JP2007509175A5 - - Google Patents
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- Publication number
- JP2007509175A5 JP2007509175A5 JP2006536882A JP2006536882A JP2007509175A5 JP 2007509175 A5 JP2007509175 A5 JP 2007509175A5 JP 2006536882 A JP2006536882 A JP 2006536882A JP 2006536882 A JP2006536882 A JP 2006536882A JP 2007509175 A5 JP2007509175 A5 JP 2007509175A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- hetero
- halo
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004520 1,3,4-thiadiazolyl group Chemical group 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 1
- -1 pyrrolyl Quinazolinyl Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51437303P | 2003-10-24 | 2003-10-24 | |
| US60/514,373 | 2003-10-24 | ||
| PCT/US2004/035282 WO2005040142A1 (en) | 2003-10-24 | 2004-10-22 | Novel keto-oxadiazole derivatives as cathepsin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007509175A JP2007509175A (ja) | 2007-04-12 |
| JP2007509175A5 true JP2007509175A5 (enExample) | 2007-12-06 |
| JP4769192B2 JP4769192B2 (ja) | 2011-09-07 |
Family
ID=34520197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006536882A Expired - Fee Related JP4769192B2 (ja) | 2003-10-24 | 2004-10-22 | カテプシン阻害剤としての新規な化合物及び組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7482448B2 (enExample) |
| EP (1) | EP1682524A1 (enExample) |
| JP (1) | JP4769192B2 (enExample) |
| KR (1) | KR20070008517A (enExample) |
| CN (1) | CN100543017C (enExample) |
| AU (1) | AU2004284089B2 (enExample) |
| BR (1) | BRPI0415826A (enExample) |
| CA (1) | CA2547591C (enExample) |
| IL (1) | IL175106A0 (enExample) |
| MA (1) | MA28170A1 (enExample) |
| ME (1) | MEP39608A (enExample) |
| MX (1) | MXPA06004422A (enExample) |
| NO (1) | NO20062150L (enExample) |
| NZ (1) | NZ546504A (enExample) |
| RS (1) | RS20060280A (enExample) |
| RU (1) | RU2346943C2 (enExample) |
| WO (1) | WO2005040142A1 (enExample) |
| ZA (1) | ZA200603183B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006060810A1 (en) | 2004-12-02 | 2006-06-08 | Schering Aktiengesellschaft | Sulfonamide compounds as cysteine protease inhibitors |
| PL1865940T3 (pl) | 2005-03-21 | 2013-06-28 | Virobay Inc | Alfa-ketoamidowe związki jako inhibitory proteaz cysteinowych |
| JP5215167B2 (ja) | 2005-03-22 | 2013-06-19 | ビロベイ，インコーポレイティド | システインプロテアーゼ阻害剤としてのスルホニル基含有化合物 |
| ES2392675T3 (es) | 2006-06-01 | 2012-12-12 | Sanofi | Nitrilos espirocíclicos como inhibidores de proteasa |
| DK2079683T3 (en) * | 2006-10-04 | 2015-04-27 | Virobay Inc | Difluoro-containing compounds as cysteine protease inhibitors |
| US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| WO2008104271A2 (en) | 2007-02-28 | 2008-09-04 | Sanofi-Aventis | Imaging probes |
| EP2262370A4 (en) * | 2008-04-01 | 2011-08-31 | Virobay Inc | DIFLUOROUS COMPOUNDS AS A CYSTONE PROTEASE INHIBITOR |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| BRPI0922283A2 (pt) * | 2008-12-19 | 2015-12-29 | Medivir Uk Ltd | inibidores da cistéina protease |
| US7893099B2 (en) * | 2009-06-11 | 2011-02-22 | Hoffman-La Roche Inc. | Cyclopentane derivatives |
| US20110021570A1 (en) | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| US8324417B2 (en) * | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
| US8895497B2 (en) | 2009-12-04 | 2014-11-25 | Dcb-Usa, Llc | Cathepsin S inhibitors |
| US8500766B2 (en) * | 2009-12-18 | 2013-08-06 | Colgate-Palmolive Company | Oral care implement multiple soft tissue cleaner components |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| KR20150046259A (ko) | 2012-08-23 | 2015-04-29 | 앨리오스 바이오파마 인크. | 파라믹소바이러스 바이러스성 감염의 치료용 화합물 |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
