JP2007507443A - ピリミジン−２−アミン誘導体およびａ２ｂアデノシン受容体アンタゴニストとしてのその使用 - Google Patents
ピリミジン−２−アミン誘導体およびａ２ｂアデノシン受容体アンタゴニストとしてのその使用 Download PDFInfo
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- JP2007507443A JP2007507443A JP2006530007A JP2006530007A JP2007507443A JP 2007507443 A JP2007507443 A JP 2007507443A JP 2006530007 A JP2006530007 A JP 2006530007A JP 2006530007 A JP2006530007 A JP 2006530007A JP 2007507443 A JP2007507443 A JP 2007507443A
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- 125000000217 alkyl group Chemical group 0.000 claims description 52
- 125000001424 substituent group Chemical group 0.000 claims description 39
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- 150000003839 salts Chemical class 0.000 claims description 23
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- IJJCFHWRLSIXBR-UHFFFAOYSA-N 4-(3-fluorophenyl)-n-pyridin-3-yl-5-pyrimidin-4-ylpyrimidin-2-amine Chemical compound FC1=CC=CC(C=2C(=CN=C(NC=3C=NC=CC=3)N=2)C=2N=CN=CC=2)=C1 IJJCFHWRLSIXBR-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302275A ES2229928B1 (es) | 2003-10-02 | 2003-10-02 | Nuevos derivados de pirimidin-2-amina. |
| PCT/EP2004/010644 WO2005040155A1 (en) | 2003-10-02 | 2004-09-22 | Pyrimidin-2-amine derivates and their use as a2b adenosine receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007507443A true JP2007507443A (ja) | 2007-03-29 |
| JP2007507443A5 JP2007507443A5 (enExample) | 2007-10-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2006530007A Pending JP2007507443A (ja) | 2003-10-02 | 2004-09-22 | ピリミジン−２−アミン誘導体およびａ２ｂアデノシン受容体アンタゴニストとしてのその使用 |
Country Status (24)
| Country | Link |
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| US (1) | US20070265273A1 (enExample) |
| EP (1) | EP1668000A1 (enExample) |
| JP (1) | JP2007507443A (enExample) |
| KR (1) | KR20060097010A (enExample) |
| CN (1) | CN1886402A (enExample) |
| AR (1) | AR046170A1 (enExample) |
| AU (1) | AU2004283800B8 (enExample) |
| BR (1) | BRPI0415324A (enExample) |
| CA (1) | CA2540765A1 (enExample) |
| CO (1) | CO5690593A2 (enExample) |
| EC (1) | ECSP066426A (enExample) |
| ES (1) | ES2229928B1 (enExample) |
| IL (1) | IL174771A0 (enExample) |
| MX (1) | MXPA06003525A (enExample) |
| NO (1) | NO20061952L (enExample) |
| NZ (1) | NZ546266A (enExample) |
| PE (1) | PE20050473A1 (enExample) |
| RU (1) | RU2006114746A (enExample) |
| SG (1) | SG149077A1 (enExample) |
| TW (1) | TW200526645A (enExample) |
| UA (1) | UA82563C2 (enExample) |
| UY (1) | UY28529A1 (enExample) |
| WO (1) | WO2005040155A1 (enExample) |
| ZA (1) | ZA200602139B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010534634A (ja) * | 2007-07-26 | 2010-11-11 | ノバルティス アーゲー | 炎症性またはアレルギー性状態の処置に有用なピリミジン誘導体 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2311462A1 (en) | 2004-10-15 | 2011-04-20 | Cv Therapeutics, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2274712B1 (es) * | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| DE102006046410A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten |
| ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| CN101679376A (zh) * | 2007-06-08 | 2010-03-24 | 拜尔农科股份有限公司 | 杀真菌剂杂环-嘧啶基-氨基衍生物 |
| AU2008289037B2 (en) | 2007-08-22 | 2012-03-01 | Novartis Ag | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| EA017392B1 (ru) * | 2007-08-22 | 2012-12-28 | Айрм Ллк | Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
| WO2011076725A1 (en) | 2009-12-21 | 2011-06-30 | Bayer Cropscience Ag | Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi |
| ES2579949T3 (es) * | 2010-02-05 | 2016-08-17 | Heptares Therapeutics Limited | Derivados de 1,2,4-triazin-4-amina |
| EA201390917A1 (ru) | 2010-12-21 | 2013-12-30 | Новартис Аг | Дигетероарильные соединения в качестве ингибиторов vps34 |
| WO2020146795A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
| CN112608316B (zh) | 2019-07-30 | 2022-10-21 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类腺苷受体拮抗剂 |
| CN112592354B (zh) | 2019-07-30 | 2022-05-27 | 厦门宝太生物科技股份有限公司 | 一种异噁唑并嘧啶类杂环化合物的制备方法 |
| CN115477653B (zh) * | 2022-10-11 | 2024-04-09 | 安徽省庆云医药股份有限公司 | 一种曲拉西利关键中间体及曲拉西利的制备方法 |
