IL174771A0 - Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists - Google Patents
Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonistsInfo
- Publication number
- IL174771A0 IL174771A0 IL174771A IL17477106A IL174771A0 IL 174771 A0 IL174771 A0 IL 174771A0 IL 174771 A IL174771 A IL 174771A IL 17477106 A IL17477106 A IL 17477106A IL 174771 A0 IL174771 A0 IL 174771A0
- Authority
- IL
- Israel
- Prior art keywords
- pyrimidin
- receptor antagonists
- adenosine receptor
- amine derivatives
- amine
- Prior art date
Links
- 101150078577 Adora2b gene Proteins 0.000 title 1
- 229940121359 adenosine receptor antagonist Drugs 0.000 title 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical class NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302275A ES2229928B1 (es) | 2003-10-02 | 2003-10-02 | Nuevos derivados de pirimidin-2-amina. |
| PCT/EP2004/010644 WO2005040155A1 (en) | 2003-10-02 | 2004-09-22 | Pyrimidin-2-amine derivates and their use as a2b adenosine receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL174771A0 true IL174771A0 (en) | 2006-08-20 |
Family
ID=34507890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL174771A IL174771A0 (en) | 2003-10-02 | 2006-04-03 | Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070265273A1 (enExample) |
| EP (1) | EP1668000A1 (enExample) |
| JP (1) | JP2007507443A (enExample) |
| KR (1) | KR20060097010A (enExample) |
| CN (1) | CN1886402A (enExample) |
| AR (1) | AR046170A1 (enExample) |
| AU (1) | AU2004283800B8 (enExample) |
| BR (1) | BRPI0415324A (enExample) |
| CA (1) | CA2540765A1 (enExample) |
| CO (1) | CO5690593A2 (enExample) |
| EC (1) | ECSP066426A (enExample) |
| ES (1) | ES2229928B1 (enExample) |
| IL (1) | IL174771A0 (enExample) |
| MX (1) | MXPA06003525A (enExample) |
| NO (1) | NO20061952L (enExample) |
| NZ (1) | NZ546266A (enExample) |
| PE (1) | PE20050473A1 (enExample) |
| RU (1) | RU2006114746A (enExample) |
| SG (1) | SG149077A1 (enExample) |
| TW (1) | TW200526645A (enExample) |
| UA (1) | UA82563C2 (enExample) |
| UY (1) | UY28529A1 (enExample) |
| WO (1) | WO2005040155A1 (enExample) |
| ZA (1) | ZA200602139B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005295654B2 (en) | 2004-10-15 | 2011-04-14 | Gilead Sciences, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| DE102006046410A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten |
| ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| EP2164841A1 (en) * | 2007-06-08 | 2010-03-24 | Bayer CropScience SA | Fungicide heterocyclyl-pyrimidinyl-amino derivatives |
| AU2008278966B2 (en) * | 2007-07-26 | 2012-02-23 | Novartis Ag | Pyrimidine derivatives useful for the treatment of inflammatory or allergic conditions |
| WO2009026204A1 (en) * | 2007-08-22 | 2009-02-26 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| KR20120107538A (ko) | 2007-08-22 | 2012-10-02 | 아이알엠 엘엘씨 | 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물 |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
| BR112012018358A2 (pt) | 2009-12-21 | 2016-08-09 | Bayer Cropscience Ag | tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos |
