JP2007521244A5 - - Google Patents
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- Publication number
- JP2007521244A5 JP2007521244A5 JP2005510644A JP2005510644A JP2007521244A5 JP 2007521244 A5 JP2007521244 A5 JP 2007521244A5 JP 2005510644 A JP2005510644 A JP 2005510644A JP 2005510644 A JP2005510644 A JP 2005510644A JP 2007521244 A5 JP2007521244 A5 JP 2007521244A5
- Authority
- JP
- Japan
- Prior art keywords
- desmopressin
- serum
- dosage form
- plasma
- pharmaceutical dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (15)
- 患者に投与されるときに、血漿／血清１ｍＬ当たりデスモプレシン約０．１ピコグラムから血漿／血清１ｍＬ当たりデスモプレシン約１０．０ピコグラムまでの範囲の定常的な血漿／血清中デスモプレシン濃度を確立して尿産生を減少させる、鼻腔内、舌下、頬側、経粘膜、経皮、又は皮内投与用に構成された、デスモプレシン及び薬学上許容される担体を含む、医薬剤形。
- 患者に投与されるときに、血漿／血清１ｍＬ当たりデスモプレシン約０．５ピコグラムから血漿／血清１ｍＬ当たりデスモプレシン約５．０ピコグラムまでの範囲の定常的な血漿／血清中デスモプレシン濃度を確立する、請求項１に記載の医薬剤形。
- 約０．５ｎｇから約２０μｇのデスモプレシンを含む、請求項１に記載の医薬剤形。
- 約０．０５μｇから約１０μｇのデスモプレシンを含む、請求項１に記載の医薬剤形。
- 約０．１μｇから約２μｇのデスモプレシンを含む、請求項１に記載の医薬剤形。
- 約１０ｐｇ／ｍｌを超えるデスモプレシンの血漿／血清中濃度を産生しない、請求項１に記載の医薬剤形。
- 舌下又は頬側投与用に構成された口内分散性固体である、請求項１に記載の医薬剤形。
- オープンマトリックス網状組織をさらに含み、前記オープンマトリックス網状組織が、デスモプレシンに対して不活性である水溶性又は水分散性担体材料を含む、請求項１に記載の医薬剤形。
- デスモプレシンの投与によって治療又は予防可能である疾患又は状態を治療又は予防する医薬の製造における、０．５ｎｇから約２０μｇのデスモプレシン及び薬学上許容される担体を含む医薬組成物の使用であって、前記医薬組成物が、定常的な血漿／血清中デスモプレシン濃度を約０．５ｐｇ／ｍｌから約１０．０ｐｇ／ｍｌまでの範囲に維持して、尿酸性を減少させることが可能である、上記使用。
- 前記疾患又は状態が、血友病、フォンウィルブランド病、失禁、一次性夜間遺尿症（ＰＮＥ）、夜間頻尿症、又は中枢性尿崩症である、請求項９に記載の使用。
- 前記疾患又は状態が、夜間頻尿症である、請求項９に記載の方法。
- 前記医薬組成物が、鼻腔内、舌下、頬側、経粘膜、経皮、又は皮内送達用に構成された、請求項９に記載の使用。
- 前記定常的な血漿／血清中デスモプレシン濃度が、約５ｐｇ／ｍｌ以下のレベルで維持される、請求項９に記載の使用。
- 前記定常的な血漿／血清中デスモプレシン濃度が、少なくとも４〜６時間維持される、請求項９に記載の使用。
- 尿産生が、約１０ｍｌ／分未満に少なくとも４〜６時間制限される、請求項９に記載の使用。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/035662 WO2005046707A1 (en) | 2003-11-10 | 2003-11-10 | Pharmaceutical compositions including low dosages of desmopressin |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011024804A Division JP2011116764A (ja) | 2011-02-08 | 2011-02-08 | 低用量デスモプレシンを含有する医薬組成物 |
| JP2014131839A Division JP2014177491A (ja) | 2014-06-26 | 2014-06-26 | 低用量デスモプレシンを含有する医薬組成物 |
| JP2014133867A Division JP6341777B2 (ja) | 2014-06-30 | 2014-06-30 | 低用量デスモプレシンを含有する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007521244A JP2007521244A (ja) | 2007-08-02 |
| JP2007521244A5 true JP2007521244A5 (ja) | 2007-11-01 |
| JP5596252B2 JP5596252B2 (ja) | 2014-09-24 |
Family
ID=34589310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005510644A Expired - Fee Related JP5596252B2 (ja) | 2003-11-10 | 2003-11-10 | 低用量デスモプレシンを含有する医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| EP (6) | EP2322197A2 (ja) |
| JP (1) | JP5596252B2 (ja) |
| CN (1) | CN1878563A (ja) |
| AU (1) | AU2003287591C1 (ja) |
| CA (2) | CA2866501A1 (ja) |
| WO (1) | WO2005046707A1 (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| EP2322197A2 (en) | 2003-11-10 | 2011-05-18 | Reprise Biopharmaceutics, LLC | Pharmaceutical compositions including low dosages of desmopressin |
