PT1720571E - Processo de tratamento de doenças hemolíticas - Google Patents
Processo de tratamento de doenças hemolíticas Download PDFInfo
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- PT1720571E PT1720571E PT05712607T PT05712607T PT1720571E PT 1720571 E PT1720571 E PT 1720571E PT 05712607 T PT05712607 T PT 05712607T PT 05712607 T PT05712607 T PT 05712607T PT 1720571 E PT1720571 E PT 1720571E
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- red blood
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- eculizumab
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7083786B2 (en) | 1997-04-03 | 2006-08-01 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| NZ538384A (en) * | 2002-09-06 | 2009-04-30 | Alexion Pharma Inc | Treatment for asthma using a compound which binds to or otherwise blocks the generation and/or activity of one or more complement components reptors, such as, C5a receptors |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| US20070116710A1 (en) * | 2004-02-03 | 2007-05-24 | Leonard Bell | Methods of treating hemolytic anemia |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| CA2566716C (en) * | 2004-05-14 | 2014-12-23 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2006107708A1 (en) * | 2005-04-04 | 2006-10-12 | Alexion Pharmaceuticals, Inc. | Treatment of disease caused by excess free hemoglobin |
| SI2500030T2 (sl) * | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uporaba inhibitorjev komplementarnih procesov za zdravljenje očesnih bolezni |
| RU2445975C2 (ru) * | 2006-03-02 | 2012-03-27 | Алексион Фармасьютикалз, Инк. | Продление срока выживаемости аллотрансплантата путем ингибирования активности комплемента |
| HUE066795T2 (hu) * | 2006-03-15 | 2024-09-28 | Alexion Pharma Inc | Paroxysmalis nocturnalis haemoglobinuriában szenvedõ betegek kezelése egy komplement inhibitorral |
| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| WO2008044928A1 (en) | 2006-10-10 | 2008-04-17 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Complement inhibition for improved nerve regeneration |
| RS58233B1 (sr) * | 2006-11-02 | 2019-03-29 | Genentech Inc | Humanizovana anti-faktor d antitela i njihove upotrebe |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| MX2011001371A (es) * | 2008-08-05 | 2011-06-16 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complementos c5. |
| CA2742802C (en) * | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| CN106390117A (zh) * | 2009-10-16 | 2017-02-15 | 奥默罗斯公司 | 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法 |
| US20110124019A1 (en) * | 2009-11-25 | 2011-05-26 | The Charlotte-Mecklenburg Hospital Authority | Method of using carbonic anhydrase to detect hemolysis |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| BR112012022917A2 (pt) * | 2010-03-11 | 2017-01-10 | Pfizer | anticorpos com ligação a antígeno dependente de ph |
| BR112013013354A2 (pt) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| AU2015230852B2 (en) * | 2011-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | High concentration antibody formulations |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| KR101870915B1 (ko) | 2011-04-08 | 2018-06-25 | 유니버시티 오브 레스터 | Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| PE20150159A1 (es) | 2011-12-21 | 2015-02-08 | Novartis Ag | Composiciones y metodos para anticuerpos que actuan sobre el factor p |
| CN104205155A (zh) * | 2012-03-16 | 2014-12-10 | 亚力克恩制药公司 | 给接受补体抑制剂的患者分配补体抑制药物的方法 |
| ES2670668T3 (es) * | 2012-04-06 | 2018-05-31 | Omeros Corporation | Composiciones y métodos para inhibir la MASP-1 y/o la MASP-3 para el tratamiento de la hemoglobinuria nocturna paroxísmica |
| US9579360B2 (en) * | 2012-06-20 | 2017-02-28 | The Trustees Of The University Of Pennsylvania | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| ES2768648T3 (es) | 2013-03-29 | 2020-06-23 | Alexion Pharma Inc | Composiciones y métodos para aumentar la semivida en suero de un agente terapéutico dirigido a C5 del complemento |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| US10093978B2 (en) | 2013-08-12 | 2018-10-09 | Genentech, Inc. | Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms |
| NZ719476A (en) | 2013-10-17 | 2022-07-29 | Omeros Corp | Methods for treating conditions associated with masp-2 dependent complement activation |
| MX2016014160A (es) | 2014-05-01 | 2017-02-16 | Genentech Inc | Variantes del anticuerpo anti-factor d y sus usos. |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| MY181199A (en) | 2014-12-19 | 2020-12-21 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2016117346A1 (en) | 2015-01-22 | 2016-07-28 | Chugai Seiyaku Kabushiki Kaisha | A combination of two or more anti-c5 antibodies and methods of use |
| JP6944375B2 (ja) * | 2015-03-31 | 2021-10-06 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 発作性夜間血色素尿症（ｐｎｈ）患者の亜集団の同定および処置 |
| CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
| US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
