CA2540827A1 - Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds - Google Patents

Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds Download PDF

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Publication number
CA2540827A1
CA2540827A1 CA002540827A CA2540827A CA2540827A1 CA 2540827 A1 CA2540827 A1 CA 2540827A1 CA 002540827 A CA002540827 A CA 002540827A CA 2540827 A CA2540827 A CA 2540827A CA 2540827 A1 CA2540827 A1 CA 2540827A1
Authority
CA
Canada
Prior art keywords
phenothiazine
compound
ring
methyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002540827A
Other languages
English (en)
French (fr)
Inventor
Lutz F. Schweiger
Stuart A. Craib
Andrew E. Welch
Peter F. Sharp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Aberdeen
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2540827A1 publication Critical patent/CA2540827A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Catalysts (AREA)
CA002540827A 2003-09-29 2004-09-27 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds Abandoned CA2540827A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0322756.8A GB0322756D0 (en) 2003-09-29 2003-09-29 Methods of chemical synthesis
GB0322756.8 2003-09-29
PCT/GB2004/004153 WO2005030676A1 (en) 2003-09-29 2004-09-27 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds

Publications (1)

Publication Number Publication Date
CA2540827A1 true CA2540827A1 (en) 2005-04-07

Family

ID=29287034

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002540827A Abandoned CA2540827A1 (en) 2003-09-29 2004-09-27 Methods of [11c]-radiolabelling phenothiazine and phenothiazine-like compounds

Country Status (13)

Country Link
US (1) US20060275209A1 (https=)
EP (1) EP1667947B1 (https=)
JP (1) JP2007508282A (https=)
CN (2) CN101172162A (https=)
AT (1) ATE405533T1 (https=)
AU (1) AU2004276071B2 (https=)
CA (1) CA2540827A1 (https=)
DE (1) DE602004016010D1 (https=)
ES (1) ES2313063T3 (https=)
GB (1) GB0322756D0 (https=)
PL (1) PL1667947T3 (https=)
SI (1) SI1667947T1 (https=)
WO (1) WO2005030676A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0117326D0 (en) 2001-07-16 2001-09-05 Univ Aberdeen Napthoquinone-type inhibitors of protein aggregation
CN101084204B (zh) 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
MY162640A (en) 2006-03-29 2017-06-30 Wista Lab Ltd Thioninium compounds and their use
PL2004155T3 (pl) 2006-03-29 2018-08-31 Wista Laboratories Ltd. Inhibitory agregacji białek
EP2013191B3 (en) 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
DK3121169T3 (da) 2006-07-11 2022-02-28 Wista Lab Ltd Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
CA3027974C (en) 2007-10-03 2022-03-15 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines
DK3378856T3 (da) 2009-09-24 2020-12-21 Wista Lab Ltd Krystallinske methylthioniniumchlorid-hydrater
US9192611B2 (en) 2010-11-30 2015-11-24 Wista Laboratories Ltd. Formulations comprising methylthioninium chloride
EA025033B1 (ru) 2011-02-11 2016-11-30 Уиста Лэборэтэриз Лтд. Диаминиевые соли фенотиазина и их применение
US20130315825A1 (en) * 2012-05-03 2013-11-28 Washington University Tricyclic heteroaromatic compounds as alpha-synuclein ligands
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
US11077210B2 (en) * 2013-10-31 2021-08-03 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
GB201512678D0 (en) 2015-07-20 2015-08-26 Wista Lab Ltd Methods of chemical synthesis
CN109796465B (zh) * 2017-11-16 2020-07-14 华中科技大学同济医学院附属协和医院 靶向pet显像化合物、包含该化合物的显象剂及其制备方法和用途
US20210011008A1 (en) * 2019-07-09 2021-01-14 Vanderbilt University Amyloid-binding compounds and methods of use thereof
CN115304633B (zh) * 2022-07-20 2023-12-26 山西大学 一种无重原子光动力光敏剂及其制备方法和应用
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000344685A (ja) * 1999-03-26 2000-12-12 Bf Kenkyusho:Kk アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
JP4275819B2 (ja) * 1999-09-17 2009-06-10 飯田 秀博 デメチルラクロプライドの非求核性酸塩およびこれを用いる［ｃ−１１］ラクロプライドの製造法
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0113121D0 (en) * 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers

Also Published As

Publication number Publication date
SI1667947T1 (sl) 2009-02-28
DE602004016010D1 (de) 2008-10-02
EP1667947A1 (en) 2006-06-14
CN101172162A (zh) 2008-05-07
AU2004276071A1 (en) 2005-04-07
AU2004276071B2 (en) 2011-02-03
CN1886353B (zh) 2010-06-02
ATE405533T1 (de) 2008-09-15
PL1667947T3 (pl) 2009-01-30
ES2313063T3 (es) 2009-03-01
GB0322756D0 (en) 2003-10-29
HK1087394A1 (en) 2006-10-13
EP1667947B1 (en) 2008-08-20
JP2007508282A (ja) 2007-04-05
WO2005030676A1 (en) 2005-04-07
CN1886353A (zh) 2006-12-27
US20060275209A1 (en) 2006-12-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued