IL174771A0 - Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists - Google Patents
Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonistsInfo
- Publication number
- IL174771A0 IL174771A0 IL174771A IL17477106A IL174771A0 IL 174771 A0 IL174771 A0 IL 174771A0 IL 174771 A IL174771 A IL 174771A IL 17477106 A IL17477106 A IL 17477106A IL 174771 A0 IL174771 A0 IL 174771A0
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidin
- receptor antagonists
- adenosine receptor
- amine derivatives
- amine
- Prior art date
Links
- 101150078577 Adora2b gene Proteins 0.000 title 1
- 229940121359 adenosine receptor antagonist Drugs 0.000 title 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical class NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302275A ES2229928B1 (es) | 2003-10-02 | 2003-10-02 | Nuevos derivados de pirimidin-2-amina. |
| PCT/EP2004/010644 WO2005040155A1 (en) | 2003-10-02 | 2004-09-22 | Pyrimidin-2-amine derivates and their use as a2b adenosine receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL174771A0 true IL174771A0 (en) | 2006-08-20 |
Family
ID=34507890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL174771A IL174771A0 (en) | 2003-10-02 | 2006-04-03 | Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070265273A1 (enExample) |
| EP (1) | EP1668000A1 (enExample) |
| JP (1) | JP2007507443A (enExample) |
| KR (1) | KR20060097010A (enExample) |
| CN (1) | CN1886402A (enExample) |
| AR (1) | AR046170A1 (enExample) |
| AU (1) | AU2004283800B8 (enExample) |
| BR (1) | BRPI0415324A (enExample) |
| CA (1) | CA2540765A1 (enExample) |
| CO (1) | CO5690593A2 (enExample) |
| EC (1) | ECSP066426A (enExample) |
| ES (1) | ES2229928B1 (enExample) |
| IL (1) | IL174771A0 (enExample) |
| MX (1) | MXPA06003525A (enExample) |
| NO (1) | NO20061952L (enExample) |
| NZ (1) | NZ546266A (enExample) |
| PE (1) | PE20050473A1 (enExample) |
| RU (1) | RU2006114746A (enExample) |
| SG (1) | SG149077A1 (enExample) |
| TW (1) | TW200526645A (enExample) |
| UA (1) | UA82563C2 (enExample) |
| UY (1) | UY28529A1 (enExample) |
| WO (1) | WO2005040155A1 (enExample) |
| ZA (1) | ZA200602139B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2391103C2 (ru) | 2004-10-15 | 2010-06-10 | Си Ви Терапьютикс, Инк. | Способ предупреждения и лечения ремоделирования дыхательных путей и воспаления легких с применением антагонистов аденозиновых рецепторов a2b |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| DE102006046410A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten |
| ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| RU2471793C2 (ru) * | 2007-06-08 | 2013-01-10 | Байер Кропсайенс Аг | Фунгицид на основе гетероциклил-пиримидинил-аминопроизводных |
| BRPI0813629A2 (pt) * | 2007-07-26 | 2018-07-10 | Novartis Ag | derivados de pirimidina úteis no tratamento de condições inflamatórias ou alérgicas |
| WO2009026276A1 (en) | 2007-08-22 | 2009-02-26 | Irm Llc | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| WO2009026204A1 (en) * | 2007-08-22 | 2009-02-26 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
| AR079545A1 (es) | 2009-12-21 | 2012-02-01 | Bayer Cropscience Ag | Tienilpiri(mi)dinilazol |
| SG183146A1 (en) * | 2010-02-05 | 2012-09-27 | Heptares Therapeutics Ltd | 1,2,4-triazine-4-amine derivatives |
| WO2012085815A1 (en) | 2010-12-21 | 2012-06-28 | Novartis Ag | Bi-heteroaryl compounds as vps34 inhibitors |
| JOP20210164A1 (ar) | 2019-01-11 | 2023-01-30 | Omeros Corp | طرق وتركيبات علاج السرطان |
| CN112625050B (zh) | 2019-07-30 | 2021-10-01 | 杭州阿诺生物医药科技有限公司 | 一种a2a和/或a2b受体抑制剂的制备方法 |
| CN112608316B (zh) | 2019-07-30 | 2022-10-21 | 厦门宝太生物科技股份有限公司 | 一种吡唑并三嗪类腺苷受体拮抗剂 |
