ATE405533T1 - Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen - Google Patents
Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungenInfo
- Publication number
- ATE405533T1 ATE405533T1 AT04768696T AT04768696T ATE405533T1 AT E405533 T1 ATE405533 T1 AT E405533T1 AT 04768696 T AT04768696 T AT 04768696T AT 04768696 T AT04768696 T AT 04768696T AT E405533 T1 ATE405533 T1 AT E405533T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- group
- phenothiazine
- radiolabelling
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000000163 radioactive labelling Methods 0.000 title abstract 4
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 4
- 125000002091 cationic group Chemical group 0.000 abstract 2
- OIRDBPQYVWXNSJ-UHFFFAOYSA-N methyl trifluoromethansulfonate Chemical compound COS(=O)(=O)C(F)(F)F OIRDBPQYVWXNSJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000002600 positron emission tomography Methods 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 abstract 1
- 208000034799 Tauopathies Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229950000688 phenothiazine Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0322756.8A GB0322756D0 (en) | 2003-09-29 | 2003-09-29 | Methods of chemical synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405533T1 true ATE405533T1 (de) | 2008-09-15 |
Family
ID=29287034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04768696T ATE405533T1 (de) | 2003-09-29 | 2004-09-27 | Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060275209A1 (https=) |
| EP (1) | EP1667947B1 (https=) |
| JP (1) | JP2007508282A (https=) |
| CN (2) | CN1886353B (https=) |
| AT (1) | ATE405533T1 (https=) |
| AU (1) | AU2004276071B2 (https=) |
| CA (1) | CA2540827A1 (https=) |
| DE (1) | DE602004016010D1 (https=) |
| ES (1) | ES2313063T3 (https=) |
| GB (1) | GB0322756D0 (https=) |
| PL (1) | PL1667947T3 (https=) |
| SI (1) | SI1667947T1 (https=) |
| WO (1) | WO2005030676A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0100119D0 (en) | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0106953D0 (en) | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0117326D0 (en) | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| CN101084204B (zh) | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| ES2349322T7 (es) | 2006-03-29 | 2019-10-17 | Wista Lab Ltd | Sales de 3,7-diamino-10H-fenotiazina y su utilización |
| SI2004155T1 (en) | 2006-03-29 | 2018-05-31 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
| WO2007110630A1 (en) | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd. | Thioninium compounds and their use |
| MY148145A (en) | 2006-07-11 | 2013-03-15 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| CA2701075C (en) | 2007-10-03 | 2019-02-12 | Wista Laboratories Ltd. | Therapeutic use of diaminophenothiazines. |
| MX355627B (es) | 2009-09-24 | 2018-04-25 | Wista Lab Ltd | Clorhidratos de metiltioninio (azul de metileno) cristalinos. |
| JP6093707B2 (ja) | 2010-11-30 | 2017-03-08 | ウィスタ ラボラトリーズ リミテッド | 化合物製剤 |
| JP5898701B2 (ja) | 2011-02-11 | 2016-04-13 | ウィスタ ラボラトリーズ リミテッド | フェノチアジンジアミニウム塩およびそれらの使用 |
| US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
| US11001562B2 (en) | 2013-10-31 | 2021-05-11 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| JP7023604B2 (ja) | 2013-10-31 | 2022-02-22 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 近赤外蛍光造影バイオイメージング剤及びその使用方法 |
| GB201512678D0 (en) | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN109796465B (zh) * | 2017-11-16 | 2020-07-14 | 华中科技大学同济医学院附属协和医院 | 靶向pet显像化合物、包含该化合物的显象剂及其制备方法和用途 |
| US20210011008A1 (en) * | 2019-07-09 | 2021-01-14 | Vanderbilt University | Amyloid-binding compounds and methods of use thereof |
| CN115304633B (zh) * | 2022-07-20 | 2023-12-26 | 山西大学 | 一种无重原子光动力光敏剂及其制备方法和应用 |
| US12440585B2 (en) | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000344685A (ja) * | 1999-03-26 | 2000-12-12 | Bf Kenkyusho:Kk | アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物 |
| JP4275819B2 (ja) * | 1999-09-17 | 2009-06-10 | 飯田 秀博 | デメチルラクロプライドの非求核性酸塩およびこれを用いる［ｃ−１１］ラクロプライドの製造法 |
| GB0106953D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| GB0113121D0 (en) * | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
