JP2007502826A5 - - Google Patents
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- Publication number
- JP2007502826A5 JP2007502826A5 JP2006523970A JP2006523970A JP2007502826A5 JP 2007502826 A5 JP2007502826 A5 JP 2007502826A5 JP 2006523970 A JP2006523970 A JP 2006523970A JP 2006523970 A JP2006523970 A JP 2006523970A JP 2007502826 A5 JP2007502826 A5 JP 2007502826A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- derivative
- lower alkyl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 44
- 229910052739 hydrogen Inorganic materials 0.000 claims 40
- 239000001257 hydrogen Substances 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 239000002253 acid Substances 0.000 claims 30
- 230000000844 anti-bacterial effect Effects 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 150000002431 hydrogen Chemical class 0.000 claims 17
- 150000001721 carbon Chemical group 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 230000000843 anti-fungal effect Effects 0.000 claims 11
- 230000002924 anti-infective effect Effects 0.000 claims 11
- 230000000845 anti-microbial effect Effects 0.000 claims 11
- 230000002421 anti-septic effect Effects 0.000 claims 11
- 230000000840 anti-viral effect Effects 0.000 claims 11
- 229940121375 antifungal agent Drugs 0.000 claims 11
- 150000002148 esters Chemical class 0.000 claims 11
- 230000003330 sporicidal effect Effects 0.000 claims 11
- 125000001309 chloro group Chemical group Cl* 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000001246 bromo group Chemical group Br* 0.000 claims 8
- 125000001589 carboacyl group Chemical group 0.000 claims 8
- 125000002346 iodo group Chemical group I* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000003937 drug carrier Substances 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 230000007774 longterm Effects 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 3
- 241000233866 Fungi Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- JJQITYDTBUXIDS-UHFFFAOYSA-N 2-(dibromoamino)-2-methylpropane-1-sulfonic acid Chemical compound BrN(Br)C(C)(C)CS(O)(=O)=O JJQITYDTBUXIDS-UHFFFAOYSA-N 0.000 claims 2
- QYNRGGHZWCUZLK-UHFFFAOYSA-N 2-(dichloroamino)-2-methylpropane-1-sulfonic acid Chemical compound ClN(Cl)C(C)(C)CS(O)(=O)=O QYNRGGHZWCUZLK-UHFFFAOYSA-N 0.000 claims 2
- OXIWSCWSIBBUDO-UHFFFAOYSA-N 3-(dichloroamino)-2,2,3-trimethylbutanoic acid Chemical compound ClN(Cl)C(C)(C)C(C)(C)C(O)=O OXIWSCWSIBBUDO-UHFFFAOYSA-N 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical group C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- LDSLVJUAHMPZBB-UHFFFAOYSA-N 2-(diiodoamino)ethanesulfonic acid Chemical compound OS(=O)(=O)CCN(I)I LDSLVJUAHMPZBB-UHFFFAOYSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 231100001274 therapeutic index Toxicity 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49620703P | 2003-08-18 | 2003-08-18 | |
| US60/496,207 | 2003-08-18 | ||
| PCT/US2004/026603 WO2005020896A2 (en) | 2003-08-18 | 2004-08-17 | N,n-dihalogenated amino acids and derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502826A JP2007502826A (ja) | 2007-02-15 |
| JP2007502826A5 true JP2007502826A5 (enExample) | 2007-08-23 |
| JP4994033B2 JP4994033B2 (ja) | 2012-08-08 |
Family
ID=34272488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523970A Expired - Fee Related JP4994033B2 (ja) | 2003-08-18 | 2004-08-17 | Ｎ，ｎ−ジハロゲン化アミノ酸および誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7462361B2 (enExample) |
