ES2229928B1 - Nuevos derivados de pirimidin-2-amina. - Google Patents

Nuevos derivados de pirimidin-2-amina.

Info

Publication number
ES2229928B1
ES2229928B1 ES200302275A ES200302275A ES2229928B1 ES 2229928 B1 ES2229928 B1 ES 2229928B1 ES 200302275 A ES200302275 A ES 200302275A ES 200302275 A ES200302275 A ES 200302275A ES 2229928 B1 ES2229928 B1 ES 2229928B1
Authority
ES
Spain
Prior art keywords
optionally substituted
linear
branched
group
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200302275A
Other languages
English (en)
Spanish (es)
Other versions
ES2229928A1 (es
Inventor
Bernat Vidal Juan
Cristina Esteve Trias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to ES200302275A priority Critical patent/ES2229928B1/es
Priority to UY28529A priority patent/UY28529A1/es
Priority to CNA2004800346926A priority patent/CN1886402A/zh
Priority to US10/574,101 priority patent/US20070265273A1/en
Priority to CA002540765A priority patent/CA2540765A1/en
Priority to BRPI0415324-3A priority patent/BRPI0415324A/pt
Priority to KR1020067006384A priority patent/KR20060097010A/ko
Priority to SG200809684-4A priority patent/SG149077A1/en
Priority to NZ546266A priority patent/NZ546266A/en
Priority to PCT/EP2004/010644 priority patent/WO2005040155A1/en
Priority to EP04765506A priority patent/EP1668000A1/en
Priority to JP2006530007A priority patent/JP2007507443A/ja
Priority to ZA200602139A priority patent/ZA200602139B/en
Priority to UAA200604615A priority patent/UA82563C2/uk
Priority to AU2004283800A priority patent/AU2004283800B8/en
Priority to MXPA06003525A priority patent/MXPA06003525A/es
Priority to RU2006114746/04A priority patent/RU2006114746A/ru
Priority to PE2004000948A priority patent/PE20050473A1/es
Priority to ARP040103547A priority patent/AR046170A1/es
Priority to TW093129574A priority patent/TW200526645A/zh
Publication of ES2229928A1 publication Critical patent/ES2229928A1/es
Priority to EC2006006426A priority patent/ECSP066426A/es
Priority to CO06032147A priority patent/CO5690593A2/es
Priority to IL174771A priority patent/IL174771A0/en
Priority to NO20061952A priority patent/NO20061952L/no
Application granted granted Critical
Publication of ES2229928B1 publication Critical patent/ES2229928B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES200302275A 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina. Expired - Fee Related ES2229928B1 (es)

Priority Applications (24)

