CA2545457A1 - 11-o-methylgeldanamycin compounds - Google Patents
11-o-methylgeldanamycin compounds Download PDFInfo
- Publication number
- CA2545457A1 CA2545457A1 CA002545457A CA2545457A CA2545457A1 CA 2545457 A1 CA2545457 A1 CA 2545457A1 CA 002545457 A CA002545457 A CA 002545457A CA 2545457 A CA2545457 A CA 2545457A CA 2545457 A1 CA2545457 A1 CA 2545457A1
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- Prior art keywords
- compound according
- compound
- formula
- cancer
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- CNRHKAUBQSMJQZ-WTHQLRERSA-N [(3r,5s,6r,7s,8e,10s,11s,12z,14e)-5,6,11,21-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate Chemical class N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](OC)[C@@H](OC)C[C@H](C)CC2=C(OC)C(=O)C=C1C2=O CNRHKAUBQSMJQZ-WTHQLRERSA-N 0.000 title description 10
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- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51947903P | 2003-11-12 | 2003-11-12 | |
| US60/519,479 | 2003-11-12 | ||
| PCT/US2004/011638 WO2005056531A1 (en) | 2003-11-12 | 2004-04-16 | 11-o-methylgeldanamycin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2545457A1 true CA2545457A1 (en) | 2005-06-23 |
Family
ID=34676572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002545457A Abandoned CA2545457A1 (en) | 2003-11-12 | 2004-04-16 | 11-o-methylgeldanamycin compounds |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6870049B1 (enExample) |
| EP (1) | EP1682514A4 (enExample) |
| JP (1) | JP4717003B2 (enExample) |
| CA (1) | CA2545457A1 (enExample) |
| WO (1) | WO2005056531A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
| WO2007059116A2 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Geldanamycin derivatives and pharmaceutical compositions thereof |
| US20070207992A1 (en) * | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| DE102006044472A1 (de) * | 2006-09-21 | 2008-04-03 | Discovery Partner International Gmbh | Geldanamycin-Derivate |
| EP2200653A2 (en) * | 2007-09-10 | 2010-06-30 | University of Massachusetts | Mitochondria-targeted anti-tumour agents |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987035A (en) | 1974-04-05 | 1976-10-19 | University Of Illinois Foundation | Biologically active compounds |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| JPS5874651A (ja) | 1981-09-17 | 1983-05-06 | Takeda Chem Ind Ltd | マクベシン誘導体およびその製造法 |
| US4421687A (en) | 1981-09-26 | 1983-12-20 | Takeda Chemical Industries, Limited | Macbecin derivatives |
| JPS59102398A (ja) | 1982-12-03 | 1984-06-13 | Takeda Chem Ind Ltd | 新規抗生物質およびその製造法 |
| JPS63218620A (ja) | 1987-03-09 | 1988-09-12 | Kyowa Hakko Kogyo Co Ltd | 癌化細胞の正常化剤 |
| JPH0446120A (ja) | 1990-06-11 | 1992-02-17 | Kyowa Hakko Kogyo Co Ltd | 血管新生抑制剤 |
| CA2127457A1 (en) | 1992-01-06 | 1993-07-22 | Walter P. Cullen | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| JPH08502488A (ja) | 1992-10-14 | 1996-03-19 | アメリカ合衆国 | 前立腺癌および初期神経悪性疾患に対するベンゾキノイドアンサマイシンの殺腫瘍活性 |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| EP0706516A1 (en) | 1993-06-29 | 1996-04-17 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| WO1996034525A1 (en) | 1995-05-02 | 1996-11-07 | The Regents Of The University Of California | Inducement of thermotolerance with benzoquinonoid ansamycins |
| WO2000003737A2 (en) | 1998-07-17 | 2000-01-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-soluble drugs and methods for their production |
| US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| WO2002036574A1 (en) * | 2000-11-06 | 2002-05-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Geldanamycin derivatives useful for the treatment of cancer |
| DE60213386T2 (de) | 2001-03-30 | 2006-11-23 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Geldanamycinderivate zur krebsbehandlung |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003013430A2 (en) | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| CA2474508A1 (en) | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| RU2005133199A (ru) * | 2003-03-28 | 2006-02-10 | Козан Байосайенсиз, Инк. (Us) | Устройства, способы и композиции для предупреждения рестеноза |
-
2004
- 2004-04-16 US US10/826,446 patent/US6870049B1/en not_active Expired - Lifetime
- 2004-04-16 JP JP2006539449A patent/JP4717003B2/ja not_active Expired - Fee Related
- 2004-04-16 WO PCT/US2004/011638 patent/WO2005056531A1/en not_active Ceased
- 2004-04-16 EP EP04750158A patent/EP1682514A4/en not_active Withdrawn
- 2004-04-16 CA CA002545457A patent/CA2545457A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1682514A1 (en) | 2006-07-26 |
| JP4717003B2 (ja) | 2011-07-06 |
| JP2007510718A (ja) | 2007-04-26 |
| US6870049B1 (en) | 2005-03-22 |
| EP1682514A4 (en) | 2008-07-16 |
| WO2005056531A1 (en) | 2005-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |