ATE478839T1 - Verfahren zur herstellung von kristallinem dexloxiglumid - Google Patents
Verfahren zur herstellung von kristallinem dexloxiglumidInfo
- Publication number
- ATE478839T1 ATE478839T1 AT04743871T AT04743871T ATE478839T1 AT E478839 T1 ATE478839 T1 AT E478839T1 AT 04743871 T AT04743871 T AT 04743871T AT 04743871 T AT04743871 T AT 04743871T AT E478839 T1 ATE478839 T1 AT E478839T1
- Authority
- AT
- Austria
- Prior art keywords
- dexloxiglumide
- producing crystalline
- crystalline dexloxiglumide
- morphological
- favor
- Prior art date
Links
- QNQZBKQEIFTHFZ-GOSISDBHSA-N dexloxiglumide Chemical compound CCCCCN(CCCOC)C(=O)[C@@H](CCC(O)=O)NC(=O)C1=CC=C(Cl)C(Cl)=C1 QNQZBKQEIFTHFZ-GOSISDBHSA-N 0.000 title abstract 2
- 229950010525 dexloxiglumide Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000474A ITTO20030474A1 (it) | 2003-06-23 | 2003-06-23 | Procedimento per la preparazione di dexloxiglumide |
| PCT/IB2004/002208 WO2004113271A2 (en) | 2003-06-23 | 2004-06-21 | A method for the preparation of crystalline dexloxiglumide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478839T1 true ATE478839T1 (de) | 2010-09-15 |
Family
ID=33524063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04743871T ATE478839T1 (de) | 2003-06-23 | 2004-06-21 | Verfahren zur herstellung von kristallinem dexloxiglumid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7662994B2 (https=) |
| EP (1) | EP1646607B1 (https=) |
| JP (1) | JP5197955B2 (https=) |
| AT (1) | ATE478839T1 (https=) |
| AU (1) | AU2004249526B2 (https=) |
| CA (1) | CA2529018C (https=) |
| DE (1) | DE602004028830D1 (https=) |
| DK (1) | DK1646607T3 (https=) |
| ES (1) | ES2351662T3 (https=) |
| IT (1) | ITTO20030474A1 (https=) |
| PT (1) | PT1646607E (https=) |
| WO (1) | WO2004113271A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863330B2 (en) * | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1217123B (it) | 1987-02-05 | 1990-03-14 | Rotta Research Lab | Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
| DE69112917T2 (de) * | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
| US7122083B2 (en) * | 2002-04-02 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Apparatus and process used in growing crystals |
-
2003
- 2003-06-23 IT IT000474A patent/ITTO20030474A1/it unknown
-
2004
- 2004-06-21 CA CA2529018A patent/CA2529018C/en not_active Expired - Fee Related
- 2004-06-21 PT PT04743871T patent/PT1646607E/pt unknown
- 2004-06-21 AU AU2004249526A patent/AU2004249526B2/en not_active Ceased
- 2004-06-21 WO PCT/IB2004/002208 patent/WO2004113271A2/en not_active Ceased
- 2004-06-21 AT AT04743871T patent/ATE478839T1/de active
- 2004-06-21 EP EP04743871A patent/EP1646607B1/en not_active Expired - Lifetime
- 2004-06-21 ES ES04743871T patent/ES2351662T3/es not_active Expired - Lifetime
- 2004-06-21 DK DK04743871.8T patent/DK1646607T3/da active
- 2004-06-21 DE DE602004028830T patent/DE602004028830D1/de not_active Expired - Lifetime
- 2004-06-21 JP JP2006516595A patent/JP5197955B2/ja not_active Expired - Fee Related
- 2004-06-21 US US10/562,013 patent/US7662994B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1089750A1 (en) | 2006-12-08 |
| EP1646607A2 (en) | 2006-04-19 |
| EP1646607B1 (en) | 2010-08-25 |
| ES2351662T3 (es) | 2011-02-09 |
| WO2004113271A2 (en) | 2004-12-29 |
| AU2004249526A1 (en) | 2004-12-29 |
| CA2529018A1 (en) | 2004-12-29 |
| AU2004249526B2 (en) | 2011-02-24 |
| PT1646607E (pt) | 2010-10-12 |
| DE602004028830D1 (de) | 2010-10-07 |
| WO2004113271A3 (en) | 2005-01-27 |
| CA2529018C (en) | 2013-05-28 |
| US7662994B2 (en) | 2010-02-16 |
| WO2004113271A8 (en) | 2005-05-06 |
| US20060154987A1 (en) | 2006-07-13 |
| ITTO20030474A1 (it) | 2004-12-24 |
| JP2007521253A (ja) | 2007-08-02 |
| DK1646607T3 (da) | 2010-11-22 |
| JP5197955B2 (ja) | 2013-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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