JP2007512376A5 - - Google Patents
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- Publication number
- JP2007512376A5 JP2007512376A5 JP2006541728A JP2006541728A JP2007512376A5 JP 2007512376 A5 JP2007512376 A5 JP 2007512376A5 JP 2006541728 A JP2006541728 A JP 2006541728A JP 2006541728 A JP2006541728 A JP 2006541728A JP 2007512376 A5 JP2007512376 A5 JP 2007512376A5
- Authority
- JP
- Japan
- Prior art keywords
- linear
- carbon atoms
- branched
- dihydroxyvitamin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- 102000000536 PPAR gamma Human genes 0.000 claims 2
- 108010016731 PPAR gamma Proteins 0.000 claims 2
- 239000011612 calcitriol Substances 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- PKFBWEUIKKCWEW-WEZTXPJVSA-N (1r,3r)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1C[C@@H](O)C[C@H](O)C1 PKFBWEUIKKCWEW-WEZTXPJVSA-N 0.000 claims 1
- UHMPCVGLSKFXHR-NAQZCRMNSA-N (1r,3r)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2s)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](CCCC(C)(C)O)C)=C\C=C1C[C@@H](O)C(=C)[C@H](O)C1 UHMPCVGLSKFXHR-NAQZCRMNSA-N 0.000 claims 1
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- AEDMQUAPBVOJNN-UHFFFAOYSA-N [3-[2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl]-1,2,4-oxadiazol-5-yl]methanol Chemical compound O1C(CO)=NC(C=2SC(=NC=2)N2CCC(CC2)OC=2C(=CC=CC=2)C(F)(F)F)=N1 AEDMQUAPBVOJNN-UHFFFAOYSA-N 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52481303P | 2003-11-25 | 2003-11-25 | |
| US52479803P | 2003-11-25 | 2003-11-25 | |
| PCT/US2004/039625 WO2005051323A2 (en) | 2003-11-25 | 2004-11-24 | Vitamin d analogs for obesity prevention and treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007512376A JP2007512376A (ja) | 2007-05-17 |
| JP2007512376A5 true JP2007512376A5 (enExample) | 2008-01-24 |
Family
ID=41057499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541728A Abandoned JP2007512376A (ja) | 2003-11-25 | 2004-11-24 | 肥満症の予防及び治療用ビタミンｄ類似体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8188064B2 (enExample) |
| EP (1) | EP1689412A4 (enExample) |
| JP (1) | JP2007512376A (enExample) |
| AU (1) | AU2004293092A1 (enExample) |
| CA (1) | CA2544502A1 (enExample) |
| MX (1) | MXPA06005887A (enExample) |
| WO (1) | WO2005051323A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122533B2 (en) * | 1999-11-29 | 2006-10-17 | The United States Of America As Represented By The Department Of Health And Human Services | Cosalane compounds and methods for their use |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| WO2005018658A1 (en) * | 2003-08-20 | 2005-03-03 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| AU2005309804B9 (en) * | 2004-11-22 | 2011-12-08 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-(20S)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
| MX2007006545A (es) * | 2004-11-22 | 2007-09-21 | Wisconsin Alumni Res Found | 2a-metil-19-nor-1a-hidroxi-homopregnacalciferol y sus usos. |
| EP1824818A2 (en) | 2004-11-22 | 2007-08-29 | Wisconsin Alumni Research Foundation | 2ALFA-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1ALFA-HYDROXYVITAMIN D3 AND THEIR USES |
| ES2358914T3 (es) * | 2004-11-22 | 2011-05-16 | Wisconsin Alumni Research Foundation | 2-metileno-19,21-dinor-1alfa-hidroxi-bishomopregnacalciferol. |
| WO2006057914A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s)-1alpha-hydroxy-trishomopregnacalciferol |
| EP1817278B1 (en) * | 2004-11-22 | 2010-06-30 | Wisconsin Alumni Research Foundation | 2-methylene-18,19-dinor-1alfa-hydroxy-homopregnacalciferol and its uses |
| CA2588038A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20r)-1-.alpha.-hydroxy-bishomopregnacalciferol |
| US7244719B2 (en) * | 2004-11-22 | 2007-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and its uses |
| MX2007006546A (es) * | 2004-11-22 | 2007-08-17 | Wisconsin Alumni Res Found | Analogos de 17,20(e)-deshidro vitamina d y sus usos. |
| NZ561076A (en) * | 2005-02-11 | 2010-01-29 | Wisconsin Alumni Res Found | 2-methylene-19-nor-(20S-24EPI)-1alpha,25-dihydroxyvitamin-D2 |
| US8114393B2 (en) * | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| CA2623481A1 (en) * | 2005-09-22 | 2007-04-05 | Wisconsin Alumni Research Foundation | 19,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin d3 |
| US7803789B2 (en) | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| JP2009532482A (ja) * | 2006-04-05 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | １α−ヒドロキシ−２−（３’−ヒドロキシプロピリデン）−１９−ノル−ビタミンＤ化合物類及びそれらの製造及び使用方法 |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| NZ570712A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| AU2007234717B2 (en) * | 2006-04-06 | 2012-04-19 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| JP2009532460A (ja) | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| JP2009532459A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | １，２または３，２複素環を有する１９−ノル−ビタミンｄアナログ |
