CN100577742C - 花青染料标记试剂 - Google Patents

花青染料标记试剂 Download PDF

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Publication number
CN100577742C
CN100577742C CN200480032219A CN200480032219A CN100577742C CN 100577742 C CN100577742 C CN 100577742C CN 200480032219 A CN200480032219 A CN 200480032219A CN 200480032219 A CN200480032219 A CN 200480032219A CN 100577742 C CN100577742 C CN 100577742C
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CN
China
Prior art keywords
group
radicals
compound
dyestuff
definition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200480032219A
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English (en)
Chinese (zh)
Other versions
CN1875073A (zh
Inventor
R·M·维斯特
N·博斯沃尔思
R·B·穆朱姆达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carnegie Mellon University
Original Assignee
Amersham Biosciences UK Ltd
Carnegie Mellon University
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Publication date
Application filed by Amersham Biosciences UK Ltd, Carnegie Mellon University filed Critical Amersham Biosciences UK Ltd
Publication of CN1875073A publication Critical patent/CN1875073A/zh
Application granted granted Critical
Publication of CN100577742C publication Critical patent/CN100577742C/zh
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Laminated Bodies (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200480032219A 2003-10-31 2004-10-29 花青染料标记试剂 Expired - Fee Related CN100577742C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51642803P 2003-10-31 2003-10-31
US60/516,428 2003-10-31

Publications (2)

Publication Number Publication Date
CN1875073A CN1875073A (zh) 2006-12-06
CN100577742C true CN100577742C (zh) 2010-01-06

Family

ID=34572883

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480032219A Expired - Fee Related CN100577742C (zh) 2003-10-31 2004-10-29 花青染料标记试剂

Country Status (7)

Country Link
US (2) US7750163B2 (enExample)
EP (2) EP2360211A1 (enExample)
JP (1) JP4943156B2 (enExample)
CN (1) CN100577742C (enExample)
AT (1) ATE522580T1 (enExample)
ES (1) ES2372395T3 (enExample)
WO (1) WO2005044923A1 (enExample)

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CN102608051A (zh) * 2012-02-21 2012-07-25 中国科学院化学研究所 用于诊断白血病的试剂盒

