JP2007502124A - 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド - Google Patents

改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド Download PDF

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JP2007502124A
JP2007502124A JP2006523448A JP2006523448A JP2007502124A JP 2007502124 A JP2007502124 A JP 2007502124A JP 2006523448 A JP2006523448 A JP 2006523448A JP 2006523448 A JP2006523448 A JP 2006523448A JP 2007502124 A JP2007502124 A JP 2007502124A
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seq
kred
polypeptide
sequence
kred polypeptide
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JP2007502124A5 (enExample
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エス. クリストファー デービス,
ステファーヌ ジェイ. ジェンヌ,
アンケ クレベル,
ジャルト ダブリュー. ユイスマン,
リサ マリー ニューマン,
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コデクシス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

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  • Enzymes And Modification Thereof (AREA)
JP2006523448A 2003-08-11 2004-08-11 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド Pending JP2007502124A (ja)

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US49419503P 2003-08-11 2003-08-11
US54568204P 2004-02-18 2004-02-18
PCT/US2004/026655 WO2005017135A1 (en) 2003-08-11 2004-08-11 Improved ketoreductase polypeptides and related polynucleotides

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US (2) US7629157B2 (enExample)
EP (1) EP1654354A1 (enExample)
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CA (1) CA2533838A1 (enExample)
IL (1) IL173191A (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539952A (ja) * 2007-10-01 2010-12-24 コデクシス, インコーポレイテッド アゼチジノンの生産のためのケトレダクターゼポリペプチド
WO2011145211A1 (ja) * 2010-05-21 2011-11-24 明治製菓株式会社 ケトレダクターゼ変異体
JP2022536500A (ja) * 2019-06-13 2022-08-17 アシムケム ラボラトリーズ (ティエンジン) カンパニー リミテッド ケトレダクターゼ突然変異体及びキラルアルコールの生産方法

