JP2007508282A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007508282A5 JP2007508282A5 JP2006530567A JP2006530567A JP2007508282A5 JP 2007508282 A5 JP2007508282 A5 JP 2007508282A5 JP 2006530567 A JP2006530567 A JP 2006530567A JP 2006530567 A JP2006530567 A JP 2006530567A JP 2007508282 A5 JP2007508282 A5 JP 2007508282A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- phenothiazine
- independently
- compound
- polycyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 49
- -1 phenothiazine compound Chemical class 0.000 claims 25
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 19
- 125000003367 polycyclic group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 15
- 229950000688 phenothiazine Drugs 0.000 claims 12
- 125000002091 cationic group Chemical group 0.000 claims 11
- 125000006413 ring segment Chemical group 0.000 claims 11
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 238000000746 purification Methods 0.000 claims 5
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims 4
- 208000034799 Tauopathies Diseases 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 4
- 239000007900 aqueous suspension Substances 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000002990 phenothiazines Chemical class 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 201000000849 skin cancer Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- 239000003341 Bronsted base Substances 0.000 claims 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 2
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 2
- OIRDBPQYVWXNSJ-BJUDXGSMSA-N methyl trifluoromethanesulfonate Chemical compound [11CH3]OS(=O)(=O)C(F)(F)F OIRDBPQYVWXNSJ-BJUDXGSMSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 125000001302 tertiary amino group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 229910052786 argon Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000005341 cation exchange Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- OIRDBPQYVWXNSJ-UHFFFAOYSA-N methyl trifluoromethansulfonate Chemical compound COS(=O)(=O)C(F)(F)F OIRDBPQYVWXNSJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000907 methylthioninium chloride Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000000163 radioactive labelling Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0322756.8A GB0322756D0 (en) | 2003-09-29 | 2003-09-29 | Methods of chemical synthesis |
| PCT/GB2004/004153 WO2005030676A1 (en) | 2003-09-29 | 2004-09-27 | Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508282A JP2007508282A (ja) | 2007-04-05 |
| JP2007508282A5 true JP2007508282A5 (https=) | 2007-11-08 |
Family
ID=29287034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530567A Pending JP2007508282A (ja) | 2003-09-29 | 2004-09-27 | フェノチアジン及びフェノチアジン類似化合物の［１１ｃ］−放射標識方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060275209A1 (https=) |
| EP (1) | EP1667947B1 (https=) |
| JP (1) | JP2007508282A (https=) |
| CN (2) | CN101172162A (https=) |
| AT (1) | ATE405533T1 (https=) |
| AU (1) | AU2004276071B2 (https=) |
| CA (1) | CA2540827A1 (https=) |
| DE (1) | DE602004016010D1 (https=) |
| ES (1) | ES2313063T3 (https=) |
| GB (1) | GB0322756D0 (https=) |
| PL (1) | PL1667947T3 (https=) |
| SI (1) | SI1667947T1 (https=) |
| WO (1) | WO2005030676A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0106953D0 (en) | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| CN101084204B (zh) | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| MY162640A (en) | 2006-03-29 | 2017-06-30 | Wista Lab Ltd | Thioninium compounds and their use |
| PL2004155T3 (pl) | 2006-03-29 | 2018-08-31 | Wista Laboratories Ltd. | Inhibitory agregacji białek |
| EP2013191B3 (en) | 2006-03-29 | 2019-02-27 | Wista Laboratories Ltd. | 3,7-diamino-10h-phenothiazine salts and their use |
| DK3121169T3 (da) | 2006-07-11 | 2022-02-28 | Wista Lab Ltd | Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser |
| CA3027974C (en) | 2007-10-03 | 2022-03-15 | Wista Laboratories Ltd. | Therapeutic use of diaminophenothiazines |
| DK3378856T3 (da) | 2009-09-24 | 2020-12-21 | Wista Lab Ltd | Krystallinske methylthioniniumchlorid-hydrater |
