JP2007504260A5 - - Google Patents
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- Publication number
- JP2007504260A5 JP2007504260A5 JP2006525712A JP2006525712A JP2007504260A5 JP 2007504260 A5 JP2007504260 A5 JP 2007504260A5 JP 2006525712 A JP2006525712 A JP 2006525712A JP 2006525712 A JP2006525712 A JP 2006525712A JP 2007504260 A5 JP2007504260 A5 JP 2007504260A5
- Authority
- JP
- Japan
- Prior art keywords
- hcv
- interferon
- treatment
- liver diseases
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015181 infectious disease Diseases 0.000 description 3
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0320638.0 | 2003-09-03 | ||
| GBGB0320638.0A GB0320638D0 (en) | 2003-09-03 | 2003-09-03 | Organic compounds |
| PCT/EP2004/009804 WO2005021028A1 (en) | 2003-09-03 | 2004-09-02 | Use of modified cyclosporins for the treatment of hcv disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504260A JP2007504260A (ja) | 2007-03-01 |
| JP2007504260A5 true JP2007504260A5 (cg-RX-API-DMAC7.html) | 2007-10-11 |
| JP4688806B2 JP4688806B2 (ja) | 2011-05-25 |
Family
ID=28686843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525712A Expired - Fee Related JP4688806B2 (ja) | 2003-09-03 | 2004-09-02 | Ｈｃｖ障害の処置のための修飾シクロスポリンの使用 |
Country Status (29)
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1091975B1 (fr) | 1998-07-01 | 2005-12-14 | Debiopharm S.A. | Nouvelle cyclosporine ayant un profil d'activite ameliore |
| EP1603512A2 (en) | 2003-03-17 | 2005-12-14 | Albany Molecular Research, Inc. | Novel cyclosporins |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) * | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| RU2394589C2 (ru) * | 2004-07-14 | 2010-07-20 | Новартис Аг | Применение комбинации циклоспорина и пэгилированного интерферона для лечения гепатита с (hcv) |
| US7378391B2 (en) | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| CN101056648B (zh) * | 2004-10-01 | 2012-08-15 | 德比奥法姆股份有限公司 | [d-meala]3-[etval]4环孢菌素用于丙型肝炎感染治疗的应用以及包含所述[d-meala]3-[etval]4-环孢菌素的药物组合物 |
| US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| RU2399628C2 (ru) * | 2004-10-01 | 2010-09-20 | Скайнексис, Инк. | Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с |
| JP2008515886A (ja) | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキンおよびそれらの医用薬剤としての有用性 |
| US7696167B2 (en) | 2004-11-22 | 2010-04-13 | Astellas Pharma Inc. | Cyclic peptide compound |
| CA2587586A1 (en) * | 2004-12-23 | 2006-07-06 | Novartis Ag | Compounds for flaviviridae treatment |
| BRPI0519345A2 (pt) | 2004-12-23 | 2009-01-20 | Novartis Ag | composiÇço para tratamento do hcv |
| US20090221598A1 (en) * | 2005-06-17 | 2009-09-03 | Kai Lin | Use of Sanglifehrin in HCV |
| KR20080059270A (ko) * | 2005-09-30 | 2008-06-26 | 싸이넥시스, 인크. | Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물 |
| WO2007041631A1 (en) | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION |
| CN101316606B (zh) * | 2005-09-30 | 2015-05-27 | 西尼克斯公司 | 治疗和预防丙型肝炎感染的方法和药物组合物 |
| CN101305019B (zh) * | 2005-10-26 | 2012-12-12 | 安斯泰来制药有限公司 | 新的环肽化合物 |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| JP5377293B2 (ja) | 2006-05-19 | 2013-12-25 | スシネキス インク | 眼疾患の治療及び予防方法 |
| KR101089112B1 (ko) * | 2006-06-02 | 2011-12-06 | 피씨 제스띠옹 에스.아.에스. | 활성 전자 관리 |
| EP2073831A1 (en) * | 2006-10-12 | 2009-07-01 | Novartis AG | Use of modified cyclosporins |
| WO2008069917A2 (en) * | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| EP2124992A2 (en) | 2007-01-04 | 2009-12-02 | Debiopharm S.A. | Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy |
| BRPI0810203A2 (pt) | 2007-05-02 | 2014-10-14 | Astellas Pharma Inc | Compostos peptídeos cíclicos. |
| WO2009028418A1 (ja) | 2007-08-24 | 2009-03-05 | Sapporo Medical University | シクロスポリンａ結合タンパク質 |
| US9090671B2 (en) | 2008-06-06 | 2015-07-28 | Scynexis, Inc. | Macrocyclic peptides |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| US20130190223A1 (en) * | 2008-07-30 | 2013-07-25 | Isotechnika Pharma Inc. | Nonimmunosuppressive cyclosporine analogue molecules |