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
BRPI0413498A (pt) 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
EP1908845A4 (en) * 2005-07-20 2010-10-06 Kaneka Corp PROCESS FOR THE PRODUCTION OF 2- (AMINOMETHYL-N-SUBSTITUTED) 3-HYDROXYBUTYRIC ACID L ESTER WITH OPTICAL ACTIVITY
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
WO2008100251A1 (en) 2007-02-13 2008-08-21 Ls9, Inc. Modified microorganism uses therefor
DE102006010994A1 (de) * 2006-03-09 2007-09-13 Wacker Chemie Ag Verfahren zur enzymatischen Herstellung von chiralen Alkoholen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
EP2194119A3 (en) 2006-05-19 2010-09-22 LS9, Inc. Production of fatty acids and derivatives thereof
KR20090083900A (ko) 2006-10-02 2009-08-04 코덱시스, 인코포레이티드 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법
WO2008103248A1 (en) * 2007-02-08 2008-08-28 Codexis, Inc. Ketoreductases and uses thereof
CA3035878C (en) 2007-03-28 2023-01-03 REG Life Sciences, LLC Enhanced production of fatty acid derivatives
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
US8748143B2 (en) 2007-09-13 2014-06-10 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
WO2009042984A1 (en) 2007-09-28 2009-04-02 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2009045507A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Processes for preparing an intermediate of sitagliptin via enzymatic reduction
EP2285948B1 (en) 2008-03-03 2014-01-08 Joule Unlimited Technologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
CN102066561B (zh) 2008-06-13 2013-09-25 科德克希思公司 合成多核苷酸变体的方法
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
ES2438576T3 (es) 2008-06-24 2014-01-17 Codexis, Inc. Procesos biocatalíticos para la preparación de compuestos de prolina bicíclica fusionada considerablemente pura estereoméricamente
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
EP2329014B1 (en) 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
BRPI0914440A8 (pt) 2008-10-17 2016-01-19 Joule Unlimited Inc Método para produção biogênica de etanol e cianobactéria geneticamente modificada
CN102325864B (zh) 2008-12-23 2016-01-27 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
DK3354727T3 (da) 2009-01-08 2020-11-16 Codexis Inc Transaminasepolypeptider
EP2401369B1 (en) 2009-02-26 2014-12-24 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
WO2010099501A2 (en) 2009-02-26 2010-09-02 Codexis, Inc. Transaminase biocatalysts
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
WO2010107644A2 (en) 2009-03-17 2010-09-23 Codexis, Inc. Variant endoglucanases and related polynucleotides
BRPI1015313B1 (pt) 2009-04-27 2021-06-01 Genomatica, Inc. Método fermentativo para produzir um éster de ácido graxo empregando um microorganismo geneticamente modificado e método para a produção de ésteres de ácidos graxos
WO2010135624A2 (en) 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
DK3409765T3 (da) 2009-06-22 2021-09-27 Codexis Inc Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer
CN102471781B (zh) 2009-06-30 2015-03-18 科德克希思公司 以脂肪醇形成酰基CoA还原酶(FAR)产生脂肪醇
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
DK2478137T3 (da) 2009-09-18 2017-11-27 Codexis Inc Reduceret kodonmutagenese
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
US8895271B2 (en) 2009-12-08 2014-11-25 Codexis, Inc. Synthesis of prazole compounds
US8715962B2 (en) 2010-03-31 2014-05-06 Codexis, Inc. Production of geranyl diphosphate
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
HUE038434T2 (hu) * 2010-06-17 2018-10-29 Codexis Inc Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
US8574878B2 (en) 2010-06-28 2013-11-05 Behnaz Behrouzian Fatty alcohol forming acyl reductases (FARs) and methods of use thereof
WO2012024100A2 (en) 2010-08-16 2012-02-23 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
US9322027B2 (en) 2010-08-20 2016-04-26 Shell Oil Company Expression constructs comprising fungal promoters
WO2012031072A1 (en) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031073A1 (en) * 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
JP5933557B2 (ja) * 2010-09-14 2016-06-15 カウンスル オブ サイエンティフィック アンド インダストリアル リサーチ 高流束中空繊維限外濾過膜及びその調製方法
WO2012046254A2 (en) * 2010-10-08 2012-04-12 Cadila Healthcare Limited Process for preparing an intermediate of sitagliptin via enzymatic conversion
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
EP2726651B1 (en) 2011-06-28 2018-11-07 Codexis, Inc. Protein variant generation by region shuffling
US9109209B2 (en) 2011-09-08 2015-08-18 Codexis, Inc. Biocatalysts and methods for the synthesis of substituted lactams
KR20140091700A (ko) 2011-10-19 2014-07-22 시플라 리미티드 엔도텔린 수용체 길항제의 제조방법
WO2013074650A1 (en) 2011-11-18 2013-05-23 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
EP2794893A4 (en) 2011-12-20 2015-08-12 Codexis Inc PRODUCTION OF SATURATED FATTY ALCOHOLS FROM GENETICALLY MODIFIED MICROORGANISMS
US9139821B2 (en) 2012-03-23 2015-09-22 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
HRP20191632T1 (hr) 2012-03-23 2019-12-13 Novartis Ag Kemijski postupak dobivanja spiroindolona i njihovih međuprodukata
US20150133698A1 (en) 2012-04-20 2015-05-14 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
CN104428412B (zh) 2012-05-08 2017-09-08 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
CN107904216B (zh) 2012-05-11 2021-06-29 科德克希思公司 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法
US9650655B2 (en) 2012-07-20 2017-05-16 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
WO2014093070A1 (en) 2012-12-14 2014-06-19 Codexis, Inc. Modified native beta-ketoacyl-acp synthases and engineered microorganisms