| DK2531492T3 (en) * | 2010-02-05 | 2016-07-04 | Heptares Therapeutics Ltd | 1,2,4-triazin-4-amine derivatives |
| KR20130130030A (ko) | 2010-12-21 | 2013-11-29 | 노파르티스 아게 | Vps34 억제제로서의 비-헤테로아릴 화합물 |
| CN113727999A (zh) | 2019-01-11 | 2021-11-30 | 奥默罗斯公司 | 用于治疗癌症的方法和组合物 |
| CN112608330B (zh) | 2019-07-30 | 2021-09-28 | 杭州阿诺生物医药科技有限公司 | A2a和/或a2b受体抑制剂 |
| CN112479956A (zh) | 2019-07-30 | 2021-03-12 | 杭州阿诺生物医药科技有限公司 | 一种用于制备腺苷受体抑制剂中间体的方法 |
| CN115477653B (zh) * | 2022-10-11 | 2024-04-09 | 安徽省庆云医药股份有限公司 | 一种曲拉西利关键中间体及曲拉西利的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US176399A (en) * | 1876-04-18 | Improvement in boxes for packing crackers | ||
| US42891A (en) * | 1864-05-24 | Improvement in water-engines | ||
| US23763A (en) * | 1859-04-26 | Method of adjusting the knives of rotary cutter-heads for planing wood | ||
| US22106A (en) * | 1858-11-23 | Truss-bridge | ||
| US275038A (en) * | 1883-04-03 | Ors to themselves | ||
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| HUP0300927A2 (hu) * | 2000-04-26 | 2003-07-28 | Eisai Co., Ltd. | Új pirimidinszármazékok és ezeket tartalmazó defekációt elősegítő gyógyszerkészítmények |
| US6641549B2 (en) * | 2001-02-05 | 2003-11-04 | Bsn Medical, Inc. | Custom-moldable support for patellar tendinitis |
| TWI330183B (enExample) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| WO2003057689A1 (en) * | 2002-01-02 | 2003-07-17 | Fujisawa Pharmaceutical Co., Ltd. | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-10-02 ES ES200302275A patent/ES2229928B1/es not_active Expired - Fee Related
-
2004
- 2004-09-21 UY UY28529A patent/UY28529A1/es not_active Application Discontinuation
- 2004-09-22 SG SG200809684-4A patent/SG149077A1/en unknown
- 2004-09-22 EP EP04765506A patent/EP1668000A1/en not_active Withdrawn
- 2004-09-22 CN CNA2004800346926A patent/CN1886402A/zh active Pending
- 2004-09-22 CA CA002540765A patent/CA2540765A1/en not_active Abandoned
- 2004-09-22 BR BRPI0415324-3A patent/BRPI0415324A/pt not_active IP Right Cessation
- 2004-09-22 ZA ZA200602139A patent/ZA200602139B/en unknown
- 2004-09-22 NZ NZ546266A patent/NZ546266A/en unknown
- 2004-09-22 KR KR1020067006384A patent/KR20060097010A/ko not_active Ceased
- 2004-09-22 WO PCT/EP2004/010644 patent/WO2005040155A1/en not_active Ceased
- 2004-09-22 AU AU2004283800A patent/AU2004283800B8/en not_active Ceased
- 2004-09-22 UA UAA200604615A patent/UA82563C2/uk unknown
- 2004-09-22 MX MXPA06003525A patent/MXPA06003525A/es unknown
- 2004-09-22 RU RU2006114746/04A patent/RU2006114746A/ru not_active Application Discontinuation
- 2004-09-22 JP JP2006530007A patent/JP2007507443A/ja active Pending
- 2004-09-22 US US10/574,101 patent/US20070265273A1/en not_active Abandoned
- 2004-09-28 PE PE2004000948A patent/PE20050473A1/es not_active Application Discontinuation
- 2004-09-30 AR ARP040103547A patent/AR046170A1/es unknown
- 2004-09-30 TW TW093129574A patent/TW200526645A/zh unknown
-
2006
- 2006-03-16 EC EC2006006426A patent/ECSP066426A/es unknown
- 2006-03-31 CO CO06032147A patent/CO5690593A2/es not_active Application Discontinuation
- 2006-04-03 IL IL174771A patent/IL174771A0/en unknown