| CA2738280A1 (en) * | 2008-09-24 | 2010-04-01 | Astellas Pharma Inc. | Peptide compound and method for producing the same |
| CA2741829A1 (en) * | 2008-11-06 | 2010-05-14 | Debio Recherche Pharmaceutique S.A. | Cycloundecadepsipeptide compounds and use of said compounds as a medicament |
| US8536114B2 (en) * | 2008-12-31 | 2013-09-17 | Scynexis, Inc. | Macrocycles |
| KR20110111321A (ko) | 2009-01-30 | 2011-10-10 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체 |
| US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| WO2011063076A1 (en) | 2009-11-19 | 2011-05-26 | Itherx Pharmaceuticals, Inc. | Methods of treating hepatitis c virus with oxoacetamide compounds |
| WO2011070364A1 (en) | 2009-12-09 | 2011-06-16 | Scynexis, Inc. | Novel cyclic peptides |
| US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| MX2013003903A (es) | 2010-10-05 | 2013-05-20 | Novartis Ag | Nuevos tratamientos de infeccion por el virus de hepatitis c. |
| MX2013006052A (es) | 2010-11-30 | 2013-06-18 | Novartis Ag | Nuevos tratamientos de la infeccion por el virus de hepatitis c. |
| JO3337B1 (ar) | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| AU2011342284C1 (en) | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| US20140018289A1 (en) | 2011-03-31 | 2014-01-16 | Novartis Ag | New treatments of Hepatitis C virus infection |
| BR112013024809A2 (pt) | 2011-04-01 | 2016-09-06 | Novartis Ag | tratamento para infecção com vírus de hepatite b sozinho ou em combinação com vírus de hepatite delta e doenças do fígado associadas |
| CA2832829A1 (en) | 2011-04-13 | 2012-10-18 | Novartis Ag | Treatment of hepatitis c virus infection with alisporivir |
| CN103826654A (zh) | 2011-09-27 | 2014-05-28 | 诺华股份有限公司 | 用于治疗丙型肝炎病毒感染的阿拉泊韦 |
| WO2013169616A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmacokinetic modulation with alisporivir |
| AU2013267435B2 (en) | 2012-06-01 | 2017-11-09 | Allergan, Inc. | Cyclosporin A analogs |
| WO2014085623A1 (en) | 2012-11-28 | 2014-06-05 | Enanta Pharmaceuticals, Inc. | Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues |
| WO2015008223A1 (en) | 2013-07-17 | 2015-01-22 | Novartis Ag | Treatment of hepatitis c virus infection with alisporivir and ribavirin |
| US9221878B2 (en) | 2013-08-26 | 2015-12-29 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| WO2015136455A1 (en) | 2014-03-13 | 2015-09-17 | Novartis Ag | New treatments of hepatitis c virus infection |
| US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| TW201639873A (zh) | 2015-01-08 | 2016-11-16 | 歐樂根公司 | Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物 |
| EP4199937A1 (en) * | 2020-08-24 | 2023-06-28 | Nanomerics Ltd | Viral inhibitors |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| JP2514950B2 (ja) | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質，その製造法および中間体 |
| GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| DE69124459T3 (de) * | 1990-11-02 | 2001-05-31 | Novartis Ag, Basel | Zyklosporine |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| ES2126658T3 (es) | 1992-10-21 | 1999-04-01 | Yoshitomi Pharmaceutical | Compuesto de 2-amino-1,3-propanodiol e inmunosupresor. |
| ATE214940T1 (de) | 1993-11-10 | 2002-04-15 | Enzon Inc | Verbesserte interferon-polymerkonjugate |
| EP0778263B1 (en) | 1994-08-22 | 2002-01-09 | Welfide Corporation | Benzene compound and medicinal use thereof |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JP3786447B2 (ja) * | 1995-03-31 | 2006-06-14 | エーザイ株式会社 | Ｃ型肝炎の予防・治療剤 |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| FR2757522B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757521B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757520B1 (fr) | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent |
| EP1319651B1 (en) | 1997-04-04 | 2005-06-29 | Mitsubishi Pharma Corporation | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor |
| JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
| GB9811854D0 (en) * | 1998-06-02 | 1998-07-29 | Ciba Geigy Ag | Organic compounds |
