JP2007520494A - 溶血性疾患の処置方法 - Google Patents
溶血性疾患の処置方法 Download PDFInfo
- Publication number
- JP2007520494A JP2007520494A JP2006551599A JP2006551599A JP2007520494A JP 2007520494 A JP2007520494 A JP 2007520494A JP 2006551599 A JP2006551599 A JP 2006551599A JP 2006551599 A JP2006551599 A JP 2006551599A JP 2007520494 A JP2007520494 A JP 2007520494A
- Authority
- JP
- Japan
- Prior art keywords
- subject
- compound
- red blood
- administering
- type iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000002949 hemolytic effect Effects 0.000 title claims abstract description 81
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 75
- 201000010099 disease Diseases 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims description 394
- 150000001875 compounds Chemical class 0.000 claims abstract description 249
- 230000000295 complement effect Effects 0.000 claims abstract description 143
- 230000000694 effects Effects 0.000 claims abstract description 57
- 239000012634 fragment Substances 0.000 claims abstract description 29
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 23
- 210000003743 erythrocyte Anatomy 0.000 claims description 189
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 80
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 79
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 79
- 210000001772 blood platelet Anatomy 0.000 claims description 73
- 210000001995 reticulocyte Anatomy 0.000 claims description 60
- 206010018910 Haemolysis Diseases 0.000 claims description 59
- 238000004519 manufacturing process Methods 0.000 claims description 51
- 230000008588 hemolysis Effects 0.000 claims description 48
- 108090000623 proteins and genes Proteins 0.000 claims description 45
- 102000004169 proteins and genes Human genes 0.000 claims description 42
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 38
- 230000002829 reductive effect Effects 0.000 claims description 38
- 239000003112 inhibitor Substances 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 35
- 102000003951 Erythropoietin Human genes 0.000 claims description 31
- 108090000394 Erythropoietin Proteins 0.000 claims description 31
- 229940105423 erythropoietin Drugs 0.000 claims description 31
- 230000009467 reduction Effects 0.000 claims description 30
- 201000001505 hemoglobinuria Diseases 0.000 claims description 24
- 210000002966 serum Anatomy 0.000 claims description 24
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 23
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 23
- 210000003714 granulocyte Anatomy 0.000 claims description 23
- 208000007536 Thrombosis Diseases 0.000 claims description 21
- 108091093037 Peptide nucleic acid Proteins 0.000 claims description 18
- 108020004459 Small interfering RNA Proteins 0.000 claims description 18
- 239000004055 small Interfering RNA Substances 0.000 claims description 18
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 17
- XGUFMAUYGBDFJS-UHFFFAOYSA-N 6'-formyl-2,3,4'-trihydroxy-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1h-naphthalene-8,2'-3h-1-benzofuran]-7'-carboxylic acid Chemical compound C1C(C(=CC(C=O)=C2C(O)=O)O)=C2OC21C1(C)CC(O)C(O)C(C)(C)C1CCC2C XGUFMAUYGBDFJS-UHFFFAOYSA-N 0.000 claims description 17
- 108091023037 Aptamer Proteins 0.000 claims description 17
- 101710172562 Cobra venom factor Proteins 0.000 claims description 17
- 108010053085 Complement Factor H Proteins 0.000 claims description 17
- 102000016550 Complement Factor H Human genes 0.000 claims description 17
- 102000007079 Peptide Fragments Human genes 0.000 claims description 17
- 108010033276 Peptide Fragments Proteins 0.000 claims description 17
- 108091008103 RNA aptamers Proteins 0.000 claims description 17
- 230000000692 anti-sense effect Effects 0.000 claims description 17
- MQQNFDZXWVTQEH-UHFFFAOYSA-N nafamostat Chemical compound C1=CC(N=C(N)N)=CC=C1C(=O)OC1=CC=C(C=C(C=C2)C(N)=N)C2=C1 MQQNFDZXWVTQEH-UHFFFAOYSA-N 0.000 claims description 17
