IL173191A - Ketoreductase polypeptides and related polynucleotides - Google Patents

Ketoreductase polypeptides and related polynucleotides

Info

Publication number
IL173191A
IL173191A IL173191A IL17319106A IL173191A IL 173191 A IL173191 A IL 173191A IL 173191 A IL173191 A IL 173191A IL 17319106 A IL17319106 A IL 17319106A IL 173191 A IL173191 A IL 173191A
Authority
IL
Israel
Prior art keywords
related polynucleotides
ketoreductase polypeptides
ketoreductase
polypeptides
polynucleotides
Prior art date
Application number
IL173191A
Other languages
English (en)
Other versions
IL173191A0 (en
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IL173191A0 publication Critical patent/IL173191A0/en
Publication of IL173191A publication Critical patent/IL173191A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL173191A 2003-08-11 2006-01-17 Ketoreductase polypeptides and related polynucleotides IL173191A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49419503P 2003-08-11 2003-08-11
US54568204P 2004-02-18 2004-02-18
PCT/US2004/026655 WO2005017135A1 (en) 2003-08-11 2004-08-11 Improved ketoreductase polypeptides and related polynucleotides

Publications (2)

Publication Number Publication Date
IL173191A0 IL173191A0 (en) 2006-06-11
IL173191A true IL173191A (en) 2010-12-30

Family

ID=34197992

Family Applications (1)

Application Number Title Priority Date Filing Date
IL173191A IL173191A (en) 2003-08-11 2006-01-17 Ketoreductase polypeptides and related polynucleotides

Country Status (6)

