EA012279B1 - Композиция, включающая ингибитор pde4 и ингибитор pde5 - Google Patents
Композиция, включающая ингибитор pde4 и ингибитор pde5 Download PDFInfo
- Publication number
- EA012279B1 EA012279B1 EA200501690A EA200501690A EA012279B1 EA 012279 B1 EA012279 B1 EA 012279B1 EA 200501690 A EA200501690 A EA 200501690A EA 200501690 A EA200501690 A EA 200501690A EA 012279 B1 EA012279 B1 EA 012279B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- pharmaceutically acceptable
- methyl
- acceptable salt
- ρόε5
- Prior art date
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03011609 | 2003-05-22 | ||
| PCT/EP2004/050869 WO2004103407A2 (en) | 2003-05-22 | 2004-05-19 | Composition comprising a pde4 inhibitor and a pde5 inhibitor |
Publications (2)
| Publication Number | Publication Date |
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| EA200501690A1 EA200501690A1 (ru) | 2006-06-30 |
| EA012279B1 true EA012279B1 (ru) | 2009-08-28 |
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Country Status (23)
| Country | Link |
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| EP (1) | EP1628682B1 (enExample) |
| JP (1) | JP2006528229A (enExample) |
| KR (1) | KR20060012004A (enExample) |
| CN (1) | CN1791429A (enExample) |
| AU (1) | AU2004241749B2 (enExample) |
| BR (1) | BRPI0410326A (enExample) |
| CA (1) | CA2525946C (enExample) |
| CO (1) | CO5660275A2 (enExample) |
| EA (1) | EA012279B1 (enExample) |
| EC (1) | ECSP056173A (enExample) |
| GE (1) | GEP20084342B (enExample) |
| IL (1) | IL171306A (enExample) |
| IS (1) | IS8181A (enExample) |
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| UA (1) | UA83041C2 (enExample) |
| WO (1) | WO2004103407A2 (enExample) |
| ZA (1) | ZA200508116B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| ME00524B (me) | 2003-03-10 | 2011-10-10 | Astrazeneca Ab | Novi postupak za dobijanje roflumilasta |
| WO2005023253A1 (en) | 2003-09-05 | 2005-03-17 | Altana Pharma Ag | Use of pde4 inhibitors for the treatment of diabetes mellitus |
| US20070254928A1 (en) * | 2004-05-10 | 2007-11-01 | Altana Pharma Ag | Use of Roflumilast for the Prophylaxis or Treatment of Emphysema |
| EP1874308A1 (en) | 2005-03-08 | 2008-01-09 | Nycomed GmbH | Roflumilast for the treatment of diabetes mellitus |
| WO2006094942A1 (en) * | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| EP1861074B1 (en) | 2005-03-16 | 2013-04-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| DE102005016345A1 (de) * | 2005-04-09 | 2006-10-12 | Bayer Healthcare Ag | Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| KR101358479B1 (ko) | 2005-04-19 | 2014-02-06 | 다케다 게엠베하 | 폐고혈압 치료용 로플루밀라스트 |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| UA98466C2 (uk) | 2006-07-05 | 2012-05-25 | Нікомед Гмбх | КОМБІНАЦІЯ ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ Й ІНГІБІТОРА ФОСФОДІЕСТЕРАЗИ 4, ПРИЗНАЧЕНА ДЛЯ ЛІКУВАННЯ ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ ЛЕГЕНІВ |
| KR101129868B1 (ko) * | 2006-10-04 | 2012-04-12 | 화이자 프로덕츠 인코포레이티드 | 칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체 |
| WO2010013925A2 (en) * | 2008-07-31 | 2010-02-04 | Dong-A Pharmaceutical. Co., Ltd. | Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof |
| JP2014526461A (ja) * | 2011-09-09 | 2014-10-06 | エスケー ケミカルズ カンパニー，リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| EA201791271A1 (ru) * | 2012-05-31 | 2018-01-31 | Фенекс Фармасьютикалз Аг | ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| US10058545B2 (en) * | 2016-08-09 | 2018-08-28 | Cipla Limited | Method of treating pulmonary arterial hypertension |
| CN107648224A (zh) * | 2017-10-31 | 2018-02-02 | 泰州中国医药城中医药研究院 | 一种治疗和预防心力衰竭药物及其在制药中的应用 |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| CN108976107B (zh) * | 2018-08-23 | 2021-03-23 | 南方医科大学 | 3-芳基-4-烷氧基苄胺衍生物及其制备方法和应用 |
| CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2021175250A1 (en) * | 2020-03-03 | 2021-09-10 | Aptorum Therapeutics Limited | Compounds and methods for treating diseases and/or conditions caused by coronavirus |
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| WO2002064584A1 (en) * | 2001-02-15 | 2002-08-22 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
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| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| CZ290266B6 (cs) | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| NZ291507A (en) * | 1994-08-29 | 1997-12-19 | Yamanouchi Pharma Co Ltd | 1,8-naphthyridine derivatives; medicaments |
| US6127363A (en) * | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| HU230154B1 (hu) | 1997-11-12 | 2015-09-28 | Bayer Intellectual Property Gmbh | Eljárás 2-es helyzetben fenil-szubszituenst hordozó imidazo-triazinon-származékok előállítására |
| US6417190B1 (en) * | 1998-12-17 | 2002-07-09 | Boehringer Ingelheim Pharma Kg | Tricyclic nitrogen heterocycles as PDE IV inhibitors |
| TW200400821A (en) * | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| JP2004530705A (ja) * | 2001-05-25 | 2004-10-07 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 閉塞性気道疾患及びその他の炎症性疾患を治療するためのｐｄｅ４インヒビター及びチオトロピウム又はその誘導体の組み合わせ |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US20030216407A1 (en) * | 2002-01-31 | 2003-11-20 | Pfizer Inc. | Use of PDE5 inhibitors in the treatment of scarring |
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- 2004-05-19 CN CNA2004800133493A patent/CN1791429A/zh active Pending
- 2004-05-19 UA UAA200511710A patent/UA83041C2/ru unknown
- 2004-05-19 JP JP2006530210A patent/JP2006528229A/ja active Pending
- 2004-05-19 WO PCT/EP2004/050869 patent/WO2004103407A2/en not_active Ceased
- 2004-05-19 MX MXPA05012302A patent/MXPA05012302A/es active IP Right Grant
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- 2004-05-19 BR BRPI0410326-2A patent/BRPI0410326A/pt active Search and Examination
- 2004-05-19 RS YU20050858A patent/RS52730B/sr unknown
- 2004-05-19 US US10/556,888 patent/US20060094723A1/en not_active Abandoned
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- 2005-11-17 EC EC2005006173A patent/ECSP056173A/es unknown
- 2005-12-12 MA MA28653A patent/MA27855A1/fr unknown
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- 2005-12-16 CO CO05126935A patent/CO5660275A2/es active IP Right Grant
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| WO2002064584A1 (en) * | 2001-02-15 | 2002-08-22 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
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Also Published As
| Publication number | Publication date |
|---|---|
| CO5660275A2 (es) | 2006-07-31 |
| NZ544040A (en) | 2009-03-31 |
| AU2004241749A1 (en) | 2004-12-02 |
| KR20060012004A (ko) | 2006-02-06 |
| AU2004241749B2 (en) | 2010-03-25 |
| IS8181A (is) | 2005-12-14 |
| JP2006528229A (ja) | 2006-12-14 |
| WO2004103407A3 (en) | 2005-02-17 |
| CA2525946A1 (en) | 2004-12-02 |
| EP1628682A2 (en) | 2006-03-01 |
| UA83041C2 (ru) | 2008-06-10 |
| ZA200508116B (en) | 2007-01-31 |
| TNSN05265A1 (en) | 2007-07-10 |
| GEP20084342B (en) | 2008-03-25 |
| RS52730B (sr) | 2013-08-30 |
| WO2004103407A2 (en) | 2004-12-02 |
| CN1791429A (zh) | 2006-06-21 |
| EA200501690A1 (ru) | 2006-06-30 |
| ECSP056173A (es) | 2006-04-19 |
| US20060094723A1 (en) | 2006-05-04 |
| RS20050858A (sr) | 2007-12-31 |
| US20100234382A1 (en) | 2010-09-16 |
| NO333501B1 (no) | 2013-06-24 |
| BRPI0410326A (pt) | 2006-05-23 |
| MA27855A1 (fr) | 2006-04-03 |
| EP1628682B1 (en) | 2013-09-25 |
| IL171306A (en) | 2013-08-29 |
| NO20055941L (no) | 2005-12-14 |
| US20120196867A1 (en) | 2012-08-02 |
| CA2525946C (en) | 2013-01-29 |
| MXPA05012302A (es) | 2006-01-30 |
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