JP2006528229A5 - - Google Patents
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- JP2006528229A5 JP2006528229A5 JP2006530210A JP2006530210A JP2006528229A5 JP 2006528229 A5 JP2006528229 A5 JP 2006528229A5 JP 2006530210 A JP2006530210 A JP 2006530210A JP 2006530210 A JP2006530210 A JP 2006530210A JP 2006528229 A5 JP2006528229 A5 JP 2006528229A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dihydro
- pharmaceutically acceptable
- pharmaceutical composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 19
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims 15
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 15
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 13
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 13
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 12
- -1 4,8-dipiperidinopyrimido [5,4-d] pyrimidine-2,6-diyl Chemical group 0.000 claims 11
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 7
- WOXKDUGGOYFFRN-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 0.000 claims 7
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 claims 5
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims 5
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical group FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 5
- 229960002586 roflumilast Drugs 0.000 claims 5
- 229960003310 sildenafil Drugs 0.000 claims 5
- 229960000835 tadalafil Drugs 0.000 claims 5
- 229960002381 vardenafil Drugs 0.000 claims 5
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims 4
- KHXXMSARUQULRI-UHFFFAOYSA-N 3-(cyclopropylmethoxy)-n-(3,5-dichloro-1-hydroxypyridin-4-ylidene)-4-(difluoromethoxy)benzamide Chemical compound ClC1=CN(O)C=C(Cl)C1=NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 KHXXMSARUQULRI-UHFFFAOYSA-N 0.000 claims 4
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 claims 4
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims 4
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- WWXPHRJCGKFIQK-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]-3-(2-methylpropanoyl)-2-propylindole-6-carboxamide Chemical compound CCCC1=C(C(=O)C(C)C)C2=CC=C(C(N)=O)C=C2N1CC1=CC=CC=C1Cl WWXPHRJCGKFIQK-UHFFFAOYSA-N 0.000 claims 2
- QUUJQFQTLSFCKW-UHFFFAOYSA-N 1-[4-(1,3-benzodioxol-5-ylmethylamino)-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1C1=NC(NCC=2C=C3OCOC3=CC=2)=C(C=C(Cl)C=C2)C2=N1 QUUJQFQTLSFCKW-UHFFFAOYSA-N 0.000 claims 2
- MFKZGAAAKCDLHM-UHFFFAOYSA-N 1-cyclopentyl-6-(3-ethoxypyridin-4-yl)-3-ethyl-5H-pyrazolo[3,4-d]pyrimidin-4-one Chemical compound CCOC1=CN=CC=C1C(N1)=NC(=O)C2=C1N(C1CCCC1)N=C2CC MFKZGAAAKCDLHM-UHFFFAOYSA-N 0.000 claims 2
- DAJWIIRGQKQYAW-UHFFFAOYSA-N 2-(2-propoxyphenyl)-3,7-dihydropurin-6-one;2-(2-propoxyphenyl)-1,2,5,9-tetrahydropurin-6-one Chemical compound CCCOC1=CC=CC=C1C1N=C2N=CNC2C(=O)N1.CCCOC1=CC=CC=C1C(NC1=O)=NC2=C1NC=N2 DAJWIIRGQKQYAW-UHFFFAOYSA-N 0.000 claims 2
- JEMJAABFSYOLAP-UHFFFAOYSA-N 2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester Chemical compound C12=CC=NC(OCC=3N=CC=CN=3)=C2C(=O)N(CC=2C=C(C)N=CC=2)C(C(=O)OC)=C1C1=CC(OC)=C(OC)C(OC)=C1 JEMJAABFSYOLAP-UHFFFAOYSA-N 0.000 claims 2
- LNSWDTFYXQGHQZ-UHFFFAOYSA-N 2-imidazol-1-yl-6-methoxy-n-(2-methoxyethyl)quinazolin-4-amine Chemical compound N=1C2=CC=C(OC)C=C2C(NCCOC)=NC=1N1C=CN=C1 LNSWDTFYXQGHQZ-UHFFFAOYSA-N 0.000 claims 2
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 claims 2