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US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
DE102006029454A1 (de) * 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
ATE480596T1 (de) 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
WO2007100711A2 (en) * 2006-02-24 2007-09-07 Investigen, Inc. Methods and compositions for detecting polynucleotides
WO2008103702A2 (en) 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
BRPI0811588A2 (pt) * 2007-05-16 2014-10-21 Ge Healthcare As Agente de formação de imagem, composição farmacêutica, kit para a preparação da mesma, conjugado, corante de cianina, e, métodos de formação de imagem óptica in vivo do corpo de um mamífero e de detecção, avaliação do estágio, diagnóstico, monitoração da progressão da doença ou monitoração do tratamento de um estado de doença do corpo de um mamífero
CA2685553C (en) * 2007-05-16 2017-03-28 Ge Healthcare As Peptide imaging agents
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
CN101723874B (zh) * 2008-10-31 2013-09-11 深圳迈瑞生物医疗电子股份有限公司 花菁类化合物及其在生物样品染色中的用途
CN102272106A (zh) 2008-11-07 2011-12-07 通用医疗公司 用于体内和体外成像的单官能羰花青染料
CN101750476B (zh) * 2008-12-08 2015-06-03 深圳迈瑞生物医疗电子股份有限公司 血液分析试剂及其使用方法
US8729276B2 (en) * 2009-04-17 2014-05-20 Korea Institute Of Science And Technology Cyanine compound for labeling biomolecule and preparation method thereof
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
GB2478359B (en) * 2010-03-05 2018-09-12 Innova Biosciences Ltd Conjugation reactions
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
WO2012001063A1 (en) 2010-06-29 2012-01-05 Ge Healthcare As Dye compositions and dye syntheses
WO2012040108A2 (en) * 2010-09-20 2012-03-29 Caliper Life Sciences Multivalent fluorescent probes
EP2625281A2 (en) * 2010-10-06 2013-08-14 EMD Millipore Corporation Cyanine compounds, conjugates and method of use
EP3029027B1 (en) 2010-12-21 2018-06-27 Pierce Biotechnology, Inc. Fluorescent compounds
US8877892B2 (en) 2011-03-15 2014-11-04 Innova Biosciences Limited Conjugation reactions
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2758475B1 (en) 2011-09-23 2017-04-26 Illumina Cambridge Limited Dyes for labelling molecular ligands
US9631096B2 (en) * 2012-01-20 2017-04-25 Cornell University Dye compositions, methods of preparation, conjugates thereof, and methods of use
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US20140072515A9 (en) 2012-03-02 2014-03-13 Greg Hermanson Cyanine compounds
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
US8809551B1 (en) 2013-03-08 2014-08-19 Illumina Cambridge Limited Polymethine compounds and their use as fluorescent labels
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US20160176819A1 (en) * 2014-12-19 2016-06-23 Washington University Asymmetrically charged nir fluorophores
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) * 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
KR20170101360A (ko) * 2016-02-26 2017-09-06 에스에프씨 주식회사 시아닌계 화합물, 이를 포함하는 생체분자 표지용 염료, 키트 및 조영제 조성물
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
CN108752406A (zh) * 2018-05-29 2018-11-06 苏州百源基因技术有限公司 一种荧光标记的核苷酸及其制备方法和用途
JP7359869B2 (ja) * 2019-12-19 2023-10-11 富士フイルム株式会社 化合物及びこれを用いた蛍光標識生体物質
CA3167456A1 (en) * 2020-02-10 2021-08-19 C-Biomex Co., Ltd. Amphoteric fluorescent substance capable of being attached to biomaterials
US11964965B2 (en) 2020-05-08 2024-04-23 On Target Laboratories, LLC Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
WO2021228939A1 (en) * 2020-05-12 2021-11-18 Universite De Strasbourg Fluorogenic dimer compound, useful as a probe for detection of endogenous receptors

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US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
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JPH0531330A (ja) * 1991-07-31 1993-02-09 Riken Corp 排ガス浄化方法
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EP1525265B1 (en) * 2002-05-10 2011-07-20 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
EP2360211A1 (en) * 2003-10-31 2011-08-24 GE Healthcare Limited Fluorescently-labelled target components

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102608051A (zh) * 2012-02-21 2012-07-25 中国科学院化学研究所 用于诊断白血病的试剂盒

Also Published As

Publication number Publication date
EP2360211A1 (en) 2011-08-24
JP4943156B2 (ja) 2012-05-30
ATE522580T1 (de) 2011-09-15
US20070203343A1 (en) 2007-08-30
WO2005044923A1 (en) 2005-05-19
ES2372395T3 (es) 2012-01-19
CN1875073A (zh) 2006-12-06
HK1093520A1 (en) 2007-03-02
US8148539B2 (en) 2012-04-03
US20100267937A1 (en) 2010-10-21
EP1678258B1 (en) 2011-08-31
EP1678258A1 (en) 2006-07-12
JP2007510031A (ja) 2007-04-19
US7750163B2 (en) 2010-07-06

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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: GENERAL ELECTRIC MEDICAL CARE GROUP YING CO., LTD.

Free format text: FORMER NAME: AMOSON BIOLOGICAL SCIENCES BRITAIN CO., LTD.

CP03 Change of name, title or address

Address after: Buckinghamshire

Co-patentee after: Carnegie Mellon Univ.

Patentee after: General electric medical group UK Limited

Address before: Buckinghamshire

Co-patentee before: Carnegie Mellon Univ.

Patentee before: Amerson Biological Sciences UK Limited

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100106

Termination date: 20141029

EXPY Termination of patent right or utility model