- 229950009865 nafamostat Drugs 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 239000003001 serine protease inhibitor Substances 0.000 claims description 17
- 150000003384 small molecules Chemical class 0.000 claims description 17
- 238000004820 blood count Methods 0.000 claims description 15
- 230000011132 hemopoiesis Effects 0.000 claims description 15
- 208000004998 Abdominal Pain Diseases 0.000 claims description 14
- 208000019505 Deglutition disease Diseases 0.000 claims description 14
- 208000010228 Erectile Dysfunction Diseases 0.000 claims description 13
- 201000001881 impotence Diseases 0.000 claims description 13
- 102000006395 Globulins Human genes 0.000 claims description 10
- 108010044091 Globulins Proteins 0.000 claims description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- 150000003431 steroids Chemical class 0.000 claims description 7
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- 230000000781 anti-lymphocytic effect Effects 0.000 claims description 5
- 230000001494 anti-thymocyte effect Effects 0.000 claims description 5
- 239000003146 anticoagulant agent Substances 0.000 claims description 5
- 229940127219 anticoagulant drug Drugs 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 5
- 230000007812 deficiency Effects 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- 229960003444 immunosuppressant agent Drugs 0.000 claims description 5
- 239000003018 immunosuppressive agent Substances 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 16
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 12
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 12
- 229960003284 iron Drugs 0.000 claims 3
- 108091027076 Spiegelmer Proteins 0.000 claims 2
- 230000013632 homeostatic process Effects 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 abstract description 54
- 229960002224 eculizumab Drugs 0.000 abstract description 25
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 abstract description 5
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 abstract description 5
- 229950003203 pexelizumab Drugs 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 description 47
- 102000001554 Hemoglobins Human genes 0.000 description 34
- 108010054147 Hemoglobins Proteins 0.000 description 34
- 208000024891 symptom Diseases 0.000 description 27
- 102100031506 Complement C5 Human genes 0.000 description 23
- 101000941598 Homo sapiens Complement C5 Proteins 0.000 description 22
- 102100022133 Complement C3 Human genes 0.000 description 15
- 101000901154 Homo sapiens Complement C3 Proteins 0.000 description 15
- 108010034753 Complement Membrane Attack Complex Proteins 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 230000024203 complement activation Effects 0.000 description 14
- 206010016256 fatigue Diseases 0.000 description 14
- 230000009089 cytolysis Effects 0.000 description 12
- 206010022822 Intravascular haemolysis Diseases 0.000 description 11
- 208000007502 anemia Diseases 0.000 description 11
- 206010010904 Convulsion Diseases 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 10
- 230000037361 pathway Effects 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 230000006037 cell lysis Effects 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 102000014702 Haptoglobin Human genes 0.000 description 7
- 108050005077 Haptoglobin Proteins 0.000 description 7
- 229940024606 amino acid Drugs 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000003285 pharmacodynamic effect Effects 0.000 description 7
- 238000002203 pretreatment Methods 0.000 description 7
- 210000002700 urine Anatomy 0.000 description 7
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000003776 cleavage reaction Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 230000007017 scission Effects 0.000 description 6
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 description 5
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 description 5