| CA2639585A1 (en) * | 2006-04-06 | 2007-10-06 | Wisconsin Alumni Research Foundation | 2-methylene-1.alpha., 25-dihydroxy-18, 19, 21-trinorvitamin d3 and uses thereof |
| DE602007012216D1 (de) * | 2006-04-10 | 2011-03-10 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen mit einer 1,1-dimethylpropyl-seitenkette |
| JP2010504995A (ja) * | 2006-09-28 | 2010-02-18 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−（２０ｒ，２５ｓ）−１９，２７−ジノル−（２２ｅ）−ビタミンｄ類縁体 |
| CA2662864A1 (en) | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs |
| CA2710954C (en) * | 2007-12-28 | 2015-07-21 | Wisconsin Alumni Research Foundation | (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs |
| ATE552239T1 (de) * | 2007-12-28 | 2012-04-15 | Wisconsin Alumni Res Found | 2-methylen-20-methyl-19,24,25,26,27-pentanor- vitamin-d-analoga |
| CA2715811A1 (en) * | 2008-03-06 | 2009-09-11 | Wisconsin Alumni Research Foundation | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound |
| US7888339B2 (en) | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US8222236B2 (en) | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| US8399439B2 (en) * | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
| CA2781889A1 (en) * | 2009-11-30 | 2011-06-03 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-nor-(20s)-1.alpha.-hydroxyvitamin d3 |
| EP2556053B1 (en) * | 2010-03-23 | 2015-07-29 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1alpha,25-hydroxyvitamin d3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US8420839B1 (en) * | 2011-10-05 | 2013-04-16 | Wisconsin Alumni Research Foundation | Crystallization of 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol |
| US9416102B2 (en) * | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
| CN104211579B (zh) * | 2014-09-04 | 2016-01-06 | 上海皓元生物医药科技有限公司 | 一种用于制备维生素d及其类似物的中间体化合物ii的方法 |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| CN104447211A (zh) * | 2014-12-12 | 2015-03-25 | 重庆华邦制药有限公司 | 维生素d类药物的中间体化合物及制备方法 |
| US10494337B2 (en) * | 2015-05-26 | 2019-12-03 | Wisconsin Alumni Research Foundation | (20S)-1-α,25-dihydroxy-24,24-difluoro-19-nor-vitamin D3 analogs and their pharmaceutical uses |
| CN117777121A (zh) | 2016-10-24 | 2024-03-29 | 詹森药业有限公司 | 化合物及其用途 |
| EA201991650A1 (ru) | 2017-01-06 | 2020-01-20 | Юманити Терапьютикс, Инк. | Способы лечения неврологических расстройств |
| WO2019084157A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES THEREOF |
| AU2019238326B2 (en) | 2018-03-23 | 2025-03-06 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
| JP7742775B2 (ja) | 2019-01-24 | 2025-09-22 | ヤンセン ファーマシューティカ エヌ．ベー． | 化合物及びその使用 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| IL319526A (en) | 2022-09-30 | 2025-05-01 | Extend Biosciences Inc | Long-acting parathyroid hormone |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| EP1745787B1 (en) * | 1999-04-01 | 2016-11-09 | Johns Hopkins University | NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1-alpha 25-DIHYDROXY VITAMIN D3 |
| US7704979B2 (en) * | 2000-09-01 | 2010-04-27 | The University Of Tennessee Research Foundation | Materials and methods for the treatment or prevention of obesity |
| US6384087B1 (en) * | 2000-09-01 | 2002-05-07 | University Of Tennesseee Research Corporation, Inc. | Materials and methods for the treatment or prevention of obesity |
| AU7544501A (en) * | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| KR20040095237A (ko) * | 2002-03-29 | 2004-11-12 | 위스콘신 얼럼나이 리서어치 화운데이션 | 1α-히드록시-2-메틸렌-19-노르-호모프레그나칼시페롤의합성 방법 |
| WO2005018658A1 (en) * | 2003-08-20 | 2005-03-03 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| WO2005027929A1 (en) | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen |
| EP1667689A1 (en) * | 2003-09-19 | 2006-06-14 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone |
| KR20060040746A (ko) | 2003-09-19 | 2006-05-10 | 화이자 프로덕츠 인크. | 2-알킬리덴-19-노르-비타민 ｄ 유도체와 에스트로겐효능제/길항제의 조합물을 포함하는 제약 조성물 및 방법 |
| WO2005027931A1 (en) | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| AU2005309804B9 (en) * | 2004-11-22 | 2011-12-08 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-(20S)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
| EP1824818A2 (en) * | 2004-11-22 | 2007-08-29 | Wisconsin Alumni Research Foundation | 2ALFA-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1ALFA-HYDROXYVITAMIN D3 AND THEIR USES |
-
2004
- 2004-11-24 JP JP2006541728A patent/JP2007512376A/ja not_active Abandoned
- 2004-11-24 US US10/997,698 patent/US8188064B2/en not_active Expired - Fee Related
- 2004-11-24 AU AU2004293092A patent/AU2004293092A1/en not_active Abandoned
- 2004-11-24 MX MXPA06005887A patent/MXPA06005887A/es active IP Right Grant
- 2004-11-24 EP EP04812196A patent/EP1689412A4/en not_active Withdrawn
- 2004-11-24 WO PCT/US2004/039625 patent/WO2005051323A2/en not_active Ceased
- 2004-11-24 CA CA002544502A patent/CA2544502A1/en not_active Abandoned
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