- NIBCDDKWFDEBEP-UHFFFAOYSA-N 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-propoxyphenyl]-2-(pyridin-2-ylmethyl)-4h-pyrazolo[4,3-d]pyrimidin-7-one Chemical compound CCCOC1=CC=C(S(=O)(=O)N2CCN(CC)CC2)C=C1C(NC1=C2CC)=NC(=O)C1=NN2CC1=CC=CC=N1 NIBCDDKWFDEBEP-UHFFFAOYSA-N 0.000 claims 2
- NMKUPEWPVORTPC-UHFFFAOYSA-N 3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1h-imidazo[4,5-g]quinazoline-2-thione Chemical compound C=12C=C3NC(=S)N(CC)C3=CC2=NC=NC=1NCC1=CC=CC=C1N1CCC(CO)CC1 NMKUPEWPVORTPC-UHFFFAOYSA-N 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- VDXZLVXFVYDBNH-UHFFFAOYSA-N 4-[(3-chloro-4-methoxyphenyl)methylamino]-1-(4-hydroxypiperidin-1-yl)phthalazine-6-carbonitrile Chemical compound C1=C(Cl)C(OC)=CC=C1CNC(C1=CC(=CC=C11)C#N)=NN=C1N1CCC(O)CC1 VDXZLVXFVYDBNH-UHFFFAOYSA-N 0.000 claims 2
- LNMMZMTWCOIELH-UHFFFAOYSA-N 4-methyl-5-pyridin-4-yl-1,3-thiazole-2-carboxamide Chemical compound N1=C(C(N)=O)SC(C=2C=CN=CC=2)=C1C LNMMZMTWCOIELH-UHFFFAOYSA-N 0.000 claims 2
- OJQQFXIVAUZCJB-UHFFFAOYSA-N 6-[5-(4-methylpiperazin-1-yl)sulfonyl-2-propoxyphenyl]-1,5-dihydroimidazo[4,5-g]quinazolin-8-one Chemical compound C1=C(C=2NC(=O)C3=CC=4NC=NC=4C=C3N=2)C(OCCC)=CC=C1S(=O)(=O)N1CCN(C)CC1 OJQQFXIVAUZCJB-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- ZVNYJIZDIRKMBF-UHFFFAOYSA-N Vesnarinone Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)N1CCN(C=2C=C3CCC(=O)NC3=CC=2)CC1 ZVNYJIZDIRKMBF-UHFFFAOYSA-N 0.000 claims 2
- CCXIVOGMSQZBSB-UHFFFAOYSA-N [5-(1-benzyl-6-fluoroindazol-3-yl)furan-2-yl]methanol Chemical compound O1C(CO)=CC=C1C(C1=CC=C(F)C=C11)=NN1CC1=CC=CC=C1 CCXIVOGMSQZBSB-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims 2
- 229950001653 cilomilast Drugs 0.000 claims 2
- 230000001627 detrimental effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- UVNXNSUKKOLFBM-UHFFFAOYSA-N imidazo[2,1-b][1,3,4]thiadiazole Chemical compound N1=CSC2=NC=CN21 UVNXNSUKKOLFBM-UHFFFAOYSA-N 0.000 claims 2
- ORZROTLRYOYVPB-UHFFFAOYSA-N methyl 2-(4-aminophenyl)-1-oxo-7-(pyridin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)isoquinoline-3-carboxylate Chemical compound C12=CC=C(OCC=3N=CC=CC=3)C=C2C(=O)N(C=2C=CC(N)=CC=2)C(C(=O)OC)=C1C1=CC(OC)=C(OC)C(OC)=C1 ORZROTLRYOYVPB-UHFFFAOYSA-N 0.000 claims 2
- ZISFCTXLAXIEMV-GFCCVEGCSA-N n-[(3,4-dimethoxyphenyl)methyl]-2-[[(2r)-1-hydroxypropan-2-yl]amino]-5-nitrobenzamide Chemical compound C1=C(OC)C(OC)=CC=C1CNC(=O)C1=CC([N+]([O-])=O)=CC=C1N[C@H](C)CO ZISFCTXLAXIEMV-GFCCVEGCSA-N 0.000 claims 2
- RJQRCOMHVBLQIH-UHFFFAOYSA-N pentane-1-sulfonic acid Chemical compound CCCCCS(O)(=O)=O RJQRCOMHVBLQIH-UHFFFAOYSA-N 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- IYFNEFQTYQPVOC-UHFFFAOYSA-N udenafil Chemical compound C1=C(C=2NC=3C(CCC)=NN(C)C=3C(=O)N=2)C(OCCC)=CC=C1S(=O)(=O)NCCC1CCCN1C IYFNEFQTYQPVOC-UHFFFAOYSA-N 0.000 claims 2
- QMNWYGTWTXOQTP-UHFFFAOYSA-N 1h-triazin-6-one Chemical compound O=C1C=CN=NN1 QMNWYGTWTXOQTP-UHFFFAOYSA-N 0.000 claims 1
- QDPNAMRLQRQPMR-UHFFFAOYSA-N 3-ethyl-5-[5-(4-ethylpiperazin-1-yl)sulfonyl-2-(2-methoxyethoxy)pyridin-3-yl]-2-(pyridin-2-ylmethyl)-4h-pyrazolo[4,3-d]pyrimidin-7-one Chemical compound C1CN(CC)CCN1S(=O)(=O)C1=CN=C(OCCOC)C(C=2NC(=O)C3=NN(CC=4N=CC=CC=4)C(CC)=C3N=2)=C1 QDPNAMRLQRQPMR-UHFFFAOYSA-N 0.000 claims 1
- FFCZQVKVWGGQFB-UHFFFAOYSA-N 9h-pyrido[3,4-b]indole-1,4-dione Chemical compound N1C2=CC=CC=C2C2=C1C(=O)N=CC2=O FFCZQVKVWGGQFB-UHFFFAOYSA-N 0.000 claims 1