- 108010019673 Darbepoetin alfa Proteins 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 108010089414 Anaphylatoxins Proteins 0.000 description 4
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 4
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 229960005029 darbepoetin alfa Drugs 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 102100025680 Complement decay-accelerating factor Human genes 0.000 description 3
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 description 3
- 102100026553 Mannose-binding protein C Human genes 0.000 description 3
- 108700022034 Opsonin Proteins Proteins 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000020411 cell activation Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 239000004074 complement inhibitor Substances 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000000770 proinflammatory effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
- 230000003582 thrombocytopenic effect Effects 0.000 description 3
- 108010069112 Complement System Proteins Proteins 0.000 description 2
- 102000000989 Complement System Proteins Human genes 0.000 description 2
- 229940124073 Complement inhibitor Drugs 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- 208000005872 Diffuse Esophageal Spasm Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010018901 Haemoglobinaemia Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 101710110798 Mannose-binding protein C Proteins 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010030184 Oesophageal spasm Diseases 0.000 description 2
- 206010033661 Pancytopenia Diseases 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 241000219492 Quercus Species 0.000 description 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 230000005983 bone marrow dysfunction Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 230000004154 complement system Effects 0.000 description 2
- 229930182912 cyclosporin Natural products 0.000 description 2
- 208000024389 cytopenia Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 150000003278 haem Chemical group 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000007475 hemolytic anemia Diseases 0.000 description 2
- 230000032226 immune complex clearance Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000032424 nitric oxide homeostasis Effects 0.000 description 2
- 230000014207 opsonization Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 108700040669 phosphatidylinositol glycan-class A Proteins 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000009589 serological test Methods 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 230000016160 smooth muscle contraction Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 2
- 229960005080 warfarin Drugs 0.000 description 2
- 206010069754 Acquired gene mutation Diseases 0.000 description 1
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 description 1
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 108010009575 CD55 Antigens Proteins 0.000 description 1
- 101710091342 Chemotactic peptide Proteins 0.000 description 1
- 108010078804 Classical Pathway Complement C5 Convertase Proteins 0.000 description 1
- 108010028773 Complement C5 Proteins 0.000 description 1
- 108090000056 Complement factor B Proteins 0.000 description 1
- 102000003712 Complement factor B Human genes 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 108010017480 Hemosiderin Proteins 0.000 description 1
- 101100440311 Homo sapiens C5 gene Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 108010058683 Immobilized Proteins Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 description 1
- 101710117390 Mannan-binding lectin serine protease 1 Proteins 0.000 description 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 description 1
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 description 1
- 108010087870 Mannose-Binding Lectin Proteins 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000008425 Protein deficiency Diseases 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000001766 X chromosome Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 1
- 229940115115 aranesp Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005482 chemotactic factor Substances 0.000 description 1
- PRQROPMIIGLWRP-BZSNNMDCSA-N chemotactic peptide Chemical compound CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-BZSNNMDCSA-N 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 125000002228 disulfide group Chemical group 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- -1 etc. Chemical compound 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000002480 immunoprotective effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000008722 morphological abnormality Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 230000004983 pleiotropic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108010014806 prothrombinase complex Proteins 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 238000009774 resonance method Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000037439 somatic mutation Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000007332 vesicle formation Effects 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/771,552 US20050169921A1 (en) | 2004-02-03 | 2004-02-03 | Method of treating hemolytic disease |
| PCT/US2005/003225 WO2005074607A2 (en) | 2004-02-03 | 2005-02-03 | Method of treating hemolytic disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011065075A Division JP2011126917A (ja) | 2004-02-03 | 2011-03-23 | 溶血性疾患の処置方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520494A true JP2007520494A (ja) | 2007-07-26 |
| JP2007520494A5 JP2007520494A5 (enExample) | 2008-03-27 |
Family
ID=34808492
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551599A Withdrawn JP2007520494A (ja) | 2004-02-03 | 2005-02-03 | 溶血性疾患の処置方法 |
| JP2011065075A Withdrawn JP2011126917A (ja) | 2004-02-03 | 2011-03-23 | 溶血性疾患の処置方法 |
| JP2013145341A Expired - Lifetime JP5873047B2 (ja) | 2004-02-03 | 2013-07-11 | 溶血性疾患の処置方法 |
| JP2015015028A Withdrawn JP2015083611A (ja) | 2004-02-03 | 2015-01-29 | 溶血性疾患の処置方法 |
| JP2017000897A Pending JP2017057234A (ja) | 2004-02-03 | 2017-01-06 | 溶血性疾患の処置方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011065075A Withdrawn JP2011126917A (ja) | 2004-02-03 | 2011-03-23 | 溶血性疾患の処置方法 |
| JP2013145341A Expired - Lifetime JP5873047B2 (ja) | 2004-02-03 | 2013-07-11 | 溶血性疾患の処置方法 |
| JP2015015028A Withdrawn JP2015083611A (ja) | 2004-02-03 | 2015-01-29 | 溶血性疾患の処置方法 |
| JP2017000897A Pending JP2017057234A (ja) | 2004-02-03 | 2017-01-06 | 溶血性疾患の処置方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20050169921A1 (enExample) |
| EP (7) | EP2522362A1 (enExample) |
| JP (5) | JP2007520494A (enExample) |
| KR (1) | KR101197799B1 (enExample) |
| CN (4) | CN1938047A (enExample) |
| AU (1) | AU2005209854B2 (enExample) |
| CA (1) | CA2554632A1 (enExample) |
| CY (1) | CY1113190T1 (enExample) |
| DK (1) | DK1720571T3 (enExample) |
| ES (1) | ES2389093T3 (enExample) |
| IL (2) | IL177003A0 (enExample) |
| NZ (1) | NZ549328A (enExample) |
| PL (1) | PL1720571T3 (enExample) |
| PT (1) | PT1720571E (enExample) |
| SI (1) | SI1720571T1 (enExample) |
| WO (1) | WO2005074607A2 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012508262A (ja) * | 2008-11-10 | 2012-04-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2013521772A (ja) * | 2010-03-11 | 2013-06-13 | ライナット ニューロサイエンス コーポレイション | ｐＨ依存性の抗原結合を有する抗体 |
| JP2014512363A (ja) * | 2011-04-08 | 2014-05-22 | ユニバーシティー オブ レスター | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2015523999A (ja) * | 2012-06-20 | 2015-08-20 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 歯周炎および歯周炎に関連する疾患を処置または予防する方法 |
| JP2016520542A (ja) * | 2013-03-29 | 2016-07-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体ｃ５を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
