MA28170A1 - Nouveaux derives de ceto-oxadiazole comme inhibiteurs de la cathepsine - Google Patents

Nouveaux derives de ceto-oxadiazole comme inhibiteurs de la cathepsine

Info

Publication number
MA28170A1
MA28170A1 MA29048A MA29048A MA28170A1 MA 28170 A1 MA28170 A1 MA 28170A1 MA 29048 A MA29048 A MA 29048A MA 29048 A MA29048 A MA 29048A MA 28170 A1 MA28170 A1 MA 28170A1
Authority
MA
Morocco
Prior art keywords
novel
ceto
oxadiazole derivatives
cathepsin inhibitors
inhibitors
Prior art date
Application number
MA29048A
Other languages
English (en)
Inventor
Sukanthini Thurairatnam
David John Aldous
Vincent Leroy
Andreas Paul Timm
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MA28170A1 publication Critical patent/MA28170A1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/107—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with two aryl or substituted aryl radicals attached in positions 2 and 5
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)

Abstract

Nouveaux inhibiteurs des cathepsines S, K, B, et L, sels pharmaceutiquement acceptables et N-oxvdes de ceux-ci, leurs utilisations comme agents thérapeutiques et méthodes pour leur production.
MA29048A 2003-10-24 2006-05-23 Nouveaux derives de ceto-oxadiazole comme inhibiteurs de la cathepsine MA28170A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51437303P 2003-10-24 2003-10-24

Publications (1)

Publication Number Publication Date
MA28170A1 true MA28170A1 (fr) 2006-09-01

Family

ID=34520197

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29048A MA28170A1 (fr) 2003-10-24 2006-05-23 Nouveaux derives de ceto-oxadiazole comme inhibiteurs de la cathepsine

Country Status (19)

Country Link
US (1) US7482448B2 (fr)
EP (1) EP1682524A1 (fr)
JP (1) JP4769192B2 (fr)
KR (1) KR20070008517A (fr)
CN (1) CN100543017C (fr)
AU (1) AU2004284089B2 (fr)
BR (1) BRPI0415826A (fr)
CA (1) CA2547591C (fr)
HK (1) HK1101871A1 (fr)
IL (1) IL175106A0 (fr)
MA (1) MA28170A1 (fr)
ME (1) MEP39608A (fr)
MX (1) MXPA06004422A (fr)
NO (1) NO20062150L (fr)
NZ (1) NZ546504A (fr)
RS (1) RS20060280A (fr)
RU (1) RU2346943C2 (fr)
WO (1) WO2005040142A1 (fr)
ZA (1) ZA200603183B (fr)

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EA017874B1 (ru) 2005-03-21 2013-03-29 Вайробей, Инк. Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз
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UA100669C2 (ru) 2006-06-01 2013-01-25 Санофі-Авентіс Спироциклические нитрилы как ингибиторы протеазы, способ их получения (варианты) и лекарственное средство на их основе
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US8500766B2 (en) * 2009-12-18 2013-08-06 Colgate-Palmolive Company Oral care implement multiple soft tissue cleaner components
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NZ704666A (en) * 2012-08-23 2018-05-25 Alios Biopharma Inc Compounds for the treatment of paramoxyvirus viral infections
US20220193048A1 (en) 2019-04-05 2022-06-23 Universite De Bretagne Occidentale Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning

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CA2547591C (fr) 2010-08-17
WO2005040142B1 (fr) 2005-07-14
CN100543017C (zh) 2009-09-23
RS20060280A (en) 2008-08-07
AU2004284089A1 (en) 2005-05-06
RU2346943C2 (ru) 2009-02-20
RU2006117788A (ru) 2007-11-27
KR20070008517A (ko) 2007-01-17
WO2005040142A9 (fr) 2005-06-09
JP2007509175A (ja) 2007-04-12
EP1682524A1 (fr) 2006-07-26
IL175106A0 (en) 2006-09-05
NO20062150L (no) 2006-05-12
US20060189657A1 (en) 2006-08-24
ZA200603183B (en) 2007-09-26
CN1898219A (zh) 2007-01-17
AU2004284089B2 (en) 2009-11-26
MXPA06004422A (es) 2006-07-03
BRPI0415826A (pt) 2007-01-02
HK1101871A1 (en) 2007-10-26
MEP39608A (en) 2011-02-10
JP4769192B2 (ja) 2011-09-07
WO2005040142A1 (fr) 2005-05-06
CA2547591A1 (fr) 2005-05-06
NZ546504A (en) 2009-01-31
US7482448B2 (en) 2009-01-27

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