| EP1091975B1 (fr) | 1998-07-01 | 2005-12-14 | Debiopharm S.A. | Nouvelle cyclosporine ayant un profil d'activite ameliore |
| CN1328387C (zh) | 2000-07-13 | 2007-07-25 | 三共株式会社 | 氨基醇衍生物 |
| AU2001285331B2 (en) | 2000-08-31 | 2006-04-06 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
| EP1372695A2 (en) * | 2000-10-19 | 2004-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Cell damage inhibitor |
| JP2002125683A (ja) * | 2000-10-27 | 2002-05-08 | Tokyoto Igaku Kenkyu Kiko | インターフェロンの有効性を予測する方法並びにそれに用いられるプライマー及びプローブ |
| SK11942003A3 (sk) | 2001-03-26 | 2004-03-02 | Novartis Ag | Deriváty 2-aminopropanolu, ich použitie a farmaceutická kompozícia, ktorá ich obsahuje |
| JP2002316985A (ja) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| DE60223699T2 (de) | 2001-09-27 | 2008-10-30 | Kyorin Pharmaceutical Co., Ltd. | Diarylsulfidderivat, dessen additionssalz und immunsuppressivum |
| CA2460640C (en) | 2001-09-27 | 2011-03-29 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same |
| DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
| ATE441654T1 (de) | 2002-01-18 | 2009-09-15 | Merck & Co Inc | Edg-rezeptoragonisten |
| US20030213603A1 (en) * | 2002-05-14 | 2003-11-20 | Fisher David B. | Dual use extension apparatus for a tool |
| JP2005533824A (ja) | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
| GB0313444D0 (en) | 2003-06-11 | 2003-07-16 | Midland Medical Technologies L | Modular dysplasia cup |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| CN101056648B (zh) | 2004-10-01 | 2012-08-15 | 德比奥法姆股份有限公司 | [d-meala]3-[etval]4环孢菌素用于丙型肝炎感染治疗的应用以及包含所述[d-meala]3-[etval]4-环孢菌素的药物组合物 |
| BRPI0519345A2 (pt) | 2004-12-23 | 2009-01-20 | Novartis Ag | composiÇço para tratamento do hcv |
-
2003
- 2003-09-03 GB GBGB0320638.0A patent/GB0320638D0/en not_active Ceased
-
2004
- 2004-09-02 NZ NZ545495A patent/NZ545495A/en not_active IP Right Cessation
- 2004-09-02 BR BRPI0414062A patent/BRPI0414062B8/pt not_active IP Right Cessation
- 2004-09-02 AU AU2004268382A patent/AU2004268382A1/en not_active Abandoned
- 2004-09-02 WO PCT/EP2004/009804 patent/WO2005021028A1/en not_active Ceased
- 2004-09-02 PT PT04764762T patent/PT1663287E/pt unknown
- 2004-09-02 MX MXPA06002394A patent/MXPA06002394A/es active IP Right Grant
- 2004-09-02 KR KR1020067004342A patent/KR101116968B1/ko not_active Expired - Fee Related
- 2004-09-02 US US10/570,097 patent/US7968518B2/en active Active
- 2004-09-02 DE DE602004022061T patent/DE602004022061D1/de not_active Expired - Lifetime
- 2004-09-02 CN CNA2004800246044A patent/CN1842343A/zh active Pending
- 2004-09-02 ES ES04764762T patent/ES2328361T3/es not_active Expired - Lifetime
- 2004-09-02 EP EP04764762A patent/EP1663287B1/en not_active Expired - Lifetime
- 2004-09-02 HR HR20090535T patent/HRP20090535T1/hr unknown
- 2004-09-02 JP JP2006525712A patent/JP4688806B2/ja not_active Expired - Fee Related
- 2004-09-02 SI SI200431200T patent/SI1663287T1/sl unknown
- 2004-09-02 RU RU2006110533/15A patent/RU2389501C2/ru not_active IP Right Cessation
- 2004-09-02 CA CA2537137A patent/CA2537137C/en not_active Expired - Fee Related
- 2004-09-02 PL PL04764762T patent/PL1663287T3/pl unknown
- 2004-09-02 SG SG200809555-6A patent/SG149063A1/en unknown
- 2004-09-02 EP EP06125649.1A patent/EP1797892B1/en not_active Expired - Lifetime
- 2004-09-02 TW TW093126578A patent/TWI342782B/zh not_active IP Right Cessation
- 2004-09-02 DK DK04764762T patent/DK1663287T3/da active
-
2006
- 2006-02-22 ZA ZA200601550A patent/ZA200601550B/en unknown
- 2006-02-23 IL IL173909A patent/IL173909A/en active IP Right Grant
- 2006-03-02 TN TNP2006000071A patent/TNSN06071A1/en unknown
- 2006-03-10 MA MA28865A patent/MA28032A1/fr unknown
- 2006-03-24 IS IS8371A patent/IS2917B/is unknown
- 2006-03-31 NO NO20061479A patent/NO20061479L/no not_active Application Discontinuation
-
2008
- 2008-07-09 AU AU2008203031A patent/AU2008203031B2/en not_active Ceased
-
2009
- 2009-09-16 CY CY20091100955T patent/CY1110506T1/el unknown
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