JP2007510031A5 - - Google Patents

Info

Publication number

JP2007510031A5

JP2007510031A5 JP2006537422A JP2006537422A JP2007510031A5 JP 2007510031 A5 JP2007510031 A5 JP 2007510031A5 JP 2006537422 A JP2006537422 A JP 2006537422A JP 2006537422 A JP2006537422 A JP 2006537422A JP 2007510031 A5 JP2007510031 A5 JP 2007510031A5

Authority

JP

Japan

Prior art keywords

groups

group

compound

sulfobutyl

methyl

Prior art date

2004-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 21
• 239000001257 hydrogen Substances 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• -1 succinimidyl ester Chemical class 0.000 claims 5
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 4
• ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 4
• 125000004429 atom Chemical group 0.000 claims 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 claims 3
• 125000000542 sulfonic acid group Chemical group 0.000 claims 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 125000002619 bicyclic group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 125000002950 monocyclic group Chemical group 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 125000004430 oxygen atom Chemical group O* 0.000 claims 2
• UGIZUKGTKCHOEO-UHFFFAOYSA-N (2e)-2-[(2e,4z)-5-[1-(5-carboxypentyl)-3-methyl-5-sulfo-3-(4-sulfobutyl)indol-1-ium-2-yl]penta-2,4-dienylidene]-3-methyl-1,3-bis(4-sulfobutyl)indole-5-sulfonate Chemical compound OC(=O)CCCCCN1C2=CC=C(S(O)(=O)=O)C=C2C(C)(CCCCS(O)(=O)=O)\C1=C/C=C/C=C/C1=[N+](CCCCS(O)(=O)=O)C2=CC=C(S([O-])(=O)=O)C=C2C1(C)CCCCS(O)(=O)=O UGIZUKGTKCHOEO-UHFFFAOYSA-N 0.000 claims 1
• AXDOQVSFBHMFSE-UHFFFAOYSA-N 1-benzyl-2-[(1e,3e,5e)-5-[1-(5-carboxypentyl)-3-methyl-5-sulfo-3-(4-sulfobutyl)indol-2-ylidene]penta-1,3-dienyl]-3-methyl-3-(4-sulfobutyl)indol-1-ium-5-sulfonate Chemical compound OC(=O)CCCCCN1C2=CC=C(S(O)(=O)=O)C=C2C(C)(CCCCS(O)(=O)=O)\C1=C/C=C/C=C/C(C(C1=CC(=CC=C11)S([O-])(=O)=O)(C)CCCCS(O)(=O)=O)=[N+]1CC1=CC=CC=C1 AXDOQVSFBHMFSE-UHFFFAOYSA-N 0.000 claims 1
• BLTBKTKORYZZSS-UHFFFAOYSA-N 2-[5-[1-(5-carboxypentyl)-3-methyl-5-sulfo-3-(4-sulfobutyl)indol-1-ium-2-yl]penta-2,4-dienylidene]-1-ethyl-3-methyl-3-(4-sulfobutyl)indole-5-sulfonate Chemical compound OS(=O)(=O)CCCCC1(C)C2=CC(S([O-])(=O)=O)=CC=C2[N+](CC)=C1\C=C\C=C\C=C\1C(CCCCS(O)(=O)=O)(C)C2=CC(S(O)(=O)=O)=CC=C2N/1CCCCCC(O)=O BLTBKTKORYZZSS-UHFFFAOYSA-N 0.000 claims 1
• QFRWHAVRZLUMIB-UHFFFAOYSA-N 2-[7-[1-(5-carboxypentyl)-3-methyl-5-sulfo-3-(4-sulfobutyl)indol-1-ium-2-yl]hepta-2,4,6-trienylidene]-1-ethyl-3-methyl-3-(4-sulfobutyl)indole-5-sulfonate Chemical compound OS(=O)(=O)CCCCC1(C)C2=CC(S([O-])(=O)=O)=CC=C2[N+](CC)=C1\C=C\C=C\C=C\C=C\1C(CCCCS(O)(=O)=O)(C)C2=CC(S(O)(=O)=O)=CC=C2N/1CCCCCC(O)=O QFRWHAVRZLUMIB-UHFFFAOYSA-N 0.000 claims 1
• KCLLGUBEMHHCRQ-UHFFFAOYSA-N 2-[7-[5-(carboxymethyl)-3-methyl-1,3-bis(4-sulfobutyl)indol-1-ium-2-yl]hepta-2,4,6-trienylidene]-1-ethyl-3-methyl-3-(4-sulfobutyl)indole-5-sulfonate Chemical compound OS(=O)(=O)CCCCC1(C)C2=CC(S([O-])(=O)=O)=CC=C2[N+](CC)=C1\C=C\C=C\C=C\C=C\1C(CCCCS(O)(=O)=O)(C)C2=CC(CC(O)=O)=CC=C2N/1CCCCS(O)(=O)=O KCLLGUBEMHHCRQ-UHFFFAOYSA-N 0.000 claims 1
• PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 210000000170 cell membrane Anatomy 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 150000002540 isothiocyanates Chemical class 0.000 claims 1
• 238000002372 labelling Methods 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 150000008300 phosphoramidites Chemical class 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1