JP2007501859A - γ−セクレターゼ阻害剤としての架橋ｎ−アリールスルホニルピペリジン - Google Patents
γ−セクレターゼ阻害剤としての架橋ｎ−アリールスルホニルピペリジン Download PDFInfo
- Publication number
- JP2007501859A JP2007501859A JP2006532943A JP2006532943A JP2007501859A JP 2007501859 A JP2007501859 A JP 2007501859A JP 2006532943 A JP2006532943 A JP 2006532943A JP 2006532943 A JP2006532943 A JP 2006532943A JP 2007501859 A JP2007501859 A JP 2007501859A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- aryl
- cycloalkyl
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C[C@@]1C*(CCC2)NC2C1 Chemical compound C[C@@]1C*(CCC2)NC2C1 0.000 description 13
- SFVGADXTCNCSFW-UHFFFAOYSA-N CC(NC(CC1)CN1C1CCN(C)CC1)=O Chemical compound CC(NC(CC1)CN1C1CCN(C)CC1)=O SFVGADXTCNCSFW-UHFFFAOYSA-N 0.000 description 1
- PJVJMLGVCRBDKA-UHFFFAOYSA-N CCN(CC1)CCC1N(C)C1CN(C)CC1 Chemical compound CCN(CC1)CCC1N(C)C1CN(C)CC1 PJVJMLGVCRBDKA-UHFFFAOYSA-N 0.000 description 1
- BUHRTPXALUXAGG-UHFFFAOYSA-N CN(CC1)CCC1N1CCCC1 Chemical compound CN(CC1)CCC1N1CCCC1 BUHRTPXALUXAGG-UHFFFAOYSA-N 0.000 description 1
- GPASDLXNNAPVRX-UHFFFAOYSA-N CN(CC1)CCC1N1CCCCC1 Chemical compound CN(CC1)CCC1N1CCCCC1 GPASDLXNNAPVRX-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- SSQYWNQTFPQFAK-UHFFFAOYSA-N C[C@@H](NC(CC1)CN1C1CCNCC1)[U] Chemical compound C[C@@H](NC(CC1)CN1C1CCNCC1)[U] SSQYWNQTFPQFAK-UHFFFAOYSA-N 0.000 description 1
- MHGANNIOQVGFAA-VDXKJAMUSA-N O=C(CC(C[C@H]1CC2)C2C1S(c(cc1)ccc1Cl)(=O)=O)C(CC1)CCC1N1CCCCC1 Chemical compound O=C(CC(C[C@H]1CC2)C2C1S(c(cc1)ccc1Cl)(=O)=O)C(CC1)CCC1N1CCCCC1 MHGANNIOQVGFAA-VDXKJAMUSA-N 0.000 description 1
- SYZQHLQMJQQQBX-ZIQQCPBXSA-N O=C(N(CC1)CCC1N1CCCCC1)O[C@@H](C(C1)C1C1CCC2)C2N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound O=C(N(CC1)CCC1N1CCCCC1)O[C@@H](C(C1)C1C1CCC2)C2N1S(c(cc1)ccc1Cl)(=O)=O SYZQHLQMJQQQBX-ZIQQCPBXSA-N 0.000 description 1
- RQDSZQPYNHZEQY-JXUZGUSMSA-N OC(C[C@H]1CC2)C2C1S(c(cc1)ccc1Cl)(=O)=O Chemical compound OC(C[C@H]1CC2)C2C1S(c(cc1)ccc1Cl)(=O)=O RQDSZQPYNHZEQY-JXUZGUSMSA-N 0.000 description 1
- ZQTYQMYDIHMKQB-UHFFFAOYSA-N OC1C(CC2)CC2C1 Chemical compound OC1C(CC2)CC2C1 ZQTYQMYDIHMKQB-UHFFFAOYSA-N 0.000 description 1
- JNCYKERLFIXCSR-RCNMZAFISA-N O[C@H](C1CCC2)C=CC2C1S(c(cc1)ccc1Cl)(=O)=O Chemical compound O[C@H](C1CCC2)C=CC2C1S(c(cc1)ccc1Cl)(=O)=O JNCYKERLFIXCSR-RCNMZAFISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47014603P | 2003-05-13 | 2003-05-13 | |
| PCT/US2004/014671 WO2004101562A2 (en) | 2003-05-13 | 2004-05-11 | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007501859A true JP2007501859A (ja) | 2007-02-01 |
| JP2007501859A5 JP2007501859A5 (enExample) | 2007-06-28 |
Family
ID=33452372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006532943A Pending JP2007501859A (ja) | 2003-05-13 | 2004-05-11 | γ−セクレターゼ阻害剤としての架橋ｎ−アリールスルホニルピペリジン |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7368457B2 (enExample) |
| EP (1) | EP1641801B9 (enExample) |
| JP (1) | JP2007501859A (enExample) |
| CN (1) | CN1820010A (enExample) |
| AR (1) | AR044294A1 (enExample) |
| AT (1) | ATE401328T1 (enExample) |
| CA (1) | CA2525124A1 (enExample) |
| CL (1) | CL2004001011A1 (enExample) |
| DE (1) | DE602004015110D1 (enExample) |
| ES (1) | ES2308206T3 (enExample) |
| MX (1) | MXPA05012268A (enExample) |
| PE (1) | PE20050555A1 (enExample) |
| TW (1) | TW200510405A (enExample) |
| WO (1) | WO2004101562A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528865A (ja) * | 2009-06-02 | 2012-11-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１βヒドロキシステロイドデヒドロゲナーゼ１のカルバマート及びウレアインヒビター |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| CA2570183A1 (en) | 2004-06-30 | 2006-01-12 | Schering Corporation | Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors |
| CN101426860A (zh) * | 2005-08-19 | 2009-05-06 | 伊兰医药品股份有限公司 | γ-分泌酶的桥连N-环磺酰氨基抑制剂 |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| EP2475428B1 (en) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| SG11201402660YA (en) | 2011-12-21 | 2014-10-30 | Novira Therapeutics Inc | Hepatitis b antiviral agents |
| SG10201605291WA (en) | 2012-08-28 | 2016-08-30 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| PT2961732T (pt) | 2013-02-28 | 2017-06-26 | Janssen Sciences Ireland Uc | Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b |
