JP2009525981A5 - - Google Patents
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- JP2009525981A5 JP2009525981A5 JP2008553486A JP2008553486A JP2009525981A5 JP 2009525981 A5 JP2009525981 A5 JP 2009525981A5 JP 2008553486 A JP2008553486 A JP 2008553486A JP 2008553486 A JP2008553486 A JP 2008553486A JP 2009525981 A5 JP2009525981 A5 JP 2009525981A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- insufficient
- disease
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 4
- 210000002374 sebum Anatomy 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- 230000037067 skin hydration Effects 0.000 claims 4
- 230000037303 wrinkles Effects 0.000 claims 4
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 201000006409 renal osteodystrophy Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 201000006035 X-linked dominant hypophosphatemic rickets Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 208000011111 hypophosphatemic rickets Diseases 0.000 claims 1
- -1 t-butyldimethylsilyl groups Chemical group 0.000 claims 1
- 208000032349 type 2B vitamin D-dependent rickets Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74321906P | 2006-02-02 | 2006-02-02 | |
| US60/743,219 | 2006-02-02 | ||
| PCT/US2007/061404 WO2007092721A2 (en) | 2006-02-02 | 2007-01-31 | Vitamin d analog: rak, methods and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525981A JP2009525981A (ja) | 2009-07-16 |
| JP2009525981A5 true JP2009525981A5 (enExample) | 2009-11-26 |
| JP5113766B2 JP5113766B2 (ja) | 2013-01-09 |
Family
ID=38330725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553486A Expired - Fee Related JP5113766B2 (ja) | 2006-02-02 | 2007-01-31 | ビタミンｄ類似体：ｒａｋ、その方法および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7803789B2 (enExample) |
| EP (1) | EP1984329B1 (enExample) |
| JP (1) | JP5113766B2 (enExample) |
| AT (1) | ATE451352T1 (enExample) |
| AU (1) | AU2007212185B2 (enExample) |
| CA (1) | CA2637302C (enExample) |
| DE (1) | DE602007003691D1 (enExample) |
| ES (1) | ES2339402T3 (enExample) |
| NZ (1) | NZ569690A (enExample) |
| WO (1) | WO2007092721A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009532459A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | １，２または３，２複素環を有する１９−ノル−ビタミンｄアナログ |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| NZ570712A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| JP2009532460A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| AU2007234717B2 (en) * | 2006-04-06 | 2012-04-19 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| CA2639585A1 (en) * | 2006-04-06 | 2007-10-06 | Wisconsin Alumni Research Foundation | 2-methylene-1.alpha., 25-dihydroxy-18, 19, 21-trinorvitamin d3 and uses thereof |
| DE602007012216D1 (de) * | 2006-04-10 | 2011-03-10 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen mit einer 1,1-dimethylpropyl-seitenkette |
| MX2010007263A (es) * | 2007-12-28 | 2011-03-15 | Wisconsin Alumni Res Foundation Star | Análogos de vitamina d-2-metilen-(20s, 25s)-19, 26-dinor. |
| MX2010007264A (es) * | 2007-12-28 | 2011-03-15 | Wisconsin Alumni Res Foundation Star | Análogos de vitamina d 2-metilen-(20s, 25r)-19, 26-dinor. |
| US7879829B2 (en) * | 2008-07-10 | 2011-02-01 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2-dihydrofuran ring |
| US8399439B2 (en) | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| US8217023B2 (en) | 2009-10-02 | 2012-07-10 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring |
| CA2776462C (en) * | 2009-10-02 | 2017-04-18 | Wisconsin Alumni Research Foundation | (20s,22e)-2-methylene-19-nor-22-ene-1.alpha.,25-dihydroxyvitamin d3 analogs |
| JP2013540764A (ja) * | 2010-09-30 | 2013-11-07 | ウイスコンシン アラムニ リサーチ ファンデーション | 結晶形の（２０Ｒ，２５Ｓ）−２−メチレン−１９，２６−ジノル−１α，２５−ジヒドロキシビタミンＤ３ |
| EP2721004B1 (en) * | 2011-06-14 | 2017-07-26 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5552392A (en) | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US6392071B1 (en) | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| CA2410880C (en) | 2000-05-31 | 2009-03-03 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds |
| AU7544501A (en) | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| EP1392323B1 (en) | 2001-05-22 | 2008-10-08 | Bioxell S.p.a. | Use of a vitamin d3 analogue for the treatment of autoimmune diabetes |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| GB0305332D0 (en) | 2003-03-10 | 2003-04-09 | Leuven K U Res & Dev | Biological evaluation of novel vitamin D analogues |
| US6894037B2 (en) * | 2003-07-03 | 2005-05-17 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses |
| US20050009792A1 (en) | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| KR20060040746A (ko) | 2003-09-19 | 2006-05-10 | 화이자 프로덕츠 인크. | 2-알킬리덴-19-노르-비타민 ｄ 유도체와 에스트로겐효능제/길항제의 조합물을 포함하는 제약 조성물 및 방법 |
| US7053075B2 (en) | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
| JP2007512376A (ja) | 2003-11-25 | 2007-05-17 | ウイスコンシン アラムニ リサーチ ファンデーション | 肥満症の予防及び治療用ビタミンｄ類似体 |
| EP1824818A2 (en) * | 2004-11-22 | 2007-08-29 | Wisconsin Alumni Research Foundation | 2ALFA-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1ALFA-HYDROXYVITAMIN D3 AND THEIR USES |
| CA2603328A1 (en) * | 2005-03-29 | 2006-10-05 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(23s)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone and 2-methylene-19-nor-(23r)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone |
| CA2605727A1 (en) | 2005-05-03 | 2006-11-09 | Wisconsin Alumni Research Foundation | 19,26,27-trinor-1.alpha.,25-dihydroxyvitamin d3 compounds |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| WO2008035207A2 (en) | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
-
2007
- 2007-01-30 US US11/669,053 patent/US7803789B2/en not_active Expired - Fee Related
- 2007-01-31 AU AU2007212185A patent/AU2007212185B2/en not_active Ceased
- 2007-01-31 DE DE602007003691T patent/DE602007003691D1/de active Active
- 2007-01-31 JP JP2008553486A patent/JP5113766B2/ja not_active Expired - Fee Related
- 2007-01-31 CA CA2637302A patent/CA2637302C/en not_active Expired - Fee Related
- 2007-01-31 ES ES07763622T patent/ES2339402T3/es active Active
- 2007-01-31 WO PCT/US2007/061404 patent/WO2007092721A2/en not_active Ceased
- 2007-01-31 NZ NZ569690A patent/NZ569690A/en not_active IP Right Cessation
- 2007-01-31 AT AT07763622T patent/ATE451352T1/de not_active IP Right Cessation
- 2007-01-31 EP EP07763622A patent/EP1984329B1/en not_active Not-in-force
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