| US11884742B2 (en) | 2004-06-10 | 2024-01-30 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| EP1545611B1 (en) * | 2002-09-06 | 2016-11-09 | Alexion Pharmaceuticals, Inc. | Method of treatment of asthma using antibodies to complement component c5 |
| US9415102B2 (en) * | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| US20070116710A1 (en) * | 2004-02-03 | 2007-05-24 | Leonard Bell | Methods of treating hemolytic anemia |
| EP2338511A3 (en) * | 2004-05-14 | 2012-07-25 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2006107708A1 (en) * | 2005-04-04 | 2006-10-12 | Alexion Pharmaceuticals, Inc. | Treatment of disease caused by excess free hemoglobin |
| DK2500030T4 (en) * | 2005-11-04 | 2018-10-29 | Genentech Inc | Use of complement pathway inhibitors for the treatment of eye diseases |
| BRPI0708424A2 (pt) * | 2006-03-02 | 2011-05-31 | Alexion Pharma Inc | prolongamento da sobreviência de uma aloenxerto por inibição da atividade do complemento |
| HUE066795T2 (hu) | 2006-03-15 | 2024-09-28 | Alexion Pharma Inc | Paroxysmalis nocturnalis haemoglobinuriában szenvedõ betegek kezelése egy komplement inhibitorral |
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| LT3028716T (lt) | 2006-10-10 | 2020-12-10 | Regenesance B.V. | Komplemento slopinimas nervų regeneracijos pagerinimui |
| CN106084055A (zh) | 2006-11-02 | 2016-11-09 | 健泰科生物技术公司 | 人源化的抗‑d因子抗体 |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| EP3150635A3 (en) * | 2009-10-16 | 2017-06-21 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
| US20110124019A1 (en) * | 2009-11-25 | 2011-05-26 | The Charlotte-Mecklenburg Hospital Authority | Method of using carbonic anhydrase to detect hemolysis |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| AU2015230852B2 (en) * | 2011-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | High concentration antibody formulations |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| SG10201703249PA (en) | 2011-12-21 | 2017-05-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| WO2013137912A2 (en) * | 2012-03-16 | 2013-09-19 | Alexion Pharmaceuticals, Inc. | Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor |
| NZ629675A (en) * | 2012-04-06 | 2017-02-24 | Omeros Corp | Compositions and methods of inhibiting masp-1, masp-2 and/or masp-3 for treatment of paroxysmal nocturnal hemoglobinuria |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| MX2016001854A (es) | 2013-08-12 | 2016-09-06 | Genentech Inc | Composiciones y metodo para tratar condiciones asociadas con el complemento. |
| RS61351B1 (sr) | 2013-10-17 | 2021-02-26 | Omeros Corp | Postupci za lečenje stanja udruženih sa aktivacijom komplementa zavisnom od masp-2 |
| SG11201608868PA (en) | 2014-05-01 | 2016-11-29 | Genentech Inc | Anti-factor d antibody variants and uses thereof |
| EA201791366A1 (ru) | 2014-12-19 | 2018-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к c5 и способы их применения |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| US20180016327A1 (en) | 2015-01-22 | 2018-01-18 | Chugai Seiyaku Kabushiki Kaisha | A Combination of Two or More Anti-C5 Antibodies and Methods of Use |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| WO2016160756A2 (en) * | 2015-03-31 | 2016-10-06 | Alexion Pharmaceuticlas, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patents |
| JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体変異体コンジュゲート及びその使用 |
| TW201730211A (zh) | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
| CN108401431B (zh) | 2015-12-18 | 2022-01-25 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
| IL263481B2 (en) | 2016-06-14 | 2024-06-01 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| IT201600121482A1 (it) * | 2016-11-30 | 2018-05-30 | Univ Degli Studi Di Verona | Fattore H per l’uso nel trattamento e/o prevenzione della formazione di eterotrombi in pazienti affetti da anemia falciforme |
| TWI828672B (zh) | 2017-01-31 | 2024-01-11 | 日商中外製藥股份有限公司 | 用於治療或預防c5相關疾病的醫藥組合物以及治療或預防c5相關疾病的方法 |