| MX353412B (es) | 2013-04-03 | 2018-01-10 | Janssen Sciences Ireland Uc | Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| CA2909742C (en) | 2013-05-17 | 2020-08-04 | Janssen Sciences Ireland Uc | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| LT3024819T (lt) | 2013-07-25 | 2018-06-11 | Janssen Sciences Ireland Uc | Pirolamido dariniai, turintys glioksamido pakaitų, ir jų panaudojimas kaip vaistų hepatito b gydymui |
| NZ717629A (en) | 2013-10-23 | 2021-12-24 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US20150216938A1 (en) | 2014-02-05 | 2015-08-06 | Novira Therapeutics Inc. | Combination therapy for treatment of hbv infections |
| DK3102572T3 (en) | 2014-02-06 | 2019-02-04 | Janssen Sciences Ireland Uc | SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B |
| EP3115362B1 (en) * | 2014-03-06 | 2019-06-12 | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. | Piperidine derivatives as orexin receptor antagonist |
| HK1247147A1 (zh) | 2015-03-19 | 2018-09-21 | 诺维拉治疗公司 | 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法 |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| AR106192A1 (es) | 2015-09-29 | 2017-12-20 | Novira Therapeutics Inc | Formas cristalinas de un agente antiviral contra la hepatitis b |
| WO2017181141A2 (en) | 2016-04-15 | 2017-10-19 | Novira Therapeutics, Inc. | Combinations and methods comprising a capsid assembly inhibitor |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2019175657A1 (en) | 2018-03-14 | 2019-09-19 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| MX2021010145A (es) | 2019-02-22 | 2021-09-14 | Janssen Sciences Ireland Unlimited Co | Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb. |
| JP2022532526A (ja) | 2019-05-06 | 2022-07-15 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｈｂｖ感染又はｈｂｖ誘導性疾患の処置において有用なアミド誘導体 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04247081A (ja) * | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| WO2000050391A1 (en) | 1999-02-26 | 2000-08-31 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
-
2004
- 2004-05-11 WO PCT/US2004/014671 patent/WO2004101562A2/en not_active Ceased
- 2004-05-11 US US10/842,783 patent/US7368457B2/en not_active Expired - Fee Related
- 2004-05-11 TW TW093113229A patent/TW200510405A/zh unknown
- 2004-05-11 ES ES04751862T patent/ES2308206T3/es not_active Expired - Lifetime
- 2004-05-11 AR ARP040101597A patent/AR044294A1/es not_active Application Discontinuation
- 2004-05-11 MX MXPA05012268A patent/MXPA05012268A/es not_active Application Discontinuation
- 2004-05-11 AT AT04751862T patent/ATE401328T1/de not_active IP Right Cessation
- 2004-05-11 DE DE602004015110T patent/DE602004015110D1/de not_active Expired - Lifetime
- 2004-05-11 CL CL200401011A patent/CL2004001011A1/es unknown
- 2004-05-11 EP EP04751862A patent/EP1641801B9/en not_active Expired - Lifetime
- 2004-05-11 PE PE2004000484A patent/PE20050555A1/es not_active Application Discontinuation
- 2004-05-11 CA CA002525124A patent/CA2525124A1/en not_active Abandoned
- 2004-05-11 JP JP2006532943A patent/JP2007501859A/ja active Pending
- 2004-05-11 CN CNA200480019637XA patent/CN1820010A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
Non-Patent Citations (2)
| Title |
|---|
| JPN5006015838, ＭＯＭＯＳＥ， ＴＡＫＥＦＵＭＩ, ＨＥＴＥＲＯＣＹＣＬＥＳ, 1977, Ｖ６ Ｎ４, Ｐ４６９−４７４ * |
| JPN6010066104, Ｗａｎｇ， Ｈｕｉｎｉｎｇ ｅｔ ａｌ．， Ｆｅｎｘｉ Ｈｕａｘｕｅ （１９９１）， １９（１１）， １３０８−１３１０ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528865A (ja) * | 2009-06-02 | 2012-11-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１βヒドロキシステロイドデヒドロゲナーゼ１のカルバマート及びウレアインヒビター |
| US9163012B2 (en) | 2009-06-02 | 2015-10-20 | Vitae Pharmaceuticals, Inc. | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050555A1 (es) | 2005-07-19 |
| US7368457B2 (en) | 2008-05-06 |
| CL2004001011A1 (es) | 2005-03-18 |
| CN1820010A (zh) | 2006-08-16 |
| EP1641801A2 (en) | 2006-04-05 |
| US20040229902A1 (en) | 2004-11-18 |
| ATE401328T1 (de) | 2008-08-15 |
| WO2004101562A2 (en) | 2004-11-25 |
| EP1641801B9 (en) | 2009-02-25 |
| CA2525124A1 (en) | 2004-11-25 |
| MXPA05012268A (es) | 2006-02-10 |
| AR044294A1 (es) | 2005-09-07 |
| TW200510405A (en) | 2005-03-16 |
| EP1641801B1 (en) | 2008-07-16 |
| ES2308206T3 (es) | 2008-12-01 |
| WO2004101562A3 (en) | 2005-02-10 |
| DE602004015110D1 (de) | 2008-08-28 |
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