EP2935572B1 (en) 2012-12-21 2020-09-30 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines
WO2014113521A1 (en) 2013-01-18 2014-07-24 Codexis, Inc. Engineered biocatalysts useful for carbapenem synthesis
CN115927231A (zh) 2013-02-28 2023-04-07 科德克希思公司 用于工业生物催化的工程化转氨酶多肽
EP2970927A4 (en) 2013-03-15 2016-10-12 Merck Sharp & Dohme IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES
KR101876172B1 (ko) * 2013-04-17 2018-07-10 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 케톤의 거울상 이성질체 선택적 환원을 위한 디자이너 세포 및 거울상 이성질체 풍부한 알콜의 효율적인 생산에서의 이의 용도
DK3068793T3 (da) 2013-11-13 2021-03-22 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
US9133488B2 (en) 2013-12-30 2015-09-15 University Of Alaska Fairbanks Synthetic methods and compounds related thereto
ES2686695T3 (es) 2014-04-22 2018-10-19 C-Lecta Gmbh Cetorreductasas
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104659287B (zh) * 2015-03-12 2017-05-31 京东方科技集团股份有限公司 像素界定层及制备方法、显示基板及制备方法、显示装置
CA2983620A1 (en) 2015-05-07 2016-11-10 Codexis, Inc. Penicillin-g acylases
CA3021009A1 (en) 2016-05-05 2017-11-09 Codexis, Inc. Penicillin-g acylases
US10184117B2 (en) 2016-06-09 2019-01-22 Codexis, Inc. Biocatalysts and methods for hydroxylation of chemical compounds
WO2017218325A1 (en) 2016-06-15 2017-12-21 Codexis, Inc. Engineered beta-glucosidases and glucosylation methods
EP3515926B1 (en) 2016-08-26 2023-10-25 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US10745681B2 (en) 2017-01-05 2020-08-18 Codexis, Inc. Penicillin-G acylases
SG11201906480QA (en) 2017-02-03 2019-08-27 Codexis Inc Engineered glycosyltransferases and steviol glycoside glucosylation methods
US11021729B2 (en) 2017-04-27 2021-06-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
PL3635101T3 (pl) 2017-05-08 2021-12-13 Codexis, Inc. Poddane inżynierii warianty ligazy
CA3064574A1 (en) 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
CN111051506B (zh) 2017-06-27 2023-11-24 科德克希思公司 青霉素g酰化酶
CN111417724A (zh) 2017-06-30 2020-07-14 科德克希思公司 T7 rna聚合酶变体
CN111032863B (zh) 2017-06-30 2024-10-22 科德克希思公司 T7 rna聚合酶变体
WO2019012095A1 (en) * 2017-07-14 2019-01-17 C-Lecta Gmbh TCO-reductase
SG11202003094PA (en) 2017-11-07 2020-05-28 Codexis Inc Transglutaminase variants
US11015180B2 (en) 2017-12-13 2021-05-25 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
ES3018269T3 (en) 2017-12-13 2025-05-14 Glaxosmithkline Ip Dev Ltd Carboxyesterase biocatalysts
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
WO2020014048A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered deoxyribose-phosphate aldolases
WO2020016749A2 (en) 2018-07-16 2020-01-23 Novartis Ag Chemical process for preparing phenylpiperidinyl indole derivatives
EP3830106A4 (en) 2018-07-30 2022-07-06 Codexis, Inc. MANIPULATED GLYCOSYLTRANSFERASES AND METHODS FOR STEVIOL GLYCOSIDE GLUCOSYLATION
US10961550B2 (en) 2018-09-26 2021-03-30 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CN113286876A (zh) * 2018-10-26 2021-08-20 T·巴尔 用于生物降解酒精的组合物和方法
IL282456B2 (en) 2018-10-29 2025-07-01 Codexis Inc Engineered dna polymerase variants
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
US12215359B2 (en) 2019-05-01 2025-02-04 Codexis, Inc. Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds
EP3963057A4 (en) 2019-05-01 2023-06-14 Codexis, Inc. MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
CA3142636A1 (en) 2019-07-02 2021-01-07 Codexis, Inc. Engineered sucrose phosphorylase variant enzymes
EP4501403A3 (en) 2019-08-30 2025-05-14 Société des Produits Nestlé S.A. Engineered lipase variants
CA3149870A1 (en) 2019-09-12 2021-03-18 Codexis, Inc. Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine
CN114729374B (zh) * 2019-11-22 2024-12-17 株式会社Api 羰基还原酶、编码该酶的核酸、以及利用它们的光学活性化合物的制造方法
IL293038A (en) 2019-11-26 2022-07-01 Codexis Inc Biocatalysts and methods for hydroxylation of chemical compounds
CA3168922A1 (en) 2020-02-04 2021-08-12 Codexis, Inc. Engineered leucine decarboxylases
WO2021207200A2 (en) 2020-04-10 2021-10-14 Codexis, Inc. Engineered transaminase polypeptides
US11959108B2 (en) 2020-08-28 2024-04-16 Codexis, Inc. Engineered protease variants
KR20230145027A (ko) 2020-08-28 2023-10-17 코덱시스, 인코포레이티드 조작된 아밀라제 변이체
WO2022066155A1 (en) 2020-09-24 2022-03-31 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CN112410276B (zh) * 2020-11-27 2023-03-21 江苏阿尔法药业股份有限公司 一种2-氯-1-(3,4-二氟苯基)乙酮还原酶重组菌株及构建方法和应用
US11898174B2 (en) 2020-12-18 2024-02-13 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
US12110521B2 (en) 2021-05-21 2024-10-08 Syntis Bio, Inc. Engineered methionine gamma lyase variants
CN117813376A (zh) * 2021-08-13 2024-04-02 科德克希思公司 工程化核苷脱氧核糖基转移酶变体酶
JP2024539636A (ja) 2021-10-15 2024-10-29 コデクシス, インコーポレイテッド 操作されたdnaポリメラーゼバリアント
CA3265252A1 (en) 2022-08-26 2024-02-29 Tesaro Inc BIOCATALYSTS AND ASSOCIATED PROCESSES
AR131406A1 (es) 2022-12-20 2025-03-19 Novartis Ag Método de ligación de ácidos nucleicos
AR131405A1 (es) 2022-12-20 2025-03-19 Novartis Ag Ligasas modificadas y usos de las mismas
WO2024150146A1 (en) 2023-01-12 2024-07-18 Novartis Ag Engineered ketoreductase polypeptides
WO2025235589A1 (en) 2024-05-08 2025-11-13 Codexis, Inc. Dna polymerase variants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035025A1 (en) * 1997-02-07 1998-08-13 Kaneka Corporation Novel carbonyl reductase, gene that encodes the same, and method of utilizing these
WO1999023242A1 (en) * 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
WO2003004653A1 (en) * 2001-07-02 2003-01-16 Kaneka Corporation Method of modifying enzyme and oxidoreductase variant