Country Link
US (2) US7629157B2 (enExample)
EP (1) EP1654354A1 (enExample)
JP (1) JP2007502124A (enExample)
CA (1) CA2533838A1 (enExample)
IL (1) IL173191A (enExample)
WO (1) WO2005017135A1 (enExample)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1537222B1 (en) 2002-08-09 2011-03-09 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
US7132267B2 (en) 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
JP5090910B2 (ja) * 2005-07-20 2012-12-05 株式会社カネカ 光学活性２−（ｎ−置換アミノメチル）−３−ヒドロキシ酪酸エステル類の製造方法
AT502395B1 (de) * 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
WO2008100251A1 (en) 2007-02-13 2008-08-21 Ls9, Inc. Modified microorganism uses therefor
DE102006010994A1 (de) * 2006-03-09 2007-09-13 Wacker Chemie Ag Verfahren zur enzymatischen Herstellung von chiralen Alkoholen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
WO2007136762A2 (en) 2006-05-19 2007-11-29 Ls9, Inc. Production of fatty acids and derivatives thereof
EP2066788B1 (en) * 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
WO2008103248A1 (en) * 2007-02-08 2008-08-28 Codexis, Inc. Ketoreductases and uses thereof
CN106987532B (zh) 2007-03-28 2021-06-08 基因组股份公司 提高脂肪酸衍生物的产量
WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
KR101586503B1 (ko) 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
WO2009042984A1 (en) 2007-09-28 2009-04-02 Codexis, Inc. Ketoreductase polypeptides and uses thereof
KR20100065387A (ko) * 2007-10-01 2010-06-16 코덱시스, 인코포레이티드 아제티디논 제조를 위한 케토리덕타제 폴리펩티드
TW200936764A (en) * 2007-10-03 2009-09-01 Teva Pharma Processes for preparing an intermediate of sitagliptin via enzymatic reduction
EP2706111A1 (en) 2008-03-03 2014-03-12 Joule Unlimited Technologies, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
HUE041367T2 (hu) 2008-06-13 2019-05-28 Codexis Inc Eljárás polinukleotid-változatok szintézisére
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
EP2307419B1 (en) 2008-06-24 2013-11-06 Codexis, Inc. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010027710A2 (en) * 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
SI2329014T1 (sl) 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
CN103725717A (zh) 2008-10-17 2014-04-16 焦耳无限科技公司 微生物的乙醇生产
CA2747516C (en) 2008-12-23 2019-11-05 Ls9, Inc. Methods and compositions related to thioesterase enzymes
CN102341494B (zh) 2009-01-08 2014-10-15 科德克希思公司 转氨酶多肽
US8293507B2 (en) 2009-02-26 2012-10-23 Codexis, Inc. Transaminase biocatalysts
CA2752818A1 (en) 2009-02-26 2010-09-02 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
EP2408908B1 (en) 2009-03-17 2015-05-27 Codexis, Inc. Variant endoglucanases and related polynucleotides
BRPI1015313B1 (pt) 2009-04-27 2021-06-01 Genomatica, Inc. Método fermentativo para produzir um éster de ácido graxo empregando um microorganismo geneticamente modificado e método para a produção de ésteres de ácidos graxos
BRPI1010920B1 (pt) 2009-05-22 2020-04-28 Codexis Inc processo para a produção biológica de álcoois graxos
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
WO2011005527A2 (en) 2009-06-22 2011-01-13 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
RU2012102900A (ru) 2009-06-30 2013-08-10 Кодексис, Инк. Получение жирных спиртов с помощью образующих жирные спирты ацил-коа-редуктаз (fаr)
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
DK2478137T3 (da) 2009-09-18 2017-11-27 Codexis Inc Reduceret kodonmutagenese
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
US8986965B2 (en) 2010-03-31 2015-03-24 Codexis, Inc. Production of monoterpenes
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
US8697409B2 (en) 2010-05-21 2014-04-15 Meiji Seika Pharma Co., Ltd. Ketoreductase mutant
HUE038434T2 (hu) * 2010-06-17 2018-10-29 Codexis Inc Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
CA2804019A1 (en) 2010-06-28 2012-01-12 Codexis, Inc. Fatty alcohol forming acyl reductases (fars) and methods of use thereof
WO2012024100A2 (en) 2010-08-16 2012-02-23 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
WO2012024104A2 (en) 2010-08-16 2012-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
WO2012024662A2 (en) 2010-08-20 2012-02-23 Codexis, Inc. Expression constructs comprising fungal promoters
WO2012031073A1 (en) * 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031072A1 (en) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
JP5933557B2 (ja) * 2010-09-14 2016-06-15 カウンスル オブ サイエンティフィック アンド インダストリアル リサーチ 高流束中空繊維限外濾過膜及びその調製方法
CN103228658A (zh) * 2010-10-08 2013-07-31 卡迪拉保健有限公司 用于通过酶促转化制备西他列汀的中间体的方法
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
EP2726651B1 (en) 2011-06-28 2018-11-07 Codexis, Inc. Protein variant generation by region shuffling
US9109209B2 (en) 2011-09-08 2015-08-18 Codexis, Inc. Biocatalysts and methods for the synthesis of substituted lactams
AU2012324612A1 (en) * 2011-10-19 2014-05-15 Cipla Limited Process for the preparation of an endothelin receptor antagonist
CN104053771B (zh) 2011-11-18 2016-11-09 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
WO2013096082A1 (en) 2011-12-20 2013-06-27 Codexis, Inc. Fatty alcohol forming acyl reductase (far) variants and methods of use
SI2828256T1 (sl) 2012-03-23 2019-11-29 Novartis Ag Kemijski postopek za pripravo spiroindolonov in njihovih vmesnih spojin
DK2828385T3 (en) 2012-03-23 2018-03-12 Codexis Inc BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
WO2013159055A1 (en) 2012-04-20 2013-10-24 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
ES2712682T3 (es) 2012-05-08 2019-05-14 Codexis Inc Biocatalizadores y métodos para la hidroxilación de compuestos químicos
DK2847214T3 (en) 2012-05-11 2018-03-12 Codexis Inc CONSTRUCTED IMINE REDUCTIONS AND PROCEDURES FOR THE REDUCED AMINING OF KETON AND AMINE COMPOUNDS
WO2014015278A1 (en) 2012-07-20 2014-01-23 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
WO2014093070A1 (en) 2012-12-14 2014-06-19 Codexis, Inc. Modified native beta-ketoacyl-acp synthases and engineered microorganisms
EP2935572B1 (en) 2012-12-21 2020-09-30 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines
US9540622B2 (en) 2013-01-18 2017-01-10 Codexis, Inc. Engineered biocatalysts useful for carbapenem synthesis
CN105164263B (zh) 2013-02-28 2022-07-01 科德克希思公司 用于工业生物催化的工程化转氨酶多肽
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
JP6330028B2 (ja) * 2013-04-17 2018-05-23 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ ケトンのエナンチオ選択性還元のためのデザイナー細胞及びエナンチオ濃縮アルコールの効率的製造におけるその使用
DK3068793T3 (da) 2013-11-13 2021-03-22 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
US9133488B2 (en) 2013-12-30 2015-09-15 University Of Alaska Fairbanks Synthetic methods and compounds related thereto
CN121203988A (zh) 2014-04-22 2025-12-26 C-乐克塔股份有限公司 酮还原酶
EP3256577B1 (en) 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104659287B (zh) * 2015-03-12 2017-05-31 京东方科技集团股份有限公司 像素界定层及制备方法、显示基板及制备方法、显示装置
HUE053863T2 (hu) 2015-05-07 2021-07-28 Codexis Inc Penicillin-G acilázok
MX389364B (es) 2016-05-05 2025-03-19 Codexis Inc Penicilina g acilasas
WO2017213758A1 (en) 2016-06-09 2017-12-14 Codexis, Inc. Biocatalysts and methods for hydroxylation of chemical compounds
JP2019517801A (ja) 2016-06-15 2019-06-27 コデクシス， インコーポレイテッド 操作されたβ−グルコシダーゼおよびグルコシル化方法
US11046936B2 (en) 2016-08-26 2021-06-29 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
MX2019008096A (es) 2017-01-05 2019-09-04 Codexis Inc Penicilina g acilasas.
KR102606350B1 (ko) 2017-02-03 2023-11-23 코덱시스, 인코포레이티드 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
CA3061133A1 (en) 2017-04-27 2018-11-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
JP7401902B2 (ja) 2017-05-08 2023-12-20 コデクシス， インコーポレイテッド 遺伝子操作されたリガーゼバリアント
CA3064574A1 (en) 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
EP3645713A4 (en) 2017-06-27 2021-06-30 Codexis, Inc. PENICILLIN-G ACYLASES
JP7588391B2 (ja) 2017-06-30 2024-11-22 コデクシス， インコーポレイテッド Ｔ７ ｒｎａポリメラーゼバリアント
AU2018292104B2 (en) 2017-06-30 2025-03-27 Codexis, Inc. T7 RNA polymerase variants
WO2019012095A1 (en) 2017-07-14 2019-01-17 C-Lecta Gmbh TCO-reductase
EP3706780A4 (en) 2017-11-07 2021-12-22 Codexis, Inc. TRANSGLUTAMINASE VARIANTS
SG11202004185PA (en) 2017-12-13 2020-06-29 Codexis Inc Carboxyesterase polypeptides for amide coupling
CA3085261A1 (en) 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Carboxyesterase biocatalysts
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
AU2019300836B2 (en) 2018-07-09 2025-09-04 Codexis, Inc. Engineered deoxyribose-phosphate aldolases
CN112513025B (zh) 2018-07-16 2025-03-25 诺华股份有限公司 用于制备苯基哌啶基吲哚衍生物的化学方法
IL319918A (en) 2018-07-30 2025-05-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside
JP7261874B2 (ja) 2018-09-26 2023-04-20 カラマズー・ホールディングス・インコーポレイテッド 変性されたホップ生成物の製造のための酵素的方法
WO2020084621A1 (en) * 2018-10-26 2020-04-30 Tami Bar Compositions and methods for biodegrading alcohol
EP3874033A4 (en) 2018-10-29 2022-08-03 Codexis, Inc. ENGINEERED DNA POLYMERASE VARIANTS
EP3893860A4 (en) 2018-12-14 2023-03-29 Codexis, Inc. ENGINEERED TYROSINE AMMONIA LYASE
EP3911738A4 (en) 2019-01-15 2023-03-01 Codexis, Inc. MODIFIED TRANSAMINASE POLYPEPTIDES
CN114127272B (zh) 2019-05-01 2025-05-27 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
JP7677630B2 (ja) 2019-05-01 2025-05-15 コデクシス， インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP7375052B2 (ja) * 2019-06-13 2023-11-07 アシムケム ラボラトリーズ （ティエンジン） カンパニー リミテッド ケトレダクターゼ突然変異体及びキラルアルコールの生産方法
KR20220028053A (ko) 2019-07-02 2022-03-08 코덱시스, 인코포레이티드 조작된 수크로스 포스포릴라제 변이체 효소
MX2022002473A (es) 2019-08-30 2022-08-02 Codexis Inc Variantes de lipasa modificadas geneticamente.
EP4027969A4 (en) 2019-09-12 2023-09-27 Codexis, Inc. PEROXIDASE ACTIVITY TOWARDS 10-ACETYL -3,7-DIHYDROXYPHENOXAZINE
WO2021100848A1 (ja) * 2019-11-22 2021-05-27 株式会社エーピーアイ コーポレーション カルボニル還元酵素、これをコードする核酸、及びこれらを利用した光学活性化合物の製造方法
JP7720098B2 (ja) 2019-11-26 2025-08-07 コデクシス， インコーポレイテッド 化合物のヒドロキシル化のための生体触媒および方法
AU2021216389A1 (en) 2020-02-04 2022-08-11 Syntis Bio, Inc. Engineered leucine decarboxylases
US11788071B2 (en) 2020-04-10 2023-10-17 Codexis, Inc. Engineered transaminase polypeptides
US11959108B2 (en) 2020-08-28 2024-04-16 Codexis, Inc. Engineered protease variants
JP2023539634A (ja) 2020-08-28 2023-09-15 コデクシス， インコーポレイテッド 操作されたアミラーゼバリアント
WO2022066155A1 (en) 2020-09-24 2022-03-31 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CN112410276B (zh) * 2020-11-27 2023-03-21 江苏阿尔法药业股份有限公司 一种2-氯-1-(3,4-二氟苯基)乙酮还原酶重组菌株及构建方法和应用
JP2024500102A (ja) 2020-12-18 2024-01-04 コデクシス， インコーポレイテッド 操作されたウリジンホスホリラーゼ改変体酵素
CA3220735A1 (en) 2021-05-21 2022-11-24 Codexis, Inc. Engineered methionine gamma lyase variants
KR20240045297A (ko) * 2021-08-13 2024-04-05 코덱시스, 인코포레이티드 조작된 뉴클레오시드 데옥시리보실트랜스퍼라제 변이체 효소
CN118103501A (zh) 2021-10-15 2024-05-28 科德克希思公司 工程化dna聚合酶变体
CA3236731A1 (en) 2021-11-01 2023-05-04 Jonathan Benjamin ASFAHA Engineered leucine decarboxylases
JP2025527748A (ja) 2022-08-26 2025-08-22 テサロ， インコーポレイテッド 生体触媒およびその方法
AR131406A1 (es) 2022-12-20 2025-03-19 Novartis Ag Método de ligación de ácidos nucleicos
AR131405A1 (es) 2022-12-20 2025-03-19 Novartis Ag Ligasas modificadas y usos de las mismas
EP4649143A1 (en) 2023-01-12 2025-11-19 Novartis AG Engineered ketoreductase polypeptides
WO2025235589A1 (en) 2024-05-08 2025-11-13 Codexis, Inc. Dna polymerase variants

