JP2007502102A5 - - Google Patents
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- Publication number
- JP2007502102A5 JP2007502102A5 JP2006522868A JP2006522868A JP2007502102A5 JP 2007502102 A5 JP2007502102 A5 JP 2007502102A5 JP 2006522868 A JP2006522868 A JP 2006522868A JP 2006522868 A JP2006522868 A JP 2006522868A JP 2007502102 A5 JP2007502102 A5 JP 2007502102A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- microorganism
- vitamin
- polypeptide
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 28
- 102000040430 polynucleotide Human genes 0.000 claims 18
- 108091033319 polynucleotide Proteins 0.000 claims 18
- 239000002157 polynucleotide Substances 0.000 claims 18
- 244000005700 microbiome Species 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 10
- 229930003268 Vitamin C Natural products 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000011718 vitamin C Substances 0.000 claims 10
- 235000019154 vitamin C Nutrition 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 239000000758 substrate Substances 0.000 claims 9
- 239000002609 medium Substances 0.000 claims 7
- 108010053002 L-sorbosone dehydrogenase Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000002211 L-ascorbic acid Substances 0.000 claims 4
- 235000000069 L-ascorbic acid Nutrition 0.000 claims 4
- 229960005070 ascorbic acid Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000000284 resting effect Effects 0.000 claims 4
- 241000589220 Acetobacter Species 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 claims 3
- DCNMIDLYWOTSGK-KVQBGUIXSA-N L-xylo-hexos-2-ulose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C=O DCNMIDLYWOTSGK-KVQBGUIXSA-N 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 229960002920 sorbitol Drugs 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000588722 Escherichia Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- VBUYCZFBVCCYFD-JJYYJPOSSA-M 2-dehydro-D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)C([O-])=O VBUYCZFBVCCYFD-JJYYJPOSSA-M 0.000 claims 1
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 claims 1
- -1 2-keto-L-gronate Chemical compound 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- 241000589236 Gluconobacter Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000235017 Zygosaccharomyces Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- RKFLKNFLAJISPF-OGXRZFKVSA-L calcium;(3s,4s)-3,4,6-trihydroxy-2,5-dioxohexanoate Chemical compound [Ca+2].OCC(=O)[C@@H](O)[C@H](O)C(=O)C([O-])=O.OCC(=O)[C@@H](O)[C@H](O)C(=O)C([O-])=O RKFLKNFLAJISPF-OGXRZFKVSA-L 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000909 electrodialysis Methods 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03017677.0 | 2003-08-14 | ||
| EP03017677 | 2003-08-14 | ||
| PCT/CH2004/000511 WO2005017159A2 (en) | 2003-08-14 | 2004-08-16 | Microbial production of l-ascorbic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502102A JP2007502102A (ja) | 2007-02-08 |
| JP2007502102A5 true JP2007502102A5 (https=) | 2007-10-04 |
| JP4896718B2 JP4896718B2 (ja) | 2012-03-14 |
Family
ID=34178381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006522868A Expired - Fee Related JP4896718B2 (ja) | 2003-08-14 | 2004-08-16 | 微生物によるｌ−アスコルビン酸の製造 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7700723B2 (https=) |
| EP (2) | EP2348113B1 (https=) |
| JP (1) | JP4896718B2 (https=) |
| KR (1) | KR101311562B1 (https=) |
| CN (2) | CN104004776A (https=) |
| BR (1) | BRPI0413542A (https=) |
| EA (1) | EA009287B1 (https=) |
| ES (2) | ES2421294T3 (https=) |
| WO (2) | WO2005017172A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006084724A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Novel gene rcs 28 |
| WO2006084645A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Novel gene rcs 10 |
| US20080193972A1 (en) * | 2005-02-11 | 2008-08-14 | Bastian Chevreux | Gene Rcs 25 |
| WO2006084719A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Fermentive vitamin c production |
| US20080176297A1 (en) * | 2005-02-11 | 2008-07-24 | Bastien Chevreux | Gene Rcs 21 |
| WO2006084737A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Gene rcs 23 |
| WO2006084717A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Gene sms 02 |
| WO2006084643A2 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Novel gene vcs 07 |
| US20080305532A1 (en) * | 2005-02-11 | 2008-12-11 | Bastien Chevreux | Gene For Coenzyme Pqq Synthesis Protein B From Gluconobacter Oxydans |
| CN101316929A (zh) | 2005-09-08 | 2008-12-03 | 帝斯曼知识产权资产管理有限公司 | 新颖的基因sms 37 |
