JP2008514704A5 - - Google Patents
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- Publication number
- JP2008514704A5 JP2008514704A5 JP2007534675A JP2007534675A JP2008514704A5 JP 2008514704 A5 JP2008514704 A5 JP 2008514704A5 JP 2007534675 A JP2007534675 A JP 2007534675A JP 2007534675 A JP2007534675 A JP 2007534675A JP 2008514704 A5 JP2008514704 A5 JP 2008514704A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- hydrogen
- group
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RGACWXDYKJJHSQ-SNVBAGLBSA-N CO[C@@](C(F)(F)F)(C(OC)=O)c1ccccc1 Chemical compound CO[C@@](C(F)(F)F)(C(OC)=O)c1ccccc1 RGACWXDYKJJHSQ-SNVBAGLBSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61470704P | 2004-09-30 | 2004-09-30 | |
| US60/614,707 | 2004-09-30 | ||
| PCT/US2005/034277 WO2006039215A2 (en) | 2004-09-30 | 2005-09-26 | Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514704A JP2008514704A (ja) | 2008-05-08 |
| JP2008514704A5 true JP2008514704A5 (https=) | 2008-11-20 |
| JP4953455B2 JP4953455B2 (ja) | 2012-06-13 |
Family
ID=35789244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534675A Expired - Fee Related JP4953455B2 (ja) | 2004-09-30 | 2005-09-26 | 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）として有用な新規なベンゾイミダゾール誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7348438B2 (https=) |
| EP (1) | EP1812406B1 (https=) |
| JP (1) | JP4953455B2 (https=) |
| CN (1) | CN101133036B (https=) |
| AR (1) | AR050967A1 (https=) |
| AU (1) | AU2005292317B2 (https=) |
| CA (1) | CA2582347C (https=) |
| TW (1) | TW200624424A (https=) |
| WO (1) | WO2006039215A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2582347C (en) * | 2004-09-30 | 2014-09-23 | Janssen Pharmaceutica N.V. | Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
| ES2318556T3 (es) * | 2004-11-02 | 2009-05-01 | Pfizer, Inc. | Derivados de sulfonil bencimidazol. |
| EP1984343B1 (en) * | 2006-01-24 | 2013-02-27 | Janssen Pharmaceutica N.V. | 2-substituted benzimidazoles as selective androgen receptor modulators (sarms) |
| JP5275236B2 (ja) * | 2006-09-29 | 2013-08-28 | スミスクライン ビーチャム コーポレーション | 置換されたインドール化合物 |
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009123164A1 (ja) * | 2008-04-02 | 2009-10-08 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有するヘテロ環誘導体 |
| US8501957B2 (en) * | 2008-12-10 | 2013-08-06 | China Medical University | Benzimidazole compounds and their use as anticancer agents |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| JP5718060B2 (ja) | 2009-02-06 | 2015-05-13 | 株式会社日本触媒 | ポリアクリル酸（塩）系親水性樹脂およびその製造方法 |
| EP2471845B1 (en) | 2009-08-27 | 2017-02-15 | Nippon Shokubai Co., Ltd. | Water-absorbing resin based on polyacrylic acid (salt) and process for producing same |
| JP5801203B2 (ja) | 2009-09-29 | 2015-10-28 | 株式会社日本触媒 | 粒子状吸水剤及びその製造方法 |
| RU2015137617A (ru) * | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| CN109608661B (zh) | 2013-08-28 | 2021-09-10 | 株式会社日本触媒 | 凝胶粉碎装置、及聚丙烯酸(盐)系吸水性树脂粉末的制造方法、以及吸水性树脂粉末 |
| EP3040362B1 (en) | 2013-08-28 | 2018-08-08 | Nippon Shokubai Co., Ltd. | Gel pulverization device, and related method for manufacturing superabsorbent polymer powder |
| CN120230046A (zh) * | 2023-12-29 | 2025-07-01 | 杭州壹瑞医药科技有限公司 | Trpv3抑制剂及其制备和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1087561A (en) * | 1963-02-16 | 1967-10-18 | Fisons Pest Control Ltd | Fluorinated benzimidazoles and compositions containing them |
| US3271249A (en) * | 1963-06-24 | 1966-09-06 | S B Penick & Co Inc | Dihalobenzimidazoles for poultry disease treatment |
| US3443015A (en) * | 1967-05-29 | 1969-05-06 | Lilly Co Eli | Nematocidal methods employing 2-perfluoroalkylbenzimidazoles |
| DE2022504A1 (de) * | 1970-05-08 | 1971-11-25 | Hoechst Ag | Benzimidazolderivate,ihre Herstellung und Verwendung als Akarizide |
| US3897432A (en) * | 1971-04-21 | 1975-07-29 | Merck & Co Inc | Substituted benzimidazole derivatives |
| US3987182A (en) * | 1974-06-17 | 1976-10-19 | Schering Corporation | Novel benzimidazoles useful as anti-androgens |
| JPS5731617A (en) * | 1980-07-30 | 1982-02-20 | Nippon Shinyaku Co Ltd | Carcinostatic agent |
| IT1196133B (it) * | 1984-06-06 | 1988-11-10 | Ausonia Farma Srl | Derivati furanici con attivita' antiulcera |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| US5149698A (en) * | 1987-08-11 | 1992-09-22 | Glaxo Group Limited | Chloroaniline derivatives |
| JP2695419B2 (ja) * | 1987-11-20 | 1997-12-24 | 工業技術院長 | ２−（ポリフルオロアルキル）ハロゲノベンズイミダゾール類、その製造法およびそれを有効成分とする殺虫、殺ダニ剤 |
| GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
| FR2658511B1 (fr) * | 1990-02-16 | 1992-06-19 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5128359A (en) | 1990-02-16 | 1992-07-07 | Laboratoires Upsa | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation |
| EP0461040A1 (fr) * | 1990-06-08 | 1991-12-11 | Roussel Uclaf | Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
| AU6369696A (en) * | 1995-07-17 | 1997-02-18 | Fuji Photo Film Co., Ltd. | Benzimidazole compounds |
| WO1997024334A1 (en) * | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US6369092B1 (en) * | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6348032B1 (en) * | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
| AU2002348394A1 (en) * | 2001-10-25 | 2003-05-06 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| CA2582347C (en) * | 2004-09-30 | 2014-09-23 | Janssen Pharmaceutica N.V. | Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms) |
-
2005
- 2005-09-26 CA CA2582347A patent/CA2582347C/en not_active Expired - Fee Related
- 2005-09-26 US US11/235,581 patent/US7348438B2/en not_active Expired - Lifetime
- 2005-09-26 AU AU2005292317A patent/AU2005292317B2/en not_active Ceased
- 2005-09-26 EP EP05801890.4A patent/EP1812406B1/en not_active Not-in-force
- 2005-09-26 JP JP2007534675A patent/JP4953455B2/ja not_active Expired - Fee Related
- 2005-09-26 WO PCT/US2005/034277 patent/WO2006039215A2/en not_active Ceased
- 2005-09-26 CN CN2005800406777A patent/CN101133036B/zh not_active Expired - Fee Related
- 2005-09-29 AR ARP050104118A patent/AR050967A1/es active IP Right Grant
- 2005-09-29 TW TW094133856A patent/TW200624424A/zh unknown
-
2008
- 2008-01-25 US US12/019,764 patent/US7795446B2/en not_active Expired - Fee Related
-
2010
- 2010-08-03 US US12/849,378 patent/US20100298383A1/en not_active Abandoned
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