| CN115477653B (zh) * | 2022-10-11 | 2024-04-09 | 安徽省庆云医药股份有限公司 | 一种曲拉西利关键中间体及曲拉西利的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US176399A (en) * | 1876-04-18 | Improvement in boxes for packing crackers | ||
| US23763A (en) * | 1859-04-26 | Method of adjusting the knives of rotary cutter-heads for planing wood | ||
| US42891A (en) * | 1864-05-24 | Improvement in water-engines | ||
| US275038A (en) * | 1883-04-03 | Ors to themselves | ||
| US22106A (en) * | 1858-11-23 | Truss-bridge | ||
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| NZ521633A (en) * | 2000-04-26 | 2005-01-28 | Eisai Co Ltd | Use of an adenosine A2 or A2b recpetor antagonist for promoting bowel movement |
| US6641549B2 (en) * | 2001-02-05 | 2003-11-04 | Bsn Medical, Inc. | Custom-moldable support for patellar tendinitis |
| TWI330183B (enExample) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| US20050043315A1 (en) * | 2002-01-02 | 2005-02-24 | Hideo Tsutsumi | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-10-02 ES ES200302275A patent/ES2229928B1/es not_active Expired - Fee Related
-
2004
- 2004-09-21 UY UY28529A patent/UY28529A1/es not_active Application Discontinuation
- 2004-09-22 SG SG200809684-4A patent/SG149077A1/en unknown
- 2004-09-22 RU RU2006114746/04A patent/RU2006114746A/ru not_active Application Discontinuation
- 2004-09-22 NZ NZ546266A patent/NZ546266A/en unknown
- 2004-09-22 US US10/574,101 patent/US20070265273A1/en not_active Abandoned
- 2004-09-22 ZA ZA200602139A patent/ZA200602139B/en unknown
- 2004-09-22 JP JP2006530007A patent/JP2007507443A/ja active Pending
- 2004-09-22 BR BRPI0415324-3A patent/BRPI0415324A/pt not_active IP Right Cessation
- 2004-09-22 WO PCT/EP2004/010644 patent/WO2005040155A1/en not_active Ceased
- 2004-09-22 CN CNA2004800346926A patent/CN1886402A/zh active Pending
- 2004-09-22 EP EP04765506A patent/EP1668000A1/en not_active Withdrawn
- 2004-09-22 CA CA002540765A patent/CA2540765A1/en not_active Abandoned
- 2004-09-22 KR KR1020067006384A patent/KR20060097010A/ko not_active Ceased
- 2004-09-22 UA UAA200604615A patent/UA82563C2/uk unknown
- 2004-09-22 MX MXPA06003525A patent/MXPA06003525A/es unknown
- 2004-09-22 AU AU2004283800A patent/AU2004283800B8/en not_active Ceased
- 2004-09-28 PE PE2004000948A patent/PE20050473A1/es not_active Application Discontinuation
- 2004-09-30 AR ARP040103547A patent/AR046170A1/es unknown
- 2004-09-30 TW TW093129574A patent/TW200526645A/zh unknown
-
2006
- 2006-03-16 EC EC2006006426A patent/ECSP066426A/es unknown
- 2006-03-31 CO CO06032147A patent/CO5690593A2/es not_active Application Discontinuation
- 2006-04-03 IL IL174771A patent/IL174771A0/en unknown
- 2006-05-02 NO NO20061952A patent/NO20061952L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2229928A1 (es) | 2005-04-16 |
| EP1668000A1 (en) | 2006-06-14 |
| NO20061952L (no) | 2006-06-26 |
| TW200526645A (en) | 2005-08-16 |
| US20070265273A1 (en) | 2007-11-15 |
| WO2005040155A1 (en) | 2005-05-06 |
| ZA200602139B (en) | 2007-06-27 |
| CO5690593A2 (es) | 2006-10-31 |
| AU2004283800B2 (en) | 2009-05-07 |
| SG149077A1 (en) | 2009-01-29 |
| NZ546266A (en) | 2008-10-31 |
| MXPA06003525A (es) | 2006-06-08 |
| ECSP066426A (es) | 2006-10-17 |
| JP2007507443A (ja) | 2007-03-29 |
| AU2004283800A1 (en) | 2005-05-06 |
| ES2229928B1 (es) | 2006-07-01 |
| AU2004283800B8 (en) | 2009-06-18 |
| PE20050473A1 (es) | 2005-08-24 |
| CN1886402A (zh) | 2006-12-27 |
| AR046170A1 (es) | 2005-11-30 |
| BRPI0415324A (pt) | 2006-12-05 |
| WO2005040155A8 (en) | 2006-04-20 |
| RU2006114746A (ru) | 2007-11-20 |
| UA82563C2 (uk) | 2008-04-25 |
| CA2540765A1 (en) | 2005-05-06 |
| UY28529A1 (es) | 2005-04-29 |
| KR20060097010A (ko) | 2006-09-13 |
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