JP2007510718A5 - - Google Patents
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- Publication number
- JP2007510718A5 JP2007510718A5 JP2006539449A JP2006539449A JP2007510718A5 JP 2007510718 A5 JP2007510718 A5 JP 2007510718A5 JP 2006539449 A JP2006539449 A JP 2006539449A JP 2006539449 A JP2006539449 A JP 2006539449A JP 2007510718 A5 JP2007510718 A5 JP 2007510718A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- nitrogen
- cancer
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KGHCTQBSAXEKSO-SGIWWJKMSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC KGHCTQBSAXEKSO-SGIWWJKMSA-N 0.000 description 2
- HVOYZOQVDYHUPF-UHFFFAOYSA-N CNCCN(C)C Chemical compound CNCCN(C)C HVOYZOQVDYHUPF-UHFFFAOYSA-N 0.000 description 1
- NBCUUUHWGYGHNW-UHFFFAOYSA-N CNCCN1CC1 Chemical compound CNCCN1CC1 NBCUUUHWGYGHNW-UHFFFAOYSA-N 0.000 description 1
- GHRFMGAHWCWXEG-UHFFFAOYSA-N CNCCN1CCC1 Chemical compound CNCCN1CCC1 GHRFMGAHWCWXEG-UHFFFAOYSA-N 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N CNCCc1c[nH]cn1 Chemical compound CNCCc1c[nH]cn1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- OPTVWVTZZUXRTH-NQXVYZFTSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN(C)C)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN(C)C)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC OPTVWVTZZUXRTH-NQXVYZFTSA-N 0.000 description 1
- AHGRLBFPDJETNY-HWQVIYOQSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC AHGRLBFPDJETNY-HWQVIYOQSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51947903P | 2003-11-12 | 2003-11-12 | |
| US60/519,479 | 2003-11-12 | ||
| PCT/US2004/011638 WO2005056531A1 (en) | 2003-11-12 | 2004-04-16 | 11-o-methylgeldanamycin compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510718A JP2007510718A (ja) | 2007-04-26 |
| JP2007510718A5 true JP2007510718A5 (enExample) | 2007-06-14 |
| JP4717003B2 JP4717003B2 (ja) | 2011-07-06 |
Family
ID=34676572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539449A Expired - Fee Related JP4717003B2 (ja) | 2003-11-12 | 2004-04-16 | １１−ｏ−メチルゲルダナマイシン化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6870049B1 (enExample) |
| EP (1) | EP1682514A4 (enExample) |
| JP (1) | JP4717003B2 (enExample) |
| CA (1) | CA2545457A1 (enExample) |
| WO (1) | WO2005056531A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259156B2 (en) * | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
| WO2007059116A2 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Geldanamycin derivatives and pharmaceutical compositions thereof |
| WO2007098229A2 (en) * | 2006-02-21 | 2007-08-30 | Michigan State University | Geldanamycin derivatives and method of use thereof |
| DE102006044472A1 (de) * | 2006-09-21 | 2008-04-03 | Discovery Partner International Gmbh | Geldanamycin-Derivate |
| EP2200653A2 (en) | 2007-09-10 | 2010-06-30 | University of Massachusetts | Mitochondria-targeted anti-tumour agents |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987035A (en) | 1974-04-05 | 1976-10-19 | University Of Illinois Foundation | Biologically active compounds |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| JPS5874651A (ja) | 1981-09-17 | 1983-05-06 | Takeda Chem Ind Ltd | マクベシン誘導体およびその製造法 |
| US4421687A (en) | 1981-09-26 | 1983-12-20 | Takeda Chemical Industries, Limited | Macbecin derivatives |
| JPS59102398A (ja) | 1982-12-03 | 1984-06-13 | Takeda Chem Ind Ltd | 新規抗生物質およびその製造法 |
| JPS63218620A (ja) | 1987-03-09 | 1988-09-12 | Kyowa Hakko Kogyo Co Ltd | 癌化細胞の正常化剤 |
| JPH0446120A (ja) | 1990-06-11 | 1992-02-17 | Kyowa Hakko Kogyo Co Ltd | 血管新生抑制剤 |
| BR9207024A (pt) | 1992-01-06 | 1995-12-05 | Pfizer | Processo e utilizações para 4,5-DI-hidrogeldanamicina e sua hidroquinona |
| JPH08502488A (ja) | 1992-10-14 | 1996-03-19 | アメリカ合衆国 | 前立腺癌および初期神経悪性疾患に対するベンゾキノイドアンサマイシンの殺腫瘍活性 |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| CA2166320A1 (en) | 1993-06-29 | 1995-01-12 | Randall James Gallaschun | Ansamycin derivatives as antioncogene and anticancer agents |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| CA2218523A1 (en) | 1995-05-02 | 1996-11-07 | William J. Welch | Inducement of thermotolerance with benzoquinonoid ansamycins |
| JP2002520369A (ja) | 1998-07-17 | 2002-07-09 | アメリカ合衆国 | 水溶性薬剤およびその製造方法 |
| US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| WO2002036574A1 (en) * | 2000-11-06 | 2002-05-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Geldanamycin derivatives useful for the treatment of cancer |
| JP4213472B2 (ja) * | 2001-03-30 | 2009-01-21 | アメリカ合衆国 | ゲルダナマイシン誘導体及びそれを用いる癌の治療方法 |
| AU2002330998A1 (en) | 2001-08-06 | 2003-02-24 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003066005A2 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| KR20050119665A (ko) * | 2003-03-28 | 2005-12-21 | 코산 바이오사이언시즈, 인코포레이티드 | 재발협착증을 예방하기 위한 장치, 방법 및 조성물 |
-
2004
- 2004-04-16 WO PCT/US2004/011638 patent/WO2005056531A1/en not_active Ceased
- 2004-04-16 US US10/826,446 patent/US6870049B1/en not_active Expired - Lifetime
- 2004-04-16 EP EP04750158A patent/EP1682514A4/en not_active Withdrawn
- 2004-04-16 JP JP2006539449A patent/JP4717003B2/ja not_active Expired - Fee Related
- 2004-04-16 CA CA002545457A patent/CA2545457A1/en not_active Abandoned
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