-
2003
- 2003-09-29 GB GBGB0322756.8A patent/GB0322756D0/en not_active Ceased
-
2004
- 2004-09-27 EP EP04768696A patent/EP1667947B1/en not_active Expired - Lifetime
- 2004-09-27 ES ES04768696T patent/ES2313063T3/es not_active Expired - Lifetime
- 2004-09-27 CN CN2004800350118A patent/CN1886353B/zh not_active Expired - Fee Related
- 2004-09-27 JP JP2006530567A patent/JP2007508282A/ja active Pending
- 2004-09-27 CA CA002540827A patent/CA2540827A1/en not_active Abandoned
- 2004-09-27 SI SI200430921T patent/SI1667947T1/sl unknown
- 2004-09-27 CN CNA2007101666344A patent/CN101172162A/zh active Pending
- 2004-09-27 AT AT04768696T patent/ATE405533T1/de not_active IP Right Cessation
- 2004-09-27 PL PL04768696T patent/PL1667947T3/pl unknown
- 2004-09-27 DE DE602004016010T patent/DE602004016010D1/de not_active Expired - Lifetime
- 2004-09-27 WO PCT/GB2004/004153 patent/WO2005030676A1/en not_active Ceased
- 2004-09-27 AU AU2004276071A patent/AU2004276071B2/en not_active Ceased
- 2004-09-27 US US10/573,882 patent/US20060275209A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1667947B1 (en) | 2008-08-20 |
| EP1667947A1 (en) | 2006-06-14 |
| SI1667947T1 (sl) | 2009-02-28 |
| AU2004276071B2 (en) | 2011-02-03 |
| AU2004276071A1 (en) | 2005-04-07 |
| CN1886353A (zh) | 2006-12-27 |
| PL1667947T3 (pl) | 2009-01-30 |
| HK1087394A1 (en) | 2006-10-13 |
| CN1886353B (zh) | 2010-06-02 |
| WO2005030676A1 (en) | 2005-04-07 |
| ES2313063T3 (es) | 2009-03-01 |
| CN101172162A (zh) | 2008-05-07 |
| DE602004016010D1 (de) | 2008-10-02 |
| JP2007508282A (ja) | 2007-04-05 |
| CA2540827A1 (en) | 2005-04-07 |
| US20060275209A1 (en) | 2006-12-07 |
| GB0322756D0 (en) | 2003-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE405533T1 (de) | Verfahren zur ä11cü-radiomarkierung von phenthiazin und phenothiazinartige verbindungen | |
| PT907379E (pt) | Agentes de contraste bioactivados para imagiologia de diagnostico | |
| EA200300845A1 (ru) | Модифицированные антитела и способы применения | |
| EA200300507A1 (ru) | Радиофармацевтические агенты для диагностики болезни альцгеймера | |
| CY1106784T1 (el) | Υποκατεστημενα παραγωγα φαινυλ προπιονικου οξεος ως συναγωνιστες του ανθρωπινου υπεροξυσωματικου πολλαπλασιαστη - ενεργοποιημενου υποδοχεα αλφα (ppar) | |
| WO2002016333A3 (en) | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease | |
| ATE478062T1 (de) | Zusammensetzungen und verfahren zur in vivo abbildung von loeslichen beta-amyloid | |
| DK2157192T3 (da) | Sammensætninger til diagnose og terapi af sygdomme forbundet med afvigende ekspression af futriner (R-spondiner) | |
| WO2001038303A3 (fr) | Analogues de la vitamine d | |
| BR0311189A (pt) | Composições farmacêuticas contendo polimorfo a de flibanserin | |
| DE602005023782D1 (de) | Pyrrolidinderivate zur behandlung einer von der reninaktivität abhängigen krankheit | |
| EP1706145A4 (en) | AUTOANTIC BODY USED IN TUMOR IMAGING AND CANCER TREATMENT AS A CARRIER FOR PHARMACEUTICAL COMPOUNDS | |
| AU5314694A (en) | New agents for diagnosis of vascular diseases | |
| WO2004064869A3 (en) | Amyloid-binding, metal-chelating agents | |
| DE60207612D1 (de) | Verbindungen zur bilddarstellung der alzheimer-krankenheit | |
| MX2007011009A (es) | Compuestos de piperidina 3,4,5-substituidos. | |
| BR0011728A (pt) | Método de inibir a agregação de proteìna amilóide e imagem de depósitos de amilóide | |
| WO2010051196A8 (en) | Novel substituted azabenzoxazoles | |
| NZ591824A (en) | Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system | |
| WO2002046767A3 (en) | Diagnosis and treatment of alzheimer's disease | |
| US20120107240A1 (en) | Probes and methods of melanoma imaging | |
| DE60005952T8 (de) | Lösliche hla-g enthaltende zusammensetzungen zur behandlung entzündlicher hautkrankheiten | |
| BR0009573A (pt) | Composições e métodos para o tratamento e diagnose do câncer de mama | |
| ATE399758T1 (de) | Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten | |
| PL336897A1 (en) | Novel salts of bpc peptides, pharmaceutic compositions conatining them and method of obtaining such salts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |