|
US7776314B2
(en)
|
2002-06-17 |
2010-08-17 |
Grunenthal Gmbh |
Abuse-proofed dosage system
|
|
DE10252667A1
(de)
*
|
2002-11-11 |
2004-05-27 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
DE102005005446A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Bruchfeste Darreichungsformen mit retardierter Freisetzung
|
|
US8075872B2
(en)
|
2003-08-06 |
2011-12-13 |
Gruenenthal Gmbh |
Abuse-proofed dosage form
|
|
US20070048228A1
(en)
|
2003-08-06 |
2007-03-01 |
Elisabeth Arkenau-Maric |
Abuse-proofed dosage form
|
|
DE10336400A1
(de)
|
2003-08-06 |
2005-03-24 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte Darreichungsform
|
|
DE10361596A1
(de)
|
2003-12-24 |
2005-09-29 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
|
DE102004032051A1
(de)
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
|
|
DE10360793A1
(de)
*
|
2003-12-23 |
2005-07-28 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
DE102004032049A1
(de)
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte, orale Darreichungsform
|
|
DE102005005449A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
|
DE102005016460A1
(de)
*
|
2005-04-11 |
2006-10-19 |
Grünenthal GmbH |
Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
|
|
DE102006019597A1
(de)
|
2006-04-27 |
2007-10-31 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
DE102006033114A1
(de)
|
2006-07-18 |
2008-01-24 |
Grünenthal GmbH |
Spirocyclische Azaindol-Derivate
|
|
EP1894938A1
(en)
*
|
2006-08-31 |
2008-03-05 |
Evonik Degussa GmbH |
New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions
|
|
DE102006046745A1
(de)
*
|
2006-09-29 |
2008-04-03 |
Grünenthal GmbH |
Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
|
|
DE102007009319A1
(de)
*
|
2007-02-22 |
2008-08-28 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
DE102007009235A1
(de)
|
2007-02-22 |
2008-09-18 |
Grünenthal GmbH |
Spirocyclische Cyclohexan-Derivate
|
|
DE102007011485A1
(de)
|
2007-03-07 |
2008-09-11 |
Grünenthal GmbH |
Darreichungsform mit erschwertem Missbrauch
|
|
US8716308B2
(en)
|
2008-01-11 |
2014-05-06 |
Albany Molecular Research, Inc. |
(1-azinone)-substituted pyridoindoles
|
|
KR101616246B1
(ko)
|
2008-01-25 |
2016-05-02 |
그뤼넨탈 게엠베하 |
약제학적 투여형
|
|
AU2009228647B2
(en)
|
2008-03-27 |
2013-07-04 |
Grunenthal Gmbh |
Substituted spirocyclic cyclohexane derivatives
|
|
EP2280941B1
(de)
|
2008-03-27 |
2015-05-06 |
Grünenthal GmbH |
(hetero-)aryl-cyclohexan-derivate
|
|
JP5529843B2
(ja)
|
2008-03-27 |
2014-06-25 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
置換シクロヘキシルジアミン
|
|
CN102046591B
(zh)
|
2008-03-27 |
2014-12-03 |
格吕伦塔尔有限公司 |
羟甲基环己胺
|
|
ES2464102T3
(es)
|
2008-03-27 |
2014-05-30 |
Grünenthal GmbH |
Derivados de 4-aminociclohexano sustituidos
|
|
ES2375543T3
(es)
*
|
2008-03-27 |
2012-03-01 |
Grünenthal GmbH |
Derivados de espiro(5.5)undecano.
|
|
AU2009243681B2
(en)
|
2008-05-09 |
2013-12-19 |
Grunenthal Gmbh |
Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
|
|
SI2356123T1
(sl)
|
2008-11-13 |
2013-01-31 |
F. Hoffmann-La Roche Ag |
Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni
|
|
WO2011003012A1
(en)
*
|
2009-07-01 |
2011-01-06 |
Albany Molecular Research, Inc. |
Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
|
|
US9073925B2
(en)
*
|
2009-07-01 |
2015-07-07 |
Albany Molecular Research, Inc. |
Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
|
|
US8637501B2
(en)
*
|
2009-07-01 |
2014-01-28 |
Albany Molecular Research, Inc. |
Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
|
|
US8629158B2
(en)
*
|
2009-07-01 |
2014-01-14 |
Albany Molecular Research, Inc. |
Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
|
|
WO2011009602A1
(en)
|
2009-07-22 |
2011-01-27 |
Grünenthal GmbH |
Hot-melt extruded controlled release dosage form
|
|
TWI473628B
(zh)
|
2009-07-22 |
2015-02-21 |
|
用於對氧化敏感之類鴉片藥劑之抗破壞劑型
|
|
UA107943C2
(xx)
|
2009-11-16 |
2015-03-10 |
Lilly Co Eli |
Сполуки спіропіперидину як антагоністи рецептора orl-1
|
|
ES2436241T3
(es)
*
|
2009-11-16 |
2013-12-27 |
Eli Lilly And Company |
Compuestos de espiropiperidina como antagonistas de receptor oral-1
|
|
SI3070091T1
(sl)
*
|
2010-06-24 |
2019-08-30 |
Leo Pharma A/S |
Derivati benzodioksola kot zaviralci fosfodiesteraze
|
|
TWI582092B
(zh)
|
2010-07-28 |
2017-05-11 |
歌林達股份有限公司 |
順式-四氫-螺旋(環己烷-1,1’-吡啶[3,4-b]吲哚)-4-胺-衍生物
|
|
TWI501788B
(zh)
|
2010-09-02 |
2015-10-01 |
|
含陰離子聚合物之抗破碎劑型
|
|
WO2012028318A1
(en)
|
2010-09-02 |
2012-03-08 |
Grünenthal GmbH |
Tamper resistant dosage form comprising an anionic polymer
|
|
CA2808219C
(en)
|
2010-09-02 |
2019-05-14 |
Gruenenthal Gmbh |
Tamper resistant dosage form comprising inorganic salt
|
|
US8993765B2
(en)
|
2010-12-21 |
2015-03-31 |
Albany Molecular Research, Inc. |
Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
|
|
WO2012088038A2
(en)
|
2010-12-21 |
2012-06-28 |
Albany Molecular Research, Inc. |
Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
|
|
ES2648129T3
(es)
|
2011-07-29 |
2017-12-28 |
Grünenthal GmbH |
Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
|
|
AU2012289764B2
(en)
|
2011-07-29 |
2017-03-02 |
Grünenthal GmbH |
Tamper-resistant tablet providing immediate drug release
|
|
WO2013113857A1
(en)
*
|
2012-02-03 |
2013-08-08 |
Grünenthal GmbH |
(1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome
|
|
US20130225625A1
(en)
|
2012-02-28 |
2013-08-29 |
Grunenthal Gmbh |
Tamper-resistant pharmaceutical dosage form comprising nonionic surfactant
|
|
US20130225697A1
(en)
|
2012-02-28 |
2013-08-29 |
Grunenthal Gmbh |
Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
|
|
PL2838512T3
(pl)
|
2012-04-18 |
2018-12-31 |
Grünenthal GmbH |
Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
|
|
NO2846835T3
(https=)
|
2012-05-11 |
2018-02-03 |
|
|
|
US10064945B2
(en)
|
2012-05-11 |
2018-09-04 |
Gruenenthal Gmbh |
Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
|
|
US9320725B2
(en)
|
2012-05-18 |
2016-04-26 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid
|
|
US9308196B2
(en)
*
|
2012-05-18 |
2016-04-12 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
|
|
US9320729B2
(en)
*
|
2012-05-18 |
2016-04-26 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
|
|
US9855286B2
(en)
|
2012-05-18 |
2018-01-02 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
|
|
US20130310385A1
(en)
|
2012-05-18 |
2013-11-21 |
Gruenenthal Gmbh |
Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
|
|
US20130310435A1
(en)
*
|
2012-05-18 |
2013-11-21 |
Gruenenthal Gmbh |
Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
|
|
US8912226B2
(en)
*
|
2012-05-18 |
2014-12-16 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
|
|
US9345689B2
(en)
*
|
2012-05-18 |
2016-05-24 |
Gruenenthal Gmbh |
Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant
|
|
PT2970284T
(pt)
|
2013-03-15 |
2018-02-08 |
Gruenenthal Gmbh |
Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina
|
|
AU2014273227B2
(en)
|
2013-05-29 |
2019-08-15 |
Grunenthal Gmbh |
Tamper-resistant dosage form containing one or more particles
|
|
JP6466417B2
(ja)
|
2013-05-29 |
2019-02-06 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
|
|
JP6449871B2
(ja)
|
2013-07-12 |
2019-01-09 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
エチレン−酢酸ビニルポリマーを含有する改変防止剤形
|
|
EP3073994A1
(en)
|
2013-11-26 |
2016-10-05 |
Grünenthal GmbH |
Preparation of a powdery pharmaceutical composition by means of cryo-milling
|
|
CA2933983A1
(en)
|
2013-12-16 |
2015-06-25 |
Grunenthal Gmbh |
Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion
|
|
EP3142646A1
(en)
|
2014-05-12 |
2017-03-22 |
Grünenthal GmbH |
Tamper resistant immediate release capsule formulation comprising tapentadol
|
|
EA201692388A1
(ru)
|
2014-05-26 |
2017-05-31 |
Грюненталь Гмбх |
Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
|
|
BR112017000762A2
(pt)
|
2014-07-15 |
2017-11-21 |
Gruenenthal Gmbh |
derivados de azaspiro(4.5)decano substituído.
|
|
TW201607923A
(zh)
|
2014-07-15 |
2016-03-01 |
歌林達有限公司 |
被取代之氮螺環(4.5)癸烷衍生物
|
|
EP3253376A1
(en)
|
2015-02-03 |
2017-12-13 |
Grünenthal GmbH |
Tamper-resistant dosage form comprising a polyethylene glycol graft copolymer
|
|
BR112017021475A2
(pt)
|
2015-04-24 |
2018-07-10 |
Gruenenthal Gmbh |
forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
|
|
WO2017042325A1
(en)
|
2015-09-10 |
2017-03-16 |
Grünenthal GmbH |
Protecting oral overdose with abuse deterrent immediate release formulations
|
|
US11248238B2
(en)
|
2015-10-22 |
2022-02-15 |
Juno Therapeutics Gmbh |
Methods, kits, agents and apparatuses for transduction
|
|
CA3029869A1
(en)
|
2016-07-06 |
2018-01-11 |
Grunenthal Gmbh |
Reinforced pharmaceutical dosage form
|
|
GB202306662D0
(en)
|
2023-05-05 |
2023-06-21 |
Union Therapeutics As |
Dosage regimen
|