JP2009532458A5 - - Google Patents
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- JP2009532458A5 JP2009532458A5 JP2009503690A JP2009503690A JP2009532458A5 JP 2009532458 A5 JP2009532458 A5 JP 2009532458A5 JP 2009503690 A JP2009503690 A JP 2009503690A JP 2009503690 A JP2009503690 A JP 2009503690A JP 2009532458 A5 JP2009532458 A5 JP 2009532458A5
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- Prior art keywords
- pharmaceutical composition
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- biological condition
- disease
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- 150000001875 compounds Chemical class 0.000 claims description 36
- 239000008194 pharmaceutical composition Substances 0.000 claims description 28
- 241001465754 Metazoa Species 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 208000029725 Metabolic bone disease Diseases 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000006239 protecting group Chemical group 0.000 claims description 6
- -1 triethylsilyl group Chemical group 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims description 4
- 208000001132 Osteoporosis Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 206010025135 lupus erythematosus Diseases 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 210000002374 sebum Anatomy 0.000 claims description 4
- 230000028327 secretion Effects 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 230000037394 skin elasticity Effects 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 208000015943 Coeliac disease Diseases 0.000 claims description 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 3
- 208000011231 Crohn disease Diseases 0.000 claims description 3
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 3
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 3
- 206010052779 Transplant rejections Diseases 0.000 claims description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 208000013558 Developmental Bone disease Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010049088 Osteopenia Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010072610 Skeletal dysplasia Diseases 0.000 claims description 2
- 201000006035 X-linked dominant hypophosphatemic rickets Diseases 0.000 claims description 2
- AEDMQUAPBVOJNN-UHFFFAOYSA-N [3-[2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl]-1,2,4-oxadiazol-5-yl]methanol Chemical compound O1C(CO)=NC(C=2SC(=NC=2)N2CCC(CC2)OC=2C(=CC=CC=2)C(F)(F)F)=N1 AEDMQUAPBVOJNN-UHFFFAOYSA-N 0.000 claims description 2
- 210000001789 adipocyte Anatomy 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 208000011111 hypophosphatemic rickets Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 208000032349 type 2B vitamin D-dependent rickets Diseases 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 206010038433 renal dysplasia Diseases 0.000 claims 1
- 208000007442 rickets Diseases 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 206010061218 Inflammation Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74438306P | 2006-04-06 | 2006-04-06 | |
| PCT/IB2007/003167 WO2008035207A2 (en) | 2006-04-06 | 2007-04-06 | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532458A JP2009532458A (ja) | 2009-09-10 |
| JP2009532458A5 true JP2009532458A5 (enExample) | 2010-05-20 |
Family
ID=39200904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503690A Ceased JP2009532458A (ja) | 2006-04-06 | 2007-04-06 | ２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7648972B2 (enExample) |
| EP (1) | EP2001842B1 (enExample) |
| JP (1) | JP2009532458A (enExample) |
| AU (1) | AU2007298652A1 (enExample) |
| CA (1) | CA2646909A1 (enExample) |
| MX (1) | MX2008012673A (enExample) |
| NZ (1) | NZ570814A (enExample) |
| WO (1) | WO2008035207A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005020842D1 (de) | 2004-11-22 | 2010-06-02 | Wisconsin Alumni Res Found | 17,20(e)-dehydro-vitamin-d-analoga und deren verwendungen |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| EP2021320A2 (en) * | 2006-04-06 | 2009-02-11 | Wisconsin Alumni Research Foundation | 2-substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof |
| US8575136B2 (en) * | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| MX2008012913A (es) * | 2006-04-06 | 2009-03-06 | Wisconsin Alumni Res Found | 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos. |
| MX2008012673A (es) * | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos. |
| AU2007234717B2 (en) * | 2006-04-06 | 2012-04-19 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| EP2069297A1 (en) * | 2006-09-28 | 2009-06-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs |
| CA2662864A1 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin d analogs |
| WO2011088209A2 (en) | 2010-01-13 | 2011-07-21 | Cytochroma Inc. | 1-deoxy analogs of vitamin d-related compounds |
| WO2011119610A2 (en) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| US8993547B2 (en) * | 2011-06-14 | 2015-03-31 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses |
| JP6397695B2 (ja) * | 2014-08-25 | 2018-09-26 | 学校法人自治医科大学 | 抗ピロリ菌剤 |
| CN107095876B (zh) * | 2017-05-24 | 2019-12-03 | 上海交通大学医学院 | 二苯基联烯基氧膦化合物在制备治疗肺癌药物中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188345A (en) * | 1978-07-26 | 1980-02-12 | Wisconsin Alumni Research Foundation | Fluorovitamin D compounds and processes for their preparation |
| US4411833A (en) * | 1982-05-26 | 1983-10-25 | Wisconsin Alumni Research Foundation | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US6291444B1 (en) * | 1993-06-16 | 2001-09-18 | Wisconsin Alumni Research Foundation | Treatment of t-cell immunodeficiencies with vitamin D compounds |
| US5880114A (en) * | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5825133A (en) * | 1996-09-25 | 1998-10-20 | Rockwell International | Resonant inverter for hot cathode fluorescent lamps |
| NZ336924A (en) * | 1997-02-13 | 2001-06-29 | Bone Care Int Inc | Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US6382071B1 (en) * | 2000-08-07 | 2002-05-07 | Gilbert A. Bertani | Bola capturing apparatus |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| US20030018017A1 (en) | 2001-01-25 | 2003-01-23 | Deluca Hector F. | Method of treatment of type I diabetes |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| PT1453798E (pt) * | 2001-12-13 | 2009-01-23 | Wisconsin Alumni Res Found | (20s)-1alfa-hidroxi-2-metileno-19-nor-bishomopregnacalciferol e suas utilizações |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| KR20050120787A (ko) * | 2003-04-10 | 2005-12-23 | 위스콘신 얼럼나이 리서어치 화운데이션 | 2-프로필리덴-19-노르-비타민 ｄ 화합물 |
| ATE350043T1 (de) * | 2003-07-03 | 2007-01-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-20(s)-25-methyl-1alpha- hydroxycalciferol und seine verwendungen |
| US20050009792A1 (en) * | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| CA2544502A1 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| WO2006057884A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| MX2008012673A (es) | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos. |
-
2007
- 2007-04-06 MX MX2008012673A patent/MX2008012673A/es active IP Right Grant
- 2007-04-06 JP JP2009503690A patent/JP2009532458A/ja not_active Ceased
- 2007-04-06 WO PCT/IB2007/003167 patent/WO2008035207A2/en not_active Ceased
- 2007-04-06 AU AU2007298652A patent/AU2007298652A1/en not_active Abandoned
- 2007-04-06 CA CA002646909A patent/CA2646909A1/en not_active Abandoned
- 2007-04-06 EP EP07848820A patent/EP2001842B1/en not_active Not-in-force
- 2007-04-06 NZ NZ570814A patent/NZ570814A/en not_active IP Right Cessation
- 2007-04-06 US US11/697,418 patent/US7648972B2/en not_active Expired - Fee Related