| DE60305043T2 (de) | 2003-11-13 | 2006-11-30 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
| SE0600482L (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
| EA014213B1 (ru) | 2007-02-27 | 2010-10-29 | Ивакс Фармасьютикалз Айэлэнд | Дозирующий ингалятор |
| ES2319054B1 (es) | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | Composicion farmaceutica oral de desmopresina. |
| CA2988753A1 (en) | 2007-08-06 | 2009-02-12 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| ES2462465T5 (es) * | 2008-05-21 | 2018-02-28 | Ferring B.V. | Desmopresina bucodispersable para aumentar el periodo inicial del sueño no alterado por nocturia |
| US20100286045A1 (en) * | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| JP5731396B2 (ja) * | 2008-12-22 | 2015-06-10 | アラガン，インコーポレイティド | 鼻腔内デスモプレシン投与 |
| MX343193B (es) | 2009-06-18 | 2016-10-26 | Allergan Inc | Administracion segura de desmopresina. |
| AU2014293140A1 (en) | 2013-07-23 | 2016-03-03 | Serenity Pharmaceuticals Llc | Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor |
| KR20240015735A (ko) * | 2013-07-23 | 2024-02-05 | 세레니티 파마슈티컬즈 엘엘씨 | 베타-3-아드레날린 수용체 작용제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
| WO2015063602A1 (en) * | 2013-10-29 | 2015-05-07 | Ferring B.V. | Desmopressin and blood glucose |
| ES2923438T3 (es) | 2014-11-20 | 2022-09-27 | Serenity Pharmaceuticals Llc | Composiciones que comprenden bajas dosis de desmopresina en combinación con un antagonista del receptor alfaadrenérgico |
| CN108601798A (zh) * | 2016-01-29 | 2018-09-28 | 小林光 | 固体制剂、固体制剂的制备方法及析氢方法 |
| WO2018037819A1 (ja) | 2016-08-23 | 2018-03-01 | 小林 光 | 配合物及びその製造方法、並びに水素供給方法 |
| WO2018037818A1 (ja) | 2016-08-23 | 2018-03-01 | 小林 光 | 水素供給材及びその製造方法、並びに水素供給方法 |
| MY195591A (en) * | 2017-01-11 | 2023-02-02 | Ferring Bv | A Fast Disintegrating Pharmaceutical Composition |
| CN114432424B (zh) * | 2021-12-27 | 2023-06-27 | 南通联亚药业股份有限公司 | 一种稳定的铝塑包装去氨加压素片剂 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072668A (en) | 1973-11-06 | 1978-02-07 | The Salk Institute For Biological Studies | LH-RH Analogs |
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| US4285858A (en) * | 1979-10-30 | 1981-08-25 | Mt. Sinai School Of Medicine Of The City University Of N.Y. | Vasopressin analogs |
| IE53696B1 (en) | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
| GB2111423B (en) | 1981-12-02 | 1985-06-26 | Wyeth John & Brother Ltd | Making quick-dissolving pills |
| DE3264450D1 (en) | 1981-12-11 | 1985-08-01 | Wyeth John & Brother Ltd | Process and apparatus for freezing a liquid medium |
| EP0084705B1 (en) | 1981-12-11 | 1987-01-14 | JOHN WYETH & BROTHER LIMITED | Process for preparing solid shaped articles |
| US5188825A (en) | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
| AU666509B2 (en) | 1991-12-24 | 1996-02-15 | Yamanouchi Pharmaceutical Co., Ltd. | Intrabuccally disintegrating preparation and production thereof |
