JP2007509059A - 癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン - Google Patents
癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン Download PDFInfo
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- JP2007509059A JP2007509059A JP2006535368A JP2006535368A JP2007509059A JP 2007509059 A JP2007509059 A JP 2007509059A JP 2006535368 A JP2006535368 A JP 2006535368A JP 2006535368 A JP2006535368 A JP 2006535368A JP 2007509059 A JP2007509059 A JP 2007509059A
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- heteroaryl
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Reverberation, Karaoke And Other Acoustics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51185103P | 2003-10-16 | 2003-10-16 | |
| PCT/US2004/034185 WO2005037285A1 (en) | 2003-10-16 | 2004-10-15 | 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of raf kinase for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509059A true JP2007509059A (ja) | 2007-04-12 |
| JP2007509059A5 JP2007509059A5 (https=) | 2007-09-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006535368A Pending JP2007509059A (ja) | 2003-10-16 | 2004-10-15 | 癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7691866B2 (https=) |
| EP (1) | EP1680122A1 (https=) |
| JP (1) | JP2007509059A (https=) |
| KR (1) | KR20070029110A (https=) |
| CN (1) | CN1882345A (https=) |
| AU (1) | AU2004281154A1 (https=) |
| CA (1) | CA2542329A1 (https=) |
| IL (1) | IL174470A0 (https=) |
| MX (1) | MXPA06003607A (https=) |
| WO (1) | WO2005037285A1 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007518824A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP2010540483A (ja) * | 2007-09-27 | 2010-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ５ａ受容体アンタゴニストとしてのキノリン誘導体 |
| JP2014529612A (ja) * | 2011-08-26 | 2014-11-13 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
| US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| JP2008521900A (ja) | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US20060292537A1 (en) * | 2005-06-27 | 2006-12-28 | Arcturus Media, Inc. | System and method for conducting multimedia karaoke sessions |
| WO2007067444A1 (en) * | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Bicyclic compounds with kinase inhibitory activity |
| US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| DE602007006835D1 (de) * | 2006-07-20 | 2010-07-08 | Amgen Inc | Substituierte pyridonverbindungen und anwendungsverfahren |
| US20100216791A1 (en) * | 2006-08-17 | 2010-08-26 | Astrazeneca | Pyridinylquinazolinamine derivatives and their use as b-raf inhibitors |
| TW200829566A (en) * | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| CA2678725A1 (en) * | 2007-02-20 | 2008-08-28 | The Mobile Star Corp. | Self operated computerized karaoke recording booth |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| BRPI0818003A2 (pt) * | 2007-10-18 | 2019-09-24 | Novartis Ag | inibidores de csf-1r, composições e métodos de uso |
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| JP2007518824A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP4932495B2 (ja) * | 2004-01-23 | 2012-05-16 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP2010540483A (ja) * | 2007-09-27 | 2010-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ５ａ受容体アンタゴニストとしてのキノリン誘導体 |
| JP2014529612A (ja) * | 2011-08-26 | 2014-11-13 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2016216503A (ja) * | 2011-08-26 | 2016-12-22 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2017082011A (ja) * | 2011-09-14 | 2017-05-18 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| US10065932B2 (en) | 2011-09-14 | 2018-09-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
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| US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
Also Published As
| Publication number | Publication date |
|---|---|
| US7691866B2 (en) | 2010-04-06 |
| US20090317359A1 (en) | 2009-12-24 |
| CN1882345A (zh) | 2006-12-20 |
| KR20070029110A (ko) | 2007-03-13 |
| EP1680122A1 (en) | 2006-07-19 |
| MXPA06003607A (es) | 2006-06-05 |
| IL174470A0 (en) | 2006-08-01 |
| CA2542329A1 (en) | 2005-04-28 |
| WO2005037285A1 (en) | 2005-04-28 |
| US20050084835A1 (en) | 2005-04-21 |
| US20050085482A1 (en) | 2005-04-21 |
| AU2004281154A1 (en) | 2005-04-28 |
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