| CN122355874A (zh) * | 2026-06-08 | 2026-07-10 | 天津楷特药业有限公司 | 一种手性α-羟基-偕胺肟醚的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2381023A1 (fr) | 1977-02-18 | 1978-09-15 | Delalande Sa | Nouveaux oligopeptides trifluoromethyles derives de la l-alanine, leur procede de preparation et leur application en therapeutique |
| FR2605009B1 (fr) * | 1986-06-13 | 1989-06-09 | Ayi Ayicoue | Nouveaux peptides contenant un acide a-amine b-monofluore ou b,b-difluore dans leur structure dont des enkephalines et derives d'enkephalines |
| CA2045578A1 (en) * | 1989-01-31 | 1990-08-01 | Megumi Kawai | Anaphylatoxin-receptor ligands |
| US5223485A (en) | 1989-01-31 | 1993-06-29 | Abbott Laboratories | Anaphylatoxin-receptor ligands |
| JPH0449298A (ja) * | 1990-06-19 | 1992-02-18 | Univ New York State | 新規なエンケファリン誘導体および鎮痛剤 |
| JP3605158B2 (ja) * | 1994-12-09 | 2004-12-22 | 塩野義製薬株式会社 | Ｈｉｖプロテアーゼ阻害剤 |
| DE19642591A1 (de) * | 1996-10-15 | 1998-04-16 | Basf Ag | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
| SK112899A3 (en) * | 1997-02-26 | 2001-05-10 | Pfizer | Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor |
| ID20812A (id) | 1997-07-09 | 1999-03-11 | Takeda Chemical Industries Ltd | Senyawa polyol, produk dan penggunaannya |
| KR20010041905A (ko) * | 1998-03-16 | 2001-05-25 | 시토비아 인크. | 디펩티드 카스파제 억제제 및 이의 용도 |
| GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
| EA200100972A1 (ru) * | 1999-03-15 | 2002-02-28 | Аксис Фармасьютикалз, Инк. | Новые соединения и композиции как ингибиторы протеаз |
| TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
| DE60229114D1 (en) | 2001-03-02 | 2008-11-13 | Axys Pharm Inc | Cathepsincystein-proteasehemmer |
| GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
| JP2004535422A (ja) | 2001-06-01 | 2004-11-25 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新しい化合物および組成物 |
| US6982263B2 (en) * | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| RU2312861C2 (ru) * | 2002-03-05 | 2007-12-20 | Мерк Фросст Кэнада Лтд. | Ингибиторы катепсин-цистеинпротеазы |
| AU2003220441A1 (en) | 2002-04-09 | 2003-10-27 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
| EP1503997A1 (en) | 2002-05-14 | 2005-02-09 | Axys Pharmaceuticals, Inc. | Cysteine protease inhibitors |
-
2004
- 2004-10-22 RU RU2006117788/04A patent/RU2346943C2/ru not_active IP Right Cessation
- 2004-10-22 ME MEP-396/08A patent/MEP39608A/xx unknown
- 2004-10-22 EP EP04796294A patent/EP1682524A1/en not_active Withdrawn
- 2004-10-22 MX MXPA06004422A patent/MXPA06004422A/es active IP Right Grant
- 2004-10-22 CN CNB2004800389122A patent/CN100543017C/zh not_active Expired - Fee Related
- 2004-10-22 RS YUP-2006/0280A patent/RS20060280A/sr unknown
- 2004-10-22 JP JP2006536882A patent/JP4769192B2/ja not_active Expired - Fee Related
- 2004-10-22 WO PCT/US2004/035282 patent/WO2005040142A1/en not_active Ceased
- 2004-10-22 NZ NZ546504A patent/NZ546504A/en not_active IP Right Cessation
- 2004-10-22 BR BRPI0415826-1A patent/BRPI0415826A/pt not_active Application Discontinuation
- 2004-10-22 KR KR1020067008096A patent/KR20070008517A/ko not_active Withdrawn
- 2004-10-22 CA CA2547591A patent/CA2547591C/en not_active Expired - Fee Related
- 2004-10-22 AU AU2004284089A patent/AU2004284089B2/en not_active Ceased
-
2006
- 2006-04-20 ZA ZA200603183A patent/ZA200603183B/en unknown
- 2006-04-23 IL IL175106A patent/IL175106A0/en unknown
- 2006-04-24 US US11/409,601 patent/US7482448B2/en not_active Expired - Fee Related
- 2006-05-12 NO NO20062150A patent/NO20062150L/no unknown
- 2006-05-23 MA MA29048A patent/MA28170A1/fr unknown