JP2008514707A5 - - Google Patents

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Publication number
JP2008514707A5
JP2008514707A5 JP2007534694A JP2007534694A JP2008514707A5 JP 2008514707 A5 JP2008514707 A5 JP 2008514707A5 JP 2007534694 A JP2007534694 A JP 2007534694A JP 2007534694 A JP2007534694 A JP 2007534694A JP 2008514707 A5 JP2008514707 A5 JP 2008514707A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halogen
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007534694A
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English (en)
Japanese (ja)
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JP2008514707A (ja
JP4953456B2 (ja
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Application filed filed Critical
Priority claimed from PCT/US2005/034462 external-priority patent/WO2006039243A1/en
Publication of JP2008514707A publication Critical patent/JP2008514707A/ja
Publication of JP2008514707A5 publication Critical patent/JP2008514707A5/ja
Application granted granted Critical
Publication of JP4953456B2 publication Critical patent/JP4953456B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007534694A 2004-09-30 2005-09-26 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体 Expired - Fee Related JP4953456B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61475104P 2004-09-30 2004-09-30
US60/614,751 2004-09-30
PCT/US2005/034462 WO2006039243A1 (en) 2004-09-30 2005-09-26 Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)

Publications (3)

Publication Number Publication Date
JP2008514707A JP2008514707A (ja) 2008-05-08
JP2008514707A5 true JP2008514707A5 (https=) 2008-11-20
JP4953456B2 JP4953456B2 (ja) 2012-06-13

Family

ID=35825468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007534694A Expired - Fee Related JP4953456B2 (ja) 2004-09-30 2005-09-26 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体

Country Status (10)

Country Link
US (3) US7566733B2 (https=)
EP (1) EP1805147B1 (https=)
JP (1) JP4953456B2 (https=)
CN (1) CN101065363B (https=)
AR (1) AR050966A1 (https=)
AU (1) AU2005292345B9 (https=)
CA (1) CA2582356A1 (https=)
MY (1) MY147985A (https=)
TW (1) TW200621725A (https=)
WO (1) WO2006039243A1 (https=)

Families Citing this family (48)

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US9119680B2 (en) 2004-10-20 2015-09-01 Vertiflex, Inc. Interspinous spacer
US7763074B2 (en) 2004-10-20 2010-07-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8123807B2 (en) 2004-10-20 2012-02-28 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US9161783B2 (en) 2004-10-20 2015-10-20 Vertiflex, Inc. Interspinous spacer
US8273108B2 (en) 2004-10-20 2012-09-25 Vertiflex, Inc. Interspinous spacer
US8123782B2 (en) 2004-10-20 2012-02-28 Vertiflex, Inc. Interspinous spacer
US8613747B2 (en) 2004-10-20 2013-12-24 Vertiflex, Inc. Spacer insertion instrument
US8425559B2 (en) 2004-10-20 2013-04-23 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US8317864B2 (en) 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8012207B2 (en) 2004-10-20 2011-09-06 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US8167944B2 (en) 2004-10-20 2012-05-01 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US9023084B2 (en) 2004-10-20 2015-05-05 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for stabilizing the motion or adjusting the position of the spine
US8152837B2 (en) 2004-10-20 2012-04-10 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US8128662B2 (en) 2004-10-20 2012-03-06 Vertiflex, Inc. Minimally invasive tooling for delivery of interspinous spacer
US8277488B2 (en) 2004-10-20 2012-10-02 Vertiflex, Inc. Interspinous spacer
US8409282B2 (en) 2004-10-20 2013-04-02 Vertiflex, Inc. Systems and methods for posterior dynamic stabilization of the spine
US8945183B2 (en) 2004-10-20 2015-02-03 Vertiflex, Inc. Interspinous process spacer instrument system with deployment indicator
MX2007005290A (es) * 2004-11-02 2007-07-09 Pfizer Derivados de sulfonilbencimidazol.
WO2009086010A2 (en) 2004-12-06 2009-07-09 Vertiflex, Inc. Spacer insertion instrument
ES2402305T3 (es) * 2006-01-24 2013-04-30 Janssen Pharmaceutica N.V. Benzimidazolas 2-sustituidas nuevas como moduladores del receptor de andrógeno selectivo (SARMS)
US8845726B2 (en) 2006-10-18 2014-09-30 Vertiflex, Inc. Dilator
CA2684461C (en) 2007-04-16 2015-06-30 Vertiflex Inc. Interspinous spacer
MX2009011281A (es) * 2007-04-20 2010-03-08 Univ New York State Res Found Benzimidazol y composiciones farmaceuticas del mismo.
AU2009206098B2 (en) 2008-01-15 2014-10-30 Vertiflex, Inc. Interspinous spacer
ES2488990T3 (es) 2008-02-22 2014-09-01 Radius Health, Inc. Moduladores selectivos del receptor de andrógenos
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
WO2009123164A1 (ja) * 2008-04-02 2009-10-08 塩野義製薬株式会社 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体
US8740948B2 (en) 2009-12-15 2014-06-03 Vertiflex, Inc. Spinal spacer for cervical and other vertebra, and associated systems and methods
MX338831B (es) 2010-02-04 2016-05-03 Radius Health Inc Moduladores selectivos de receptores de androgenos.
EP2568806B1 (en) 2010-05-12 2016-05-11 Radius Health, Inc. Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
US9675303B2 (en) 2013-03-15 2017-06-13 Vertiflex, Inc. Visualization systems, instruments and methods of using the same in spinal decompression procedures
US10287617B2 (en) 2014-03-11 2019-05-14 Colorado State University Research Foundation Methods for in vitro—in vivo efficacy determination
FI3834824T3 (fi) 2014-03-28 2025-12-05 Univ Duke Estrogeenireseptoripositiivisen rintasyövän hoito selektiivisellä estrogeenireseptorin modulaattorilla
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
WO2015171814A1 (en) 2014-05-07 2015-11-12 Vertiflex, Inc. Spinal nerve decompression systems, dilation systems, and methods of using the same
CA2977044C (en) 2015-01-17 2023-06-27 Jean X. Jiang Small molecules for the treatment of primary cancer and cancer metastasis
LT3474841T (lt) 2016-06-22 2022-06-10 Ellipses Pharma Ltd Ar+ krūties vėžio gydymo būdai
KR102707399B1 (ko) 2017-01-05 2024-09-13 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US11400096B2 (en) 2017-10-19 2022-08-02 Board Of Regents, The University Of Texas System Small molecules for the treatment of autoimmune disorders
IL279853B2 (en) 2018-07-04 2025-01-01 Radius Pharmaceuticals Inc Polymorphic forms of RAD 1901-2HCL
CN113348163B (zh) 2019-02-12 2024-10-08 雷迪厄斯制药公司 方法和化合物
US12102542B2 (en) 2022-02-15 2024-10-01 Boston Scientific Neuromodulation Corporation Interspinous spacer and methods and systems utilizing the interspinous spacer
US12433646B2 (en) 2023-02-21 2025-10-07 Boston Scientific Neuromodulation Corporation Interspinous spacer with actuator locking arrangements and methods and systems
US12390340B2 (en) 2023-03-15 2025-08-19 Boston Scientific Neuromodulation Corporation Interspinous spacer with a range of deployment positions and methods and systems
CN120230046A (zh) * 2023-12-29 2025-07-01 杭州壹瑞医药科技有限公司 Trpv3抑制剂及其制备和应用

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US3325271A (en) * 1963-07-17 1967-06-13 United States Borax Chem Herbicidal composition and method employing substituted benzimidazoles
US3897432A (en) * 1971-04-21 1975-07-29 Merck & Co Inc Substituted benzimidazole derivatives
SE357932B (https=) * 1972-01-27 1973-07-16 Malaga Ab
US3987182A (en) * 1974-06-17 1976-10-19 Schering Corporation Novel benzimidazoles useful as anti-androgens
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
JPH05163246A (ja) * 1991-12-17 1993-06-29 Nippon Oil & Fats Co Ltd ペルフルオロ−オキサ−アルキル基含有ベンズイミダゾール誘導体及びその製造方法
GB9310069D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Heterocyclic compounds

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