| EP1931785A2 (en) * | 2005-09-09 | 2008-06-18 | DSMIP Assets B.V. | Novel gene gms 01 |
| CN101292025A (zh) * | 2005-09-09 | 2008-10-22 | 帝斯曼知识产权资产管理有限公司 | 来自Gluconobacter oxydans的NADP依赖性葡糖脱氢酶 |
| FR2906817B1 (fr) * | 2006-10-04 | 2012-04-06 | Gervais Danone Sa | Procede de culture pour favoriser la production de vitamine k2 par les bacteries lactiques et ses applications a la preparation de produits alimentaires |
| EP1918382A1 (en) * | 2006-11-02 | 2008-05-07 | DSMIP Assets B.V. | Semi-continuous cascade fermentation process for pantothenate production |
| EP1918383A1 (en) * | 2006-11-02 | 2008-05-07 | DSMIP Assets B.V. | Semi-continuous fermentation process for pantothenate production |
| CN101918575A (zh) * | 2008-01-10 | 2010-12-15 | 帝斯曼知识产权资产管理有限公司 | 新颖的基因sms 44 |
| CN103073601B (zh) * | 2013-02-01 | 2015-08-19 | 东北制药集团股份有限公司 | 一种2-酮基-l-古龙酸溶液加晶种的可控浓缩结晶方法 |
| NZ743055A (en) * | 2013-03-08 | 2020-03-27 | Xyleco Inc | Equipment protecting enclosures |
| AU2014241191A1 (en) | 2013-03-27 | 2015-10-22 | Sample Technologies, Inc. | Recombinant phage and bacterial detection methods |
| CN105531382A (zh) * | 2013-06-19 | 2016-04-27 | 六品科技公司 | 基于噬菌体的细菌检测法 |
| CA2921883C (en) * | 2013-08-23 | 2020-03-24 | Sandoz Ag | Novel adsorbent composition and use thereof |
| WO2015148680A1 (en) * | 2014-03-25 | 2015-10-01 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
| CN116053017B (zh) * | 2022-11-04 | 2023-08-22 | 医波(厦门)科技有限公司 | 一种复合磁性微球及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082785A (en) | 1987-01-30 | 1992-01-21 | Hoffmann-La Roche Inc. | Biosynthesis of 2 keto-l-gulonic acid |
| EP0373181B1 (en) | 1988-01-14 | 1995-11-08 | F. Hoffmann-La Roche Ag | Novel coenzyme independent l-sorbosone dehydrogenase |
| EP0911415B1 (en) * | 1990-09-17 | 2005-12-07 | DSM IP Assets B.V. | Microbiological manufacture of L-ascorbic acid |
| US5376544A (en) | 1992-09-08 | 1994-12-27 | Rutgers The State University Of New Jersey | Enzymes for the production of 2-keto-L-gulonic acid |
| AU6731896A (en) * | 1995-07-17 | 1997-02-18 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Cyclitol |
| DE69821326T2 (de) * | 1997-12-01 | 2004-11-18 | Dsm Ip Assets B.V. | Aldehyd-Dehydrogenase |
| US20020012979A1 (en) * | 1998-06-08 | 2002-01-31 | Alan Berry | Vitamin c production in microorganisms and plants |
| GB0119864D0 (en) * | 2001-08-15 | 2001-10-10 | Cerestar Holding Bv | Process for the manufacture of 2-keto-L-gulonic acid |
| US20050153412A1 (en) * | 2002-04-22 | 2005-07-14 | Tatsuo Hoshino | Aldehyde dehydrogenase II |
| CN1659275A (zh) * | 2002-06-06 | 2005-08-24 | Dsmip资产有限公司 | 醛脱氢酶 |
| KR101070110B1 (ko) * | 2002-09-27 | 2011-10-05 | 디에스엠 아이피 어셋츠 비.브이. | 알데히드 데하이드로게나제 유전자 |
| KR101021234B1 (ko) | 2002-09-27 | 2011-03-11 | 디에스엠 아이피 어셋츠 비.브이. | 미생물에 의한 비타민 ｃ의 생성 방법 |
| EP1543137A1 (en) * | 2002-09-27 | 2005-06-22 | DSM IP Assets B.V. | Process for producing vitamin c |
| CN1914326B (zh) | 2004-01-30 | 2012-04-18 | 帝斯曼知识产权资产管理有限公司 | 维生素c的微生物生产方法 |
| US20080226126A1 (en) * | 2005-01-31 | 2008-09-18 | Yoshinori Ohno | Object-Tracking Apparatus, Microscope System, and Object-Tracking Program |
| WO2006084719A1 (en) | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Fermentive vitamin c production |
-
2004
- 2004-08-16 WO PCT/CH2004/000512 patent/WO2005017172A1/en not_active Ceased
- 2004-08-16 CN CN201410171433.3A patent/CN104004776A/zh active Pending
- 2004-08-16 BR BRPI0413542-3A patent/BRPI0413542A/pt not_active Application Discontinuation
- 2004-08-16 ES ES04738146T patent/ES2421294T3/es not_active Expired - Lifetime
- 2004-08-16 EA EA200600408A patent/EA009287B1/ru not_active IP Right Cessation
- 2004-08-16 JP JP2006522868A patent/JP4896718B2/ja not_active Expired - Fee Related
- 2004-08-16 EP EP10184019.7A patent/EP2348113B1/en not_active Expired - Lifetime
- 2004-08-16 ES ES10184019.7T patent/ES2593811T3/es not_active Expired - Lifetime
- 2004-08-16 CN CN200480023361.2A patent/CN1882691B/zh not_active Expired - Fee Related
- 2004-08-16 KR KR1020067003014A patent/KR101311562B1/ko not_active Expired - Fee Related
- 2004-08-16 WO PCT/CH2004/000511 patent/WO2005017159A2/en not_active Ceased
- 2004-08-16 EP EP04738146.2A patent/EP1664303B1/en not_active Expired - Lifetime
- 2004-08-16 US US10/567,763 patent/US7700723B2/en not_active Expired - Lifetime
-
2010
- 2010-02-08 US US12/701,748 patent/US8338144B2/en not_active Expired - Fee Related
-
2012
- 2012-11-21 US US13/683,487 patent/US20130217080A1/en not_active Abandoned
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