| IL105553A (en) | 1992-05-06 | 1998-01-04 | Janssen Pharmaceutica Inc | Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water |
| US5500413A (en) * | 1993-06-29 | 1996-03-19 | Ferring Ab | Process for manufacture of 1-deamino-8-D-arginine vasopressin |
| DE69424940T2 (de) * | 1993-06-29 | 2000-12-28 | Ferring B.V., Hoofdorp | Synthese zyklischer peptide |
| DE69429119T2 (de) | 1993-07-09 | 2002-07-18 | R.P. Scherer Corp., Troy | Verfahren zur herstellung von gefriergetrockneten arzneistoffdosierungsformen |
| US5738875A (en) | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| GB9421836D0 (en) | 1994-10-28 | 1994-12-14 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances |
| US5837287A (en) | 1994-10-28 | 1998-11-17 | R P Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| US5989835A (en) * | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
| US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| GB9702799D0 (en) | 1997-02-12 | 1997-04-02 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms |
| US5925730A (en) | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| US5976577A (en) | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
| GB9722682D0 (en) | 1997-10-27 | 1997-12-24 | Scherer Ltd R P | Pharmaceutical products |
| US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| GB9901819D0 (en) | 1999-01-27 | 1999-03-17 | Scherer Corp R P | Pharmaceutical compositions |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| DE10001390A1 (de) | 2000-01-14 | 2001-07-19 | Hepavec Ag Fuer Gentherapie | Zelllinie zur Herstellung und Produktion von Schafadenovirusvektoren |
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| NZ535861A (en) * | 2002-05-07 | 2006-11-30 | Ferring Bv | Desmopressin acetate in an orodispersible dosage form that disintegrates in the mouth within 10 seconds |
| EP2322197A2 (en) | 2003-11-10 | 2011-05-18 | Reprise Biopharmaceutics, LLC | Pharmaceutical compositions including low dosages of desmopressin |
-
2003
- 2003-11-10 EP EP11000467A patent/EP2322197A2/en not_active Withdrawn
- 2003-11-10 CA CA2866501A patent/CA2866501A1/en not_active Abandoned
- 2003-11-10 EP EP03781836A patent/EP1689419A4/en not_active Withdrawn
- 2003-11-10 CN CNA2003801106751A patent/CN1878563A/zh active Pending
- 2003-11-10 EP EP11000468A patent/EP2322198A2/en not_active Withdrawn
- 2003-11-10 AU AU2003287591A patent/AU2003287591C1/en not_active Ceased
- 2003-11-10 EP EP11000466A patent/EP2322196A2/en not_active Withdrawn
- 2003-11-10 WO PCT/US2003/035662 patent/WO2005046707A1/en active Application Filing
- 2003-11-10 EP EP11000465A patent/EP2322195A2/en not_active Withdrawn
- 2003-11-10 CA CA2545194A patent/CA2545194C/en not_active Expired - Lifetime
- 2003-11-10 EP EP11000464A patent/EP2322194A2/en not_active Withdrawn
- 2003-11-10 JP JP2005510644A patent/JP5596252B2/ja not_active Expired - Fee Related
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