2529018C CA 2529018 C CA2529018 C CA 2529018C CA 2529018 A CA2529018 A CA 2529018A CA 2529018 A CA2529018 A CA 2529018A CA 2529018 C CA2529018 C CA 2529018C
Authority
CA
Canada
Prior art keywords
dexloxiglumide
particle size
pharmaceutical composition
average particle
isopropyl ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2529018A
Other languages
English (en)
French (fr)
Other versions
CA2529018A1 (en
Inventor
Francesco Makovec
Lucio Claudio Rovati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm Biotech SRL
Original Assignee
Rottapharm SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm SpA filed Critical Rottapharm SpA
Publication of CA2529018A1 publication Critical patent/CA2529018A1/en
Application granted granted Critical
Publication of CA2529018C publication Critical patent/CA2529018C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2529018A 2003-06-23 2004-06-21 A method for the preparation of crystalline dexloxiglumide and products obtained thereby Expired - Fee Related CA2529018C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000474A ITTO20030474A1 (it) 2003-06-23 2003-06-23 Procedimento per la preparazione di dexloxiglumide
ITTO2003A000474 2003-06-23
PCT/IB2004/002208 WO2004113271A2 (en) 2003-06-23 2004-06-21 A method for the preparation of crystalline dexloxiglumide

Publications (2)

Publication Number Publication Date
CA2529018A1 CA2529018A1 (en) 2004-12-29
CA2529018C true CA2529018C (en) 2013-05-28

Family

ID=33524063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2529018A Expired - Fee Related CA2529018C (en) 2003-06-23 2004-06-21 A method for the preparation of crystalline dexloxiglumide and products obtained thereby

Country Status (12)

Country Link
US (1) US7662994B2 (https=)
EP (1) EP1646607B1 (https=)
JP (1) JP5197955B2 (https=)
AT (1) ATE478839T1 (https=)
AU (1) AU2004249526B2 (https=)
CA (1) CA2529018C (https=)
DE (1) DE602004028830D1 (https=)
DK (1) DK1646607T3 (https=)
ES (1) ES2351662T3 (https=)
IT (1) ITTO20030474A1 (https=)
PT (1) PT1646607E (https=)
WO (1) WO2004113271A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863330B2 (en) * 2006-06-14 2011-01-04 Rottapharm S.P.A. Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217123B (it) 1987-02-05 1990-03-14 Rotta Research Lab Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
DE69112917T2 (de) * 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
US7122083B2 (en) * 2002-04-02 2006-10-17 E. I. Du Pont De Nemours And Company Apparatus and process used in growing crystals

Also Published As

Publication number Publication date
HK1089750A1 (en) 2006-12-08
EP1646607A2 (en) 2006-04-19
EP1646607B1 (en) 2010-08-25
ES2351662T3 (es) 2011-02-09
WO2004113271A2 (en) 2004-12-29
AU2004249526A1 (en) 2004-12-29
CA2529018A1 (en) 2004-12-29
AU2004249526B2 (en) 2011-02-24
PT1646607E (pt) 2010-10-12
DE602004028830D1 (de) 2010-10-07
WO2004113271A3 (en) 2005-01-27
US7662994B2 (en) 2010-02-16
WO2004113271A8 (en) 2005-05-06
US20060154987A1 (en) 2006-07-13
ITTO20030474A1 (it) 2004-12-24
JP2007521253A (ja) 2007-08-02
DK1646607T3 (da) 2010-11-22
JP5197955B2 (ja) 2013-05-15
ATE478839T1 (de) 2010-09-15

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MKLA Lapsed

Effective date: 20180621