| EP (2) | EP2725008A1 (enExample) |
| JP (1) | JP4994033B2 (enExample) |
| KR (1) | KR101057609B1 (enExample) |
| CN (1) | CN1902158B (enExample) |
| AR (1) | AR047757A1 (enExample) |
| AU (1) | AU2004268546B2 (enExample) |
| BR (1) | BRPI0413660A (enExample) |
| CA (1) | CA2535926C (enExample) |
| DK (1) | DK1656095T3 (enExample) |
| ES (1) | ES2444845T3 (enExample) |
| IL (1) | IL173726A (enExample) |
| MX (1) | MXPA06001898A (enExample) |
| NZ (1) | NZ545654A (enExample) |
| PL (1) | PL1656095T3 (enExample) |
| PT (1) | PT1656095E (enExample) |
| SG (1) | SG149043A1 (enExample) |
| SI (1) | SI1656095T1 (enExample) |
| TW (1) | TWI376364B (enExample) |
| WO (1) | WO2005020896A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393522B2 (en) * | 2000-01-12 | 2008-07-01 | Novabay Pharmaceuticals, Inc. | Physiologically balanced, ionized, acidic solution and methodology for use in wound healing |
| JP5140218B2 (ja) | 2001-09-14 | 2013-02-06 | 有限会社コヒーレントテクノロジー | 表面洗浄・表面処理に適した帯電アノード水の製造用電解槽及びその製造法、並びに使用方法 |
| MXPA03007923A (es) | 2001-12-05 | 2005-02-17 | Micromed Lab Inc | Metodo y aparato para producir agua potencial oxidativa reductiva positiva y negativa. |
| CA2535926C (en) * | 2003-08-18 | 2012-10-09 | Novacal Pharmaceuticals, Inc. | N,n-dihalogenated amino acids and derivatives |
| US9168318B2 (en) | 2003-12-30 | 2015-10-27 | Oculus Innovative Sciences, Inc. | Oxidative reductive potential water solution and methods of using the same |
| TWI386201B (zh) * | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| CA2602522C (en) | 2005-03-23 | 2014-09-09 | Oculus Innovative Sciences, Inc. | Method of treating skin ulcers using oxidative reductive potential water solution |
| US9498548B2 (en) | 2005-05-02 | 2016-11-22 | Oculus Innovative Sciences, Inc. | Method of using oxidative reductive potential water solution in dental applications |
| JP2009511493A (ja) * | 2005-10-06 | 2009-03-19 | ノバベイ・ファーマシューティカルズ・インコーポレイテッド | Ｎ−ハロゲン化アミノ酸を使用する、尿路感染症（ｕｔｉ）を含む細菌感染症および真菌感染症の予防のためのシステムおよび方法 |
| JP5723084B2 (ja) | 2006-01-20 | 2015-05-27 | オキュラス イノヴェイティヴ サイエンシズ、インコーポレイテッド | 酸化還元電位水溶液を用いた副鼻腔炎の予防または治療方法 |
| US20070292489A1 (en) * | 2006-06-14 | 2007-12-20 | Mansour Bassiri | Method for treatment of wound treatment using aganocides |
| TW200843787A (en) | 2006-12-29 | 2008-11-16 | Novabay Pharmaceuticals Inc | N-halogenated amino compounds and derivatives; compositions and methods of using them |
| US20080288019A1 (en) * | 2007-01-31 | 2008-11-20 | Adam Heller | Electrochemical management of pain |
| UY31059A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado |
| UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
| UY31056A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Fromulaciones aminocido n-halogenado y metodos de limpieza y desinfeccion |
| UY31057A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado que contiene acido alifatico |
| US7524512B2 (en) * | 2007-07-13 | 2009-04-28 | Di Bartolomeo Joseph R | Composition and method for the prevention and relief of the symptoms of an incompetent or patulous Eustachian tube |
| UY31055A1 (es) * | 2008-02-01 | 2008-10-31 | Alcon Res Ltd | Sales antimicrobianas de aminoacido n-halogenado |
| EP2265267B1 (en) | 2008-04-10 | 2016-09-21 | Waldemar Gottardi | Compositions comprising n-halogenated or n, n-dihalogenated amine for treatment and prophylaxis of bronchopulmonary infections |
