PE20081389A1 - Uso de profarmacos de analogos de gaba para tratar enfermedades - Google Patents
Uso de profarmacos de analogos de gaba para tratar enfermedadesInfo
- Publication number
- PE20081389A1 PE20081389A1 PE2007001760A PE2007001760A PE20081389A1 PE 20081389 A1 PE20081389 A1 PE 20081389A1 PE 2007001760 A PE2007001760 A PE 2007001760A PE 2007001760 A PE2007001760 A PE 2007001760A PE 20081389 A1 PE20081389 A1 PE 20081389A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- acid
- treat diseases
- gaba analog
- isobutanoyloxyetoxy
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN METODO DE TRATAMIENTO DE MIGRANA, FIBROMIALGIA, ESCLEROSIS LATERAL AMIOTROFICA, ENFERMEDAD DE PARKINSON, ASMA, ENTRE OTROS, QUE COMPRENDE ADMINISTRAR A UN PACIENTE UN COMPUESTO QUE ES UN PROFARMACO DE ANALOGOS DE GABA DE FORMULA (I) O (II) EN DONDE R1 ES H, ALQUILO(C1-C6), ARILO(C5-C12), CICLOALQUILO(C3-C15), ENTRE OTROS; R2 Y R3 SON CADA UNO H, ALQUILO(C1-C6), ALCOXICARBONILO, CICLOALQUILO(C3-C15), ENTRE OTROS; R4 ES ACILO, ALQUILO(C1-C6), ARILO(C5-C12), ENTRE OTROS, SIENDO COMPUESTOS PREFERIDOS: EL ACIDO 1-{[(a-ISOBUTANOILOXIETOXI)-CARBONIL]AMINOMETIL}-1-CICLOHEXANOACETICO Y EL ACIDO 3-{[(a-ISOBUTANOILOXIETOXI)-CARBONIL]AMINOMETIL}-5-METILHEXANOICO. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA DE TIPO ORAL DE LIBERACION SOSTENIDA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87356106P | 2006-12-08 | 2006-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081389A1 true PE20081389A1 (es) | 2008-11-19 |
Family
ID=39186816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001760A PE20081389A1 (es) | 2006-12-08 | 2007-12-10 | Uso de profarmacos de analogos de gaba para tratar enfermedades |
Country Status (13)
Country | Link |
---|---|
US (2) | US20080161393A1 (es) |
EP (1) | EP2101752A1 (es) |
JP (1) | JP2010512314A (es) |
CN (1) | CN101652133A (es) |
AR (1) | AR064212A1 (es) |
AU (1) | AU2007332904A1 (es) |
BR (1) | BRPI0720252A2 (es) |
CA (1) | CA2672044A1 (es) |
EA (1) | EA200970487A1 (es) |
MX (1) | MX2009006080A (es) |
PE (1) | PE20081389A1 (es) |
TW (1) | TW200845959A (es) |
WO (1) | WO2008073257A1 (es) |
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WO2005019163A2 (en) * | 2003-08-20 | 2005-03-03 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
KR20060119971A (ko) * | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Gaba 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
MXPA06002619A (es) * | 2003-09-12 | 2006-06-05 | Warner Lambert Co | Procedimiento para el tratamiento de trastornos de depresion y ansiedad mediante terapia de combinacion. |
CN1871021B (zh) * | 2003-09-17 | 2010-07-28 | 什诺波特有限公司 | 用gaba类似物的前药治疗或预防多动腿综合征 |
EP1670750A1 (en) * | 2003-09-25 | 2006-06-21 | Warner-Lambert Company LLC | Prodrugs of amino acids with affinity for the alpha2delta- protein |
SI1677767T1 (sl) * | 2003-10-14 | 2011-11-30 | Xenoport Inc | Kristalinična oblika analoga gama-aminomaslene kisline |
US20050209319A1 (en) * | 2004-03-18 | 2005-09-22 | Xenoport, Inc. | Treatment of local pain |
BRPI0517227B8 (pt) * | 2004-11-04 | 2021-05-25 | Xenoport Inc | comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido |
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US20070049627A1 (en) * | 2005-08-23 | 2007-03-01 | Tran Pierre V | Treating vulvodynia using prodrugs of GABA analogs |
EP1928450A2 (en) * | 2005-08-26 | 2008-06-11 | Xenoport, Inc. | Treating premature ejaculation using gabapentin and pregabalin prodrugs |
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US7868043B2 (en) * | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
-
2007
- 2007-12-06 MX MX2009006080A patent/MX2009006080A/es not_active Application Discontinuation
- 2007-12-06 EP EP07867636A patent/EP2101752A1/en not_active Withdrawn
- 2007-12-06 WO PCT/US2007/024944 patent/WO2008073257A1/en active Application Filing
- 2007-12-06 EA EA200970487A patent/EA200970487A1/ru unknown
- 2007-12-06 BR BRPI0720252-0A patent/BRPI0720252A2/pt not_active Application Discontinuation
- 2007-12-06 US US12/001,067 patent/US20080161393A1/en not_active Abandoned
- 2007-12-06 AU AU2007332904A patent/AU2007332904A1/en not_active Abandoned
- 2007-12-06 CN CN200780051141A patent/CN101652133A/zh active Pending
- 2007-12-06 CA CA002672044A patent/CA2672044A1/en not_active Abandoned
- 2007-12-06 JP JP2009540287A patent/JP2010512314A/ja active Pending
- 2007-12-07 TW TW096146838A patent/TW200845959A/zh unknown
- 2007-12-10 AR ARP070105514A patent/AR064212A1/es unknown
- 2007-12-10 PE PE2007001760A patent/PE20081389A1/es not_active Application Discontinuation
-
2011
- 2011-10-27 US US13/283,469 patent/US20120041061A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA200970487A1 (ru) | 2009-12-30 |
WO2008073257A1 (en) | 2008-06-19 |
AU2007332904A1 (en) | 2008-06-19 |
CA2672044A1 (en) | 2008-06-19 |
CN101652133A (zh) | 2010-02-17 |
BRPI0720252A2 (pt) | 2014-01-07 |
AR064212A1 (es) | 2009-03-18 |
MX2009006080A (es) | 2009-07-14 |
EP2101752A1 (en) | 2009-09-23 |
TW200845959A (en) | 2008-12-01 |
US20120041061A1 (en) | 2012-02-16 |
US20080161393A1 (en) | 2008-07-03 |
JP2010512314A (ja) | 2010-04-22 |
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