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| EP1283056A1 (en) * | 2000-04-26 | 2003-02-12 | Eisai Co., Ltd. | Medicinal compositions promoting bowel movement |
| WO2003035639A1 (en) * | 2001-10-22 | 2003-05-01 | Eisai Co., Ltd. | Pyrimidine compound and medicinal composition thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US176399A (en) * | 1876-04-18 | Improvement in boxes for packing crackers | ||
| US42891A (en) * | 1864-05-24 | Improvement in water-engines | ||
| US275038A (en) * | 1883-04-03 | Ors to themselves | ||
| US23763A (en) * | 1859-04-26 | Method of adjusting the knives of rotary cutter-heads for planing wood | ||
| US22106A (en) * | 1858-11-23 | Truss-bridge | ||
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| US6641549B2 (en) * | 2001-02-05 | 2003-11-04 | Bsn Medical, Inc. | Custom-moldable support for patellar tendinitis |
| WO2003057689A1 (en) * | 2002-01-02 | 2003-07-17 | Fujisawa Pharmaceutical Co., Ltd. | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-10-02 ES ES200302275A patent/ES2229928B1/es not_active Expired - Fee Related
-
2004
- 2004-09-21 UY UY28529A patent/UY28529A1/es not_active Application Discontinuation
- 2004-09-22 ZA ZA200602139A patent/ZA200602139B/en unknown
- 2004-09-22 AU AU2004283800A patent/AU2004283800B8/en not_active Ceased
- 2004-09-22 RU RU2006114746/04A patent/RU2006114746A/ru not_active Application Discontinuation
- 2004-09-22 CA CA002540765A patent/CA2540765A1/en not_active Abandoned
- 2004-09-22 EP EP04765506A patent/EP1668000A1/en not_active Withdrawn
- 2004-09-22 SG SG200809684-4A patent/SG149077A1/en unknown
- 2004-09-22 MX MXPA06003525A patent/MXPA06003525A/es unknown
- 2004-09-22 NZ NZ546266A patent/NZ546266A/en unknown
- 2004-09-22 WO PCT/EP2004/010644 patent/WO2005040155A1/en not_active Ceased
- 2004-09-22 JP JP2006530007A patent/JP2007507443A/ja active Pending
- 2004-09-22 BR BRPI0415324-3A patent/BRPI0415324A/pt not_active IP Right Cessation
- 2004-09-22 UA UAA200604615A patent/UA82563C2/uk unknown
- 2004-09-22 CN CNA2004800346926A patent/CN1886402A/zh active Pending
- 2004-09-22 US US10/574,101 patent/US20070265273A1/en not_active Abandoned
- 2004-09-22 KR KR1020067006384A patent/KR20060097010A/ko not_active Ceased
- 2004-09-28 PE PE2004000948A patent/PE20050473A1/es not_active Application Discontinuation
- 2004-09-30 TW TW093129574A patent/TW200526645A/zh unknown
- 2004-09-30 AR ARP040103547A patent/AR046170A1/es unknown
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2006
- 2006-03-16 EC EC2006006426A patent/ECSP066426A/es unknown
- 2006-03-31 CO CO06032147A patent/CO5690593A2/es not_active Application Discontinuation
- 2006-04-03 IL IL174771A patent/IL174771A0/en unknown
- 2006-05-02 NO NO20061952A patent/NO20061952L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1283056A1 (en) * | 2000-04-26 | 2003-02-12 | Eisai Co., Ltd. | Medicinal compositions promoting bowel movement |
| WO2003035639A1 (en) * | 2001-10-22 | 2003-05-01 | Eisai Co., Ltd. | Pyrimidine compound and medicinal composition thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010534634A (ja) * | 2007-07-26 | 2010-11-11 | ノバルティス アーゲー | 炎症性またはアレルギー性状態の処置に有用なピリミジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| AR046170A1 (es) | 2005-11-30 |
| SG149077A1 (en) | 2009-01-29 |
| ZA200602139B (en) | 2007-06-27 |
| NO20061952L (no) | 2006-06-26 |
| CO5690593A2 (es) | 2006-10-31 |
| NZ546266A (en) | 2008-10-31 |
| UA82563C2 (uk) | 2008-04-25 |
| KR20060097010A (ko) | 2006-09-13 |
| AU2004283800B2 (en) | 2009-05-07 |
| RU2006114746A (ru) | 2007-11-20 |
| AU2004283800A1 (en) | 2005-05-06 |
| WO2005040155A1 (en) | 2005-05-06 |
| BRPI0415324A (pt) | 2006-12-05 |
| PE20050473A1 (es) | 2005-08-24 |
| EP1668000A1 (en) | 2006-06-14 |
| ES2229928A1 (es) | 2005-04-16 |
| TW200526645A (en) | 2005-08-16 |
| US20070265273A1 (en) | 2007-11-15 |
| MXPA06003525A (es) | 2006-06-08 |
| IL174771A0 (en) | 2006-08-20 |
| WO2005040155A8 (en) | 2006-04-20 |
| ECSP066426A (es) | 2006-10-17 |
| CN1886402A (zh) | 2006-12-27 |
| CA2540765A1 (en) | 2005-05-06 |
| UY28529A1 (es) | 2005-04-29 |
| ES2229928B1 (es) | 2006-07-01 |
| AU2004283800B8 (en) | 2009-06-18 |
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