| US20110091570A1 (en) * | 2008-04-15 | 2011-04-21 | Waldemar Gottardi | Compositions and Devices for Antisepsis and Anticoagulation |
| AU2009281998A1 (en) * | 2008-08-12 | 2010-02-18 | Novabay Pharmaceuticals, Inc. | Antimicrobial gel formulations |
| JP5753785B2 (ja) * | 2008-11-07 | 2015-07-22 | ノバベイ・ファーマシューティカルズ・インコーポレイテッドＮｏｖａｂａｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 抗菌オキサゾリジノン、ヒダントインおよびイミダゾリジノン組成物 |
| EP2341886B1 (en) | 2008-11-07 | 2015-08-26 | NovaBay Pharmaceuticals, Inc. | Antimicrobial n-chlorinated compositions |
| WO2010091280A1 (en) | 2009-02-06 | 2010-08-12 | Alcon Research, Ltd. | N-halogenated amino acid formulations comprising phosphine or amine oxides |
| CA2756760A1 (en) * | 2009-03-27 | 2010-11-04 | Gojo Industries, Inc. | Compositions and methods for screening and using compounds antagonizing spore-surface interactions |
| WO2010124237A1 (en) * | 2009-04-24 | 2010-10-28 | Novabay Pharmaceuticals Inc. | Methods of treating infections of the nail |
| MX348304B (es) | 2009-06-15 | 2017-06-02 | Invekra S A P I De C V | Solucion que contiene acido hipocloroso y metodos para usar la misma. |
| BR112012019565A2 (pt) * | 2010-02-04 | 2016-08-16 | Novabay Pharmaceuticals Inc | formulações antimicrobianas com base em polissacarídeo |
| AU2011317223A1 (en) * | 2010-10-19 | 2013-05-23 | Novabay Pharmaceuticals, Inc. | Antimicrobial polyether and polyol compounds |
| WO2012157699A1 (ja) * | 2011-05-18 | 2012-11-22 | 味の素株式会社 | 動物用免疫賦活剤、それを含む飼料及びその製造方法 |
| US9642780B2 (en) | 2011-06-15 | 2017-05-09 | Rls Global Ab | Detection and removal of carious dentin tissue |
| US9028807B2 (en) | 2012-04-05 | 2015-05-12 | Ues, Inc. | Synthesis models for antimicrobial agents via the halogenation of organic/inorganic composites |
| SE536581C2 (sv) | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
| DK3469117T3 (da) | 2016-06-09 | 2022-02-28 | De Nora Holdings Us Inc | Elektrolytisk fremstilling af organiske chloraminopløsninger |
| US11172683B2 (en) * | 2018-01-30 | 2021-11-16 | Buckman Laboratories International, Inc. | Synergistic combinations of monochloramine and organic acid, and methods of using the same for microbial control |
| CN111116406B (zh) * | 2019-12-31 | 2020-12-25 | 吉林大学 | 一种能在物品表面形成杀菌涂层的卤胺及在物品表面形成杀菌涂层的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998945A (en) | 1972-06-12 | 1976-12-21 | National Patent Development Corporation | Dental treatment |
| US3950536A (en) * | 1974-02-01 | 1976-04-13 | Sol Joseph Barer | N,N-Dichloro substituted aminocarboxylic acids as bactericides and fungicides |
| US4015008A (en) * | 1974-02-01 | 1977-03-29 | National Patent Development Corporation | N,N-dichloro substituted aminocarboxylic acids as microbiocides |
| US3966796A (en) | 1974-06-14 | 1976-06-29 | Interx Research Corporation | N-chloro-amino acid derivatives activity |
| US4045578A (en) | 1974-06-14 | 1977-08-30 | Interx Research Corporation | N-chloro-amino acid derivatives exhibiting antibacterial activity |
| US4386103A (en) * | 1981-01-30 | 1983-05-31 | Merck & Co., Inc. | Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents |
| US5055492A (en) | 1985-06-14 | 1991-10-08 | Masonic Medical Research Laboratory | Method for affecting reproductive cycle of insects |
| US5096700A (en) | 1990-09-28 | 1992-03-17 | The Procter & Gamble Company | Halogenated aminohexanoates and aminobutyrates antimicrobial agents |