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
DE69731317T2 (de) * 1997-02-07 2006-02-23 Kaneka Corp. Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung
WO1999023242A1 (en) * 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
US6531308B2 (en) * 1997-11-04 2003-03-11 Eli Lilly And Company Ketoreductase gene and protein from yeast
WO1999032434A1 (en) * 1997-12-19 1999-07-01 Warner-Lambert Export Limited Process for the synthesis of 1,3-diols
DE69910562T2 (de) * 1998-04-30 2004-06-17 Kaneka Corp. Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
CA2305564C (en) * 1998-08-05 2008-06-17 Kaneka Corporation Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
JP4707233B2 (ja) * 1998-11-12 2011-06-22 ジェイエム エレクトロニクス リミテッド エルエルシー 多重基準、高精度スイッチング増幅器
WO2001004336A1 (de) * 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
JP4510351B2 (ja) * 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
US6492868B2 (en) * 2000-08-14 2002-12-10 Larry Kirn Dynamic range enhancement technique
EP1416050A4 (en) 2001-07-02 2004-12-22 Kaneka Corp METHOD FOR ENZYME MODIFICATION AND OXIDOREEDUCTASE VARIANT
CA2474905A1 (en) 2002-03-18 2003-09-25 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with high solvent and temperature stability
EP1537222B1 (en) * 2002-08-09 2011-03-09 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
US7132267B2 (en) * 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
DE102004029112B4 (de) 2004-06-11 2007-06-21 Julich Chiral Solutions Gmbh Alkoholdehydrogenase zur stereoselektiven Gewinnung von Hydroxyverbindungen

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WO2005017135A8 (en) 2012-06-14
EP1654354A1 (en) 2006-05-10
CA2533838A1 (en) 2005-02-24
US7833767B2 (en) 2010-11-16
WO2005017135A1 (en) 2005-02-24
JP2007502124A (ja) 2007-02-08
US20100028972A1 (en) 2010-02-04
US20060195947A1 (en) 2006-08-31
IL173191A0 (en) 2006-06-11

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