JP4717003B2 - １１−ｏ−メチルゲルダナマイシン化合物 - Google Patents

１１−ｏ−メチルゲルダナマイシン化合物 Download PDF

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Publication number
JP4717003B2
JP4717003B2 JP2006539449A JP2006539449A JP4717003B2 JP 4717003 B2 JP4717003 B2 JP 4717003B2 JP 2006539449 A JP2006539449 A JP 2006539449A JP 2006539449 A JP2006539449 A JP 2006539449A JP 4717003 B2 JP4717003 B2 JP 4717003B2
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JP
Japan
Prior art keywords
compound
substituted
cancer
compounds
geldanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2006539449A
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English (en)
Japanese (ja)
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JP2007510718A5 (enExample
JP2007510718A (ja
Inventor
ゾン クィアン ティアン
ヤオクアン リウ
ディヴィッド シー マイルズ
ザン ワン
Original Assignee
コーサン バイオサイエンシーズ， インコーポレイテッド
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Application filed by コーサン バイオサイエンシーズ， インコーポレイテッド filed Critical コーサン バイオサイエンシーズ， インコーポレイテッド
Publication of JP2007510718A publication Critical patent/JP2007510718A/ja
Publication of JP2007510718A5 publication Critical patent/JP2007510718A5/ja
Application granted granted Critical
Publication of JP4717003B2 publication Critical patent/JP4717003B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006539449A 2003-11-12 2004-04-16 １１−ｏ−メチルゲルダナマイシン化合物 Expired - Fee Related JP4717003B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51947903P 2003-11-12 2003-11-12
US60/519,479 2003-11-12
PCT/US2004/011638 WO2005056531A1 (en) 2003-11-12 2004-04-16 11-o-methylgeldanamycin compounds

Publications (3)

Publication Number Publication Date
JP2007510718A JP2007510718A (ja) 2007-04-26
JP2007510718A5 JP2007510718A5 (enExample) 2007-06-14
JP4717003B2 true JP4717003B2 (ja) 2011-07-06

Family

ID=34676572

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006539449A Expired - Fee Related JP4717003B2 (ja) 2003-11-12 2004-04-16 １１−ｏ−メチルゲルダナマイシン化合物

Country Status (5)

Country Link
US (1) US6870049B1 (enExample)
EP (1) EP1682514A4 (enExample)
JP (1) JP4717003B2 (enExample)
CA (1) CA2545457A1 (enExample)
WO (1) WO2005056531A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
WO2007059116A2 (en) * 2005-11-14 2007-05-24 Abraxis Bioscience, Inc. Geldanamycin derivatives and pharmaceutical compositions thereof
US20070207992A1 (en) * 2006-02-21 2007-09-06 Board Of Trustees Of Michigan State University Geldanamycin derivatives and method of use thereof
DE102006044472A1 (de) * 2006-09-21 2008-04-03 Discovery Partner International Gmbh Geldanamycin-Derivate
EP2200653A2 (en) * 2007-09-10 2010-06-30 University of Massachusetts Mitochondria-targeted anti-tumour agents

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987035A (en) 1974-04-05 1976-10-19 University Of Illinois Foundation Biologically active compounds
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
JPS5874651A (ja) 1981-09-17 1983-05-06 Takeda Chem Ind Ltd マクベシン誘導体およびその製造法
US4421687A (en) 1981-09-26 1983-12-20 Takeda Chemical Industries, Limited Macbecin derivatives
JPS59102398A (ja) 1982-12-03 1984-06-13 Takeda Chem Ind Ltd 新規抗生物質およびその製造法
JPS63218620A (ja) 1987-03-09 1988-09-12 Kyowa Hakko Kogyo Co Ltd 癌化細胞の正常化剤
JPH0446120A (ja) 1990-06-11 1992-02-17 Kyowa Hakko Kogyo Co Ltd 血管新生抑制剤
CA2127457A1 (en) 1992-01-06 1993-07-22 Walter P. Cullen Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone
JPH08502488A (ja) 1992-10-14 1996-03-19 アメリカ合衆国 前立腺癌および初期神経悪性疾患に対するベンゾキノイドアンサマイシンの殺腫瘍活性
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
EP0706516A1 (en) 1993-06-29 1996-04-17 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5662883A (en) 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
WO1996034525A1 (en) 1995-05-02 1996-11-07 The Regents Of The University Of California Inducement of thermotolerance with benzoquinonoid ansamycins
WO2000003737A2 (en) 1998-07-17 2000-01-27 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Water-soluble drugs and methods for their production
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
WO2002036574A1 (en) * 2000-11-06 2002-05-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Geldanamycin derivatives useful for the treatment of cancer
DE60213386T2 (de) 2001-03-30 2006-11-23 The United States Of America Represented By The Secretary, Department Of Health And Human Services Geldanamycinderivate zur krebsbehandlung
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
WO2003013430A2 (en) 2001-08-06 2003-02-20 Kosan Biosciences, Inc. Benzoquinone ansamycins
CA2474508A1 (en) 2002-02-08 2003-08-14 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
RU2005133199A (ru) * 2003-03-28 2006-02-10 Козан Байосайенсиз, Инк. (Us) Устройства, способы и композиции для предупреждения рестеноза

Also Published As

Publication number Publication date
EP1682514A1 (en) 2006-07-26
JP2007510718A (ja) 2007-04-26
US6870049B1 (en) 2005-03-22
EP1682514A4 (en) 2008-07-16
CA2545457A1 (en) 2005-06-23
WO2005056531A1 (en) 2005-06-23

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