| AU2018383751B2 (en) | 2017-12-13 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| MX2021000516A (es) | 2018-08-01 | 2021-04-12 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para usarse en el tratamiento o prevencion de una enfermedad relacionada con c5 y metodo para tratar o prevenir una enfermedad relacionada con c5. |
| CN114466660A (zh) | 2019-07-31 | 2022-05-10 | 豪夫迈·罗氏有限公司 | 通过使用抗c5抗体可伐利单抗来治疗或预防c5相关疾病的剂量和施用方案 |
| EP4003409A1 (en) | 2019-07-31 | 2022-06-01 | F. Hoffmann-La Roche AG | Dosage and administration regimen for the treatment or prevention of c5-related diseases by the use of the anti-c5 antibody crovalimab |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686100A (en) * | 1985-04-02 | 1987-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for the treatment of adult respiratory distress syndrome |
| US5135916A (en) * | 1989-06-12 | 1992-08-04 | Oklahoma Medical Research Foundation | Inhibition of complement mediated inflammatory response |
| DE3924924A1 (de) | 1989-07-27 | 1991-02-07 | Goetze Otto | Verfahren zum nachweis und/oder der quantitativen bestimmung von komplementpeptid c5a und/oder c5adesarg |
| US6074642A (en) * | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5650825A (en) * | 1995-03-31 | 1997-07-22 | Matsushita Electric Corporation Of America | Method and apparatus for sending private data instead of stuffing bits in an MPEG bit stream |
| DE19826743A1 (de) * | 1998-06-16 | 1999-12-23 | Bayer Ag | Verfahren zur Herstellung von geträgerten Polymerisationskatalysatorsystemen und Verwendung dieser zur Homo- und Copolymerisation ungesättigter Monomere |
| EP1370589B1 (en) * | 2000-12-05 | 2006-03-15 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| AU2003223288A1 (en) * | 2002-03-18 | 2003-10-08 | Alexion Pharmaceuticals, Inc. | Stratification of patient populations having or suspected of having rheumatoid arthritis |
| US7361339B2 (en) * | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
-
2004
- 2004-02-03 US US10/771,552 patent/US20050169921A1/en not_active Abandoned
-
2005
- 2005-02-03 EP EP12169513A patent/EP2522362A1/en not_active Withdrawn
- 2005-02-03 EP EP05712607A patent/EP1720571B9/en not_active Revoked
- 2005-02-03 CA CA002554632A patent/CA2554632A1/en not_active Abandoned
- 2005-02-03 CN CNA2005800106310A patent/CN1938047A/zh active Pending
- 2005-02-03 DK DK05712607.0T patent/DK1720571T3/da active
- 2005-02-03 EP EP12169519A patent/EP2522363A1/en not_active Withdrawn
- 2005-02-03 PT PT05712607T patent/PT1720571E/pt unknown
- 2005-02-03 EP EP15150658.1A patent/EP2910253A1/en not_active Withdrawn
- 2005-02-03 AU AU2005209854A patent/AU2005209854B2/en not_active Expired
- 2005-02-03 EP EP12169508A patent/EP2520311A3/en not_active Withdrawn
- 2005-02-03 JP JP2006551599A patent/JP2007520494A/ja not_active Withdrawn
- 2005-02-03 PL PL05712607T patent/PL1720571T3/pl unknown
- 2005-02-03 EP EP12169343A patent/EP2522361A1/en not_active Withdrawn
- 2005-02-03 KR KR1020067017880A patent/KR101197799B1/ko not_active Ceased
- 2005-02-03 EP EP12169526A patent/EP2522364A1/en not_active Withdrawn
- 2005-02-03 SI SI200531579T patent/SI1720571T1/sl unknown
- 2005-02-03 WO PCT/US2005/003225 patent/WO2005074607A2/en not_active Ceased
- 2005-02-03 NZ NZ549328A patent/NZ549328A/en not_active IP Right Cessation
- 2005-02-03 CN CN2013103817575A patent/CN103446584A/zh active Pending
- 2005-02-03 ES ES05712607T patent/ES2389093T3/es not_active Expired - Lifetime
- 2005-02-03 CN CN201410147793.XA patent/CN103977402A/zh active Pending
- 2005-02-03 CN CN201410147935.2A patent/CN103977403A/zh active Pending
- 2005-02-03 US US11/050,543 patent/US20050191298A1/en not_active Abandoned
-
2006
- 2006-07-20 IL IL177003A patent/IL177003A0/en unknown
-
2009
- 2009-11-19 US US12/621,792 patent/US20100068202A1/en not_active Abandoned
-
2010
- 2010-10-12 US US12/902,617 patent/US20110086040A1/en not_active Abandoned