- 2006-05-02 NO NO20061952A patent/NO20061952L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UA82563C2 (uk) | 2008-04-25 |
| TW200526645A (en) | 2005-08-16 |
| US20070265273A1 (en) | 2007-11-15 |
| PE20050473A1 (es) | 2005-08-24 |
| ECSP066426A (es) | 2006-10-17 |
| NO20061952L (no) | 2006-06-26 |
| AU2004283800A1 (en) | 2005-05-06 |
| WO2005040155A8 (en) | 2006-04-20 |
| KR20060097010A (ko) | 2006-09-13 |
| ES2229928A1 (es) | 2005-04-16 |
| UY28529A1 (es) | 2005-04-29 |
| CO5690593A2 (es) | 2006-10-31 |
| MXPA06003525A (es) | 2006-06-08 |
| AU2004283800B2 (en) | 2009-05-07 |
| AU2004283800B8 (en) | 2009-06-18 |
| ZA200602139B (en) | 2007-06-27 |
| NZ546266A (en) | 2008-10-31 |
| CA2540765A1 (en) | 2005-05-06 |
| RU2006114746A (ru) | 2007-11-20 |
| EP1668000A1 (en) | 2006-06-14 |
| ES2229928B1 (es) | 2006-07-01 |
| JP2007507443A (ja) | 2007-03-29 |
| BRPI0415324A (pt) | 2006-12-05 |
| CN1886402A (zh) | 2006-12-27 |
| SG149077A1 (en) | 2009-01-29 |
| AR046170A1 (es) | 2005-11-30 |
| WO2005040155A1 (en) | 2005-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI365879B (en) | A2b adenosine receptor antagonists | |
| IL158214A0 (en) | 8-heteroaryl xanthine adenosine a2b receptor antagonists | |
| HUP0401925A3 (en) | A2b adenosine receptor antagonists | |
| IL178365A0 (en) | Selective antagonists of a2a adenosine receptors | |
| IL181716A0 (en) | Purine derivatives as a3 and a1 adenosine receptor agonists | |
| IL190336A0 (en) | Imidazopyridine derivatives as a2b adenosine receptor antagonists | |
| IL188725A0 (en) | Pyrazine derivatives useful as adenosine receptor antagonists | |
| IL155712A0 (en) | Aminothiazoles and their use as adenosine receptor antagonists | |
| IL161716A0 (en) | ADENOSINE A2a RECEPTOR ANTAGONISTS | |
| PL3109244T3 (pl) | Wytwarzanie 2'fluoro-2'-alkilo-podstawionych lub innych ewentualnie podstawionych rybofuranozylopirymidyn i puryn oraz ich pochodnych | |
| ZA200703229B (en) | Use of A2A adenosine receptor agonists | |
| IL161572A0 (en) | Adenosine a2a receptor antagonists | |
| IL152726A0 (en) | Adenosine a2a receptor antagonists | |
| TWI349550B (en) | A thiazole derivative and adenosine a2a receptor antagonist containing the same | |
| IL186939A0 (en) | Pyrimidine derivatives and their use as | |
| IL182528A0 (en) | Purine derivatives for use as adenosin a-2a receptor antagonists | |
| EP1636229A4 (en) | ADENOSINE A1 RECEPTOR ANTAGONISTS | |
| BRPI0409787B8 (pt) | antagonistas receptores da 2-alquinil- e 2-alquenil-pirazol-[4,3-e]-1,2,4-triazol-[1,5-c]-pirimidina adenosina a2a | |
| PL1951661T3 (pl) | Antagoniści receptora glukagonu, wytwarzanie i terapeutyczne zastosowania | |
| ZA200703005B (en) | Preparation of 2'Fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | |
| IL179529A0 (en) | 3 -?? - D - RIBOFURANOSYLTHIAZOLO [4-5-d] PYRIMIDINE NUCLEOSIDES AND USES THEREOF | |
| IL178622A0 (en) | Piperazinylpiperidine derivatives as chemokine receptor antagonists | |
| PL370221A1 (en) | 2-oxazolamines and their use as 5-ht2b receptor antagonists | |
| EP1636230A4 (en) | ADENOSINE A1 RECEPTOR ANTAGONISTS | |
| HK1094192A (en) | Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists |