JP2007211003A - 視覚機能障害の予防または改善剤 - Google Patents
視覚機能障害の予防または改善剤 Download PDFInfo
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- JP2007211003A JP2007211003A JP2007001909A JP2007001909A JP2007211003A JP 2007211003 A JP2007211003 A JP 2007211003A JP 2007001909 A JP2007001909 A JP 2007001909A JP 2007001909 A JP2007001909 A JP 2007001909A JP 2007211003 A JP2007211003 A JP 2007211003A
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Abstract
本発明は網膜アポトーシスにより生じる視覚機能障害の予防または改善に有効で安全性の高い医薬品、医薬部外品または食品を提供すること。
【解決手段】 ケイヒおよびレイシカクから選ばれる1種または2種を配合したことを特徴とする視覚機能障害の予防または改善剤。
【選択図】 なし
Description
(1)ケイヒおよびレイシカクから選ばれる1種または2種を配合したことを特徴とする視覚機能障害の予防または改善剤、
(2)視覚機能障害が網膜障害である(1)に記載の予防または改善剤、
(3)ケイヒおよびレイシカクから選ばれる1種または2種を配合したことを特徴とする網膜アポトーシス抑制剤、
である。
試験にはSD系雄性ラット9週齢オス(日本チャールスリバー)を用いた。ラットに実施例6及び実施例7にて得られた液剤を10mL/Kgの用量で1日1回、2週間経口投与した。12日目に中心波長約470nmの青色光を24時間照射した。照射終了48時間後に約15時間の暗順応の後、ケタミン−キシラジン麻酔下にて網膜電図を測定し、a波およびb波の振幅(μV)を測定した。また、比較対照群として、無処置群および光照射のみを行った光照射群を設定した。なお、すべての群の例数は10とした。
試験にはSD系雄性ラット6週齢オス(日本チャールスリバー)を用いた。ラットに実施例12にて得られた液剤を10mL/Kgの用量で1日1回、10日間経口投与した。無処置群及び光照射群には精製水を投与した。12日目に中心波長約470nmの青色光を24時間照射した。照射終了48時間後に約15時間の暗順応の後、ケタミン−キシラジン麻酔下にて網膜電図を測定し、a波の振幅(μV)を測定した。また、比較対照群として、無処置群および光照射のみを行った光照射群を設定した。なお、すべての群の例数は10とした。
網膜色素上皮細胞を96穴プレートにD−MEM/F12培地を用いて1ウェル当たり1×104個になるように藩種し、CO2インキュベータ内で培養した。正常サンプル以外にはリポフスチンを約25μMになるよう添加し、さらにケイヒエキスサンプル及びレイシカクエキスサンプルには実施例1または実施例3で得られたそれぞれのエキスを100μg/mLになるよう添加した。約24時間の培養の後、中心波長約470nmの青色光をCO2インキュベータ内で1時間照射し、翌日、正常サンプルの細胞の生存率を100%としたときの各群の生存率をCell Counting Kit−8(和光純薬工業)を用いて算出した。また、細胞死の形態がアポトーシスであることはアポトーシススクリーニングキットワコー(和光純薬工業)を用いて確認した。結果を表3に示した。
Claims (3)
- ケイヒおよびレイシカクから選ばれる1種または2種を配合したことを特徴とする視覚機能障害の予防または改善剤。
- 視覚機能障害が網膜障害である請求項1に記載の予防または改善剤。
- ケイヒおよびレイシカクから選ばれる1種または2種を配合したことを特徴とする網膜アポトーシス抑制剤。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2011006333A (ja) * | 2009-06-23 | 2011-01-13 | Nippon Menaade Keshohin Kk | ウレアーゼ活性阻害剤 |
US20170182107A1 (en) * | 2014-05-23 | 2017-06-29 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for preventing or treating diabetic complications and angioedema, containing natural mixture extract as active ingredient |
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JPS60105623A (ja) * | 1983-11-15 | 1985-06-11 | Tsumura Juntendo Inc | 点眼剤の製造方法 |
JPH0643329B2 (ja) * | 1985-10-01 | 1994-06-08 | 株式会社ツムラ | アルド−スリダクタ−ゼ阻害剤 |
JP2003504333A (ja) * | 1999-07-14 | 2003-02-04 | ラクスディル リミテッド | 必須脂肪酸およびホモシステイン低下剤を含有する製剤および栄養組成物 |
JP2005281318A (ja) * | 2005-06-07 | 2005-10-13 | Oriza Yuka Kk | 美肌用組成物 |
JP2006335752A (ja) * | 2005-06-01 | 2006-12-14 | Oriza Yuka Kk | アルドース還元酵素阻害剤 |
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JPS60105623A (ja) * | 1983-11-15 | 1985-06-11 | Tsumura Juntendo Inc | 点眼剤の製造方法 |
JPH0643329B2 (ja) * | 1985-10-01 | 1994-06-08 | 株式会社ツムラ | アルド−スリダクタ−ゼ阻害剤 |
JP2003504333A (ja) * | 1999-07-14 | 2003-02-04 | ラクスディル リミテッド | 必須脂肪酸およびホモシステイン低下剤を含有する製剤および栄養組成物 |
JP2006335752A (ja) * | 2005-06-01 | 2006-12-14 | Oriza Yuka Kk | アルドース還元酵素阻害剤 |
JP2005281318A (ja) * | 2005-06-07 | 2005-10-13 | Oriza Yuka Kk | 美肌用組成物 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011006333A (ja) * | 2009-06-23 | 2011-01-13 | Nippon Menaade Keshohin Kk | ウレアーゼ活性阻害剤 |
US20170182107A1 (en) * | 2014-05-23 | 2017-06-29 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for preventing or treating diabetic complications and angioedema, containing natural mixture extract as active ingredient |
EP3146976B1 (en) * | 2014-05-23 | 2021-01-13 | Korea Institute of Oriental Medicine | Pharmaceutical composition for preventing or treating macular degeneration, containing natural mixture extract as active ingredient |
US11191801B2 (en) | 2014-05-23 | 2021-12-07 | Korea Institute Of Oriental Medicine | Pharmaceutical composition for preventing or treating diabetic complications and angioedema, containing natural mixture extract as active ingredient |
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