JP2007508336A - モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 - Google Patents
モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 Download PDFInfo
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- JP2007508336A JP2007508336A JP2006534638A JP2006534638A JP2007508336A JP 2007508336 A JP2007508336 A JP 2007508336A JP 2006534638 A JP2006534638 A JP 2006534638A JP 2006534638 A JP2006534638 A JP 2006534638A JP 2007508336 A JP2007508336 A JP 2007508336A
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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| PCT/EP2004/011093 WO2005039580A1 (en) | 2003-10-16 | 2004-10-05 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
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| US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| WO2005039580A1 (en) * | 2003-10-16 | 2005-05-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| BRPI0416691A (pt) * | 2003-11-18 | 2007-01-30 | Boehringer Ingelheim Int | forma de preparação farmacêutica sólida |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
| WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5237112B2 (ja) * | 2006-12-01 | 2013-07-17 | 日東電工株式会社 | 経皮吸収製剤 |
| KR101408488B1 (ko) * | 2006-12-01 | 2014-06-17 | 닛토덴코 가부시키가이샤 | 도네페질 함유 접착 제제의 경시적인 변색을 억제하는 방법 |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| RU2483729C2 (ru) * | 2008-05-30 | 2013-06-10 | Нитто Денко Корпорейшн | Чрескожно абсорбируемый препарат |
| EP2279739B2 (en) * | 2008-05-30 | 2018-02-28 | Nitto Denko Corporation | Donepezil-containing patch preparation and packaging thereof |
| PL2475428T3 (pl) | 2009-09-11 | 2015-12-31 | Probiodrug Ag | Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej |
| EP2533645B1 (en) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| KR20150118092A (ko) * | 2012-11-30 | 2015-10-21 | 피2디 인코퍼레이티드 | 치매 치료를 위한 치환된 벤즈트로핀 유사체들 |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| MX2021004737A (es) * | 2018-10-24 | 2021-06-04 | Saniona As | Composiciones de tropano transdermicas y metodos para usar las mismas. |
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| EP0604354A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| EP0604355A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Akyl Substituted heterocyclic compounds |
| EP0604352A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| US5444070A (en) * | 1992-12-23 | 1995-08-22 | Neurosearch A/S | Phenyl substituted heterocyclic compounds |
| WO1995028401A1 (en) * | 1994-04-19 | 1995-10-26 | Neurosearch A/S | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
| WO1997030997A1 (en) * | 1996-02-22 | 1997-08-28 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| WO2000002549A2 (en) * | 1998-07-10 | 2000-01-20 | Du Pont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
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| US554626A (en) * | 1896-02-11 | murphy | ||
| US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| US20030008791A1 (en) * | 2001-06-06 | 2003-01-09 | Lonza Inc. | Non-alcoholic hand sanitizer |
| DE10148233A1 (de) * | 2001-09-28 | 2003-04-10 | Boehringer Ingelheim Pharma | Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme |
| JP2006517567A (ja) * | 2003-02-12 | 2006-07-27 | ニューロサーチ、アクティーゼルスカブ | 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 |
| WO2005039580A1 (en) * | 2003-10-16 | 2005-05-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
-
2004
- 2004-10-05 WO PCT/EP2004/011093 patent/WO2005039580A1/en not_active Ceased
- 2004-10-05 NZ NZ547152A patent/NZ547152A/en not_active IP Right Cessation
- 2004-10-05 AT AT04790120T patent/ATE519486T1/de active
- 2004-10-05 EP EP10180538A patent/EP2269608A3/en not_active Withdrawn
- 2004-10-05 CA CA2542442A patent/CA2542442C/en not_active Expired - Fee Related
- 2004-10-05 JP JP2006534638A patent/JP2007508336A/ja active Pending
- 2004-10-05 EP EP04790120A patent/EP1675591B1/en not_active Expired - Lifetime
- 2004-10-05 DK DK04790120.2T patent/DK1675591T3/da active
- 2004-10-05 AU AU2004283425A patent/AU2004283425B2/en not_active Ceased
- 2004-10-05 MX MXPA06003762A patent/MXPA06003762A/es active IP Right Grant
- 2004-10-15 US US10/965,994 patent/US20050154009A1/en not_active Abandoned
-
2010
- 2010-04-27 US US12/768,240 patent/US20100210626A1/en not_active Abandoned
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| EP0604354A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| EP0604355A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Akyl Substituted heterocyclic compounds |
| EP0604352A2 (en) * | 1992-12-23 | 1994-06-29 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| US5444070A (en) * | 1992-12-23 | 1995-08-22 | Neurosearch A/S | Phenyl substituted heterocyclic compounds |
| WO1995028401A1 (en) * | 1994-04-19 | 1995-10-26 | Neurosearch A/S | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
| WO1997030997A1 (en) * | 1996-02-22 | 1997-08-28 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| WO2000002549A2 (en) * | 1998-07-10 | 2000-01-20 | Du Pont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| DK1675591T3 (da) | 2011-11-14 |
| ATE519486T1 (de) | 2011-08-15 |
| CA2542442C (en) | 2012-08-21 |
| EP1675591B1 (en) | 2011-08-10 |
| WO2005039580A1 (en) | 2005-05-06 |
| MXPA06003762A (es) | 2006-06-14 |
| EP1675591A1 (en) | 2006-07-05 |
| AU2004283425A1 (en) | 2005-05-06 |
| NZ547152A (en) | 2009-12-24 |
| EP2269608A2 (en) | 2011-01-05 |
| EP2269608A3 (en) | 2011-02-16 |
| US20050154009A1 (en) | 2005-07-14 |
| AU2004283425B2 (en) | 2010-07-08 |
| CA2542442A1 (en) | 2005-05-06 |
| US20100210626A1 (en) | 2010-08-19 |
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