EP0456758A4 - Anaphylatoxin-receptor ligands - Google Patents

Anaphylatoxin-receptor ligands

Info

Publication number
EP0456758A4
EP0456758A4 EP19900903567 EP90903567A EP0456758A4 EP 0456758 A4 EP0456758 A4 EP 0456758A4 EP 19900903567 EP19900903567 EP 19900903567 EP 90903567 A EP90903567 A EP 90903567A EP 0456758 A4 EP0456758 A4 EP 0456758A4
Authority
EP
European Patent Office
Prior art keywords
anaphylatoxin
receptor ligands
ligands
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900903567
Other versions
EP0456758A1 (en
Inventor
Megumi Kawai
Yat Sun Or
Paul E. Wiedeman
Jay R. Luly
Mikel P. Moyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0456758A1 publication Critical patent/EP0456758A1/en
Publication of EP0456758A4 publication Critical patent/EP0456758A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19900903567 1989-01-31 1990-01-16 Anaphylatoxin-receptor ligands Withdrawn EP0456758A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30469389A 1989-01-31 1989-01-31
US304693 1999-05-04

Publications (2)

Publication Number Publication Date
EP0456758A1 EP0456758A1 (en) 1991-11-21
EP0456758A4 true EP0456758A4 (en) 1992-07-08

Family

ID=23177579

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900903567 Withdrawn EP0456758A4 (en) 1989-01-31 1990-01-16 Anaphylatoxin-receptor ligands

Country Status (5)

Country Link
EP (1) EP0456758A4 (en)
JP (1) JPH04503073A (en)
CA (1) CA2045578A1 (en)
GR (1) GR900100052A (en)
WO (1) WO1990009162A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5386011A (en) * 1990-12-27 1995-01-31 Abbott Laboratories Hexapeptide anaphylatoxin-receptor ligands
US5387671A (en) * 1990-12-27 1995-02-07 Abbott Laboratories Hexa- and heptapeptide anaphylatoxin-receptor ligands
US5190922A (en) * 1991-06-04 1993-03-02 Abbott Laboratories Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
WO1994007518A1 (en) * 1992-09-25 1994-04-14 Abbott Laboratories Anaphylatoxin receptor ligands containing lipophilic residues
US5807824A (en) * 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
US5837499A (en) * 1993-12-06 1998-11-17 Ciba-Geigy Corporation DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
US5614370A (en) * 1994-03-18 1997-03-25 Merck & Co., Inc. Assay to identify human C5a antagonists and agonists
JP3665342B2 (en) * 1995-01-16 2005-06-29 ノーザン シドニー エリア ヘルス サービス New peptide
SE9603462D0 (en) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603468D0 (en) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603461D0 (en) * 1996-09-23 1996-09-23 Astra Ab New compounds
US6998106B1 (en) * 1998-12-01 2006-02-14 Duke University Radioconjugation of internalizing antibodies
TW200502221A (en) 2002-10-03 2005-01-16 Astrazeneca Ab Novel lactams and uses thereof
WO2004080983A1 (en) * 2003-03-14 2004-09-23 Astrazeneca Ab Novel lactams and uses thereof
EP1498422A1 (en) * 2003-07-17 2005-01-19 Jerini AG C5a Receptor Antagonists
MXPA06004422A (en) * 2003-10-24 2006-07-03 Aventis Pharma Inc Novel keto-oxadiazole derivatives as cathepsin inhibitors.
BRPI0606647A2 (en) * 2005-01-17 2009-07-14 Jerini Ag c5a receptor antagonists
EP1739078A1 (en) 2005-05-30 2007-01-03 Jerini AG Antagonists of C5a-receptor
EP2468295A1 (en) * 2010-12-21 2012-06-27 Affiris AG Vaccines based on peptides of the complement protein C5a
EP2666785A1 (en) * 2012-05-23 2013-11-27 Affiris AG Complement component C5a-based vaccine
CN103599523B (en) * 2013-11-25 2016-08-17 中国人民解放军第二军医大学 Pentapeptide metabolite application in preparing anti-inflammatory drug
US11918624B2 (en) 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692511A (en) * 1984-07-03 1987-09-08 Immunetech Pharmaceuticals Peptide antagonists for the C5a anaphylatoxin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692511A (en) * 1984-07-03 1987-09-08 Immunetech Pharmaceuticals Peptide antagonists for the C5a anaphylatoxin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. WEINSTEIN: "Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins. A Survey of recent Developments", vol. 7, 1983, pages 267-349, Marcel Dekker, Inc.; Chapter 5, A.F. SPATOLA: "Peptide backbone modifications: a structure-acitivity analysis of peptides containing amide bond surrogates" *
BIOCHEMISTRY, vol. 23, no. 4, 14th February 1984, pages 585-588, American Chemical Society; C.G. UNSON et al.: "Active site of C3a anaphylatoxin: contributions of the lipophilic and orienting residues" *
PROC. NATL. ACAD. SCI. USA, vol. 86, no. 1, January 1989, pages 292-296; K.W. MOLLISON et al.: "Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis" *
See also references of WO9009162A3 *

Also Published As

Publication number Publication date
GR900100052A (en) 1991-06-07
JPH04503073A (en) 1992-06-04
CA2045578A1 (en) 1990-08-01
WO1990009162A2 (en) 1990-08-23
WO1990009162A3 (en) 1990-11-29
EP0456758A1 (en) 1991-11-21

Similar Documents

Publication Publication Date Title
DE69030767D1 (en) Defibrillationselektrode
DE4090310D2 (en) Teleskopkrone
DE68927004D1 (en) Multiplex-synchron/asynchron-datenbus
EP0456758A4 (en) Anaphylatoxin-receptor ligands
AU108277S (en) Hedge-shears
DE3991623D2 (en) Frequenzueberwachungsanordnung
CS9005442A2 (en) Symmetrizer
CS490790A3 (en) Chaff-cutter
DE59010417D1 (en) Cyclische polyiminoether
DE4092115D2 (en) Sanitaere mischbatterie
DE4090110D2 (en) Rotationskolbenverbrennungskraftmaschine
DE4091364D2 (en) Thermosaeulen-strahlungsdetektor
DE4091275D2 (en) Steppdecke
BG49771A1 (en) Electric- bow evaparator
DE69027068D1 (en) Spiropyranverbindungen
GB2229183B (en) N-triazinyloxalamides
DE69030237D1 (en) Kalispenderzubereitung
DE4090763D2 (en) Abfallsammler
DE3991687D2 (en) Dufttresor
DE3991686D2 (en) Schmuckblende
DE4091102D2 (en) Spundlochverschluss
DE4090235D2 (en) Hauptabsperrventil
CA64463S (en) Tapeplayer
DE3991146D2 (en) Schraubverschluss
DE69024223D1 (en) Fluidmaschine

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19910715

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19920514

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19930331

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19941212