- 206010052613 Allergic bronchitis Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical group C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- BQYSXXPIBLDEEG-UHFFFAOYSA-N pyrazino[1,2-b]$b-carboline-1,4-quinone Chemical compound C1=CC=CC2=C3C=C4C(=O)N=CC(=O)N4C=C3N=C21 BQYSXXPIBLDEEG-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03011609 | 2003-05-22 | ||
| PCT/EP2004/050869 WO2004103407A2 (en) | 2003-05-22 | 2004-05-19 | Composition comprising a pde4 inhibitor and a pde5 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528229A JP2006528229A (ja) | 2006-12-14 |
| JP2006528229A5 true JP2006528229A5 (enExample) | 2007-07-05 |
Family
ID=33462087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530210A Pending JP2006528229A (ja) | 2003-05-22 | 2004-05-19 | Ｐｄｅ４阻害剤及びｐｄｅ５阻害剤を含有する組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20060094723A1 (enExample) |
| EP (1) | EP1628682B1 (enExample) |
| JP (1) | JP2006528229A (enExample) |
| KR (1) | KR20060012004A (enExample) |
| CN (1) | CN1791429A (enExample) |
| AU (1) | AU2004241749B2 (enExample) |
| BR (1) | BRPI0410326A (enExample) |
| CA (1) | CA2525946C (enExample) |
| CO (1) | CO5660275A2 (enExample) |
| EA (1) | EA012279B1 (enExample) |
| EC (1) | ECSP056173A (enExample) |
| GE (1) | GEP20084342B (enExample) |
| IL (1) | IL171306A (enExample) |
| IS (1) | IS8181A (enExample) |
| MA (1) | MA27855A1 (enExample) |
| MX (1) | MXPA05012302A (enExample) |
| NO (1) | NO333501B1 (enExample) |
| NZ (1) | NZ544040A (enExample) |
| RS (1) | RS52730B (enExample) |
| TN (1) | TNSN05265A1 (enExample) |
| UA (1) | UA83041C2 (enExample) |
| WO (1) | WO2004103407A2 (enExample) |
| ZA (1) | ZA200508116B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| DE602004023921D1 (de) | 2003-03-10 | 2009-12-17 | Nycomed Gmbh | Neues verfahren zur herstellung vonroflumilast |
| WO2005023253A1 (en) | 2003-09-05 | 2005-03-17 | Altana Pharma Ag | Use of pde4 inhibitors for the treatment of diabetes mellitus |
| EP1755595A1 (en) * | 2004-05-10 | 2007-02-28 | Altana Pharma AG | Use of roflumilast for the prophylaxis or treatment of emphysema |
| WO2006094942A1 (en) * | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| CN102600144A (zh) * | 2005-03-08 | 2012-07-25 | 奈科明有限责任公司 | 治疗糖尿病的罗氟司特 |
| US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| DE102005016345A1 (de) * | 2005-04-09 | 2006-10-12 | Bayer Healthcare Ag | Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| EA016037B1 (ru) * | 2005-04-19 | 2012-01-30 | Никомед Гмбх | Рофлумиласт для лечения лёгочной гипертензии |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| EP2359826B1 (en) | 2006-07-05 | 2013-10-30 | Takeda GmbH | Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases |
| MX2009003673A (es) * | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| WO2010013925A2 (en) * | 2008-07-31 | 2010-02-04 | Dong-A Pharmaceutical. Co., Ltd. | Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof |
| JP2014526461A (ja) * | 2011-09-09 | 2014-10-06 | エスケー ケミカルズ カンパニー，リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| WO2013178362A1 (en) * | 2012-05-31 | 2013-12-05 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma] |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| US10058545B2 (en) * | 2016-08-09 | 2018-08-28 | Cipla Limited | Method of treating pulmonary arterial hypertension |