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US6531308B2 (en) * 1997-11-04 2003-03-11 Eli Lilly And Company Ketoreductase gene and protein from yeast
DK1054860T3 (da) 1997-12-19 2007-07-02 Pfizer Ireland Pharmaceuticals Proces for syntesen af 1,3-dioler
US6344569B1 (en) 1998-04-30 2002-02-05 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
ATE375989T1 (de) 1998-08-05 2007-11-15 Kaneka Corp Verfahren zur herstellung von 3,5-dihydroxy substituierten estern als zwischenprodukte zur herstellung optisch aktiver 2-(6-(hydroxymethyl)- 1,3-dioxan-4-yl)-essigsäure-derivate
CA2349181A1 (en) 1998-11-12 2000-05-18 Larry Kirn Multi-reference, high-accuracy switching amplifier
WO2001004336A1 (de) 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
HUP0105331A3 (en) 1999-12-03 2005-10-28 Kaneka Corp Novel carbonyl reductase, gene thereof and method of using the same
US6492868B2 (en) 2000-08-14 2002-12-10 Larry Kirn Dynamic range enhancement technique
DE60315958D1 (de) 2002-03-18 2007-10-11 Biocatalytics Inc Alkohol-dehydrogenase mit hoher stabilität gegenüber lösungsmittel und temperatur
AU2003258187A1 (en) 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
BRPI0413498A (pt) * 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
DE102004029112B4 (de) 2004-06-11 2007-06-21 Julich Chiral Solutions Gmbh Alkoholdehydrogenase zur stereoselektiven Gewinnung von Hydroxyverbindungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035025A1 (en) * 1997-02-07 1998-08-13 Kaneka Corporation Novel carbonyl reductase, gene that encodes the same, and method of utilizing these
WO1999023242A1 (en) * 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
WO2003004653A1 (en) * 2001-07-02 2003-01-16 Kaneka Corporation Method of modifying enzyme and oxidoreductase variant

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539952A (ja) * 2007-10-01 2010-12-24 コデクシス, インコーポレイテッド アゼチジノンの生産のためのケトレダクターゼポリペプチド
WO2011145211A1 (ja) * 2010-05-21 2011-11-24 明治製菓株式会社 ケトレダクターゼ変異体
US8697409B2 (en) 2010-05-21 2014-04-15 Meiji Seika Pharma Co., Ltd. Ketoreductase mutant
JP2022536500A (ja) * 2019-06-13 2022-08-17 アシムケム ラボラトリーズ (ティエンジン) カンパニー リミテッド ケトレダクターゼ突然変異体及びキラルアルコールの生産方法
JP7375052B2 (ja) 2019-06-13 2023-11-07 アシムケム ラボラトリーズ (ティエンジン) カンパニー リミテッド ケトレダクターゼ突然変異体及びキラルアルコールの生産方法
US12173345B2 (en) 2019-06-13 2024-12-24 Asymchem Laboratories (Tianjin) Co., Ltd. Ketoreductase mutant and method for producing chiral alcohols

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WO2005017135A1 (en) 2005-02-24
US20100028972A1 (en) 2010-02-04
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US7629157B2 (en) 2009-12-08
WO2005017135A8 (en) 2012-06-14

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