| US9192611B2 (en) | 2010-11-30 | 2015-11-24 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
| EA025033B1 (ru) | 2011-02-11 | 2016-11-30 | Уиста Лэборэтэриз Лтд. | Диаминиевые соли фенотиазина и их применение |
| US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
| US11001562B2 (en) | 2013-10-31 | 2021-05-11 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| US11077210B2 (en) * | 2013-10-31 | 2021-08-03 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof |
| GB201512678D0 (en) | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN109796465B (zh) * | 2017-11-16 | 2020-07-14 | 华中科技大学同济医学院附属协和医院 | 靶向pet显像化合物、包含该化合物的显象剂及其制备方法和用途 |
| US20210011008A1 (en) * | 2019-07-09 | 2021-01-14 | Vanderbilt University | Amyloid-binding compounds and methods of use thereof |
| CN115304633B (zh) * | 2022-07-20 | 2023-12-26 | 山西大学 | 一种无重原子光动力光敏剂及其制备方法和应用 |
| US12440585B2 (en) | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000344685A (ja) * | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
| JP4275819B2 (ja) * | 1999-09-17 | 2009-06-10 | 飯田 秀博 | デメチルラクロプライドの非求核性酸塩およびこれを用いる［ｃ−１１］ラクロプライドの製造法 |
| GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0113121D0 (en) * | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
-
2003
- 2003-09-29 GB GBGB0322756.8A patent/GB0322756D0/en not_active Ceased
-
2004
- 2004-09-27 DE DE602004016010T patent/DE602004016010D1/de not_active Expired - Lifetime
- 2004-09-27 US US10/573,882 patent/US20060275209A1/en not_active Abandoned
- 2004-09-27 CN CNA2007101666344A patent/CN101172162A/zh active Pending
- 2004-09-27 AT AT04768696T patent/ATE405533T1/de not_active IP Right Cessation
- 2004-09-27 WO PCT/GB2004/004153 patent/WO2005030676A1/en not_active Ceased
- 2004-09-27 CA CA002540827A patent/CA2540827A1/en not_active Abandoned
- 2004-09-27 CN CN2004800350118A patent/CN1886353B/zh not_active Expired - Fee Related
- 2004-09-27 SI SI200430921T patent/SI1667947T1/sl unknown
- 2004-09-27 JP JP2006530567A patent/JP2007508282A/ja active Pending
- 2004-09-27 EP EP04768696A patent/EP1667947B1/en not_active Expired - Lifetime
- 2004-09-27 ES ES04768696T patent/ES2313063T3/es not_active Expired - Lifetime
- 2004-09-27 AU AU2004276071A patent/AU2004276071B2/en not_active Ceased
- 2004-09-27 PL PL04768696T patent/PL1667947T3/pl unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007508282A5 (https=) | ||
| Mukherjee et al. | Organoselenium chemistry: role of intramolecular interactions | |
| JP5934404B2 (ja) | ジアミノフェノチアジニウム化合物の調製方法 | |
| JP5229441B2 (ja) | 光学活性チタンサラレン化合物の製造方法 | |
| CN112574196A (zh) | 调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成 | |
| WO2015161781A1 (zh) | 一种核苷类似物及其中间体的制备方法 | |
| WO2005033064A1 (en) | Process of preparing o-carbamoyl compounds in the presence of active amine group | |
| TWI359135B (en) | Organic compounds | |
| Popkov et al. | Chiral nucleophilic glycine and alanine synthons: nickel (II) complexes of Schiff bases of (S)-N-(2, 4, 6-trimethylbenzyl) proline (2-benzoylphenyl) amide and glycine or alanine | |
| JP2007508330A (ja) | 随伴不純物が低含有量であるオキサリプラチンおよびその調製方法 | |
| AU728147B2 (en) | Method for the preparation of alpha-bromo-lactam derivatives | |
| JP2005536487A5 (https=) | ||
| CN111440102B (zh) | 一种二硫代二苯甲酰胺类化合物的制备方法 | |
| JP5569938B2 (ja) | ピロリジン誘導体及びその製造方法 | |
| JP5208939B2 (ja) | ２，２’，６，６’−四置換アミノホスフィン配位子及びその合成方法 | |
| EA002285B1 (ru) | Способ удаления тяжелых металлов из органических соединений | |
| JP2004292422A (ja) | 光学活性なアジリジン化合物及びアミン化合物の製造方法 | |
| Carretero et al. | Stereochemistry of the reactions of β-halothioethers with NaCN and AgCN | |
| RU2004124844A (ru) | Прукалоприд-n-оксид | |
| Christoffers | An Unusual Acyliminium Cyclization and Other Drawbacks during an Attempted Synthesis of a Chiral Primary α‐Phosphinoalkanamine | |
| JP4120239B2 (ja) | ９，１０−ジブロモアントラセン類の製造方法 | |
| JP5263732B2 (ja) | 光学活性１，２−ジアミン化合物の製造方法及び光学活性触媒 | |
| JP4505332B2 (ja) | 放射性遷移金属イミドヘテロ−ジホスフィン錯体、その調製およびその放射性医薬組成物 | |
| Plutecka et al. | Solid solution of two diastereomers of [3a (R, S), 7a (R, S)]-3-[(1′ R)-1-phenylethyl] perhydro-1, 3-benzothiazol-2-iminium chloride | |
| ES2846174T3 (es) | Procedimiento de producción de (S)-metacloro |