| DE4041703C2 (de) | 1990-12-24 | 1993-10-21 | Waldemar Dr Gottardi | Alkalimetallsalze des N-Chlortaurins in kristalliner Form, Verfahren zu deren Herstellung und deren Verwendung |
| JP3759757B2 (ja) | 1994-01-13 | 2006-03-29 | 相互薬工株式会社 | 殺菌剤 |
| US5593714A (en) * | 1994-12-06 | 1997-01-14 | Hirsch; Gerald P. | Method of pressure preservation of food products |
| US5753701A (en) | 1996-10-25 | 1998-05-19 | University Of Kentucky | N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters as novel safe agents for water disinfection |
| DE19712565A1 (de) | 1997-03-25 | 1998-10-01 | Thomas W Dr Stief | Arzneimittel auf der Basis eines Singulett-Sauerstoff erzeugenden Agenzes |
| DE19816102C1 (de) | 1998-04-10 | 1999-09-16 | Waldemar Gottardi | Verfahren zum Inaktivieren von Viren in Proteinlösungen, Verwendung von N-Chlortaurin in dem Verfahren sowie nach dem Verfahren hergestellte Proteinlösungen |
| CA2320556A1 (en) * | 1999-09-29 | 2001-03-29 | Queen's University At Kingston | N,n-dichlorinated omega amino acids and uses thereof |
| EP1239853B1 (de) | 2000-09-14 | 2006-11-08 | Waldemar Gottardi | Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen |
| FR2819723B1 (fr) | 2001-01-23 | 2006-11-17 | Arnaud Mainnemare | Composition halogene, son procede de preparation et ses utilisations |
| CA2535926C (en) | 2003-08-18 | 2012-10-09 | Novacal Pharmaceuticals, Inc. | N,n-dihalogenated amino acids and derivatives |
| US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| TWI386201B (zh) | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| TW200843787A (en) | 2006-12-29 | 2008-11-16 | Novabay Pharmaceuticals Inc | N-halogenated amino compounds and derivatives; compositions and methods of using them |
-
2004
- 2004-08-17 CA CA2535926A patent/CA2535926C/en not_active Expired - Fee Related
- 2004-08-17 SI SI200432128T patent/SI1656095T1/sl unknown
- 2004-08-17 JP JP2006523970A patent/JP4994033B2/ja not_active Expired - Fee Related
- 2004-08-17 DK DK04801985.5T patent/DK1656095T3/en active
- 2004-08-17 SG SG200809398-1A patent/SG149043A1/en unknown
- 2004-08-17 WO PCT/US2004/026603 patent/WO2005020896A2/en not_active Ceased
- 2004-08-17 BR BRPI0413660-8A patent/BRPI0413660A/pt not_active Application Discontinuation
- 2004-08-17 AU AU2004268546A patent/AU2004268546B2/en not_active Ceased
- 2004-08-17 MX MXPA06001898A patent/MXPA06001898A/es active IP Right Grant
- 2004-08-17 US US10/920,636 patent/US7462361B2/en active Active
- 2004-08-17 EP EP13189882.7A patent/EP2725008A1/en not_active Withdrawn
- 2004-08-17 EP EP04801985.5A patent/EP1656095B1/en not_active Expired - Lifetime
- 2004-08-17 PL PL04801985T patent/PL1656095T3/pl unknown
- 2004-08-17 ES ES04801985.5T patent/ES2444845T3/es not_active Expired - Lifetime
- 2004-08-17 CN CN2004800276919A patent/CN1902158B/zh not_active Expired - Lifetime
- 2004-08-17 KR KR1020067003300A patent/KR101057609B1/ko not_active Expired - Fee Related
- 2004-08-17 PT PT48019855T patent/PT1656095E/pt unknown
- 2004-08-17 NZ NZ545654A patent/NZ545654A/en not_active IP Right Cessation
- 2004-08-18 TW TW093124772A patent/TWI376364B/zh not_active IP Right Cessation
- 2004-08-18 AR ARP040102965A patent/AR047757A1/es unknown
-
2006
- 2006-02-14 IL IL173726A patent/IL173726A/en not_active IP Right Cessation
-
2008
- 2008-09-11 US US12/209,002 patent/US7893109B2/en not_active Expired - Lifetime
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