| MY196006A (en) | 2016-06-14 | 2023-03-06 | Regeneron Pharma | Anti-C5 Antibodies and Uses Thereof |
| JP6527643B2 (ja) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Ｉｌ−８関連疾患の治療用又は予防用組成物 |
| IT201600121482A1 (it) * | 2016-11-30 | 2018-05-30 | Univ Degli Studi Di Verona | Fattore H per l’uso nel trattamento e/o prevenzione della formazione di eterotrombi in pazienti affetti da anemia falciforme |
| IL268327B2 (en) | 2017-01-31 | 2025-09-01 | Chugai Pharmaceutical Co Ltd | Pharmaceutical preparation for use in the treatment and prevention of C5-related diseases and methods for the treatment and prevention of C5-related diseases |
| KR20200098528A (ko) | 2017-12-13 | 2020-08-20 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 조합물 및 이의 용도 |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| MX2021000516A (es) | 2018-08-01 | 2021-04-12 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para usarse en el tratamiento o prevencion de una enfermedad relacionada con c5 y metodo para tratar o prevenir una enfermedad relacionada con c5. |
| CN114466660A (zh) | 2019-07-31 | 2022-05-10 | 豪夫迈·罗氏有限公司 | 通过使用抗c5抗体可伐利单抗来治疗或预防c5相关疾病的剂量和施用方案 |
| WO2021019036A1 (en) | 2019-07-31 | 2021-02-04 | F. Hoffmann-La Roche Ag | Dosage and administration regimen for the treatment or prevention of c5-related diseases by the use of the anti-c5 antibody crovalimab |
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| US4686100A (en) * | 1985-04-02 | 1987-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Method for the treatment of adult respiratory distress syndrome |
| US5135916A (en) * | 1989-06-12 | 1992-08-04 | Oklahoma Medical Research Foundation | Inhibition of complement mediated inflammatory response |
| DE3924924A1 (de) | 1989-07-27 | 1991-02-07 | Goetze Otto | Verfahren zum nachweis und/oder der quantitativen bestimmung von komplementpeptid c5a und/oder c5adesarg |
| US6074642A (en) * | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5650825A (en) * | 1995-03-31 | 1997-07-22 | Matsushita Electric Corporation Of America | Method and apparatus for sending private data instead of stuffing bits in an MPEG bit stream |
| DE19826743A1 (de) * | 1998-06-16 | 1999-12-23 | Bayer Ag | Verfahren zur Herstellung von geträgerten Polymerisationskatalysatorsystemen und Verwendung dieser zur Homo- und Copolymerisation ungesättigter Monomere |
| DE60136656D1 (de) * | 2000-12-05 | 2009-01-02 | Alexion Pharma Inc | Rationell entworfene Antikörper |
| AU2003223288A1 (en) * | 2002-03-18 | 2003-10-08 | Alexion Pharmaceuticals, Inc. | Stratification of patient populations having or suspected of having rheumatoid arthritis |
| US7361339B2 (en) * | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
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- 2005-02-03 EP EP15150658.1A patent/EP2910253A1/en not_active Withdrawn
- 2005-02-03 CN CN2013103817575A patent/CN103446584A/zh active Pending
- 2005-02-03 EP EP12169519A patent/EP2522363A1/en not_active Withdrawn
- 2005-02-03 WO PCT/US2005/003225 patent/WO2005074607A2/en not_active Ceased
- 2005-02-03 JP JP2006551599A patent/JP2007520494A/ja not_active Withdrawn
- 2005-02-03 EP EP12169508A patent/EP2520311A3/en not_active Withdrawn
- 2005-02-03 KR KR1020067017880A patent/KR101197799B1/ko not_active Ceased
- 2005-02-03 CN CN201410147793.XA patent/CN103977402A/zh active Pending
- 2005-02-03 PL PL05712607T patent/PL1720571T3/pl unknown
- 2005-02-03 CN CN201410147935.2A patent/CN103977403A/zh active Pending
- 2005-02-03 EP EP12169526A patent/EP2522364A1/en not_active Withdrawn
- 2005-02-03 EP EP05712607A patent/EP1720571B9/en not_active Revoked
- 2005-02-03 AU AU2005209854A patent/AU2005209854B2/en not_active Expired
- 2005-02-03 NZ NZ549328A patent/NZ549328A/en not_active IP Right Cessation
- 2005-02-03 SI SI200531579T patent/SI1720571T1/sl unknown
- 2005-02-03 US US11/050,543 patent/US20050191298A1/en not_active Abandoned
- 2005-02-03 DK DK05712607.0T patent/DK1720571T3/da active
- 2005-02-03 ES ES05712607T patent/ES2389093T3/es not_active Expired - Lifetime
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2006
- 2006-07-20 IL IL177003A patent/IL177003A0/en unknown
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2009
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2010
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2011
- 2011-03-23 JP JP2011065075A patent/JP2011126917A/ja not_active Withdrawn
- 2011-12-22 US US13/335,518 patent/US20120308559A1/en not_active Abandoned
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2012
- 2012-08-30 CY CY20121100783T patent/CY1113190T1/el unknown
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2013
- 2013-07-11 JP JP2013145341A patent/JP5873047B2/ja not_active Expired - Lifetime
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2015
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- 2015-08-06 IL IL240410A patent/IL240410A0/en unknown
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2017
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