JP2007509059A - 癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン - Google Patents
癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン Download PDFInfo
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- JP2007509059A JP2007509059A JP2006535368A JP2006535368A JP2007509059A JP 2007509059 A JP2007509059 A JP 2007509059A JP 2006535368 A JP2006535368 A JP 2006535368A JP 2006535368 A JP2006535368 A JP 2006535368A JP 2007509059 A JP2007509059 A JP 2007509059A
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- heteroaryl
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Reverberation, Karaoke And Other Acoustics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51185103P | 2003-10-16 | 2003-10-16 | |
| PCT/US2004/034185 WO2005037285A1 (en) | 2003-10-16 | 2004-10-15 | 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of raf kinase for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509059A true JP2007509059A (ja) | 2007-04-12 |
| JP2007509059A5 JP2007509059A5 (OSRAM) | 2007-09-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2006535368A Pending JP2007509059A (ja) | 2003-10-16 | 2004-10-15 | 癌の処置のためのＲａｆキナーゼのインヒビターとしての、２，６−二置換キナゾリン、キノキサリン、キノリンおよびイソキノリン |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7691866B2 (OSRAM) |
| EP (1) | EP1680122A1 (OSRAM) |
| JP (1) | JP2007509059A (OSRAM) |
| KR (1) | KR20070029110A (OSRAM) |
| CN (1) | CN1882345A (OSRAM) |
| AU (1) | AU2004281154A1 (OSRAM) |
| CA (1) | CA2542329A1 (OSRAM) |
| IL (1) | IL174470A0 (OSRAM) |
| MX (1) | MXPA06003607A (OSRAM) |
| WO (1) | WO2005037285A1 (OSRAM) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007518824A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP2010540483A (ja) * | 2007-09-27 | 2010-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ５ａ受容体アンタゴニストとしてのキノリン誘導体 |
| JP2014529612A (ja) * | 2011-08-26 | 2014-11-13 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
| US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Healthcare Llc | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US7351834B1 (en) | 1999-01-13 | 2008-04-01 | Bayer Pharmaceuticals Corporation | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| DE602004007382T2 (de) | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
| DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| US7652009B2 (en) | 2004-11-30 | 2010-01-26 | Amgem Inc. | Substituted heterocycles and methods of use |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US20060292537A1 (en) * | 2005-06-27 | 2006-12-28 | Arcturus Media, Inc. | System and method for conducting multimedia karaoke sessions |
| AU2006322094A1 (en) * | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Bicyclic compounds with kinase inhibitory activity |
| US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| AU2007275682B2 (en) * | 2006-07-20 | 2012-05-17 | Amgen Inc. | Substituted pyridone compounds and methods of use |
| WO2008020203A1 (en) * | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors |
| TW200829566A (en) * | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| US20080198271A1 (en) * | 2007-02-20 | 2008-08-21 | Malki Eli | Self Operated Computerized Karaoke Recording Booth |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US20100261679A1 (en) * | 2007-10-18 | 2010-10-14 | James Sutton | CSF-1R, Inhibitors, Compositions, and Methods of Use |
| EP2226315A4 (en) | 2007-12-28 | 2012-01-25 | Carna Biosciences Inc | 2-aminoquinazoline DERIVATIVE |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| EP2265610B1 (en) * | 2008-02-29 | 2012-12-12 | Array Biopharma, Inc. | Pyrazole [3, 4-b]pyridine raf inhibitors |
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- 2004-10-15 CA CA002542329A patent/CA2542329A1/en not_active Abandoned
- 2004-10-15 MX MXPA06003607A patent/MXPA06003607A/es unknown
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- 2004-10-15 JP JP2006535368A patent/JP2007509059A/ja active Pending
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2006
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2009
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2007518824A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP4932495B2 (ja) * | 2004-01-23 | 2012-05-16 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JP2010540483A (ja) * | 2007-09-27 | 2010-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ５ａ受容体アンタゴニストとしてのキノリン誘導体 |
| JP2014529612A (ja) * | 2011-08-26 | 2014-11-13 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2016216503A (ja) * | 2011-08-26 | 2016-12-22 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| JP2017082011A (ja) * | 2011-09-14 | 2017-05-18 | ニューファーマ， インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
| US10065932B2 (en) | 2011-09-14 | 2018-09-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10759766B2 (en) | 2011-09-14 | 2020-09-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050084835A1 (en) | 2005-04-21 |
| AU2004281154A1 (en) | 2005-04-28 |
| EP1680122A1 (en) | 2006-07-19 |
| WO2005037285A1 (en) | 2005-04-28 |
| CN1882345A (zh) | 2006-12-20 |
| US20050085482A1 (en) | 2005-04-21 |
| MXPA06003607A (es) | 2006-06-05 |
| US20090317359A1 (en) | 2009-12-24 |
| CA2542329A1 (en) | 2005-04-28 |
| KR20070029110A (ko) | 2007-03-13 |
| US7691866B2 (en) | 2010-04-06 |
| IL174470A0 (en) | 2006-08-01 |
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