Application Number Priority Date Filing Date Title
ES200302275A ES2229928B1 (es) 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina.
UY28529A UY28529A1 (es) 2003-10-02 2004-09-21 Nuevos derivados de pirimidin-2-amina
MXPA06003525A MXPA06003525A (es) 2003-10-02 2004-09-22 Derivados de pirimidin-2-amina y su uso como antagonistas del receptor de adenosina a2b.
CA002540765A CA2540765A1 (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists
BRPI0415324-3A BRPI0415324A (pt) 2003-10-02 2004-09-22 composto, processo para a produção de um composto, composição farmacêutica, uso de um composto e método para o tratamento de um sujeito que sofre de uma condição patológica ou doença susceptìvel de melhora por antagonismo de receptor de adenosina a2b
KR1020067006384A KR20060097010A (ko) 2003-10-02 2004-09-22 피리미딘-2-아민 유도체 및 이들의 ａ2ｂ 아데노신 수용체길항제로서의 용도
SG200809684-4A SG149077A1 (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists
NZ546266A NZ546266A (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivatives and their use as A2B adenosine receptor antagonists
PCT/EP2004/010644 WO2005040155A1 (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivates and their use as a2b adenosine receptor antagonists
EP04765506A EP1668000A1 (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists
JP2006530007A JP2007507443A (ja) 2003-10-02 2004-09-22 ピリミジン−２−アミン誘導体およびａ２ｂアデノシン受容体アンタゴニストとしてのその使用
ZA200602139A ZA200602139B (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivatives and their use as A2B adenosine receptor antagonists
CNA2004800346926A CN1886402A (zh) 2003-10-02 2004-09-22 嘧啶－2－胺衍生物及其作为a2b腺苷受体拮抗剂的用途
AU2004283800A AU2004283800B8 (en) 2003-10-02 2004-09-22 Pyrimidin-2-amine derivates and their use as A2B adenosine receptor antagonists
US10/574,101 US20070265273A1 (en) 2003-10-02 2004-09-22 Pyrimidin-2-Amine Derivatives and Their Use as A2b Adenosine Receptor Antagonists
RU2006114746/04A RU2006114746A (ru) 2003-10-02 2004-09-22 Производные пиримидин-2-амина и их применение в качестве антагонистов аденозинового рецептора а2в
UAA200604615A UA82563C2 (uk) 2003-10-02 2004-09-22 Похідні піримідин-2-аміну і їх застосування як антагоністів аденозинового рецептора a2b
PE2004000948A PE20050473A1 (es) 2003-10-02 2004-09-28 Nuevos derivados de pirimidin-2-amina
ARP040103547A AR046170A1 (es) 2003-10-02 2004-09-30 Derivados de pirimidin-2-amina y su uso como antagonistas del receptor de adenosina a 2b
TW093129574A TW200526645A (en) 2003-10-02 2004-09-30 New pyrimidin-2-amine derivatives
EC2006006426A ECSP066426A (es) 2003-10-02 2006-03-16 Nuevos derivados de pirimidin-2-amina
CO06032147A CO5690593A2 (es) 2003-10-02 2006-03-31 Nuevos derivados de pirimidin 2-amina
IL174771A IL174771A0 (en) 2003-10-02 2006-04-03 Pyrimidin-2-amine derivatives and their use as a2b adenosine receptor antagonists
NO20061952A NO20061952L (no) 2003-10-02 2006-05-02 Pyrimidin-2-aminderivater og deres anvendelse som A2B-adenosinreseptorantagonister

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200302275A ES2229928B1 (es) 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina.

Publications (2)

Publication Number Publication Date
ES2229928A1 ES2229928A1 (es) 2005-04-16
ES2229928B1 true ES2229928B1 (es) 2006-07-01

Family

ID=34507890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200302275A Expired - Fee Related ES2229928B1 (es) 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina.

Country Status (24)