-
2011
- 2011-03-23 JP JP2011065075A patent/JP2011126917A/ja not_active Withdrawn
- 2011-12-22 US US13/335,518 patent/US20120308559A1/en not_active Abandoned
-
2012
- 2012-08-30 CY CY20121100783T patent/CY1113190T1/el unknown
-
2013
- 2013-07-11 JP JP2013145341A patent/JP5873047B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-29 JP JP2015015028A patent/JP2015083611A/ja not_active Withdrawn
- 2015-08-06 IL IL240410A patent/IL240410A0/en unknown
-
2017
- 2017-01-06 JP JP2017000897A patent/JP2017057234A/ja active Pending
Non-Patent Citations (4)
| Title |
|---|
| JPN6010072723, ＲＯＳＳＥ，Ｗ．Ｆ． ｅｔ ａｌ, "Ｉｍｍｕｎｅ−ｍｅｄｉａｔｅｄ ｈｅｍｏｌｙｔｉｃ ａｎｅｍｉａ", ＨＥＭＡＴＯＬＯＧＹ, 200401, ｐ．４８−６２ * |
| JPN6010072726, ＦＩＴＣＨ，ＪＣ． ｅｔ ａｌ, "Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｆｆｉｃａｃｙ ｏｆ ａ ｒｅｃｏｍｂｉｎａｎｔ， ｈｕｍａｎｉｚｅｄ， ｓｉｎｇｌｅ−ｃｈａｉｎ ａｎｔｉｂｏｄｙ Ｃ５ ｃｏｍｐｌｅｍｅｎ", ＣＩＲＣＵＬＡＴＩＯＮ, 1999, Ｖｏｌ． １００， Ｎｏ． ２５, ｐ．２４９９−２５０６ * |
| JPN6010072727, ＪＡＮＥ ＳＡＬＯＤＯＦ ＭＡＣＮＥＩＬ, "ｃｏｕｌｄ ｂｅ ｐａｒｏｘｙｓｍａｌ ｎｏｃｔｕｒｎａｌ ｈｅｍｏｇｌｏｂｉｎｕｒｉａ ｂｒｅａｋｔｈｒｏｕｇｈ", Ｍｅｄｓｃａｐｅ Ｍｅｄｉｃａｌ Ｎｅｗｓ, 20021213 * |
| JPN6010072730, "Ａｌｅｘｉｏｎ ｒｅｃｅｉｖｅｓ ＦＤＡ， Ｅｕｒｏｐｅａｎ ａｐｐｒｏｖａｌ ｆｏｒ ｏｒｐｈａｎ ｄｒｕｇ ｓｔａｔｕｓ ｏｆ ｎｅｗ ｔｒｅａｔｍｅｎｔ ｆｏｒ ｐａｒｏｘｙｓｍａｌ ｎｏｃｔｕ", ＴＲＡＮＳＰＬＡＮＴ ＮＥＷＳ, 20040115 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11884742B2 (en) | 2004-06-10 | 2024-01-30 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| JP2014185174A (ja) * | 2008-11-10 | 2014-10-02 | Alexion Pharmaceuticals Inc | 補体関連障害を処置するための方法および組成物 |
| JP2015155473A (ja) * | 2008-11-10 | 2015-08-27 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2012508262A (ja) * | 2008-11-10 | 2012-04-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2016196513A (ja) * | 2008-11-10 | 2016-11-24 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2018030882A (ja) * | 2008-11-10 | 2018-03-01 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2024107240A (ja) * | 2008-11-10 | 2024-08-08 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2021167362A (ja) * | 2008-11-10 | 2021-10-21 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP2013521772A (ja) * | 2010-03-11 | 2013-06-13 | ライナット ニューロサイエンス コーポレイション | ｐＨ依存性の抗原結合を有する抗体 |
| JP2014512363A (ja) * | 2011-04-08 | 2014-05-22 | ユニバーシティー オブ レスター | Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法 |
| JP2015523999A (ja) * | 2012-06-20 | 2015-08-20 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 歯周炎および歯周炎に関連する疾患を処置または予防する方法 |
| JP2016520542A (ja) * | 2013-03-29 | 2016-07-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体ｃ５を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
| JP2018111728A (ja) * | 2013-03-29 | 2018-07-19 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体ｃ５を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5873047B2 (ja) | 溶血性疾患の処置方法 | |
| AU2007328435B2 (en) | Methods of treating hemolytic anemia | |
| JP6224059B2 (ja) | 補体のインヒビターによる発作性夜間血色素尿症患者の処置 | |
| HK1175987A (en) | Method of treating hemolytic disease | |
| HK1175985A (en) | Method of treating hemolytic disease | |
| HK1175988A (en) | Method of treating hemolytic disease | |
| HK1175986A (en) | Method of treating hemolytic disease | |
| HK1175989A (en) | Method of treating hemolytic disease | |
| HK1094950B (en) | Method of treating hemolytic disease | |
| AU2013206217A1 (en) | Methods of treating hemolytic anemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080201 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080201 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101224 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110323 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110323 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110613 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110912 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110920 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111012 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111019 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20111114 |