| CN107648224A (zh) * | 2017-10-31 | 2018-02-02 | 泰州中国医药城中医药研究院 | 一种治疗和预防心力衰竭药物及其在制药中的应用 |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| CN108976107B (zh) * | 2018-08-23 | 2021-03-23 | 南方医科大学 | 3-芳基-4-烷氧基苄胺衍生物及其制备方法和应用 |
| CN116726361A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| WO2021175250A1 (en) * | 2020-03-03 | 2021-09-10 | Aptorum Therapeutics Limited | Compounds and methods for treating diseases and/or conditions caused by coronavirus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| SI0706513T1 (en) | 1993-07-02 | 2002-10-31 | Altana Pharma Ag | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| AU3265695A (en) * | 1994-08-29 | 1996-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Novel naphthyridine derivative and medicinal composition thereof |
| US6127363A (en) * | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| IL135462A0 (en) | 1997-11-12 | 2001-05-20 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| US6417190B1 (en) * | 1998-12-17 | 2002-07-09 | Boehringer Ingelheim Pharma Kg | Tricyclic nitrogen heterocycles as PDE IV inhibitors |
| TW200400821A (en) * | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| HRP20030636B1 (en) * | 2001-02-15 | 2012-05-31 | Nycomed Gmbh | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
| JP2004530705A (ja) * | 2001-05-25 | 2004-10-07 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 閉塞性気道疾患及びその他の炎症性疾患を治療するためのｐｄｅ４インヒビター及びチオトロピウム又はその誘導体の組み合わせ |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US20030216407A1 (en) * | 2002-01-31 | 2003-11-20 | Pfizer Inc. | Use of PDE5 inhibitors in the treatment of scarring |
| GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
-
2004
- 2004-05-19 EA EA200501690A patent/EA012279B1/ru not_active IP Right Cessation
- 2004-05-19 RS YU20050858A patent/RS52730B/sr unknown
- 2004-05-19 JP JP2006530210A patent/JP2006528229A/ja active Pending
- 2004-05-19 WO PCT/EP2004/050869 patent/WO2004103407A2/en not_active Ceased
- 2004-05-19 US US10/556,888 patent/US20060094723A1/en not_active Abandoned
- 2004-05-19 NZ NZ544040A patent/NZ544040A/en not_active IP Right Cessation
- 2004-05-19 UA UAA200511710A patent/UA83041C2/ru unknown
- 2004-05-19 GE GEAP20049115A patent/GEP20084342B/en unknown
- 2004-05-19 KR KR1020057021796A patent/KR20060012004A/ko not_active Ceased
- 2004-05-19 EP EP04766017.0A patent/EP1628682B1/en not_active Expired - Lifetime
- 2004-05-19 CA CA2525946A patent/CA2525946C/en not_active Expired - Fee Related
- 2004-05-19 BR BRPI0410326-2A patent/BRPI0410326A/pt active Search and Examination
- 2004-05-19 AU AU2004241749A patent/AU2004241749B2/en not_active Ceased
- 2004-05-19 MX MXPA05012302A patent/MXPA05012302A/es active IP Right Grant
- 2004-05-19 CN CNA2004800133493A patent/CN1791429A/zh active Pending
-
2005
- 2005-10-07 ZA ZA200508116A patent/ZA200508116B/en unknown
- 2005-10-09 IL IL171306A patent/IL171306A/en not_active IP Right Cessation
- 2005-10-18 TN TNP2005000265A patent/TNSN05265A1/en unknown
- 2005-11-17 EC EC2005006173A patent/ECSP056173A/es unknown
- 2005-12-12 MA MA28653A patent/MA27855A1/fr unknown
- 2005-12-14 IS IS8181A patent/IS8181A/is unknown
- 2005-12-14 NO NO20055941A patent/NO333501B1/no not_active IP Right Cessation
- 2005-12-16 CO CO05126935A patent/CO5660275A2/es active IP Right Grant
-
2010
- 2010-05-24 US US12/785,973 patent/US20100234382A1/en not_active Abandoned
-
2012
- 2012-04-12 US US13/445,675 patent/US20120196867A1/en not_active Abandoned
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