JP2007501287A5 - - Google Patents
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- Publication number
- JP2007501287A5 JP2007501287A5 JP2006533745A JP2006533745A JP2007501287A5 JP 2007501287 A5 JP2007501287 A5 JP 2007501287A5 JP 2006533745 A JP2006533745 A JP 2006533745A JP 2006533745 A JP2006533745 A JP 2006533745A JP 2007501287 A5 JP2007501287 A5 JP 2007501287A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- lower alkyl
- phenyl
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- -1 hydroxy, carboxy Chemical group 0.000 claims 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000005907 alkyl ester group Chemical group 0.000 claims 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 3
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010006895 Cachexia Diseases 0.000 claims 2
- 206010020112 Hirsutism Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 1
- 102000001307 androgen receptors Human genes 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47871203P | 2003-06-13 | 2003-06-13 | |
| US60/478,712 | 2003-06-13 | ||
| PCT/US2004/018665 WO2004113309A1 (en) | 2003-06-13 | 2004-06-12 | Thiazoline derivatives as selective androgen receptor modulators (sarms) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007501287A JP2007501287A (ja) | 2007-01-25 |
| JP2007501287A5 true JP2007501287A5 (https=) | 2007-07-26 |
| JP4898446B2 JP4898446B2 (ja) | 2012-03-14 |
Family
ID=33539114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533745A Expired - Fee Related JP4898446B2 (ja) | 2003-06-13 | 2004-06-12 | 選択的なアンドロゲン受容体モジュレーター（ｓａｒｍｓ）としてのチアゾリン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050014952A1 (https=) |
| EP (1) | EP1656360B1 (https=) |
| JP (1) | JP4898446B2 (https=) |
| CN (1) | CN1835937B (https=) |
| AT (1) | ATE370133T1 (https=) |
| AU (1) | AU2004249697B2 (https=) |
| CA (1) | CA2528764A1 (https=) |
| CY (1) | CY1106973T1 (https=) |
| DE (1) | DE602004008300T2 (https=) |
| DK (1) | DK1656360T3 (https=) |
| ES (1) | ES2291906T3 (https=) |
| PL (1) | PL1656360T3 (https=) |
| PT (1) | PT1656360E (https=) |
| WO (1) | WO2004113309A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104803916B (zh) | 2004-11-16 | 2017-08-11 | 詹森药业有限公司 | 用作选择性雄激素受体调节剂(sarms)的杂环衍生物 |
| US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
| CA2861066C (en) * | 2012-01-12 | 2024-01-02 | Yale University | Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase |
| CN103450112B (zh) * | 2013-08-07 | 2019-09-13 | 华东理工大学 | 一种n-桥连接的含氮五元杂环化合物及其制备与用途 |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| WO2019222272A1 (en) | 2018-05-14 | 2019-11-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CN113811333B (zh) | 2019-05-14 | 2024-03-12 | 诺维逊生物股份有限公司 | 靶向抗癌核激素受体的化合物 |
| WO2021097046A1 (en) | 2019-11-13 | 2021-05-20 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| KR20230160299A (ko) | 2021-03-23 | 2023-11-23 | 누베이션 바이오 인크. | 항암 핵 호르몬 수용체 표적화 화합물 |
| US12006314B2 (en) | 2021-05-03 | 2024-06-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9602949A (es) * | 1994-01-24 | 1997-06-28 | Du Pont | 2-oxa y tia-zolinas artropodicidas. |
| US6403623B1 (en) * | 1999-05-27 | 2002-06-11 | Unuversity Of Notre Dame Du Lac | Heterocyclic antituberculosis agents |
| EP1401801B1 (en) * | 2000-08-24 | 2006-11-02 | The University Of Tennessee Research Corporation | Selective androgen receptor modulators and methods of use thereof |
-
2004
- 2004-06-12 CN CN2004800230915A patent/CN1835937B/zh not_active Expired - Fee Related
- 2004-06-12 WO PCT/US2004/018665 patent/WO2004113309A1/en not_active Ceased
- 2004-06-12 DE DE602004008300T patent/DE602004008300T2/de not_active Expired - Lifetime
- 2004-06-12 AT AT04755044T patent/ATE370133T1/de active
- 2004-06-12 AU AU2004249697A patent/AU2004249697B2/en not_active Ceased
- 2004-06-12 PL PL04755044T patent/PL1656360T3/pl unknown
- 2004-06-12 DK DK04755044T patent/DK1656360T3/da active
- 2004-06-12 JP JP2006533745A patent/JP4898446B2/ja not_active Expired - Fee Related
- 2004-06-12 CA CA002528764A patent/CA2528764A1/en not_active Abandoned
- 2004-06-12 EP EP04755044A patent/EP1656360B1/en not_active Expired - Lifetime
- 2004-06-12 US US10/866,591 patent/US20050014952A1/en not_active Abandoned
- 2004-06-12 ES ES04755044T patent/ES2291906T3/es not_active Expired - Lifetime
- 2004-06-12 PT PT04755044T patent/PT1656360E/pt unknown
-
2007
- 2007-11-05 CY CY20071101413T patent/CY1106973T1/el unknown
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