Country Link
US (1) US20070265273A1 (enExample)
EP (1) EP1668000A1 (enExample)
JP (1) JP2007507443A (enExample)
KR (1) KR20060097010A (enExample)
CN (1) CN1886402A (enExample)
AR (1) AR046170A1 (enExample)
AU (1) AU2004283800B8 (enExample)
BR (1) BRPI0415324A (enExample)
CA (1) CA2540765A1 (enExample)
CO (1) CO5690593A2 (enExample)
EC (1) ECSP066426A (enExample)
ES (1) ES2229928B1 (enExample)
IL (1) IL174771A0 (enExample)
MX (1) MXPA06003525A (enExample)
NO (1) NO20061952L (enExample)
NZ (1) NZ546266A (enExample)
PE (1) PE20050473A1 (enExample)
RU (1) RU2006114746A (enExample)
SG (1) SG149077A1 (enExample)
TW (1) TW200526645A (enExample)
UA (1) UA82563C2 (enExample)
UY (1) UY28529A1 (enExample)
WO (1) WO2005040155A1 (enExample)
ZA (1) ZA200602139B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311462A1 (en) 2004-10-15 2011-04-20 Cv Therapeutics, Inc. Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists
ES2270715B1 (es) * 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ES2274712B1 (es) * 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
DE102006046410A1 (de) * 2006-09-20 2008-03-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten
ES2303776B1 (es) * 2006-12-29 2009-08-07 Laboratorios Almirall S.A. Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
CN101679376A (zh) * 2007-06-08 2010-03-24 拜尔农科股份有限公司 杀真菌剂杂环-嘧啶基-氨基衍生物
MX2010001020A (es) * 2007-07-26 2010-03-01 Novartis Ag Derivados de pirimidina utiles para el tratamiento de condiciones inflamatorias o alergicas.
AU2008289037B2 (en) 2007-08-22 2012-03-01 Novartis Ag 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
EA017392B1 (ru) * 2007-08-22 2012-12-28 Айрм Ллк Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
WO2011076725A1 (en) 2009-12-21 2011-06-30 Bayer Cropscience Ag Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi
ES2579949T3 (es) * 2010-02-05 2016-08-17 Heptares Therapeutics Limited Derivados de 1,2,4-triazin-4-amina
EA201390917A1 (ru) 2010-12-21 2013-12-30 Новартис Аг Дигетероарильные соединения в качестве ингибиторов vps34
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
CN112608316B (zh) 2019-07-30 2022-10-21 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类腺苷受体拮抗剂
CN112592354B (zh) 2019-07-30 2022-05-27 厦门宝太生物科技股份有限公司 一种异噁唑并嘧啶类杂环化合物的制备方法
CN115477653B (zh) * 2022-10-11 2024-04-09 安徽省庆云医药股份有限公司 一种曲拉西利关键中间体及曲拉西利的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763448A (en) * 1993-05-10 1998-06-09 Merck, Sharp & Dohme Limited Pyrmidine derivatives

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US42891A (en) * 1864-05-24 Improvement in water-engines
US275038A (en) * 1883-04-03 Ors to themselves
US23763A (en) * 1859-04-26 Method of adjusting the knives of rotary cutter-heads for planing wood
US22106A (en) * 1858-11-23 Truss-bridge
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
AU2001252606B2 (en) * 2000-04-26 2005-07-07 Eisai R&D Management Co., Ltd. Medicinal compositions promoting bowel movement
US6641549B2 (en) * 2001-02-05 2003-11-04 Bsn Medical, Inc. Custom-moldable support for patellar tendinitis
TWI330183B (enExample) * 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
WO2003057689A1 (en) * 2002-01-02 2003-07-17 Fujisawa Pharmaceutical Co., Ltd. Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763448A (en) * 1993-05-10 1998-06-09 Merck, Sharp & Dohme Limited Pyrmidine derivatives

Also Published As

Publication number Publication date
AR046170A1 (es) 2005-11-30
SG149077A1 (en) 2009-01-29
ZA200602139B (en) 2007-06-27
NO20061952L (no) 2006-06-26
CO5690593A2 (es) 2006-10-31
NZ546266A (en) 2008-10-31
UA82563C2 (uk) 2008-04-25
KR20060097010A (ko) 2006-09-13
AU2004283800B2 (en) 2009-05-07
RU2006114746A (ru) 2007-11-20
AU2004283800A1 (en) 2005-05-06
WO2005040155A1 (en) 2005-05-06
BRPI0415324A (pt) 2006-12-05
JP2007507443A (ja) 2007-03-29
PE20050473A1 (es) 2005-08-24
EP1668000A1 (en) 2006-06-14
ES2229928A1 (es) 2005-04-16
TW200526645A (en) 2005-08-16
US20070265273A1 (en) 2007-11-15
MXPA06003525A (es) 2006-06-08
IL174771A0 (en) 2006-08-20
WO2005040155A8 (en) 2006-04-20
ECSP066426A (es) 2006-10-17
CN1886402A (zh) 2006-12-27
CA2540765A1 (en) 2005-05-06
UY28529A1 (es) 2005-04-29
AU2004283800B8 (en) 2009-06-18

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