JP2007091733A5 - - Google Patents
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- JP2007091733A5 JP2007091733A5 JP2006235401A JP2006235401A JP2007091733A5 JP 2007091733 A5 JP2007091733 A5 JP 2007091733A5 JP 2006235401 A JP2006235401 A JP 2006235401A JP 2006235401 A JP2006235401 A JP 2006235401A JP 2007091733 A5 JP2007091733 A5 JP 2007091733A5
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- JP
- Japan
- Prior art keywords
- group
- lower alkyl
- alkyl group
- optionally
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 356
- -1 tetrahydroquinoxalinyl group Chemical group 0.000 claims 98
- 125000003545 alkoxy group Chemical group 0.000 claims 86
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 73
- 125000002252 acyl group Chemical group 0.000 claims 61
- 125000004043 oxo group Chemical group O=* 0.000 claims 57
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 52
- 125000001424 substituent group Chemical group 0.000 claims 48
- 125000003118 aryl group Chemical group 0.000 claims 43
- 125000003277 amino group Chemical group 0.000 claims 41
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 31
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 125000005936 piperidyl group Chemical group 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 26
- 125000004193 piperazinyl group Chemical group 0.000 claims 22
- 125000004076 pyridyl group Chemical group 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 20
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 18
- 125000002883 imidazolyl group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 125000003435 aroyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000002757 morpholinyl group Chemical group 0.000 claims 12
- 125000003226 pyrazolyl group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000005236 alkanoylamino group Chemical group 0.000 claims 10
- 125000001589 carboacyl group Chemical group 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 10
- 125000002541 furyl group Chemical group 0.000 claims 9
- 125000004414 alkyl thio group Chemical group 0.000 claims 8
- 125000000335 thiazolyl group Chemical group 0.000 claims 8
- 125000004104 aryloxy group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000001544 thienyl group Chemical group 0.000 claims 7
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 6
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 6
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 4
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 4
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 4
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 4
- 125000004598 dihydrobenzofuryl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 4
- 125000004639 dihydroindenyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000001041 indolyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 claims 3
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 3
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 2
- 125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000004987 dibenzofuryl group Chemical group C1(=CC=CC=2OC3=C(C21)C=CC=C3)* 0.000 claims 2
- 125000004460 dihydrobenzooxazinyl group Chemical group O1N(CCC2=C1C=CC=C2)* 0.000 claims 2
- 125000005435 dihydrobenzoxazolyl group Chemical group O1C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 claims 2
- 125000005052 dihydropyrazolyl group Chemical group N1(NCC=C1)* 0.000 claims 2
- 125000004609 dihydroquinazolinyl group Chemical group N1(CN=CC2=CC=CC=C12)* 0.000 claims 2
- 125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000003965 isoxazolidinyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000005554 pyridyloxy group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims 2
- UBZKMAIJHFLIAH-UHFFFAOYSA-N 1-(1-benzothiophen-4-yl)-4-[3-(2-methoxy-6-methyl-4-piperidin-1-ylphenoxy)propyl]piperazine Chemical compound C=1C(C)=C(OCCCN2CCN(CC2)C=2C=3C=CSC=3C=CC=2)C(OC)=CC=1N1CCCCC1 UBZKMAIJHFLIAH-UHFFFAOYSA-N 0.000 claims 1
- UZGKFAOVTJZQOP-UHFFFAOYSA-N 1-(1-benzothiophen-4-yl)-4-[3-(2-methoxy-6-methyl-4-pyrrolidin-1-ylphenoxy)propyl]piperazine Chemical compound C=1C(C)=C(OCCCN2CCN(CC2)C=2C=3C=CSC=3C=CC=2)C(OC)=CC=1N1CCCC1 UZGKFAOVTJZQOP-UHFFFAOYSA-N 0.000 claims 1
- UNOXKZWRSRTOBM-UHFFFAOYSA-N 1-[4-[4-[3-[4-(1-benzothiophen-4-yl)piperazin-1-yl]propoxy]-3-methoxy-5-methylphenyl]piperazin-1-yl]ethanone Chemical compound C=1C(C)=C(OCCCN2CCN(CC2)C=2C=3C=CSC=3C=CC=2)C(OC)=CC=1N1CCN(C(C)=O)CC1 UNOXKZWRSRTOBM-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- QWNCDHYYJATYOG-UHFFFAOYSA-N 2-phenylquinoxaline Chemical compound C1=CC=CC=C1C1=CN=C(C=CC=C2)C2=N1 QWNCDHYYJATYOG-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- DUNFVHHDUSIAOI-UHFFFAOYSA-N 4-acetyl-1-[4-[3-[4-(1-benzothiophen-4-yl)piperazin-1-yl]propoxy]-3-methoxy-5-methylphenyl]piperazin-2-one Chemical compound C=1C(C)=C(OCCCN2CCN(CC2)C=2C=3C=CSC=3C=CC=2)C(OC)=CC=1N1CCN(C(C)=O)CC1=O DUNFVHHDUSIAOI-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- FDODVZVWGKVMBO-UHFFFAOYSA-N cyclohex-2-ene-1,4-diol Chemical group OC1CCC(O)C=C1 FDODVZVWGKVMBO-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- KJNCFURRTYFBKI-UHFFFAOYSA-N methyl 4-[4-[3-[4-(1-benzothiophen-4-yl)piperazin-1-yl]propoxy]-3-formyl-5-methoxyphenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC)CCN1C(C=C1C=O)=CC(OC)=C1OCCCN1CCN(C=2C=3C=CSC=3C=CC=2)CC1 KJNCFURRTYFBKI-UHFFFAOYSA-N 0.000 claims 1
- IWMGIJONIYLYFS-UHFFFAOYSA-N methyl 4-[4-[3-[4-(1-benzothiophen-4-yl)piperazin-1-yl]propoxy]-3-methoxy-5-methylphenyl]-3-oxopiperazine-1-carboxylate Chemical compound O=C1CN(C(=O)OC)CCN1C(C=C1OC)=CC(C)=C1OCCCN1CCN(C=2C=3C=CSC=3C=CC=2)CC1 IWMGIJONIYLYFS-UHFFFAOYSA-N 0.000 claims 1
- 125000005476 oxopyrrolidinyl group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006235401A JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005251055 | 2005-08-31 | ||
| JP2005251055 | 2005-08-31 | ||
| JP2006235401A JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007091733A JP2007091733A (ja) | 2007-04-12 |
| JP2007091733A5 true JP2007091733A5 (cg-RX-API-DMAC7.html) | 2008-03-21 |
| JP4785677B2 JP4785677B2 (ja) | 2011-10-05 |
Family
ID=37709698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006235401A Expired - Fee Related JP4785677B2 (ja) | 2005-08-31 | 2006-08-31 | 複素環化合物 |
Country Status (25)
Families Citing this family (64)
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| CN112079812B (zh) * | 2020-09-29 | 2021-08-06 | 浙江大学 | 哌唑类抗精神病药物关键中间体及其电还原方法 |
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