CA2542442C - Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor - Google Patents
Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor Download PDFInfo
- Publication number
- CA2542442C CA2542442C CA2542442A CA2542442A CA2542442C CA 2542442 C CA2542442 C CA 2542442C CA 2542442 A CA2542442 A CA 2542442A CA 2542442 A CA2542442 A CA 2542442A CA 2542442 C CA2542442 C CA 2542442C
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- Canada
- Prior art keywords
- dementia
- pharmaceutically acceptable
- tropane
- solvate
- pseudodementia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
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- Biomedical Technology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| EP03023635.0 | 2003-10-16 | ||
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| EP04005819 | 2004-03-11 | ||
| EP04005819.0 | 2004-03-11 | ||
| PCT/EP2004/011093 WO2005039580A1 (en) | 2003-10-16 | 2004-10-05 | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
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| CA2542442A1 CA2542442A1 (en) | 2005-05-06 |
| CA2542442C true CA2542442C (en) | 2012-08-21 |
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| US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| JP2007508336A (ja) * | 2003-10-16 | 2007-04-05 | ニューロサーチ、アクティーゼルスカブ | モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 |
| BRPI0416691A (pt) * | 2003-11-18 | 2007-01-30 | Boehringer Ingelheim Int | forma de preparação farmacêutica sólida |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
| WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| DK2091948T3 (da) | 2006-11-30 | 2012-07-23 | Probiodrug Ag | Nye inhibitorer af glutaminylcyclase |
| EP2098235B1 (en) * | 2006-12-01 | 2013-08-21 | Nitto Denko Corporation | Method for prevention of discoloration with time of donepezil-containing skin adhesive preparation |
| RU2435570C2 (ru) * | 2006-12-01 | 2011-12-10 | Нитто Денко Корпорейшн | Композиция для чрескожного всасывания |
| EA200901140A1 (ru) | 2007-03-01 | 2010-04-30 | Пробиодруг Аг | Новое применение ингибиторов глутаминилциклазы |
| DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
| WO2009145269A1 (ja) * | 2008-05-30 | 2009-12-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 経皮吸収製剤 |
| US20110056863A1 (en) * | 2008-05-30 | 2011-03-10 | Junichi Sekiya | Adhesive preparation containing donepezil, and package of the same |
| KR101755737B1 (ko) | 2009-09-11 | 2017-07-07 | 프로비오드룩 아게 | 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 |
| CN109662964A (zh) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| EP2925309A1 (en) * | 2012-11-30 | 2015-10-07 | P2D, Inc. | Substituted benztropine analogs for treatment of dementia |
| US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| WO2020084065A1 (en) * | 2018-10-24 | 2020-04-30 | Saniona A/S | Transdermal tropane compositions and methods for using the same |
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| US554626A (en) * | 1896-02-11 | murphy | ||
| AU671163B2 (en) | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| AU672644B2 (en) | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| AU672052B2 (en) | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| JP2899418B2 (ja) * | 1994-04-19 | 1999-06-02 | ノイロサーチ アクティーゼルスカブ | トロパン誘導体、それらの製造及び用途 |
| PT885220E (pt) * | 1996-02-22 | 2001-11-30 | Neurosearch As | Derivados de tropano a sua preparacao e utilizacao |
| US6262081B1 (en) * | 1998-07-10 | 2001-07-17 | Dupont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
| AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20030008791A1 (en) * | 2001-06-06 | 2003-01-09 | Lonza Inc. | Non-alcoholic hand sanitizer |
| DE10148233A1 (de) * | 2001-09-28 | 2003-04-10 | Boehringer Ingelheim Pharma | Verbindungen zur Reduzierung übermäßiger Nahrungsaufnahme |
| US7250425B2 (en) * | 2003-02-12 | 2007-07-31 | Neurosearch A/S | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2007508336A (ja) * | 2003-10-16 | 2007-04-05 | ニューロサーチ、アクティーゼルスカブ | モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
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2004
- 2004-10-05 JP JP2006534638A patent/JP2007508336A/ja active Pending
- 2004-10-05 DK DK04790120.2T patent/DK1675591T3/da active
- 2004-10-05 WO PCT/EP2004/011093 patent/WO2005039580A1/en not_active Ceased
- 2004-10-05 AT AT04790120T patent/ATE519486T1/de active
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- 2004-10-05 AU AU2004283425A patent/AU2004283425B2/en not_active Ceased
- 2004-10-05 NZ NZ547152A patent/NZ547152A/en not_active IP Right Cessation
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- 2004-10-05 CA CA2542442A patent/CA2542442C/en not_active Expired - Fee Related
- 2004-10-05 MX MXPA06003762A patent/MXPA06003762A/es active IP Right Grant
- 2004-10-15 US US10/965,994 patent/US20050154009A1/en not_active Abandoned
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2010
- 2010-04-27 US US12/768,240 patent/US20100210626A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2542442A1 (en) | 2005-05-06 |
| NZ547152A (en) | 2009-12-24 |
| US20050154009A1 (en) | 2005-07-14 |
| EP2269608A3 (en) | 2011-02-16 |
| DK1675591T3 (da) | 2011-11-14 |
| EP1675591A1 (en) | 2006-07-05 |
| AU2004283425A1 (en) | 2005-05-06 |
| AU2004283425B2 (en) | 2010-07-08 |
| WO2005039580A1 (en) | 2005-05-06 |
| EP2269608A2 (en) | 2011-01-05 |
| ATE519486T1 (de) | 2011-08-15 |
| MXPA06003762A (es) | 2006-06-14 |
| EP1675591B1 (en) | 2011-08-10 |
| JP2007508336A (ja) | 2007-04-05 |
| US20100210626A1 (en) | 2010-08-19 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20141006 |